Fusion between Hematopoietic and Epithelial Cells in Adult Human Intestine

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Silk, Alain D ^a,b   Gast, Charles E ^b   Davies, Paige S ^a,b   Fakhari, Farnaz D ^a   Vanderbeek, Gretchen E ^a   Mori, Motomi ^b   Wong, Melissa H ^a,b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CELL FUSION; CELL LINEAGE; CELL NUCLEUS; CLINICAL ARTICLE; EPITHELIUM CELL; FEMALE; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; INTESTINE; INTESTINE EPITHELIUM; INTESTINE EPITHELIUM CELL; MALE; QUANTITATIVE ANALYSIS; STATISTICAL ANALYSIS; X CHROMOSOME; Y CHROMOSOME;

ADULT; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; CELL FUSION; CHROMOSOMES, HUMAN, X; EPITHELIAL CELLS; FEMALE; HUMANS; INTESTINES; KARYOTYPE; MALE; REPRODUCIBILITY OF RESULTS; TISSUE DONORS;

EID: 84873801060     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0055572     Document Type: Article

References (25)

1. Jiang S, Walker L, Afentoulis M, Anderson DA, Jauron-Mills L, et al. (2004) Transplanted human bone marrow contributes to vascular endothelium. Proc Natl Acad Sci U S A 101: 16891-16896.
2. Okamoto R, Yajima T, Yamazaki M, Kanai T, Mukai M, et al. (2002) Damaged epithelia regenerated by bone marrow-derived cells in the human gastrointestinal tract. Nat Med 8: 1011-1017.
3. Theise ND, Nimmakayalu M, Gardner R, Illei PB, Morgan G, et al. (2000) Liver from bone marrow in humans. Hepatology 32: 11-16.
4. Weimann JM, Charlton CA, Brazelton TR, Hackman RC, Blau HM, (2003) Contribution of transplanted bone marrow cells to Purkinje neurons in human adult brains. Proc Natl Acad Sci U S A 100: 2088-2093.
5. Yilmaz Y, Lazova R, Qumsiyeh M, Cooper D, Pawelek J, (2005) Donor Y chromosome in renal carcinoma cells of a female BMT recipient: visualization of putative BMT-tumor hybrids by FISH. Bone Marrow Transplant 35: 1021-1024.
6. Johansson CB, Youssef S, Koleckar K, Holbrook C, Doyonnas R, et al. (2008) Extensive fusion of haematopoietic cells with Purkinje neurons in response to chronic inflammation. Nat Cell Biol 10: 575-583.
7. Weimann JM, Johansson CB, Trejo A, Blau HM, (2003) Stable reprogrammed heterokaryons form spontaneously in Purkinje neurons after bone marrow transplant. Nat Cell Biol 5: 959-966.
8. Bailey AS, Willenbring H, Jiang S, Anderson DA, Schroeder DA, et al. (2006) Myeloid lineage progenitors give rise to vascular endothelium. Proc Natl Acad Sci U S A 103: 13156-13161.
9. Fujino H, Hiramatsu H, Tsuchiya A, Niwa A, Noma H, et al. (2007) Human cord blood CD34+ cells develop into hepatocytes in the livers of NOD/SCID/gamma(c)null mice through cell fusion. Faseb J 21: 3499-3510.
10. Newsome PN, Johannessen I, Boyle S, Dalakas E, McAulay KA, et al. (2003) Human cord blood-derived cells can differentiate into hepatocytes in the mouse liver with no evidence of cellular fusion. Gastroenterology 124: 1891-1900.
11. Wang X, Willenbring H, Akkari Y, Torimaru Y, Foster M, et al. (2003) Cell fusion is the principal source of bone-marrow-derived hepatocytes. Nature 422: 897-901.
12. Alvarez-Dolado M, Pardal R, Garcia-Verdugo JM, Fike JR, Lee HO, et al. (2003) Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature 425: 968-973.
13. Camargo FD, Green R, Capetanaki Y, Jackson KA, Goodell MA, (2003) Single hematopoietic stem cells generate skeletal muscle through myeloid intermediates. Nat Med 9: 1520-1527.
14. Rizvi AZ, Swain JR, Davies PS, Bailey AS, Decker AD, et al. (2006) Bone marrow-derived cells fuse with normal and transformed intestinal stem cells. Proc Natl Acad Sci U S A 103: 6321-6325.
15. Korbling M, Katz RL, Khanna A, Ruifrok AC, Rondon G, et al. (2002) Hepatocytes and epithelial cells of donor origin in recipients of peripheral-blood stem cells. N Engl J Med 346: 738-746.
16. Powell AE, Anderson EC, Davies PS, Silk AD, Pelz C, et al. (2011) Fusion between Intestinal epithelial cells and macrophages in a cancer context results in nuclear reprogramming. Cancer Res 71: 1497-1505.
17. Davies PS, Powell AE, Swain JR, Wong MH, (2009) Inflammation and proliferation act together to mediate intestinal cell fusion. PLoS One 4: e6530.
18. Spyridonidis A, Schmitt-Graff A, Tomann T, Dwenger A, Follo M, et al. (2004) Epithelial tissue chimerism after human hematopoietic cell transplantation is a real phenomenon. Am J Pathol 164: 1147-1155.
19. Ham AW, Cormack DH (1979) Histology.Philadelphia: Lippincott. xvi, 966 p., [969] leaves of plates p.
20. Uhlen M, Oksvold P, Fagerberg L, Lundberg E, Jonasson K, et al. (2010) Towards a knowledge-based Human Protein Atlas. Nat Biotechnol 28: 1248-1250.
21. Quintana-Bustamante O, Grueso E, Garcia-Escudero R, Arza E, Alvarez-Barrientos A, et al. (2012) Cell fusion reprogramming leads to a specific hepatic expression pattern during mouse bone marrow derived hepatocyte formation in vivo. PLoS One 7: e33945.
22. Vassilopoulos G, Wang PR, Russell DW, (2003) Transplanted bone marrow regenerates liver by cell fusion. Nature 422: 901-904.
23. Nygren JM, Liuba K, Breitbach M, Stott S, Thoren L, et al. (2008) Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion. Nat Cell Biol 10: 584-592.
24. Diaz D, Recio JS, Weruaga E, Alonso JR, (2012) Mild cerebellar neurodegeneration of aged heterozygous PCD mice increases cell fusion of Purkinje and bone marrow-derived cells. Cell Transplant.
25. Kemp K, Gray E, Wilkins A, Scolding N, (2012) Purkinje cell fusion and binucleate heterokaryon formation in multiple sclerosis cerebellum. Brain.