Assessing powder segregation potential by near infrared (NIR) spectroscopy and correlating segregation tendency to tabletting performance

Powder Technology

Volumn 236, Issue , 2013, Pages 85-99

  He, Xiaorong ^a   Han, Xi ^b   Ladyzhynsky, Nadia ^a   Deanne, Richard ^a  

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^b NEW JERSEY INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Cohesion; Content uniformity; Dry powder coating; Near Infrared; NIR; PAT; Segregation

Indexed keywords

COHESION; CONTENT UNIFORMITY; DRY POWDER COATINGS; NEAR INFRARED; NIR; PAT;

ADHESION; DRUG PRODUCTS; FLUIDIZATION; INFRARED DEVICES; MANUFACTURE; PARTICLE SIZE; POWDER COATINGS; SUGARS;

SEGREGATION (METALLOGRAPHY);

ACETYLSALICYLIC ACID; EXCIPIENT; LACTOSE; MAGNESIUM STEARATE; MICROCRYSTALLINE CELLULOSE;

ARTICLE; CONTROLLED STUDY; DRUG COATING; DRUG DOSAGE FORM COMPARISON; FLUIDIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NEAR INFRARED SPECTROSCOPY; PARTICLE SIZE; PHYSICAL PHENOMENA; POWDER; POWDER SEGREGATION; QUANTITATIVE ANALYSIS; SCANNING ELECTRON MICROSCOPY; SHEAR STRENGTH; TABLET CONTENT UNIFORMITY; TABLET FORMULATION; TABLET MANUFACTURE; TABLET PROPERTY;

EID: 84873745922     PISSN: 00325910     EISSN: 1873328X     Source Type: Journal    
DOI: 10.1016/j.powtec.2012.05.021     Document Type: Article

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