Autophagy is involved in nanoalumina-induced cerebrovascular toxicity

Nanomedicine: Nanotechnology, Biology, and Medicine

Volumn 9, Issue 2, 2013, Pages 212-221

  Chen, Lei ^a,b   Zhang, Bei ^a,c   Toborek, Michal ^a,c  

^a UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Autophagy; Blood brain barrier; Central nervous system; Nanoalumina

Indexed keywords

AUTOPHAGY; BLOOD-BRAIN BARRIER; BRAIN INFARCT; CENTRAL NERVOUS SYSTEMS; CEREBRAL CIRCULATION; DOSE-DEPENDENT; ENGINEERED NANOMATERIALS; ISCHEMIC STROKES; NANO-ALUMINA; NANO-CARBON; OCCLUDIN; PRE-TREATMENT; PROTEIN EXPRESSIONS; WORTMANNIN;

BLOOD; ENDOTHELIAL CELLS; GENE EXPRESSION; MAMMALS; PROTEINS; TOXICITY;

BRAIN;

ALUMINUM OXIDE; CLAUDIN 5; NANOALUMINA; NANOMATERIAL; OCCLUDIN; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOLYSOSOME; AUTOPHAGY; BLOOD BRAIN BARRIER; BRAIN CELL; BRAIN CIRCULATION; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CELL MEMBRANE POTENTIAL; CEREBROVASCULAR DISEASE; CIRCULATION; CONTROLLED STUDY; ELECTROENCEPHALOGRAM; ENDOTHELIUM CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; MALE; MIDDLE CEREBRAL ARTERY; MOUSE; NEUROTOXICITY; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SYSTEMIC THERAPY;

ALUMINUM OXIDE; ANIMALS; AUTOPHAGY; BLOOD-BRAIN BARRIER; BRAIN; CELL LINE; CEREBROVASCULAR CIRCULATION; GENE EXPRESSION REGULATION; HUMANS; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED C57BL; NANOSTRUCTURES; PERMEABILITY; PROTEOLYSIS;

MUS;

EID: 84873745470     PISSN: 15499634     EISSN: 15499642     Source Type: Journal    
DOI: 10.1016/j.nano.2012.05.017     Document Type: Article

References (21)

1. Service R.F. Nanotoxicology. Nanotechnology grows up. Science 2004, 304:1732-1734.
2. Kagan V.E., Bayir H., Shvedova A.A. Nanomedicine and nanotoxicology: two sides of the same coin. Nanomed Nanotechnol Biol Med 2005, 1:313-316.
3. Nel A., Xia T., Madler L., Li N. Toxic potential of materials at the nanolevel. Science 2006, 311:622-627.
4. Bondy S.C. The neurotoxicity of environmental aluminum is still an issue. Neurotoxicology 2010, 31:575-581.
5. Oesterling E., Chopra N., Gavalas V., Arzuaga X., Lim E.J., Sultana R., et al. Alumina nanoparticles induce expression of endothelial cell adhesion molecules. Toxicol Lett 2008, 178:160-166.
6. Chen L., Yokel R.A., Hennig B., Toborek M. Manufactured aluminum oxide nanoparticles decrease expression of tight junction proteins in brain vasculature. J Neuroimmune Pharmacol 2008, 3:286-295.
7. Zlokovic B.V. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron 2008, 57:178-201.
8. Cuervo A.M. Autophagy: in sickness and in health. Trends Cell Biol 2004, 14:70-77.
9. 2-DNA nanoconjugate stability. Small 2009, 5:1318-1325.
10. Thurn K.T., Arora H., Paunesku T., Wu A., Brown E.M., Doty C., et al. Endocytosis of titanium dioxide nanoparticles in prostate cancer PC-3M cells. Nanomed Nanotechnol Biol Med 2011, 7:123-130.
11. Vazquez C.L., Colombo M.I. Assays to assess autophagy induction and fusion of autophagic vacuoles with a degradative compartment, using monodansylcadaverine (MDC) and DQ-BSA. Methods Enzymol 2009, 452:85-95.
12. McLeland C.B., Rodriguez J., Stern S.T. Autophagy monitoring assay: qualitative analysis of MAP LC3-I to II conversion by immunoblot. Methods Mol Biol 2011, 697:199-206.
13. Chen L., Swartz K.R., Toborek M. Vessel microport technique for applications in cerebrovascular research. J Neurosci Res 2009, 87:1718-1727.
14. Neun B.W., Stern S.T. Monitoring lysosomal activity in nanoparticle-treated cells. Methods Mol Biol 2011, 697:207-212.
15. Komatsu M., Ichimura Y. Physiological significance of selective degradation of p62 by autophagy. FEBS Lett 2010, 584:1374-1378.
16. Levine B., Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008, 132:27-42.
17. Hailey D.W., Rambold A.S., Satpute-Krishnan P., Mitra K., Sougrat R., Kim P.K., et al. Mitochondria supply membranes for autophagosome biogenesis during starvation. Cell 2010, 141:656-667.
18. Nixon R.A. Autophagy in neurodegenerative disease: friend, foe or turncoat?. Trends Neurosci 2006, 29:528-535.
19. Zhong Y., Hennig B., Toborek M. Intact lipid rafts regulate HIV-1 Tat protein-induced activation of the Rho signaling and upregulation of P-glycoprotein in brain endothelial cells. J Cereb Blood Flow Metab 2010, 30:522-533.
20. Andras I.E., Pu H., Tian J., Deli M.A., Nath A., Hennig B., et al. Signaling mechanisms of HIV-1 Tat-induced alterations of claudin-5 expression in brain endothelial cells. J Cereb Blood Flow Metab 2005, 25:1159-1170.
21. Blommaart E.F., Krause U., Schellens J.P., Vreeling-Sindelarova H., Meijer A.J. The phosphatidylinositol 3-kinase inhibitors Wortmannin and Ly294002 inhibit autophagy in isolated rat hepatocytes. Eur J Biochem 1997, 243:240-246.