Discovery and structure-activity relationships of small molecules that block the human immunoglobulin G-human neonatal Fc receptor (hIgG-hFcRn) protein-protein interaction

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 5, 2013, Pages 1253-1256

  Wang, Zhaolin ^a,b   Fraley, Cara ^a,c   Mezo, Adam R ^a,d  

^a BIOGEN   (United States)

^b Ra Pharmaceuticals   (United States)

^c BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^d ELI LILLY AND COMPANY   (United States)

Author keywords

FcRn; Inhibitor; Neonatal Fc receptor; Protein protein interactions; Small molecule

Indexed keywords

AUTOANTIBODY; FC RECEPTOR; HUMAN IMMUNOGLOBULIN G; IMMUNOGLOBULIN G; LIGAND; NEONATAL FC RECEPTOR; PEPTIDE DERIVATIVE; QUINOXALINE DERIVATIVE; SYN 1327; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; EXTRACELLULAR MATRIX; IC 50; IN VITRO STUDY; MOLECULE; PROCESS OPTIMIZATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION; VIRTUAL REALITY;

DRUG EVALUATION, PRECLINICAL; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; IMMUNOGLOBULIN G; LIGANDS; PROTEIN INTERACTION DOMAINS AND MOTIFS; QUINOXALINES; RECEPTORS, FC; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84873744195     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.01.014     Document Type: Article

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