Incorporation of β-amino acids into dihydrofolate reductase by ribosomes having modifications in the peptidyltransferase center

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 5, 2013, Pages 1088-1096

  Maini, Rumit ^a   Nguyen, Dan T ^a   Chen, Shengxi ^a   Dedkova, Larisa M ^a   Chowdhury, Sandipan Roy ^a   Alcala Torano, Rafael ^a   Hecht, Sidney M ^a  

^a ARIZONA STATE UNIVERSITY   (United States)

Author keywords

Aminoacylation; Beta amino acids; Modified ribosomes; Protein synthesis

Indexed keywords

ALANINE; ALPHA AMINO ACID; ALPHA METHYL BETA ALANINE; BETA (4 BROMOPHENYL)ALANINE; BETA ALANINE; BETA AMINO ACID; BETA,BETA DIMETHYL BETA ALANINE; DIHYDROFOLATE REDUCTASE; GLUTAMIC ACID; GLYCINE; MESSENGER RNA; N 4 PENTENOYL BETA (4 BROMOPHENYL)ALANINE CYANOMETHYL ESTER; PEPTIDE FRAGMENT; PEPTIDYLTRANSFERASE; PHENYLALANINE; RNA 23S; TRANSFER RNA; UNCLASSIFIED DRUG; URACIL;

AMINO ACID METABOLISM; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CLONE; CODON; CONFORMATIONAL TRANSITION; ENZYME INHIBITION; ENZYME MODIFICATION; ENZYME STRUCTURE; ESCHERICHIA COLI; IN VITRO STUDY; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN ISOLATION; PROTEIN STABILITY; PROTEIN SYNTHESIS; RIBOSOMAL PEPTIDYLTRANSFERASE CENTER; RIBOSOME;

AMINO ACID SEQUENCE; AMINO ACIDS; BETA-ALANINE; ESCHERICHIA COLI; MOLECULAR SEQUENCE DATA; PEPTIDES; RIBOSOMES; RNA, RIBOSOMAL, 23S; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TETRAHYDROFOLATE DEHYDROGENASE;

ESCHERICHIA COLI;

EID: 84873741680     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.01.002     Document Type: Article

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