High-resolution HLA haplotype frequencies of stem cell donors in Germany with foreign parentage: How can they be used to improve unrelated donor searches?

Human Immunology

Volumn 74, Issue 3, 2013, Pages 330-340

  Pingel, Julia ^a   Solloch, Ute V ^a   Hofmann, Jan A ^a   Lange, Vinzenz ^b   Ehninger, Gerhard ^c   Schmidt, Alexander H ^a,b  

^a DKMS German Bone Marrow Donor Center   (Germany)

^b DKMS Life Science Lab   (Germany)

^c UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

HLA A ANTIGEN; HLA B ANTIGEN; HLA C ANTIGEN; HLA DQB1 ANTIGEN; HLA DRB1 ANTIGEN;

ALGORITHM; ARTICLE; AUSTRIA; BOSNIA AND HERZEGOVINA; CALCULATION; CHINA; CROATIA; FRANCE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC DIFFERENCE; GENETIC DISTANCE; GEOGRAPHY; GERMANY; GREECE; HAPLOTYPE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HETEROZYGOSITY; HLA SYSTEM; HUMAN; ITALY; KAZAKHSTAN; NETHERLANDS; PARENTHOOD; PHENOTYPE; POLAND; PORTUGAL; PRIORITY JOURNAL; PROBABILITY; REFERENCE DATABASE; ROMANIA; RUSSIAN FEDERATION; SPAIN; TURKEY (REPUBLIC); UNITED KINGDOM; UNITED STATES; UNRELATED DONORS;

AUSTRIA; BOSNIA-HERZEGOVINA; CROATIA; FRANCE; GENE FREQUENCY; GERMANY; GREAT BRITAIN; GREECE; HAPLOTYPES; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HISTOCOMPATIBILITY TESTING; HLA ANTIGENS; HUMANS; ITALY; KAZAKHSTAN; NETHERLANDS; POLAND; PORTUGAL; ROMANIA; RUSSIA; SPAIN; TAIWAN; TISSUE DONORS; TURKEY; UNITED STATES; UNRELATED DONORS;

EID: 84873739067     PISSN: 01988859     EISSN: 18791166     Source Type: Journal    
DOI: 10.1016/j.humimm.2012.10.029     Document Type: Article

References (27)

1. Gratwohl A., Baldomero H., Aljurf M., Pasquini M.C., Bouzas L.F., Yoshimi A., et al. Hematopoietic stem cell transplantation. JAMA 2010, 303:1617-1624.
2. Oran B., Weisdorf D. Allogeneic stem cell transplantation in first complete remission. Curr Opin Hematol 2011, 18:395-400.
3. Gaziev J., Lucarelli G. Hematopoietic stem cell transplantation for thalassemia. Curr Stem Cell Res Ther 2011, 6:162-169.
4. Ayala E., Tomblyn M. Hematopoietic cell transplantation for lymphomas. Cancer Control 2011, 18:246-257.
5. Andersson B. Advances in CML: the role of allogeneic hematopoietic stem cell transplantation. Clin Adv Hematol Oncol 2010, 8:746-748.
6. Cutler C. Allogeneic hematopoietic stem-cell transplantation for Myelodysplastic Syndrome. ASH Education Program Book, 2010; 1:325-9.
7. Lee S.J., Klein J., Haagenson M., Baxter-Lowe L.A., Confer D.L., Eapen M., et al. High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation. Blood 2007, 110:4576-4583.
8. Voorter C.E.M., Mulkers E., Liebelt P., Sleyster E., Van Den Berg-Loonen E.M. Reanalysis of sequence-based HLA-A, -B and -Cw typings: how ambiguous is today's SBT typing tomorrow. Tissue Antigens 2007, 70:383-389.
9. Bone Marrow Donors Worldwide. Numbers of donors in registries. http://www.bmdw.org/index.php?id=statistics. Accessed: 11-10-2012.
10. Bochtler W., Beth M., Eberhard H.P., Müller C.R. OptiMatch - a universally configurable HLA matching framework. Tissue Antigens 2008, 71:321. Abstract.
11. Spellman S., Setterholm M., Maiers M., Noreen H., Oudshoorn M., Fernandez-Vina M., et al. Advances in the selection of HLA-compatible donors: refinements in HLA typing and matching over the first 20 years of the National Marrow Donor Program Registry. Biol Blood Marrow Transplant 2008, 14:37-44.
12. Maiers M., Setterholm M. 113-P: Haplogic: the NMDP registry match algorithm. Hum Immunol 2006, 67:S127. Abstract.
13. Schmidt A.H., Solloch U.V., Pingel J., Baier D., Böhme I., Dubicka K., et al. High-resolution HLA allele and haplotype frequencies of the Polish population based on 20,653 stem cell donors. Hum Immunol 2011, 72:558-565.
14. Gonzalez-Galarza F.F., Christmas S., Middleton D., Jones A.R. Allele frequency net: a database and online repository for immune gene frequencies in worldwide populations. Nucleic Acids Res 2011, 39:D913-D919.
15. Schmidt A.H., Stahr A., Baier D., Schumacher S., Ehninger G., Rutt C. Selective recruitment of stem cell donors with rare human leukocyte antigen phenotypes. Bone Marrow Transplant 2007, 40:823-830.
16. Sanchez-Mazas A., Vidan-Jeras B., Nunes J.M., Fischer G., Little A.M., Bekmane U., et al. Strategies to work with HLA data in human populations for histocompatibility, clinical transplantation, epidemiology and population genetics: HLA-NET methodological recommendations. Int J Immunogenet 2012, 39:459-476.
17. Robinson J., Mistry K., McWilliam H., Lopez R., Parham P., Marsh S.G. The IMGT/HLA database. Nucleic Acids Res 2011, 39:D1171-D1176.
18. Schmidt A.H., Baier D., Solloch U.V., Stahr A., Cereb N., Wassmuth R., et al. Estimation of high-resolution HLA-A, -B, -C, -DRB1 allele and haplotype frequencies based on 8862 German stem cell donors and implications for strategic donor registry planning. Hum Immunol 2009, 70:895-902.
19. Bochtler W., Maiers M., Oudshoorn M., Marsh S.G.E., Raffoux C., Mueller C., et al. World marrow donor association guidelines for use of HLA nomenclature and its validation in the data exchange among hematopoietic stem cell donor registries and cord blood banks. Bone Marrow Transplant 2007, 39:737-741.
20. Excoffier L., Laval G., Schneider S. Arlequin (version 3.0): an integrated software package for population genetics data analysis. Evol Bioinform Online 2005, 1:47-50.
21. Müller C.R., Ehninger G., Goldmann S.F. Gene and haplotype frequencies for the loci HLA-A, HLA-B, and HLA-DR based on over 13,000 German blood donors. Hum Immunol 2003, 64:137-151.
22. Begovich A.B., McClure G.R., Suraj V.C., Helmuth R.C., Fildes N., Bugawan T.L., et al. Polymorphism, recombination, and linkage disequilibrium within the HLA Class II region. J Immunol 1992, 148:249-258.
23. Cavalli-Sforza L.L., Edwards A.W.F. Phylogenetic analysis. Models and estimation procedures. Am J Hum Genet 1967, 19:233-257.
24. Eberhard H-P Schätzung von hochaufgelösten HLA-Haplotypfrequenzen deutscher Blutstammzellspender und ihre Anwendung bei der Patientenversorgung 2010, Universität Ulm.
25. Schmidt A.H., Solloch U.V., Baier D., Stahr A., Wassmuth R., Ehninger G., et al. Regional differences in HLA antigen and haplotype frequency distributions in Germany and their relevance to the optimization of hematopoietic stem cell donor recruitment. Tissue Antigens 2010, 76:362-379.
26. Schmidt A.H., Solloch U.V., Baier D., Yazici B., Ozcan M., Stahr A., et al. Criteria for initiation and evaluation of minority donor programs and application to the example of donors of Turkish descent in Germany. Bone Marrow Transplant 2009, 44:405-412.
27. Ruzzante D.E. A comparison of several measures of genetic distance and population structure with microsatellite data: bias and sampling variance. Can J Fish Aquat Sci 1998, 55:1-14.