Regional differences in HLA antigen and haplotype frequency distributions in Germany and their relevance to the optimization of hematopoietic stem cell donor recruitment

Tissue Antigens

Volumn 76, Issue 5, 2010, Pages 362-379

  Schmidt, A H ^a   Solloch, U V ^a   Baier, D ^a   Stahr, A ^a   Wassmuth, R ^b,c   Ehninger, G ^c   Rutt, C ^a  

^a DKMS German Bone Marrow Donor Center   (Germany)

^b DKMS Life Science Lab   (Germany)

^c UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

Author keywords

Antigen frequency; Donor registry; Haplotype frequency; Human leukocyte antigen; Regional genetic differences

Indexed keywords

HLA A ANTIGEN; HLA B ANTIGEN; HLA DR ANTIGEN;

ARTICLE; DONOR; GENE FREQUENCY; GENETIC DISTANCE; GENETIC VARIABILITY; GEOGRAPHIC DISTRIBUTION; GERMANY; HAPLOTYPE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL;

ALLELES; FEMALE; GENE FREQUENCY; GENES, MHC CLASS I; GENES, MHC CLASS II; GERMANY; HAPLOTYPES; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HETEROZYGOTE; HLA ANTIGENS; HLA-A ANTIGENS; HLA-B ANTIGENS; HLA-DR ANTIGENS; HUMANS; MALE; REGISTRIES; TISSUE AND ORGAN PROCUREMENT; TISSUE DONORS;

EID: 78649380752     PISSN: 00012815     EISSN: 13990039     Source Type: Journal    
DOI: 10.1111/j.1399-0039.2010.01520.x     Document Type: Article

References (26)

1. Müller CR, Ehninger G, Goldmann SF. Gene and haplotype frequencies for the loci HLA-A, HLA-B, and HLA-DR based on over 13,000 German blood donors. Hum Immunol 2003: 64: 137-51.
2. Kollman C, Abella E, Baitty RL, et al. Assessment of optimal size and composition of the US National Registry of hematopoietic stem cell donors. Transplantation 2004: 78: 89-95.
3. Schmidt AH, Baier D, Solloch UV, et al. Estimation of high-resolution HLA-A, -B, -C, -DRB1 allele and haplotype frequencies based on 8862 German stem cell donors and implications for strategic donor registry planning. Hum Immunol 2009: 70: 895-902.
4. Kollman C, Howe CW, Anasetti C, et al. Donor characteristics as risk factors in recipients after transplantation of bone marrow from unrelated donors: the effect of donor age. Blood 2001: 98: 2043-51.
5. Confer DL, Miller JP. Optimal donor selection: beyond HLA. Biol Blood Marrow Transplant 2007: 13 (Suppl 1): 83-6.
6. Schmidt AH, Biesinger L, Baier D, Harf P, Rutt C. Aging of registered stem cell donors: implications for donor recruitment. Bone Marrow Transplant 2008: 41: 605-12.
7. Confer DL. The National Marrow Donor Program: meeting the needs of the medically underserved. Cancer 2001: 91: 274-8.
8. Schmidt AH, Solloch UV, Baier D, et al. Criteria for initiation and evaluation of minority donor programs and application to the example of donors of Turkish descent in Germany. Bone Marrow Transplant 2009: 44: 405-12.
9. Schmidt AH, Stahr A, Baier D, Schumacher S, Ehninger G, Rutt C. Selective recruitment of stem cell donors with rare human leukocyte antigen phenotypes. Bone Marrow Transplant 2007: 40: 823-30.
10. Lonjou C, Clayton J, Cambon-Thomsen A, Raffoux C. HLA-A, -B, -DR haplotype frequencies in France-implications for recruitment of potential stem cell donors. Transplantation 1995: 60: 375-83.
11. Rendine S, Borelli I, Barbanti M, Sacchi N, Roggero S, Curtoni ES. HLA polymorphisms in Italian bone marrow donors: a regional analysis. Tissue Antigens 1998: 52: 135-46.
12. von Keller JR. Analyse der populationsgenetischen Daten der DKMS Deutsche Knochenmarkspenderdatei. Tübingen: Eberhard Karls University, 1998.
13. Marroni F, Curcio M, Fornaciari S, et al. Microgeographic variation of HLA-A, -B, and -DR haplotype frequencies in Tuscany, Italy: implications for recruitment of bone marrow donors. Tissue Antigens 2004: 64: 478-85.
14. Lehmann SJ, Walter H, Zockler H. Über die Verteilung der Antigene des Haupthistokompatibilitätskomplexes im Raum Bremen. Anthropol Anz 1986: 44: 315-33.
15. Kowald B, Kuhn M, Walter H, Diekamp U, Stangel W, Erichsen K. Untersuchungen zur Populationsgenetik des HLA-Polymorphismus bei Blutspendern aus Bremen und Hannover. Anthropol Anz 1990: 48: 37-63.
16. Marsh SGE. http://hla.alleles.org/wmda/rel_dna_ser.txt. Last accessed on 14 July 2009.
17. Excoffier L, Laval G, Schneider S. ARLEQUIN (version 3.0): an integrated software package for population genetics data analysis. Evol Bioinform Online 2005: 1: 47-50.
18. Cavalli-Sforza LL, Edwards AW. Phylogenetic analysis. Models and estimation procedures. Am J Hum Genet 1967: 19: 233-57.
19. Simpson EH. Measurement of diversity. Nature 1949: 163: 688.
20. Spellman S, Setterholm M, Maiers M, et al. Advances in the selection of HLA-compatible donors: refinements in HLA typing and matching over the first 20 years of the National Marrow Donor Program registry. Biol Blood Marrow Transplant 2008: 14: 37-44.
21. Brühl C. Deutschland-Frankreich. Die Geburt zweier Völker. Vienna: Böhlau, 1990.
22. Goetz HW. Die "Deutschen Stämme" als Forschungsproblem. In: Beck H, Geuenich D, Steuer H, Hakelberg D, eds. Zur Geschichte der Gleichung "germanisch-deutsch". Berlin: De Gruyter, 2004, 229-53.
23. Speyer A. Germanische Sprachen. Ein vergleichender Überblick. Göttingen: Vandenhoeck & Ruprecht, 2007.
24. Münz R, Seifert W, Ulrich R. Zuwanderung nach Deutschland: Strukturen, Wirkungen, Perspektiven. Frankfurt: Campus, 1999.
25. Ritter GA, Niehuss M. Wahlen in der Bundesrepublik Deutschland: Bundestags- und Landtagswahlen 1946-1987. Munich: Beck, 1987.
26. Lee SJ, Klein J, Haagenson M, et al. High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation. Blood 2007: 110: 4576-83