Bone grafting and one-stage revision of THR-biological reconstruction and effective antimicrobial treatment using antibiotic impregnated allograft bone

HIP International

Volumn 22, Issue SUPPL.8, 2012, Pages

  Winkler, Heinz ^a  

^a Osteitis Centre   (Austria)

Author keywords

Allograft bone; Infection; One stage; Revision; Total hip replacement; Uncemented

Indexed keywords

ANTIBIOTIC AGENT; BONE CEMENT; CEPHALOSPORIN; TOBRAMYCIN; VANCOMYCIN; ANTIINFECTIVE AGENT;

ADVERSE OUTCOME; ANTIBIOTIC LOADED ALLOGRAFT BONE; ARTICLE; BONE ALLOGRAFT; BONE DEFECT; BONE TRANSPLANTATION; CEMENT SPACER; COMPUTER ASSISTED TOMOGRAPHY; HIP DISLOCATION; HUMAN; LABORATORY TEST; OUTCOME ASSESSMENT; POSTOPERATIVE CARE; PREOPERATIVE EVALUATION; PROSTHESIS LOOSENING; RECURRENT INFECTION; RESISTANCE TRAINING; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SURGICAL APPROACH; SURGICAL INFECTION; SURGICAL TECHNIQUE; TOTAL HIP PROSTHESIS; X RAY ANALYSIS; AGED; ALLOTRANSPLANTATION; BIOFILM; DRUG DELIVERY SYSTEM; ECONOMICS; HIP; HIP ARTHROPLASTY; HIP PROSTHESIS; INFECTION; INSTRUMENTATION; MALE; METHODOLOGY; PLASTIC SURGERY; PROSTHESIS; REOPERATION;

AGED; ANTI-BACTERIAL AGENTS; ARTHROPLASTY, REPLACEMENT, HIP; BIOFILMS; BONE TRANSPLANTATION; DRUG DELIVERY SYSTEMS; HIP JOINT; HIP PROSTHESIS; HUMANS; MALE; PROSTHESIS DESIGN; PROSTHESIS-RELATED INFECTIONS; RECONSTRUCTIVE SURGICAL PROCEDURES; REOPERATION; TRANSPLANTATION, HOMOLOGOUS;

EID: 84873733255     PISSN: 11207000     EISSN: None     Source Type: Journal    
DOI: 10.5301/HIP.2012.9572     Document Type: Article

References (17)

1. Jackson WO, Schmalzried TP. Limited role of direct ex-change arthroplasty in the treatment of infected total hip replacements. Clin Orthop Relat Res 2000; 381: 101-5.
2. Whittaker JP, Warren RE, Jones RS, Gregson PA. Is prolonged systemic antibiotic treatment essential in two-stage revision hip replacement for chronic Gram-positive infection? J Bone Joint Surg Br 2009; 91: 44-51.
3. Stockley I, Mockford BJ, Hoad-Reddick A, Norman P. The use of two-stage exchange arthroplasty with depot antibiotics in the absence of long-term antibiotic therapy in infected total hip replacement. J Bone Joint Surg Br 2008; 90: 145-8.
4. Costerton JW. Biofilm theory can guide the treatment of device-related orthopaedic infections. Clin Orthop Relat Res 2005; 437: 7-11.
5. Costerton JW, Montanaro L, Arciola CR. Biofilm in implant infections: its production and regulation. Int J Artif Organs 2005; 28: 1062-8.
6. El-Azizi M, Rao S, Kanchanapoom T, Khardori N. In vitro activity of vancomycin, quinupristin/dalfopristin, and linezolid against intact and disrupted biofilms of staphylococci. Ann Clin Microbiol Antimicrob 2005; 4: 2.
7. Ammon P, Stockley I. Allograft bone in two-stage revision of the hip for infection. Is it safe? J Bone Joint Surg Br 2004; 86: 962-5.
8. Hsieh PH, Shih CH, Chang YH, Lee MS, Yang WE, Shih HN. Treatment of deep infection of the hip associated with massive bone loss: two-stage revision with an antibioticloaded interim cement prosthesis followed by reconstruction with allograft. J Bone Joint Surg Br 2005; 87: 770-5.
9. Lie SA, Havelin LI, Furnes ON, Engesaeter LB, Vollset SE. Failure rates for 4762 revision total hip arthroplasties in the Norwegian Arthroplasty Register. J Bone Joint Surg Br 2004; 86: 504-9.
10. Cabo J, Euba G, Saborido A, et al. Clinical outcome and microbiological findings using antibiotic-loaded spacers in two-stage revision of prosthetic joint infections. J Infect 2011; 63: 23-31.
11. Winkler H, Janata O, Berger C, Wein W, Georgopoulos A. In vitro release of vancomycin and tobramycin from impregnated human and bovine bone grafts. J Antimicrob Chemother 2000; 46: 423-8.
12. Fages J, Marty A, Delga C, Condoret JS, Combes D, Frayssinet P. Use of supercritical CO2 for bone delipidation. Biomaterials 1994; 15: 650-6.
13. Fages J, Poirier B, Barbier Y, et al. Viral inactivation of human bone tissue using supercritical fluid extraction. ASAIO J 1998; 44: 289-93.
14. Winkler H, Stoiber A, Kaudela K, Winter F, Menschik F. One stage uncemented revision of infected total hip replacement using cancellous allograft bone impregnated with antibiotics. J Bone Joint Surg Br 2008; 90: 1580-4.
15. Zimmerli W, Trampuz A, Ochsner PE. Prosthetic-joint infections. N Engl J Med 2004; 351: 1645-54.
16. Trampuz A, Piper KE, Jacobson MJ, et al. Sonication of removed hip and knee prostheses for diagnosis of infection. N Engl J Med 2007; 357: 654-63.
17. Winkler H, Kaudela K, Stoiber A, Menschik F. Bone grafts impregnated with antibiotics as a tool for treating infected implants in orthopedic surgeryone stage revision results. Cell Tissue Bank 2006; 7: 319-23.