Potassium-induced cortical spreading depression bilaterally suppresses the electroencephalogram but only ipsilaterally affects red blood cell velocity in intraparenchymal capillaries

Journal of Neuroscience Research

Volumn 91, Issue 4, 2013, Pages 578-584

  Unekawa, Miyuki ^a   Tomita, Yutaka ^a   Toriumi, Haruki ^a   Masamoto, Kazuto ^b,c   Kanno, Iwao ^c   Suzuki, Norihiro ^a  

^a KEIO UNIVERSITY   (Japan)

^b UNIVERSITY OF ELECTRO COMMUNICATIONS   (Japan)

^c NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

Author keywords

Cerebral microcirculation; Cortical spreading depression; Electroencephalogram; RBC velocity; Transhemispheric projection

Indexed keywords

FLUORESCEIN ISOTHIOCYANATE; ISOFLURANE; POTASSIUM;

ANIMAL EXPERIMENT; ARTICLE; BLOOD OXYGEN TENSION; BRAIN BLOOD FLOW; CAPILLARY; CELL LABELING; CELL MEMBRANE DEPOLARIZATION; COMPUTER PROGRAM; CONFOCAL MICROSCOPY; ELECTROENCEPHALOGRAM; ERYTHROCYTE CIRCULATION TIME; ERYTHROCYTE KINETICS; FLUORESCENCE MICROSCOPY; GLIA CELL; HEMISPHERE; LASER SCANNING CONFOCAL FLUORESCENCE MICROSCOPY; MALE; NERVE CELL; NONHUMAN; PARIETAL LOBE; PRIORITY JOURNAL; SPREADING CORTICAL DEPRESSION; TEMPORAL LOBE;

ANIMALS; BLOOD FLOW VELOCITY; CAPILLARIES; CEREBRAL CORTEX; CEREBROVASCULAR CIRCULATION; CORTICAL SPREADING DEPRESSION; ELECTROENCEPHALOGRAPHY; ERYTHROCYTES; NEURONS; POTASSIUM CHLORIDE; RATS;

EID: 84873719216     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.23184     Document Type: Article

References (35)

1. Austin VC, Blamire AM, Grieve SM, O'Neill MJ, Styles P, Matthews PM, Sibson NR. 2003. Differences in the BOLD fMRI response to direct and indirect cortical stimulation in the rat. Magn Reson Med 49: 838-847.
2. Back T, Kohno K, Hossmann KA. 1994. Cortical negative DC deflections following middle cerebral artery occlusion and KCl-induced spreading depression: effect on blood flow, tissue oxygenation, and electroencephalogram. J Cereb Blood Flow Metab 14: 12-19.
3. Bogdanova OG, Sil'kis IG. 1999. The effects of high-frequency microstimulation of the cortex on interhemisphere synchronization in the rat motor cortex. Neurosci Behav Physiol 29: 515-522.
4. Bueš J, Burešová O, Køivánek J. 1974. The mechanism and applications of Leão's spreading depression of electroencephalographic activity. Prague: Academia.
5. Chang AY, Kuo TB, Tsai TH, Chen CF, Chan SH. 1995. Power spectral analysis of electroencephalographic desynchronization induced by cocaine in rats: correlation with evaluation of noradrenergic neurotransmission at the medial prefrontal cortex. Synapse 21: 149-157.
6. Chuquet J, Hollender L, Nimchinsky EA. 2007. High-resolution in vivo imaging of the neurovascular unit during spreading depression. J Neurosci 27: 4036-4044.
7. Conti F, Manzoni T. 1994. The neurotransmitters and postsynaptic actions of callosally projecting neurons. Behav Brain Res 64: 37-53.
8. del Zoppo GJ. 2010. The neurovascular unit in the setting of stroke. J Intern Med 267: 156-171.
9. Enager P, Gold L, Lauritzen M. 2004. Impaired neurovascular coupling by transhemispheric diaschisis in rat cerebral cortex. J Cereb Blood Flow Metab 24: 713-719.
10. Fabricius M, Lauritzen M. 1993. Transient hyperemia succeeds oligemia in the wake of cortical spreading depression. Brain Res 602: 350-353.
11. Gold L, Lauritzen M. 2002. Neuronal deactivation explains decreased cerebellar blood flow in response to focal cerebral ischemia or suppressed neocortical function. Proc Natl Acad Sci U S A 99: 7699-7704.
12. Hoffmeyer HW, Enager P, Thomsen KJ, Lauritzen MJ. 2007. Nonlinear neurovascular coupling in rat sensory cortex by activation of transcallosal fibers. J Cereb Blood Flow Metab 27: 575-587.
13. Hudetz AG. 1997. Blood flow in the cerebral capillary network: a review emphasizing observations with intravital microscopy. Microcirculation 4: 233-252.
14. Hutchinson EB, Stefanovic B, Koretsky AP, Silva AC. 2006. Spatial flow-volume dissociation of the cerebral microcirculatory response to mild hypercapnia. Neuroimage 32: 520-530.
15. Itoh Y, Suzuki N. 2012. Control of brain capillary blood flow. J Cereb Blood Flow Metab 32: 1167-1176.
16. Kocher M. 1990. Metabolic and hemodynamic activation of postischemic rat brain by cortical spreading depression. J Cereb Blood Flow Metab 10: 564-571.
17. Lauritzen M. 2001. Cortical spreading depression in migraine. Cephalalgia 21: 757-760.
18. Lauritzen M, Jorgensen MB, Diemer NH, Gjedde A, Hansen AJ. 1982. Persistent oligemia of rat cerebral cortex in the wake of spreading depression. Ann Neurol 12: 469-474.
19. Leão A. 1944. Spreading depression of activity in cerebral cortex. J Neurophysiol 7: 359-390.
20. Mayevsky A, Weiss HR. 1991. Cerebral blood flow and oxygen consumption in cortical spreading depression. J Cereb Blood Flow Metab 11: 829-836.
21. Olesen J, Larsen B, Lauritzen M. 1981. Focal hyperemia followed by spreading oligemia and impaired activation of rCBF in classic migraine. Ann Neurol 9: 344-352.
22. Olesen J, Friberg L, Olsen TS, Iversen HK, Lassen NA, Andersen AR, Karle A. 1990. Timing and topography of cerebral blood flow, aura, and headache during migraine attacks. Ann Neurol 28: 791-798.
23. Osada T, Tomita M, Suzuki N. 2006. Spindle-shaped constriction and propagated dilation of arterioles during cortical spreading depression. Neuroreport 17: 1365-1368.
24. Schiszler I, Takeda H, Tomita M, Tomita Y, Osada T, Unekawa M, Tanahashi N, Suzuki N. 2005. Software (KEIO-IS2) for automatically tracking red blood cells (RBCs) with calculation of individual RBC velocities in single capillaries of rat brain. J Cereb Blood Flow Metab 25(Suppl): S541.
25. Seylaz J, Charbonné R, Nanri K, Von Euw D, Borredon J, Kacem K, Méric P, Pinard E. 1999. Dynamic in vivo measurement of erythrocyte velocity and flow in capillaries and of microvessel diameter in the rat brain by confocal laser microscopy. J Cereb Blood Flow Metab 19: 863-870.
26. Takano T, Tian GF, Peng W, Lou N, Lovatt D, Hansen AJ, Kasischke KA, Nedergaard M. 2007. Cortical spreading depression causes and coincides with tissue hypoxia. Nat Neurosci 10: 754-762.
27. +-induced cortical spreading depression in rats. J Cereb Blood Flow Metab 25: 742-747.
28. Tomita M, Osada T, Schiszler I, Tomita Y, Unekawa M, Toriumi H, Tanahashi N, Suzuki N. 2008. Automated method for tracking vast numbers of FITC-labeled RBCs in microvessels of rat brain in vivo using a high-speed confocal microscope system. Microcirculation 15: 163-174.
29. Tomita M, Osada T, Unekawa M, Tomita Y, Toriumi H, Suzuki N. 2009. Exogenous nitric oxide increases microflow but decreases RBC attendance in single capillaries in rat cerebral cortex. Microvasc Rev Commun 3: 11-16.
30. Tomita M, Tomita Y, Unekawa M, Toriumi H, Suzuki N. 2011. Oscillating neuro-capillary coupling during cortical spreading depression as observed by tracking of FITC-labeled RBCs in single capillaries. Neuroimage 56: 1001-1010.
31. Unekawa M, Tomita M, Osada T, Tomita Y, Toriumi H, Tatarishvili J, Suzuki N. 2008. Frequency distribution function of red blood cell velocities in single capillaries of the rat cerebral cortex using intravital laser-scanning confocal microscopy with high-speed camera. Asian Biomed 2: 203-218.
32. Unekawa M, Tomita M, Tomita Y, Toriumi H, Suzuki N. 2012. Sustained decrease and remarkable increase of red blood cell velocity in intraparenchymal capillaries associated with potassium-induced cortical spreading depression in rats. Microcirculation 19: 166-174.
33. Williams JL, Shea M, Jones SC. 1993. Evidence that heterogeneity of cerebral blood flow does not involve vascular recruitment. Am J Physiol 264: H1740-H1743.
34. Yemisci M, Gursoy-Ozdemir Y, Vural A, Can A, Topalkara K, Dalkara T. 2009. Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery. Nat Med 15: 1031-1037.
35. Zhou N, Gordon GR, Feighan D, MacVicar BA. 2010. Transient swelling, acidification, and mitochondrial depolarization occurs in neurons but not astrocytes during spreading depression. Cereb Cortex 20: 2614-2624.