Sustained Decrease and Remarkable Increase in Red Blood Cell Velocity in Intraparenchymal Capillaries Associated With Potassium-Induced Cortical Spreading Depression

Microcirculation

Volumn 19, Issue 2, 2012, Pages 166-174

  Unekawa, Miyuki ^a   Tomita, Minoru ^a   Tomita, Yutaka ^a   Toriumi, Haruki ^a   Suzuki, Norihiro ^a  

^a KEIO UNIVERSITY   (Japan)

Author keywords

Confocal fluorescence microscopy; Cortical spreading depression; Neuro capillary coupling; Red blood cell velocity; Thoroughfare channel

Indexed keywords

FLUORESCEIN ISOTHIOCYANATE; ISOFLURANE; POTASSIUM CHLORIDE;

ANESTHESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN; BRAIN BLOOD FLOW; BRAIN BLOOD VESSEL; BRAIN CAPILLARY; BRAIN TISSUE; CELL LABELING; CONFOCAL LASER MICROSCOPY; ELECTROENCEPHALOGRAM; ERYTHROCYTE; FLUORESCENCE; FLUORESCENCE MICROSCOPY; MALE; NERVE CELL; NONHUMAN; OXYGEN TENSION; PRIORITY JOURNAL; RAT; SPREADING CORTICAL DEPRESSION; VELOCITY;

ANIMALS; BLOOD FLOW VELOCITY; CAPILLARIES; CEREBRAL CORTEX; CEREBROVASCULAR CIRCULATION; ERYTHROCYTES; MALE; POTASSIUM CHLORIDE; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 84856888505     PISSN: 10739688     EISSN: 15498719     Source Type: Journal    
DOI: 10.1111/j.1549-8719.2011.00143.x     Document Type: Article

References (39)

1. Akcali D, Sayin A, Sara Y, Bolay H. Does single cortical spreading depression elicit pain behaviour in freely moving rats? Cephalalgia 30: 1195-1206, 2010.
2. Ayata C, Shin HK, Salomone S, Ozdemir-Gursoy Y, Boas DA, Dunn AK, Moskowitz MA. Pronounced hypoperfusion during spreading depression in mouse cortex. J Cereb Blood Flow Metab 24: 1172-1182, 2004.
3. Back T, Kohno K, Hossmann KA. Cortical negative DC deflections following middle cerebral artery occlusion and KCl-induced spreading depression: effect on blood flow, tissue oxygenation, and electroencephalogram. J Cereb Blood Flow Metab 14: 12-19, 1994.
4. Bell RD, Winkler EA, Sagare AP, Singh I, LaRue B, Deane R, Zlokovic BV. Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging. Neuron 68: 409-427, 2010.
5. Busija DW, Bari F, Domoki F, Horiguchi T, Shimizu K. Mechanisms involved in the cerebrovascular dilator effects of cortical spreading depression. Prog Neurobiol 86: 379-395, 2008.
6. Charles A, Brennan K. Cortical spreading depression-new insights and persistent questions. Cephalalgia 29: 1115-1124, 2009.
7. Chuquet J, Hollender L, Nimchinsky EA. High-resolution in vivo imaging of the neurovascular unit during spreading depression. J Neurosci 27: 4036-4044, 2007.
8. Fabricius M, Akgoren N, Lauritzen M. Arginine-nitric oxide pathway and cerebrovascular regulation in cortical spreading depression. Am J Physiol 269: H23-H29, 1995.
9. Hutchinson EB, Stefanovic B, Koretsky AP, Silva AC. Spatial flow-volume dissociation of the cerebral microcirculatory response to mild hypercapnia. Neuroimage 32: 520-530, 2006.
10. Kocher M. Metabolic and hemodynamic activation of postischemic rat brain by cortical spreading depression. J Cereb Blood Flow Metab 10: 564-571, 1990.
11. Lacombe P, Sercombe R, Correze JL, Springhetti V, Seylaz J. Spreading depression induces prolonged reduction of cortical blood flow reactivity in the rat. Exp Neurol 117: 278-286, 1992.
12. Lauritzen M. Pathophysiology of the migraine aura. The spreading depression theory. Brain 117(Pt. 1): 199-210, 1994.
13. Lauritzen M, Jorgensen MB, Diemer NH, Gjedde A, Hansen AJ. Persistent oligemia of rat cerebral cortex in the wake of spreading depression. Ann Neurol 12: 469-474, 1982.
14. Leão A. Spreading depression of activity in cerebral cortex. J Neurophysiol 7: 359-390, 1944.
15. Mayevsky A, Weiss HR. Cerebral blood flow and oxygen consumption in cortical spreading depression. J Cereb Blood Flow Metab 11: 829-836, 1991.
16. Nielsen AN, Fabricius M, Lauritzen M. Scanning laser-Doppler flowmetry of rat cerebral circulation during cortical spreading depression. J Vasc Res 37: 513-522, 2000.
17. Osada T, Tomita M, Suzuki N. Spindle-shaped constriction and propagated dilation of arterioles during cortical spreading depression. Neuroreport 17: 1365-1368, 2006.
18. Piilgaard H, Lauritzen M. Persistent increase in oxygen consumption and impaired neurovascular coupling after spreading depression in rat neocortex. J Cereb Blood Flow Metab 29: 1517-1527, 2009.
19. Schiszler I, Takeda H, Tomita M, Tomita Y, Osada T, Unekawa M, Tanahashi N, Suzuki N. Software (KEIO-IS2) for automatically tracking red blood cells (RBCs) with calculation of individual RBC velocities in single capillaries of rat brain. J Cereb Blood Flow Metab 25(Suppl.): S541, 2005.
20. Seylaz J, Charbonné R, Nanri K, Von Euw D, Borredon J, Kacem K, Méric P, Pinard E. Dynamic in vivo measurement of erythrocyte velocity and flow in capillaries and of microvessel diameter in the rat brain by confocal laser microscopy. J Cereb Blood Flow Metab 19: 863-870, 1999.
21. Shinohara M, Dollinger B, Brown G, Rapoport S, Sokoloff L. Cerebral glucose utilization: local changes during and after recovery from spreading cortical depression. Science 203: 188-190, 1979.
22. Sonn J, Mayevsky A. Effects of anesthesia on the responses to cortical spreading depression in the rat brain in vivo. Neurol Res 28: 206-219, 2006.
23. Sukhotinsky I, Dilekoz E, Moskowitz MA, Ayata C. Hypoxia and hypotension transform the blood flow response to cortical spreading depression from hyperemia into hypoperfusion in the rat. J Cereb Blood Flow Metab 28: 1369-1376, 2008.
24. Sukhotinsky I, Yaseen MA, Sakadzic S, Ruvinskaya S, Sims JR, Boas DA, Moskowitz MA, Ayata C. Perfusion pressure-dependent recovery of cortical spreading depression is independent of tissue oxygenation over a wide physiologic range. J Cereb Blood Flow Metab 30: 1168-1177, 2010.
25. Takano T, Tian GF, Peng W, Lou N, Lovatt D, Hansen AJ, Kasischke KA, Nedergaard M. Cortical spreading depression causes and coincides with tissue hypoxia. Nat Neurosci 10: 754-762, 2007.
26. Tomita M, Gotoh F. Local cerebral blood flow values as estimated with diffusible tracers: validity of assumptions in normal and ischemic tissue. J Cereb Blood Flow Metab 1: 403-411, 1981.
27. Tomita M, Osada T, Schiszler I, Tomita Y, Unekawa M, Toriumi H, Tanahashi N, Suzuki N. Automated method for tracking vast numbers of FITC-labeled RBCs in microvessels of rat brain in vivo using a high-speed confocal microscope system. Microcirculation 15: 163-174, 2008.
28. Tomita M, Osada T, Unekawa M, Tomita Y, Toriumi H, Suzuki N. Exogenous nitric oxide increases microflow but decreases RBC attendance in single capillaries in rat cerebral cortex. Microvasc Rev Commun 3: 11-16, 2009.
29. Tomita M, Schiszler I, Fukuuchi Y, Amano T, Tanahashi N, Kobari M, Takeda H, Tomita Y, Ohtomo M, Inoue K. A time-variable concentric wave-ring increase in light transparency and associated microflow changes during a potassium-induced spreading depression in the rat cerebral cortex. In: Brain Activation and CBF Control; Exerpta Medica International Congress Series 1235, edited by Tomita M, Kanno I, Hamel E. Amsterdam: Elsevier Science, 2002, p. 439-447.
30. +-induced cortical spreading depression in rats. J Cereb Blood Flow Metab 25: 742-747, 2005.
31. +-induced spreading depression in rats and cats. Neurosci Lett 322: 157-160, 2002.
32. Tomita M, Tomita Y, Unekawa M, Toriumi H, Suzuki N. Oscillating neuro-capillary coupling during cortical spreading depression as observed by tracking of FITC-labeled RBCs in single capillaries. NeuroImage 56: 1001-1010, 2011.
33. Unekawa M, Tomita M, Osada T, Tomita Y, Toriumi H, Tatarishvili J, Suzuki N. Frequency distribution function of red blood cell velocities in single capillaries of the rat cerebral cortex using intravital laser-scanning confocal microscopy with high-speed camera. Asian Biomed 2: 203-218, 2008.
34. Vinogradova LV, Koroleva VI, Bures J. Re-entry waves of Leao's spreading depression between neocortex and caudate nucleus. Brain Res 538: 161-164, 1991.
35. Williams JL, Shea M, Jones SC. Evidence that heterogeneity of cerebral blood flow does not involve vascular recruitment. Am J Physiol 264: H1740-H1743, 1993.
36. Wolf T, Lindauer U, Obrig H, Dreier J, Back T, Villringer A, Dirnagl U. Systemic nitric oxide synthase inhibition does not affect brain oxygenation during cortical spreading depression in rats: a noninvasive near-infrared spectroscopy and laser-Doppler flowmetry study. J Cereb Blood Flow Metab 16: 1100-1107, 1996.
37. Yemisci M, Gursoy-Ozdemir Y, Vural A, Can A, Topalkara K, Dalkara T. Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery. Nat Med 15: 1031-1037, 2009.
38. Zhang ZG, Chopp M, Maynard KI, Moskowitz MA. Cerebral blood flow changes during cortical spreading depression are not altered by inhibition of nitric oxide synthesis. J Cereb Blood Flow Metab 14: 939-943, 1994.
39. Zhou N, Gordon GR, Feighan D, MacVicar BA. Transient swelling, acidification, and mitochondrial depolarization occurs in neurons but not astrocytes during spreading depression. Cereb Cortex 20: 2614-2624, 2010.