Association of levofloxacin resistance with mortality in adult patients with invasive pneumococcal diseases: A post hoc analysis of a prospective cohort

Infection

Volumn 41, Issue 1, 2013, Pages 151-157

  Kang, C I ^a   Song, J H ^a,b   Kim, S H ^b   Chung, D R ^a   Peck, K R ^a   Thamlikitkul, V ^c   Wang, H ^d,e   So, T M ^f   Hsueh, P R ^g   Yasin, R M ^h   Carlos, C C ⁱ   Van, P H ^j   Perera, J ^k  

^a Sungkyunkwan University School of Medicine   (South Korea)

^b Asia Pacific Foundation for Infectious Diseases (APFID)   (South Korea)

^c MAHIDOL UNIVERSITY   (Thailand)

^d PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

^e PEKING UNIVERSITY PEOPLE S HOSPITAL   (China)

^f PRINCESS MARGARET HOSPITAL   (Hong Kong)

^g NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^h INSTITUTE FOR MEDICAL RESEARCH   (Malaysia)

ⁱ RESEARCH INSTITUTE FOR TROPICAL MEDICINE   (Philippines)

^j UNIVERSITY OF MEDICINE AND PHARMACY AT HO CHI MINH CITY   (Viet Nam)

^k UNIVERSITY OF COLOMBO   (Sri Lanka)

more..

Author keywords

Mortality; Pneumococcal infections; Risk factors; Streptococcus pneumoniae; Treatment outcome

Indexed keywords

AMOXICILLIN PLUS CLAVULANIC ACID; ANTIBIOTIC AGENT; CEFTAZIDIME; CEPHALOSPORIN DERIVATIVE; CORTICOSTEROID; ERYTHROMYCIN; LEVOFLOXACIN; MEROPENEM; MOXIFLOXACIN; PENICILLIN DERIVATIVE; PIPERACILLIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT;

ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; ANTIBIOTIC RESISTANCE; ARTICLE; BACTEREMIA; BACTERIUM ISOLATION; COHORT ANALYSIS; COMMUNITY ACQUIRED PNEUMONIA; CONTROLLED STUDY; DRUG FATALITY; DRUG FEVER; FEMALE; HUMAN; INDEPENDENT VARIABLE; MAJOR CLINICAL STUDY; MALE; MENINGITIS; MINIMUM INHIBITORY CONCENTRATION; MORTALITY; NONHUMAN; OBSERVATIONAL STUDY; PNEUMOCOCCAL INFECTION; POST HOC ANALYSIS; PROSPECTIVE STUDY; SEPTIC SHOCK; STREPTOCOCCUS PNEUMONIAE;

EID: 84873718805     PISSN: 03008126     EISSN: 14390973     Source Type: Journal    
DOI: 10.1007/s15010-012-0299-5     Document Type: Article

References (22)

1. Doshi SM, Rueda AM, Corrales-Medina VF, Musher DM. Anemia and community-acquired pneumococcal pneumonia. Infection. 2011;39:379-83.
2. Giner AM, Kuster SP, Zbinden R, Ruef C, Ledergerber B, Weber R. Initial management of and outcome in patients with pneumococcal bacteremia: a retrospective study at a Swiss university hospital, 2003-2009. Infection. 2011;39:519-26.
3. Choi WS, Noh JY, Huh JY, Youn YK, Kim MJ, Jo YM, Kim JY, Song JY, Park DW, Kim WJ, Kim MJ, Cheong HJ. Clinical features of invasive pneumococcal disease in Korea. Infect Chemother. 2010;42:156-61.
4. Yu VL, Chiou CC, Feldman C, Ortqvist A, Rello J, Morris AJ, Baddour LM, Luna CM, Snydman DR, Ip M, Ko WC, Chedid MB, Andremont A, Klugman KP; International Pneumococcal Study Group. An international prospective study of pneumococcal bacteremia: correlation with in vitro resistance, antibiotics administered, and clinical outcome. Clin Infect Dis. 2003;37:230-7.
5. Song JH, Jung SI, Ki HK, Shin MH, Ko KS, Son JS, Chang HH, Kim SW, Lee H, Kim YS, Oh WS, Peck KR, Chongthaleong A, Lalitha MK, Perera J, Yee TT, Jamal F, Kamarulzaman A, Carlos CC, So T; Asian Network for Surveillance of Resistant Pathogens Study Group. Clinical outcomes of pneumococcal pneumonia caused by antibiotic-resistant strains in Asian countries: a study by the Asian Network for Surveillance of Resistant Pathogens. Clin Infect Dis. 2004;38:1570-8.
6. Low DE. Quinolone resistance among pneumococci: therapeutic and diagnostic implications. Clin Infect Dis. 2004;38:S357-62.
7. Wolter N, du Plessis M, von Gottberg A, de Gouveia L, Klugman KP. Molecular characterization of emerging non-levofloxacin-susceptible pneumococci isolated from children in South Africa. J Clin Microbiol. 2009;47:1319-24.
8. Pletz MW, McGee L, Jorgensen J, Beall B, Facklam RR, Whitney CG, Klugman KP. Levofloxacin-resistant invasive Streptococcus pneumoniae in the United States: evidence for clonal spread and the impact of conjugate pneumococcal vaccine. Antimicrob Agents Chemother. 2004;48:3491-7.
9. Orr D, Wilkinson P, Moyce L, Martin S, George R, Pichon B. Incidence and epidemiology of levofloxacin resistance in Streptococcus pneumoniae: experience from a tertiary referral hospital in England. J Antimicrob Chemother. 2010;65:449-52.
10. McGee L, Goldsmith CE, Klugman KP. Fluoroquinolone resistance among clinical isolates of Streptococcus pneumoniae belonging to international multiresistant clones. J Antimicrob Chemother. 2002;49:173-6.
11. de Cueto M, Rodríguez JM, Soriano MJ, López-Cerero L, Venero J, Pascual A. Fatal levofloxacin failure in treatment of a bacteremic patient infected with Streptococcus pneumoniae with a preexisting parC mutation. J Clin Microbiol. 2008;46:1558-60.
12. Rodríguez-Avial I, Ramos B, Ríos E, Cercenado E, Ordobás M, Sanz JC; Madrid Streptococcus pneumoniae Microbiological Group. Clonal spread of levofloxacin-resistant Streptococcus pneumoniae invasive isolates in Madrid, Spain, 2007 to 2009. Antimicrob Agents Chemother. 2011;55:2469-71.
13. Dalhoff A. Resistance surveillance studies: a multifaceted problem-the fluoroquinolone example. Infection. 2012;40:239-62.
14. Kim SH, Song JH, Chung DR, Thamlikitkul V, Yang Y, Wang H, Lu M, So TM, Hsueh PR, Yasin RM, Carlos CC, Pham HV, Lalitha MK, Shimono N, Perera J, Shibl AM, Baek JY, Kang CI, Ko KS, Peck KR; ANSORP Study Group. Changing trends in antimicrobial resistance and serotypes of Streptococcus pneumoniae isolates in Asian Countries: an Asian Network for Surveillance of Resistant Pathogens (ANSORP) study. Antimicrob Agents Chemother. 2012;56:1418-26.
15. Marrie TJ, Tyrrell GJ, Garg S, Vanderkooi OG. Factors predicting mortality in invasive pneumococcal disease in adults in Alberta. Medicine (Baltimore). 2011;90:171-9.
16. Friedman ND, Kaye KS, Stout JE, McGarry SA, Trivette SL, Briggs JP, Lamm W, Clark C, MacFarquhar J, Walton AL, Reller LB, Sexton DJ. Health care-associated bloodstream infections in adults: a reason to change the accepted definition of community-acquired infections. Ann Intern Med. 2002;137:791-7.
17. Davidson R, Cavalcanti R, Brunton JL, Bast DJ, de Azavedo JC, Kibsey P, Fleming C, Low DE. Resistance to levofloxacin and failure of treatment of pneumococcal pneumonia. N Engl J Med. 2002;346:747-50.
18. Anderson KB, Tan JS, File TM Jr, DiPersio JR, Willey BM, Low DE. Emergence of levofloxacin-resistant pneumococci in immunocompromised adults after therapy for community-acquired pneumonia. Clin Infect Dis. 2003;37:376-81.
19. Ho PL, Tse WS, Tsang KW, Kwok TK, Ng TK, Cheng VC, Chan RM. Risk factors for acquisition of levofloxacin-resistant Streptococcus pneumoniae: a case-control study. Clin Infect Dis. 2001;32:701-7.
20. Klugman KP. The successful clone: the vector of dissemination of resistance in Streptococcus pneumoniae. J Antimicrob Chemother. 2002;50:1-5.
21. Eliopoulos GM. Quinolone resistance mechanisms in pneumococci. Clin Infect Dis. 2004;38:S350-6.
22. Alanee SR, McGee L, Jackson D, Chiou CC, Feldman C, Morris AJ, Ortqvist A, Rello J, Luna CM, Baddour LM, Ip M, Yu VL, Klugman KP; International Pneumococcal Study Group. Association of serotypes of Streptococcus pneumoniae with disease severity and outcome in adults: an international study. Clin Infect Dis. 2007;45:46-51.