Molecular characterization of emerging non-levofloxacin-susceptible pneumococci isolated from children in South Africa

Journal of Clinical Microbiology

Volumn 47, Issue 5, 2009, Pages 1319-1324

  Wolter, Nicole ^a,c   Du Plessis, Mignon ^a   Von Gottberg, Anne ^a   De Gouveia, Linda ^a   Klugman, Keith P ^a,b  

^a UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^b EMORY UNIVERSITY   (United States)

^c NATIONAL INSTITUTE FOR COMMUNICABLE DISEASES   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

LEVOFLOXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RIFAMPICIN; SULFAMETHOXAZOLE; TRIMETHOPRIM;

ANTIBIOTIC SENSITIVITY; ARTICLE; CHILD; DISEASE SURVEILLANCE; DRUG SENSITIVITY; GENE MUTATION; GENE TRANSFER; GENOTYPE; HUMAN; ISOLATION PROCEDURE; MAJOR CLINICAL STUDY; MINIMUM INHIBITORY CONCENTRATION; MULTILOCUS SEQUENCE TYPING; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS; SEROTYPING; SOUTH AFRICA; STREPTOCOCCUS INFECTION; TUBERCULOSIS;

ADOLESCENT; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BACTERIAL TYPING TECHNIQUES; CARRIER STATE; CHILD; CHILD, PRESCHOOL; CLUSTER ANALYSIS; DNA FINGERPRINTING; DRUG RESISTANCE, BACTERIAL; ELECTROPHORESIS, GEL, PULSED-FIELD; GENOTYPE; HUMANS; INFANT; INFANT, NEWBORN; MICROBIAL SENSITIVITY TESTS; MUTATION, MISSENSE; OFLOXACIN; PNEUMOCOCCAL INFECTIONS; SEQUENCE ANALYSIS, DNA; SEROTYPING; SOUTH AFRICA; STREPTOCOCCUS PNEUMONIAE; TUBERCULOSIS;

STREPTOCOCCUS PNEUMONIAE;

EID: 66149148587     PISSN: 00951137     EISSN: None     Source Type: Journal    
DOI: 10.1128/JCM.02280-08     Document Type: Article

References (27)

1. Balsalobre, L., M. J. Ferrandiz, J. Linares, F. Tubau, and A. G. de la Campa. 2003. Viridans group streptococci are donors in horizontal transfer of topoisomerase IV genes to Streptococcus pneumoniae. Antimicrob. Agents Chemother. 47:2072-2081. (Pubitemid 36753553)
2. Calfee, D. P. 2005. Rifamycins, p. 374-388. In G. L. Mandell, J. E. Bennett, and R. Dolin (ed.), Mandell, Douglas, and Bennett's principles and practice of infectious diseases, 6th ed. Elsevier Churchill Livingstone, Philadelphia, PA.
3. Chen, F. J., and H. J. Lo. 2003. Molecular mechanisms of fluoroquinolone resistance. J. Microbiol. Immunol. Infect. 36:1-9.
4. Clinical and Laboratory Standards Institute. 2006. Performance standards for antimicrobial susceptibility testing: 16th informational supplement. CLSI document M100-S16. Clinical and Laboratory Standards Institute, Wayne, PA.
5. Duesberg, C. B., S. Malhotra-Kumar, H. Goossens, L. McGee, K. P. Klugman, T. Welte, and M. W. Pletz. 2008. Interspecies recombination occurs frequently in quinolone resistance-determining regions of clinical isolates of Streptococcus pyogenes. Antimicrob. Agents Chemother. 52:4191-4193.
6. Eliopoulos, G. M. 2004. Quinolone resistance mechanisms in pneumococci. Clin. Infect. Dis. 38(Suppl. 4):S350-S356. (Pubitemid 38669891)
7. Enright, M. C., and B. G. Spratt. 1998. A multilocus sequence typing scheme for Streptococcus pneumoniae: identification of clones associated with serious invasive disease. Microbiology 144:3049-3060.
8. Ferrandiz, M. J., A. Fenoll, J. Linares, and A. G. de la Campa. 2000. Horizontal transfer of parC and gyrA in fluoroquinolone-resistant clinical isolates of Streptococcus pneumoniae. Antimicrob. Agents Chemother. 44:840-847. (Pubitemid 30165258)
9. Hakenbeck, R., N. Balmelle, B. Weber, C. Gardes, W. Keck, and A. de Saizieu. 2001. Mosaic genes and mosaic chromosomes: intra- and interspecies genomic variation of Streptococcus pneumoniae. Infect. Immun. 69:2477-2486.
10. Ho, P. L., T. L. Que, S. S. Chiu, R. W. Yung, T. K. Ng, D. N. Tsang, W. H. Seto, and Y. L. Lau. 2004. Fluoroquinolone and other antimicrobial resistance in invasive pneumococci, Hong Kong, 1995-2001. Emerg. Infect. Dis. 10:1250-1257.
11. Huang, T. D., L. Avrain, G. de Bilderling, and Y. Glupczynski. 2006. Streptococcus pneumoniae clinical isolate highly resistant to fluoroquinolones in a child. Pediatr. Infect. Dis. J. 25:1195-1196.
12. Jefferies, J. M., A. Smith, S. C. Clarke, C. Dowson, and T. J. Mitchell. 2004. Genetic analysis of diverse disease-causing pneumococci indicates high levels of diversity within serotypes and capsule switching. J. Clin. Microbiol. 42:5681-5688. (Pubitemid 39664353)
13. Klugman, K. P. 2003. The role of clonality in the global spread of fluoroquinolone-resistant bacteria. Clin. Infect. Dis. 36:783-785. (Pubitemid 36337984)
14. Lacks, S. A. 2004. Transformation, p. 89-115. In E. I. Tuomanen, T. J. Mitchell, D. A. Morrison, and B. G. Spratt (ed.), The pneumococcus. ASM Press, Washington, DC.
15. Lefevre, J. C., G. Faucon, A. M. Sicard, and A. M. Gasc. 1993. DNA fingerprinting of Streptococcus pneumoniae strains by pulsed-field gel electrophoresis. J. Clin. Microbiol. 31:2724-2728. (Pubitemid 23284911)
16. Mandell, L. A., L. R. Peterson, R. Wise, D. Hooper, D. E. Low, U. B. Schaad, K. P. Klugman, and P. Courvalin. 2002. The battle against emerging antibiotic resistance: should fluoroquinolones be used to treat children? Clin. Infect. Dis. 35:721-727.
17. McEllistrem, M. C., J. E. Stout, and L. H. Harrison. 2000. Simplified protocol for pulsed-field gel electrophoresis analysis of Streptococcus pneumoniae. J. Clin. Microbiol. 38:351-353. (Pubitemid 30043315)
18. Pan, X. S., J. Ambler, S. Mehtar, and L. M. Fisher. 1996. Involvement of topoisomerase IV and DNA gyrase as ciprofloxacin targets in Streptococcus pneumoniae. Antimicrob. Agents Chemother. 40:2321-2326. (Pubitemid 26328040)
19. Pletz, M. W., L. McGee, B. Beall, C. G. Whitney, and K. P. Klugman. 2005. Interspecies recombination in type II topoisomerase genes is not a major cause of fluoroquinolone resistance in invasive Streptococcus pneumoniae isolates in the United States. Antimicrob. Agents Chemother. 49:779-780. (Pubitemid 40175695)
20. Pletz, M. W., L. McGee, J. Jorgensen, B. Beall, R. R. Facklam, C. G. Whitney, and K. P. Klugman. 2004. Levofloxacin-resistant invasive Streptococcus pneumoniae in the United States: evidence for clonal spread and the impact of conjugate pneumococcal vaccine. Antimicrob. Agents Chemother. 48:3491-3497.
21. Pletz, M. W., L. McGee, C. A. Van Beneden, S. Petit, M. Bardsley, M. Barlow, and K. P. Klugman. 2006. Fluoroquinolone resistance in invasive Streptococcus pyogenes isolates due to spontaneous mutation and horizontal gene transfer. Antimicrob. Agents Chemother. 50:943-948. (Pubitemid 43327798)
22. Richter, S. S., K. P. Heilmann, S. E. Beekmann, N. J. Miller, C. L. Rice, and G. V. Doern. 2005. The molecular epidemiology of Streptococcus pneumoniae with quinolone resistance mutations. Clin. Infect. Dis. 40:225-235. (Pubitemid 40110665)
23. Ruoff, K. L., R. A. Whiley, and D. Beighton. 2003. Streptococcus, p. 405-421. In P. R. Murray, E. J. Baron, M. A. Pfaller, J. H. Jorgensen, and R. H. Yolken (ed.), Manual of clinical microbiology, 8th ed. ASM Press, Washington, DC.
24. Stanhope, M. J., S. L. Walsh, J. A. Becker, M. J. Italia, K. A. Ingraham, M. N. Gwynn, T. Mathie, J. A. Poupard, L. A. Miller, J. R. Brown, and H. Amrine-Madsen. 2005. Molecular evolution perspectives on intraspecific lateral DNA transfer of topoisomerase and gyrase loci in Streptococcus pneumoniae, with implications for fluoroquinolone resistance development and spread. Antimicrob. Agents Chemother. 49:4315-4326.
25. Tenover, F. C., R. D. Arbeit, R. V. Goering, P. A. Mickelsen, B. E. Murray, D. H. Persing, and B. Swaminathan. 1995. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J. Clin. Microbiol. 33:2233-2239.
26. von Gottberg, A., K. P. Klugman, C. Cohen, N. Wolter, L. de Gouveia, M. du Plessis, R. Mpembe, V. Quan, A. Whitelaw, R. Hoffmann, N. Govender, S. Meiring, A. M. Smith, and S. Schrag. 2008. Emergence of levofloxacin- nonsusceptible Streptococcus pneumoniae and treatment for multidrug-resistant tuberculosis in children in South Africa: a cohort observational surveillance study. Lancet 371:1108-1113.
27. von Gottberg, A., H. Ludewick, S. Bamber, C. Govind, A. W. Sturm, and K. P. Klugman. 2003. Emergence of fluoroquinolone-resistant Streptococcus pneumoniae in a South African child in a tuberculosis treatment facility. Pediatr. Infect. Dis. J. 22:1020-1021. (Pubitemid 37445084)