The nonpeptide ANG-(1-7) mimic AVE 0991 attenuates cardiac remodeling and improves baroreflex sensitivity in renovascular hypertensive rats

Life Sciences

Volumn 92, Issue 4-5, 2013, Pages 266-275

  Cunha, Thelma Maria Bedeti ^a   Lima, Wanderson Geraldo ^a   Silva, Marcelo Eustáquio ^a   Souza Santos, Robson Augusto ^b   Campagnole Santos, Maria José ^b   Alzamora, Andréia Carvalho ^a  

^a FEDERAL UNIVERSITY OF OURO PRETO   (Brazil)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Angiotensin (1 7); AVE 0991; Baroreflex sensitivity; Cardiac remodeling; Hypertension; Keywords

Indexed keywords

COLLAGEN; N ETHYLCARBAMOYL 3 [4 (5 FORMYL 4 METHOXY 2 PHENYL 1 IMIDAZOLYLMETHYL)PHENYL] 5 ISOBUTYL 2 THIOPHENESULFONAMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; ATTENUATION; BLOOD PRESSURE; BRADYCARDIA; CARDIOVASCULAR FUNCTION; CONTROLLED STUDY; DRUG EFFECT; HEART MUSCLE CELL; HEART RATE; HEART WEIGHT; HISTOPATHOLOGY; INFLAMMATORY CELL; MEAN ARTERIAL PRESSURE; NONHUMAN; PRESSORECEPTOR REFLEX; RAT; RENOVASCULAR HYPERTENSION; TACHYCARDIA; THICKNESS;

ANGIOTENSIN I; ANIMALS; ANTIHYPERTENSIVE AGENTS; BAROREFLEX; BLOOD PRESSURE; COLLAGEN; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HEART RATE; HYPERTENSION, RENOVASCULAR; IMIDAZOLES; KIDNEY; MALE; MYOCARDIUM; PEPTIDE FRAGMENTS; RATS; RATS, INBRED F344; VENTRICULAR REMODELING;

ANIMALIA; RATTUS;

EID: 84873716865     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2012.12.008     Document Type: Article

References (57)

1. A.C. Alzamora, R.A. Santos, and M.J. Campagnole-Santos Baroreflex modulation by angiotensins at the rat rostral and caudal ventrolateral medulla Am J Physiol 290 2006 R1027 R1034
2. I.F. Benter, D.I. Diz, and C.M. Ferrario Pressor and reflex sensitivity is altered in spontaneously hypertensive rats treated with angiotensin-(1-7) Hypertension 26 1995 1138 1144
3. I.F. Benter, M.H. Yousif, J.T. Anim, C. Cojocel, and D.I. Diz Angiotensin-(1-7) prevents development of severe hypertension and end-organ damage in spontaneously hypertensive rats treated with L-NAME Am J Physiol Heart Circ Physiol 290 2006 H684 H691
4. R.R. Britto, R.A. Santos, C.R. Fagundes-Moura, M.C. Khosla, and M.J. Campagnole-Santos Role of angiotensin-(1-7) in the modulation of the baroreflex in renovascular hypertensive rats Hypertension 30 1997 549 556
5. M.V. Caliari, M. de Lana, R.A. Cajá, C.M. Carneiro, M.T. Bahia, and C.A. Santos Immunohistochemical studies in acute and chronic canine chagasic cardiomyopathy Virchows Arch 441 2002 69 76
6. M.J. Campagnole-Santos, S.B. Heringer, E.N. Batista, M.C. Khosla, and R.A. Santos Differential baroreceptor reflex modulation by centrally infused angiotensin peptides Am J Physiol 263 1992 R89 R94
7. B. Casadei, and D.J. Paterson Should we still use nitrovasodilators to test baroreflex sensitivity? J Hypertens 18 2000 3 6
8. R. Casto, and M.I. Phillips Neuropeptide action in nucleus tractus solitarius: angiotensin specificity and hypertensive rats Am J Physiol 249 1985 R341 R347
9. G.Z. Chaves, S.M. Caligiorne, R.A. Santos, M.C. Khosla, and M.J. Campagnole-Santos Modulation of the baroreflex control of heart rate by angiotensin-(1-7) at the nucleus tractus solitarii of normotensive and spontaneously hypertensive rats J Hypertens 18 2000 1841 1848
10. L. Fei, A.K. Slade, A.A. Grace, M. Malik, A.J. Camm, and W.J. McKenna Ambulatory assessment of the QT interval in patients with hypertrophic cardiomyopathy: risk stratification and effect of low dose amiodarone Pacing Clin Electrophysiol 17 1994 2222 2227
11. C.M. Ferrario Contribution of angiotensin-(1-7) to cardiovascular physiology and pathology Curr Hypertens Rep 5 2003 129 134
12. C.M. Ferrario, and J. Varagic The ANG-(1-7)/ACE2/mas axis in the regulation of nephron function Am J Physiol Renal Physiol 298 2010 F1297 F1305
13. C.M. Ferrario, M.C. Chappell, E.A. Tallant, K.B. Brosnihan, and D.I. Diz Counterregulatory actions of angiotensin-(1-7) Hypertension 30 1997 535 541
14. A.J. Ferreira, T.L. Oliveira, M.C. Castro, A.P. Almeida, C.H. Castro, and M.V. Caliari Isoproterenol-induced impairment of heart function and remodeling are attenuated by the nonpeptide angiotensin-(1-7) analogue AVE 0991 Life Sci 81 2007 916 923
15. A.J. Ferreira, B.A. Jacoby, C.A. Araújo, F.A. Macedo, G.A. Silva, and A.P. Almeida The nonpeptide angiotensin-(1-7) receptor Mas agonist AVE-0991 attenuates heart failure induced by myocardial infarction Am J Physiol Heart Circ Physiol 292 2007 H1113 H1119
16. E.D. Frohlich, L.G. Navar, and R.N. Re Hypertension: the present years Hypertension 33 1999 1097 1098
17. H. Goldblatt, J. Lynch, R.F. Hanzal, and W.W. Summerville Studies on experimental hypertension: I. The production of persistent elevation of systolic blood pressure by means of renal ischemia J Exp Med 59 1934 347 379
18. B. González, P. Negredo, R. Hernando, and R. Manso Protein variants of skeletal muscle regulatory myosin light chain isoforms: prevalence in mammals, generation and transitions during muscle remodelling Pflugers Arch 443 2002 377 386
19. J.L. Grobe, A.P. Mecca, H. Mao, and M.J. Katovich Chronic angiotensin-(1-7) prevents cardiac fibrosis in DOCA-salt model of hypertension Am J Physiol Heart Circ Physiol 290 2006 H2417 H2423
20. J.L. Grobe, A.P. Mecca, M. Lingis, V. Shenoy, T.A. Bolton, and J.M. Machado Prevention of angiotensin II-induced cardiac remodeling by angiotensin-(1-7) Am J Physiol Heart Circ Physiol 292 2007 H736 H742
21. K.A. Hammond, and D.N. Janes The effects of increased protein intake on kidney size and function J Exp Biol 201 1998 2081 2090
22. J.G. He, S.L. Chen, Y.Y. Huang, Y.L. Chen, Y.G. Dong, and H. Ma The nonpeptide AVE0991 attenuates myocardial hypertrophy as induced by angiotensin II through downregulation of transforming growth factor-beta1/Smad2 expression Heart Vessels 25 2010 438 443
23. G.A. Head Role of AT1 receptors in the central control of sympathetic vasomotor function Clin Exp Pharmacol Physiol 23 Suppl. 3 1996 S93 S98
24. S. Heringer-Walther, E.N. Batista, T. Walther, M.C. Khosla, R.A. Santos, and M.J. Campagnole-Santos Baroreflex improvement in shr after ace inhibition involves angiotensin-(1-7) Hypertension 37 2001 1309 1314
25. N. Hogan, A. Kardos, D.J. Paterson, and B. Casadei Effect of exogenous nitric oxide on baroreflex function in humans Am J Physiol 277 1999 H221 H227
26. M. Iwata, R.T. Cowling, D. Gurantz, C. Moore, S. Zhang, and J.X. Yuan Angiotensin-(1-7) binds to specific receptors on cardiac fibroblasts to initiate antifibrotic and antitrophic effects Am J Physiol Heart Circ Physiol 289 2005 H2356 H2363
27. Jw McCubbin, J.H. Green, and I.H. PAGE Baroceptor function in chronic renal hypertension Circ Res 4 1956 205 210
28. H. Kawano, Y.S. Do, Y. Kawano, V. Starnes, M. Barr, and R.E. Law Angiotensin II has multiple profibrotic effects in human cardiac fibroblasts Circulation 101 2000 1130 1137
29. M.J. Klag, P.K. Whelton, B.L. Randall, J.D. Neaton, F.L. Brancati, and C.E. Ford Blood pressure and end-stage renal disease in men N Engl J Med 334 1996 13 18
30. P.I. Korner, J.R. Oliver, P. Sleight, J.P. Chalmers, and J.S. Robinson Effects of clonidine on the baroreceptor-heart rate reflex and on single aortic baroreceptor fibre discharge Eur J Pharmacol 28 1974 189 198
31. V.S. Lemos, D.M. Silva, T. Walther, N. Alenina, M. Bader, and R.A. Santos The endothelium-dependent vasodilator effect of the nonpeptide Ang(1-7) mimic AVE 0991 is abolished in the aorta of mas-knockout mice J Cardiovasc Pharmacol 46 2005 274 279
32. D. Ljutić, and P. Kes The role of arterial hypertension in the progression of non-diabetic glomerular diseases Nephrol Dial Transplant 18 Suppl. 5 2003 v28 v30
33. A.E. Loot, A.J. Roks, R.H. Henning, R.A. Tio, A.J. Suurmeijer, and F. Boomsma Angiotensin-(1-7) attenuates the development of heart failure after myocardial infarction in rats Circulation 105 2002 1548 1550
34. P. Musialek, and B. Casadei Nitrovasodilators and heart rate: more than the arterial baroreflex Cardiovasc Res 47 2000 404 405
35. L.G. Navar, A.M. Von Thun, L. Zou, S.S. el-Dahr, and K.D. Mitchell Enhancement of intrarenal angiotensin II levels in 2 kidney 1 clip and angiotensin II induced hypertension Blood Press Suppl 2 1995 88 92
36. L.G. Navar, L. Zou, A. Von Thun, C. Tarng Wang, J.D. Imig, and K.D. Mitchell Unraveling the mystery of Goldblatt hypertension News Physiol Sci 13 1998 170 176
37. Z. Pei, R. Meng, G. Li, G. Yan, C. Xu, and Z. Zhuang Angiotensin-(1-7) ameliorates myocardial remodeling and interstitial fibrosis in spontaneous hypertension: role of MMPs/TIMPs Toxicol Lett 199 2010 173 181
38. S.V. Pinheiro, A.J. Ferreira, G.T. Kitten, K.D. da Silveira, D.A. da Silva, and S.H. Santos Genetic deletion of the angiotensin-(1-7) receptor Mas leads to glomerular hyperfiltration and microalbuminuria Kidney Int 75 2009 1184 1193
39. A.C. Piratello, I. Moraes-Silva, J. Paulini, P.R. Souza, R. Sirvente, and V. Salemi Renin angiotensin system and cardiac hypertrophy after sinoaortic denervation in rats Clinics (Sao Paulo) 65 2010 1345 1350
40. J.W. Polson, R.A. Dampney, P. Boscan, A.E. Pickering, and J.F. Paton Differential baroreflex control of sympathetic drive by angiotensin II in the nucleus tractus solitarii Am J Physiol Regul Integr Comp Physiol 293 2007 R1954 R1960
41. M.C. Prieto, R.A. González-Villalobos, F.T. Botros, V.L. Martin, J. Pagán, and R. Satou Reciprocal changes in renal ACE/ANG II and ACE2/ANG 1-7 are associated with enhanced collecting duct renin in Goldblatt hypertensive rats Am J Physiol Renal Physiol 300 2011 F749 F755
42. M.C. Rodrigues, M.J. Campagnole-Santos, R.P. Machado, M.E. Silva, J.L. Rocha, and P.M. Ferreira Evidence for a role of AT(2) receptors at the CVLM in the cardiovascular changes induced by low-intensity physical activity in renovascular hypertensive rats Peptides 28 2007 1375 1382
43. J. Sadjadi, G.L. Kramer, C.H. Yu, M. Burress Welborn, M.C. Chappell, and Modrall J. Gregory Angiotensin converting enzyme-independent angiotensin ii production by chymase is up-regulated in the ischemic kidney in renovascular hypertension J Surg Res 127 2005 65 69
44. J. Sadjadi, G.L. Kramer, C.H. Yu, M.B. Welborn, and J.G. Modrall Angiotensin II exerts positive feedback on the intrarenal renin-angiotensin system by an angiotensin converting enzyme-dependent mechanism J Surg Res 129 2005 272 277
45. R.A. Santos, A.C. Simoes e Silva, C. Maric, D.M. Silva, R.P. Machado, and I. de Buhr Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas Proc Natl Acad Sci U S A 100 2003 8258 8263
46. R.A. Santos, and A.J. Ferreira Pharmacological effects of AVE 0991, a nonpeptide angiotensin-(1-7) receptor agonist Cardiovasc Drug Rev 24 2006 239 246
47. R.A. Santos, M.J. Campagnole-Santos, and S.P. Andrade Angiotensin-(1-7): an update Regul Pept 91 2000 45 62
48. D.D. Savage, J.I. Drayer, W.L. Henry, E.C. Mathews, J.H. Ware, and J.M. Gardin Echocardiographic assessment of cardiac anatomy and function in hypertensive subjects Circulation 59 1979 623 632
49. W. Schaper The regulation of gene expression in myocardial ischemia Thorac Cardiovasc Surg 46 Suppl. 2 1998 277 280
50. E.R. Soares, W.G. Lima, R.P. Machado, C.M. Carneiro, M.E. Silva, and M.C. Rodrigues Cardiac and renal effects induced by different exercise workloads in renovascular hypertensive rats Braz J Med Biol Res 44 2011 573 582
51. E.A. Tallant, C.M. Ferrario, and P.E. Gallagher Angiotensin-(1-7) inhibits growth of cardiac myocytes through activation of the mas receptor Am J Physiol Heart Circ Physiol 289 2005 H1560 H1566
52. A.J. Trask, and C.M. Ferrario Angiotensin-(1-7): pharmacology and new perspectives in cardiovascular treatments Cardiovasc Drug Rev 25 2007 162 174
53. A.M. Von Thun, R.C. Vari, S.S. el-Dahr, and L.G. Navar Augmentation of intrarenal angiotensin II levels by chronic angiotensin II infusion Am J Physiol 266 1994 120 128
54. G. Wiemer, L.W. Dobrucki, F.R. Louka, T. Malinski, and H. Heitsch AVE 0991, a nonpeptide mimic of the effects of angiotensin-(1-7) on the endothelium Hypertension 40 2002 847 852
55. W.T. Zeng, W.Y. Chen, X.Y. Leng, L.L. Tang, X.T. Sun, and C.L. Li Impairment of cardiac function and remodeling induced by myocardial infarction in rats are attenuated by the nonpeptide angiotensin-(1-7) analog AVE 0991 Cardiovasc Ther 30 2012 152 161
56. L.S. Zisman, G.E. Meixell, M.R. Bristow, and C.C. Canver Angiotensin-(1-7) formation in the intact human heart: in vivo dependence on angiotensin II as substrate Circulation 108 2003 1679 1681
57. Y. Zou, I. Komuro, T. Yamazaki, R. Aikawa, S. Kudoh, and I. Shiojima Protein kinase C, but not tyrosine kinases or Ras, plays a critical role in angiotensin II-induced activation of Raf-1 kinase and extracellular signal-regulated protein kinases in cardiac myocytes J Biol Chem 271 1996 33592 33597