The nonpeptide AVE0991 attenuates myocardial hypertrophy as induced by angiotensin II through downregulation of transforming growth factor-β1/Smad2 expression

Heart and Vessels

Volumn 25, Issue 5, 2010, Pages 438-443

  He, Jian Gui ^a   Chen, Sheng Long ^a   Huang, Yi Yi ^a   Chen, Yi Li ^a   Dong, Yu Gang ^a   Ma, Hong ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Angiotensin II; Angiotensin (1 7); AVE0991; Myocardial hypertrophy; Transforming growth factor 1 Smad2

Indexed keywords

ANGIOTENSIN II; ANGIOTENSIN[1-7][7 DEXTRO ALANINE]; LEUCINE; N ETHYLCARBAMOYL 3 [4 (5 FORMYL 4 METHOXY 2 PHENYL 1 IMIDAZOLYLMETHYL)PHENYL] 5 ISOBUTYL 2 THIOPHENESULFONAMIDE; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; TRITIUM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION;

ANGIOTENSIN II; ANIMALS; ANIMALS, NEWBORN; CARDIOMEGALY; CARDIOVASCULAR AGENTS; CELL SIZE; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; IMIDAZOLES; MYOCYTES, CARDIAC; PEPTIDE FRAGMENTS; PROTO-ONCOGENE PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; RNA, MESSENGER; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 77956030116     PISSN: 09108327     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00380-009-1213-7     Document Type: Article

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