A breakthrough therapy for dentin hypersensitivity: How dental products containing 8% arginine and calcium carbonate work to deliver effective relief of sensitive teeth

Journal of Clinical Dentistry

Volumn 20, Issue 1, 2009, Pages 23-31

  Petrou, Irene ^a   Heu, Rod ^a   Stranick, Mike ^a   Lavender, Stacey ^a   Zaidel, Lynette ^a   Cummins, Diane ^a   Sullivan, Richard J ^a   Hsueh, Carlin ^b   Gimzewski, James K ^b  

^a Oral Care Research and Development   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CALCIUM CARBONATE; CALCIUM PHOSPHATE; DIAGNOSTIC AGENT; FLUORESCEIN ISOTHIOCYANATE; FLUORESCENT DYE; TOOTHPASTE;

ARTICLE; ATOMIC FORCE MICROSCOPY; BEVERAGE; CONFOCAL MICROSCOPY; DENTIN; DENTIN SENSITIVITY; DRUG COMBINATION; DRUG EFFECT; ELECTRON ENERGY LOSS SPECTROSCOPY; ELECTRON PROBE MICROANALYSIS; HUMAN; MATERIALS TESTING; PATHOLOGY; PATHOPHYSIOLOGY; PH; PHYSIOLOGY; PRESSURE; SCANNING ELECTRON MICROSCOPY; TOOTH PULP; ULTRASTRUCTURE;

ARGININE; BEVERAGES; CALCIUM CARBONATE; CALCIUM PHOSPHATES; DENTAL PULP; DENTIN; DENTIN SENSITIVITY; DENTINAL FLUID; DRUG COMBINATIONS; ELECTRON PROBE MICROANALYSIS; FLUORESCEIN-5-ISOTHIOCYANATE; FLUORESCENT DYES; HUMANS; HYDROGEN-ION CONCENTRATION; MATERIALS TESTING; MICROSCOPY, ATOMIC FORCE; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, SCANNING; PRESSURE; SPECTROSCOPY, ELECTRON ENERGY-LOSS; TOOTHPASTE;

EID: 67650233638     PISSN: 08958831     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Hayward VB: Dentine hypersensitivity: Bleaching and restorative considerations for successful management. Int Dent J 52 (Suppl):376-384, 2002.
2. Addy M: Dentin hypersensitivity: Definition, prevalence, distribution, and aetiology. In: Toothwear and Sensitivity, Addy M, Embery G, Edgar WM, Orchardson R, eds. London, Morton Dunitz, 2000.
3. Bal J, Kundalgurki S: Tooth sensitivity prevention and treatment. Oral Health 89:33-34, 37-38, 41, 1999.
4. Brännström M, Aström A: The hydrodynamics of dentin: Its possible relationship to dentinal pain. Int Dent J 22:219-227, 1972.
5. Kramer IRH: The relationship between dentin sensitivity and movement of the contents of dentinal tubules. Br Dent J 98:391-392, 1955.
6. Matthews B, Vongsavan N: Interactions between neural and hydrodynamic mechanisms in dentine and pulp. Arch Oral Biol 39 (Suppl):87S-95S, 1994.
7. Holland GR, Närhi MN, Addy M, Gangarosa L, Orchardson R: Guidelines for the design and conduct of clinical trials on dentine hypersensitivity. J Clin Periodontal 24:808-813, 1997.
8. Addy M: Dentine hypersensitivity: New perspectives on an old problem. Int Dent J 52 (SuppI):367-375, 2002.
9. Pashley DH, Tay FR, Haywood VB, Collins MA, Drisko CL: Consensusbased recommendations for the diagnosis and management of dentin hypersensitivity. Inside Dent 4 (Spec Iss): 1-37, 2008.
10. Cummins D: Dentin hypersensitivity: From diagnosis to a breakthrough therapy for everyday sensitivity relief. J Clin Dent 20 (Spec Iss): 1-9, 2009.
11. Ide M: The differential diagnosis of sensitive teeth. Dent Update 25:462-466, 1998.
12. Renton-Harper P, Midda M: NdYAG laser treatment of dentinal hypersensitivity. Br Dent J 172:13-16, 1992.
13. Orchardson R, Gillam DG: Managing dentin hypersensitivity. JADA 137: 990-998, 2006.
14. Miller S, Truong T, Heu R, Stranick M, Bouchard D, Gaffar A: Recent advances in stannous fluoride technology: Antibacterial efficacy and mechanism of action towards hypersensitivity. Int Dent J 44 (Suppl):83-98, 1994.
15. Walters PA: Dentin hypersensitivity: A review. J Contemp Dent Pract 6:107117, 2005.
16. Markowitz K, Pashley DH: Discovering new treatments for sensitive teeth: The long path from biology to therapy. J Oral Rehabil 35:300-315, 2007.
17. Ayad F, Ayad N, Zhang YP, DeVizio W, Cummins D, Mateo LR: Comparing the efficacy in reducing dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a commercial sensitive toothpaste containing 2% potassium ion: An eight-week clinical study on Canadian adults. J Clin Dent 20 (Spec Iss): 10-16, 2009.
18. Docimo R, Montesani L, Maturo P, Costacurta M, Bartolino M, DeVizio W, Zhang YP, Cummins D, Dibart S, Mateo LR: Comparing the efficacy in reducing dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a commercial sensitive toothpaste containing 2% potassium ion: An eight-week clinical study in Rome, Italy. J Clin Dent 20 (Spec Iss):17-22, 2009.
19. Wolff MS, Kaufman H, Kleinberg I: Dentinal hypersensitivity following scaling and root planing (SRP) and dental prophylaxis. J Dent Res 80 (Spec Iss):191, 2002.
20. Schiff T, Delgado E, Zhang YP, DeVizio W, Mateo LR: A clinical investigation of the efficacy of an in-office desensitizing paste containing 8% arginine and calcium carbonate for the instant reduction of dentin hypersensitivity. Am J Dent 2009. In press.
21. Kleinberg I: SensiStat. A new saliva-based composition for simple and effective treatment of dentinal sensitivity pain. Dent Today 21:42-47, 2002.
22. Pashley DH, O'Meara JA, Kepler EE, Galloway SE, Thompson SM, Stewart FP: Dentin permeability. Effects of desensitizing dentifrices in vitro. J Periodontol 55:522-525, 1984.