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Volumn 21, Issue 5, 2013, Pages 1064-1073
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Synthesis, biological evaluation and molecular modeling of aloe-emodin derivatives as new acetylcholinesterase inhibitors
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Author keywords
Acetylcholinesterase; Aloe emodin derivatives; Alzheimer's disease; Inhibitors
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Indexed keywords
1 (4,5 DIHYDROXY 9,10 DIOXO 9,10 DIHYDROANTHRACEN 2 YL) N,N,N TRIMETHYLMETHANAMINIUM CHLORIDE;
1 (4,5 DIMETHOXY 9,10 DIOXO 9,10 DIHYDROANTHRACEN 2 YL) N,N,N TRIMETHYLMETHANAMINIUM CHLORIDE;
1 [(4,5 DIHYDROXY 9,10 DIOXO 9,10 DIHYDROANTHRACEN 2 YL)METHYL]PYRIDIN 1 IUM CHLORIDE;
1 [(4,5 DIMETHOXY 9,10 DIOXO 9,10 DIHYDROANTHRACEN 2 YL)METHYL] 1,3,5,7 TETRAAZAADAMANTAN 1 IUM CHLORIDE;
1 [(4,5 DIMETHOXY 9,10 DIOXO 9,10 DIHYDROANTHRACEN 2 YL)METHYL]PYRIDIN 1 IUM CHLORIDE;
1,8 DIMETHOXY 3 [(PHENYLIMINO)METHYL]ANTHRACENE 9,10 DIONE;
3 (ACETOXYMETHYL) 9,10 DIOXOX 9,10 DIHYDROANTHRACENE 1,8 DIYL DIACETATE;
3 (CHLOROMETHYL) 1,8 DIHYDROXYANTHRACENE 9,10 DIONE;
3 (CHLOROMETHYL) 1,8 DIMETHOXYANTHRACENE 9,10 DIONE;
3 (CHLOROMETHYL) 9,10 DIOXO 9,10 DIHYDROANTHRACENE 1,8 DIYL BIS(4 METHYLBENZENESULFONATE);
3 (HYDRAZONOMETHYL) 1,8 DIMETHOXYANTHRACENE 9,10 DIONE;
3 (HYDROXYMETHYL) 1,8 DIMETHOXYANTHRACENE 9,10 DIONE;
3 (HYDROXYMETHYL) 9,10 DIOXOX 9,10 DIHYDROANTHRACENE 1,8 DIYL BIS(4 METHYLBENZENESULFONATE);
3 [(BENZOYLOXY)METHYL] 9,10 DIOXO 9,10 DIHYDROANTHRACENE 1,8 DIYL DIBENZOATE;
4 [(4,5 DIMETHOXY 9,10 DIOXO 9,10 DIHYDROANTHRACEN 2 YL)METHOXY] 4 OXOBUTANOIC ACID;
4,5 DIHYDROXY 9,10 DIOXO 9,10 DIHYDROANTHRACENE 2 CARBALDEHYDE;
4,5 DIHYDROXY 9,10 DIOXO 9,10 DIHYDROANTHRACENE 2 CARBOXYLIC ACID;
4,5 DIMETHOXY 9,10 DIOXO 9,10 DIHYDROANTHRACENE 2 CARBALDEHYDE;
4,5 DIMETHOXY 9,10 DIOXO 9,10 DIHYDROANTHRACENE 2 CARBALDEHYDE OXIME;
4,5 DIMETHOXY 9,10 DIOXO 9,10 DIHYDROANTHRACENE 2 CARBOXYLIC ACID;
6 (ACETOXYMETHYL) 3 (4,5 DIHYDROXY 9,10 DIOXO 9,10 DIHYDROANTHRACENE 2 CARBOXAMIDO)TETRAHYDRO 2H PYRAN TRIYL TRIACETATE;
6 (ACETOXYMETHYL) 3 [[(4,5 DIHYDROXY 9,10 DIOXO 9,10 DIHYDROANTHRACEN 2 YL)METHYLENE]AMINO]TETRAHYDRO 2H PYRAN TRIYL TRIACETATE;
ALOE EMODIN;
ALOE EMODIN DERIVATIVE;
CHOLINESTERASE INHIBITOR;
N [(4,5 DIHYDROXY 9,10 DIOXO 9,10 DIHYDROANTHRACEN 2 YL)METHYL] N,N DIMETHYLBENZENAMINIUM CHLORIDE;
N [(4,5 DIMETHOXY 9,10 DIOXO 9,10 DIHYDROANTHRACEN 2 YL)METHYL] N,N DIMETHYLBENZENAMINIUM CHLORIDE;
UNCLASSIFIED DRUG;
ACYLATION;
ANIMAL TISSUE;
ANTIINFLAMMATORY ACTIVITY;
ARTICLE;
BIOLOGICAL ACTIVITY;
CATALYSIS;
CONTROLLED STUDY;
DRUG DESIGN;
DRUG POTENCY;
DRUG STRUCTURE;
DRUG SYNTHESIS;
ENZYME INHIBITION;
IC 50;
IN VITRO STUDY;
MOLECULAR DOCKING;
MOLECULAR MODEL;
NONHUMAN;
PROTON NUCLEAR MAGNETIC RESONANCE;
RAT;
THIN LAYER CHROMATOGRAPHY;
ACETYLCHOLINESTERASE;
ANTHRAQUINONES;
BINDING SITES;
CATALYTIC DOMAIN;
CHOLINESTERASE INHIBITORS;
DRUG EVALUATION, PRECLINICAL;
KINETICS;
MOLECULAR DOCKING SIMULATION;
PROTEIN BINDING;
STRUCTURE-ACTIVITY RELATIONSHIP;
TACRINE;
ALOE;
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EID: 84873707217
PISSN: 09680896
EISSN: 14643391
Source Type: Journal
DOI: 10.1016/j.bmc.2013.01.015 Document Type: Article |
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Times cited : (34)
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References (19)
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