Modification of the behavioral effects of morphine in rats by serotonin (5-HT)1A and 5-HT2A receptor agonists: Antinociception, drug discrimination, and locomotor activity

Psychopharmacology

Volumn 225, Issue 4, 2013, Pages 791-801

  Li, Jun Xu ^a,c   Shah, Aparna P ^a   Patel, Sunny K ^a   Rice, Kenner C ^b   France, Charles P ^a  

^a University of Texas Health Science Center   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c UNIVERSITY AT BUFFALO   (United States)

Author keywords

Antinociception; Drug discrimination; Locomotor activity; Opioid; Rat; Serotonin receptor

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 2,5 DIMETHOXY 4 METHYLAMPHETAMINE; MORPHINE SULFATE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; SEROTONIN 1A AGONIST; SEROTONIN 1A RECEPTOR; SEROTONIN 2A AGONIST; SEROTONIN 2A RECEPTOR; SODIUM CHLORIDE; VOLINANSERIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; BEHAVIOR CHANGE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG DISCRIMINATION; DRUG DOSE INCREASE; DRUG EFFECT; DRUG POTENTIATION; LOCOMOTION; MALE; NERVE STIMULATION; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; SPRAGUE DAWLEY RAT; TAIL FLICK TEST;

ANALGESICS; ANIMALS; DISCRIMINATION (PSYCHOLOGY); DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MORPHINE; MOTOR ACTIVITY; PAIN; PAIN MEASUREMENT; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTOR, SEROTONIN, 5-HT2A; SEROTONIN 5-HT1 RECEPTOR AGONISTS; SEROTONIN 5-HT2 RECEPTOR AGONISTS;

EID: 84873706659     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-012-2870-2     Document Type: Article

References (44)

1. Alex KD, Pehek EA (2007) Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission. Pharmacol Ther 113:296-320
2. Berge OG, Hole K, Orgen SO (1983) Attenuation of morphine-induced analgesia by p-chlorophenylalanine and p-chloroamphetamine: test-dependent effects and evidence for brainstem 5-hydroxytryptamine involvement. Brain Res 271:51-64
3. Berge OG, Fasmer OB, Ogren SO, Hole K (1985) The putative serotonin receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin antagonizes the antinociceptive effect of morphine. Neurosci Lett 54:71-75
4. Carey RJ, DePalma G, Damianopoulos E (2001) Cocaine and serotonin: a role for the 5-HT (1A) receptor site in the mediation of cocaine stimulant effects. Behav Brain Res 126:127-133
5. Carey RJ, De Palma G, Damianopoulos E (2002) 5-HT1A agonist/antagonist modification of cocaine stimulant effects: implications for cocaine mechanisms. Behav Brain Res 132:37-46
6. 1A agonists alnespirone (S-20499) and 8-OH-DPAT on extracellular 5-hydroxytryptamine in different regions of rat brain. Br J Pharmacol 122:733-741
7. Chemel BR, Roth BL, Armbruster B, Watts VJ, Nichols DE (2006) WAY-100635 is a potent dopamine D4 receptor agonist. Psychopharmacology 188:244-251
8. Coda BA, Hill HF, Schaffer RL, Luger TJ, Jacobson RC, Chapman CR (1993) Enhancement of morphine analgesia by fenfluramine in subjects receiving tailored opioid infusions. Pain 52:85-91
9. Crisp T, Stafinsky JL, Spanos LJ, Uram M, Perni VC, Donepudi HB (1991) Analgesic effects of serotonin and receptor-selective serotonin agonists in the rat spinal cord. Gen Pharmacol 22:247-251
10. Dewey WL, Harris LS, Howes JF, Nuite JA (1970) The effect of various neurohumoral modulators on the activity of morphine and the narcotic antagonists in the tail-flick and phenylquinone tests. J Pharmacol Exp Ther 175:435-442
11. Duman EN, Kesim M, Kadioglu M, Yaris E, Kalyoncu NI, Erciyes N (2004) Possible involvement of opioidergic and serotonergic mechanisms in antinociceptive effect of paroxetine in acute pain. J Pharmacol Sci 94:161-165
12. Duman EN, Kesim M, Kadioglu M, Ulku C, Kalyoncu NI, Yaris E (2006) Effect of gender on antinociceptive effect of paroxetine in hot plate test in mice. Prog Neuropsychopharmacol Biol Psychiatry 30:292-296
13. Erjavec MK, Coda BA, Nguyen Q, Donaldson G, Risler L, Shen DD (2000) Morphine-fluoxetine interactions in healthy volunteers: analgesia and side effects. J Clin Pharmacol 40:1286-1295
14. Gatch MB, Negus SS, Mello NK (1998) Antinociceptive effects of monoamine reuptake inhibitors administered alone or in combination with mu opioid agonists in rhesus monkeys. Psychopharmacology (Berl) 135:99-106
15. Hynes MD, Lochner MA, Bemis KG, Hymson DL (1985) Fluoxetine, a selective inhibitor of serotonin uptake, potentiates morphine analgesia without altering its discriminative stimulus properties or affinity for opioid receptors. Life Sci 36:2317-2323
16. Institute of Laboratory Animal Resources (2011) Guide for the care and use of laboratory animals. National Academy Press, Washington D.C
17. Kesim M, Duman EN, Kadioglu M, Yaris E, Kalyoncu NI, Erciyes N (2005) The different roles of 5-HT(2) and 5-HT(3) receptors on antinociceptive effect of paroxetine in chemical stimuli in mice. J Pharmacol Sci 97:61-66
18. Kleven MS, Koek W (1998) Discriminative stimulus effects of 8-hydroxy-2-(di-n-propylamino)tetralin in pigeons and rats: species similarities and differences. J Pharmacol Exp Ther 284:238-249
19. 1A receptors: effects of EEDQ on the ability of agonists to produce lower lip retraction in rats. Psychopharmacology 149:377-387
20. Larson AA, Takemori AE (1977) Effect of fluoxetine hydrochloride (Lilly 110140), a specific inhibitor of serotonin uptake, on morphine analgesia and the development of tolerance. Life Sci 21:1807-1811
21. Lee BS, Jun IG, Kim SH, Park JY (2012) Interaction of morphine and selective serotonin receptor inhibitors in rats experiencing inflammatory pain. J Korean Med Sci 27:430-436
22. Li JX, Becker GL, Traynor JR, Gong ZH, France CP (2007) Thienorphine: receptor binding and behavioral effects in rhesus monkeys. J Pharmacol Exp Ther 321:227-236
23. Li JX, Unzeitig A, Javors MA, Rice KC, Koek W, France CP (2009) Discriminative stimulus effects of 1-(2,5-dimethoxy-4-methylphenyl)-2- aminopropane (DOM), ketanserin, and (R)-(+)-{alpha}-(2,3-dimethoxyphenyl)-1-[2- (4-fluorophenyl)ethyl]-4-pipidinemethanol (MDL100907) in rats. J Pharmacol Exp Ther 331:671-679
24. Li JX, Koek W, Rice KC, France CP (2010) Differential effects of serotonin 5-HT1A receptor agonists on the discriminative stimulus effects of the 5-HT2A receptor agonist 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane in rats and rhesus monkeys. J Pharmacol Exp Ther 333:244-252
25. Li JX, Koek W, Rice KC, France CP (2011) Effects of direct- and indirect-acting serotonin receptor agonists on the antinociceptive and discriminative stimulus effects of morphine in rhesus monkeys. Neuropsychopharm 36:940-949
26. Liang JH, Li JX, Wang XH, Chen B, Lu Y, Zhang P, Han R, Ye XF (2004) L-type calcium channel blockers enhance 5-HTP-induced antinociception in mice. Acta Pharmacol Sin 25:644-650
27. López-Giménez JF, Vilaró MT, Palacios JM, Mengod G (2001) Mapping of 5-HT2A receptors and their mRNA in monkey brain: [3H]MDL100,907 autoradiography and in situ hybridization studies. J Comp Neurol 429:571-589
28. Lucaites VL, Krushinski JH, Schaus JM, Audia JE, Nelson DL (2005) [3H] LY334370, a novel radioligand for the 5-HT1F receptor. II. Autoradiographic localization in rat, guinea pig, monkey and human brain. Naunyn Schmiedebergs Arch Pharmacol 371:178-184
29. Mamede Rosa ML, Prado WA (1997) Antinociception induced by opioid or 5-HT agonists microinjected into the anterior pretectal nucleus of the rat. Brain Res 757:133-138
30. Millan MJ, Colpaert FC (1990) Attenuation of opioid induced antinociception by 5-HT1A partial agonists in the rat. Neuropharmacology 29:315-318
31. Millan MJ, Colpaert FC (1991) 5-hydroxytryptamine (HT)1A receptors and the tail-flick response. II. High efficacy 5-HT1A agonists attenuate morphine-induced antinociception in mice in a competitive-like manner. J Pharmacol Exp Ther 256:983-992
32. Müller CP, Carey RJ, Salloum JB, Huston JP (2003) Serotonin1A-receptor agonism attenuates the cocaine-induced increase in serotonin levels in the hippocampus and nucleus accumbens but potentiates hyperlocomotion: an in vivo microdialysis study. Neuropharmacology 44:592-603
33. Nakamura S, Ago Y, Hayashi A, Itoh S, Kakuda M, Hashimoto H, Baba A, Matsuda T (2006) Modification of cocaine-induced behavioral and neurochemical effects by serotonin1A receptor agonist/antagonist in mice. Synapse 60:479-484
34. Rochat C, Cervo L, Romandini S, Samanin R (1982) Differences in the effects of d-fenfluramine and morphine on various responses of rats to painful stimuli. Psychopharmacology (Berl) 76:188-192
35. Schreiber S, Backer MM, Yanai J, Pick CG (1996) The antinociceptive effect of fluvoxamine. Eur Neuropsychopharmacol 6:281-284
36. Singh VP, Jain NK, Kulkarni SK (2001) On the antinociceptive effect of fluoxetine, a selective serotonin reuptake inhibitor. Brain Res 915:218-226
37. Smith T, Nicholson RA (2007) Review of duloxetine in the management of diabetic peripheral neuropathic pain. Vasc Health Risk Manag 3:833-844
38. Spanagel R (1995) Modulation of drug-induced sensitization processes by endogenous opioid systems. Behav Brain Res 70:37-49
39. Thorn DA, Zhang Y, Peng B, Winter JC, Li JX (2011) Effects of imidazoline I2 receptor ligands on morphine- and tramadol-induced antinociception in rats. Eur J Pharmacol 670:435-440
40. Ullrich T, Rice KC (2000) A practical synthesis of the serotonin 5-HT2A receptor antagonist MDL 100907, its enantiomer and their 3-phenolic derivatives as precursors for [11C]labeled PET ligands. Bioorg Med Chem 8:2427-2432
41. Wang YX, Bowersox SS, Pettus M, Gao D, Wang YX, Bowersox SS, Pettus M, Gao D (1999) Antinociceptive properties of fenfluramine, a serotonin reuptake inhibitor, in a rat model of neuropathy. J Pharmacol Exp Ther 291:1008-1016
42. Woolverton WL, Johnson KM (1992) Neurobiology of cocaine abuse. Trends Pharmacol Sci 13:193-200
43. Xu W, Qiu XC, Han JS (1994) Serotonin receptor subtypes in spinal antinociception in the rat. J Pharmacol Exp Ther 269:1182-1189
44. Zarrindast MR, Zarghi A (1992) Morphine stimulates locomotor activity by an indirect dopaminergic mechanism: possible D-1 and D-2 receptor involvement. Gen Pharmacol 23:1221-1225