메뉴 건너뛰기




Volumn 92, Issue 3, 2013, Pages 261-269

Effects of odanacatib on bone mineralization density distribution in thoracic spine and femora of ovariectomized adult rhesus monkeys: A quantitative backscattered electron imaging study

Author keywords

Bone mineralization density distribution (BMDD); Cathepsin K inhibitor; Dual energy X ray absorptiometry (DXA); Nonhuman primate; Osteopenia; Quantitative backscattered electron imaging (qBEI)

Indexed keywords

ODANACATIB;

EID: 84873702251     PISSN: 0171967X     EISSN: 14320827     Source Type: Journal    
DOI: 10.1007/s00223-012-9673-7     Document Type: Article
Times cited : (19)

References (43)
  • 1
    • 0032080113 scopus 로고    scopus 로고
    • Human cathepsin K cleaves native type i and II collagens at the N-terminal end of the triple helix
    • 9560298 1:CAS:528:DyaK1cXjt12iu7s%3D
    • Kafienah W, Bromme D, Buttle DJ, Croucher LJ, Hollander AP (1998) Human cathepsin K cleaves native type I and II collagens at the N-terminal end of the triple helix. Biochem J 331(pt 3):727-732
    • (1998) Biochem J , vol.331 , Issue.PART 3 , pp. 727-732
    • Kafienah, W.1    Bromme, D.2    Buttle, D.J.3    Croucher, L.J.4    Hollander, A.P.5
  • 3
    • 33847201827 scopus 로고    scopus 로고
    • Role of cathepsin K in normal joints and in the development of arthritis
    • 17305509 10.2174/138945007779940188 1:CAS:528:DC%2BD2sXhs1ygsro%3D
    • Salminen-Mankonen HJ, Morko J, Vuorio E (2007) Role of cathepsin K in normal joints and in the development of arthritis. Curr Drug Targets 8:315-323
    • (2007) Curr Drug Targets , vol.8 , pp. 315-323
    • Salminen-Mankonen, H.J.1    Morko, J.2    Vuorio, E.3
  • 4
    • 79951655957 scopus 로고    scopus 로고
    • Osteoclast activity and subtypes as a function of physiology and pathology - Implications for future treatments of osteoporosis
    • 20851921 10.1210/er.2010-0006 1:CAS:528:DC%2BC3MXjs12rtbc%3D
    • Henriksen K, Bollerslev J, Everts V, Karsdal MA (2011) Osteoclast activity and subtypes as a function of physiology and pathology - implications for future treatments of osteoporosis. Endocr Rev 32:31-63
    • (2011) Endocr Rev , vol.32 , pp. 31-63
    • Henriksen, K.1    Bollerslev, J.2    Everts, V.3    Karsdal, M.A.4
  • 5
    • 0029809357 scopus 로고    scopus 로고
    • Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency
    • 8703060 10.1126/science.273.5279.1236 1:CAS:528:DyaK28Xltlajsrc%3D
    • Gelb BD, Shi GP, Chapman HA, Desnick RJ (1996) Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency. Science 273:1236-1238
    • (1996) Science , vol.273 , pp. 1236-1238
    • Gelb, B.D.1    Shi, G.P.2    Chapman, H.A.3    Desnick, R.J.4
  • 6
  • 7
    • 34047121220 scopus 로고    scopus 로고
    • High bone mineral density in pycnodysostotic patients with a novel mutation in the propeptide of cathepsin K
    • 17206399 10.1007/s00198-006-0311-y 1:CAS:528:DC%2BD2sXjs1ektrc%3D
    • Schilling AF, Mulhausen C, Lehmann W, Santer R, Schinke T, Rueger JM, Amling M (2007) High bone mineral density in pycnodysostotic patients with a novel mutation in the propeptide of cathepsin K. Osteoporos Int 18:659-669
    • (2007) Osteoporos Int , vol.18 , pp. 659-669
    • Schilling, A.F.1    Mulhausen, C.2    Lehmann, W.3    Santer, R.4    Schinke, T.5    Rueger, J.M.6    Amling, M.7
  • 8
    • 0034473275 scopus 로고    scopus 로고
    • Functions of cathepsin K in bone resorption. Lessons from cathepsin K deficient mice
    • 10849757 10.1007/0-306-46826-3-32 1:CAS:528:DC%2BD3cXos1yhu70%3D
    • Saftig P, Hunziker E, Everts V, Jones S, Boyde A, Wehmeyer O, Suter A, von Figura K (2000) Functions of cathepsin K in bone resorption. Lessons from cathepsin K deficient mice. Adv Exp Med Biol 477:293-303
    • (2000) Adv Exp Med Biol , vol.477 , pp. 293-303
    • Saftig, P.1    Hunziker, E.2    Everts, V.3    Jones, S.4    Boyde, A.5    Wehmeyer, O.6    Suter, A.7    Von Figura, K.8
  • 9
    • 33646870167 scopus 로고    scopus 로고
    • Mice lacking cathepsin K maintain bone remodeling but develop bone fragility despite high bone mass
    • 16753017 10.1359/jbmr.060313 1:CAS:528:DC%2BD28XlvVamtbY%3D
    • Li CY, Jepsen KJ, Majeska RJ, Zhang J, Ni R, Gelb BD, Schaffler MB (2006) Mice lacking cathepsin K maintain bone remodeling but develop bone fragility despite high bone mass. J Bone Miner Res 21:865-875
    • (2006) J Bone Miner Res , vol.21 , pp. 865-875
    • Li, C.Y.1    Jepsen, K.J.2    Majeska, R.J.3    Zhang, J.4    Ni, R.5    Gelb, B.D.6    Schaffler, M.B.7
  • 10
    • 58249097157 scopus 로고    scopus 로고
    • Bone density, strength, and formation in adult cathepsin K(-/-) mice
    • 18845279 10.1016/j.bone.2008.08.130 1:CAS:528:DC%2BD1MXhtFSmtLs%3D
    • Pennypacker B, Shea M, Liu Q, Masarachia P, Saftig P, Rodan S, Rodan G, Kimmel D (2009) Bone density, strength, and formation in adult cathepsin K(-/-) mice. Bone 44:199-207
    • (2009) Bone , vol.44 , pp. 199-207
    • Pennypacker, B.1    Shea, M.2    Liu, Q.3    Masarachia, P.4    Saftig, P.5    Rodan, S.6    Rodan, G.7    Kimmel, D.8
  • 12
    • 77953442640 scopus 로고    scopus 로고
    • Future of anticathepsin K drugs: Dual therapy for skeletal disease and atherosclerosis?
    • 20126511 10.4155/fmc.09.4 1:CAS:528:DC%2BD1MXhtFSgur7K
    • Podgorski I (2009) Future of anticathepsin K drugs: dual therapy for skeletal disease and atherosclerosis? Future Med Chem 1:21-34
    • (2009) Future Med Chem , vol.1 , pp. 21-34
    • Podgorski, I.1
  • 13
    • 77956875415 scopus 로고    scopus 로고
    • Cathepsin K inhibition reduces CTXII levels and joint pain in the guinea pig model of spontaneous osteoarthritis
    • 20692355 10.1016/j.joca.2010.07.014 1:STN:280:DC%2BC3cfjsFKqtA%3D%3D
    • McDougall JJ, Schuelert N, Bowyer J (2010) Cathepsin K inhibition reduces CTXII levels and joint pain in the guinea pig model of spontaneous osteoarthritis. Osteoarthr Cartil 18:1355-1357
    • (2010) Osteoarthr Cartil , vol.18 , pp. 1355-1357
    • McDougall, J.J.1    Schuelert, N.2    Bowyer, J.3
  • 14
    • 79952278967 scopus 로고    scopus 로고
    • The cathepsin K inhibitor odanacatib suppresses bone resorption in women with breast cancer and established bone metastases: Results of a 4-week, double-blind, randomized, controlled trial
    • 21147688 10.3816/CBC.2010.n.059 1:CAS:528:DC%2BC3MXjslCksA%3D%3D
    • Jensen AB, Wynne C, Ramirez G, He W, Song Y, Berd Y, Wang H, Mehta A, Lombardi A (2010) The cathepsin K inhibitor odanacatib suppresses bone resorption in women with breast cancer and established bone metastases: results of a 4-week, double-blind, randomized, controlled trial. Clin Breast Cancer 10:452-458
    • (2010) Clin Breast Cancer , vol.10 , pp. 452-458
    • Jensen, A.B.1    Wynne, C.2    Ramirez, G.3    He, W.4    Song, Y.5    Berd, Y.6    Wang, H.7    Mehta, A.8    Lombardi, A.9
  • 17
    • 84863116822 scopus 로고    scopus 로고
    • Odanacatib treatment increases hip bone mass and cortical thickness by preserving endocortical bone formation and stimulating periosteal bone formation in the ovariectomized adult rhesus monkey
    • 22113921 10.1002/jbmr.1477 1:CAS:528:DC%2BC38XisFejt7o%3D
    • Cusick T, Chen CM, Pennypacker BL, Pickarski M, Kimmel DB, Scott BB, le Duong T (2012) Odanacatib treatment increases hip bone mass and cortical thickness by preserving endocortical bone formation and stimulating periosteal bone formation in the ovariectomized adult rhesus monkey. J Bone Miner Res 27:524-537
    • (2012) J Bone Miner Res , vol.27 , pp. 524-537
    • Cusick, T.1    Chen, C.M.2    Pennypacker, B.L.3    Pickarski, M.4    Kimmel, D.B.5    Scott, B.B.6    Le Duong, T.7
  • 19
    • 79953146730 scopus 로고    scopus 로고
    • Odanacatib, a new drug for the treatment of osteoporosis: Review of the results in postmenopausal women
    • 20948576
    • Perez-Castrillon JL, Pinacho F, De Luis D, Lopez-Menendez M, Duenas Laita A (2010) Odanacatib, a new drug for the treatment of osteoporosis: review of the results in postmenopausal women. J Osteoporos 2010:401581
    • (2010) J Osteoporos , vol.2010 , pp. 401581
    • Perez-Castrillon, J.L.1    Pinacho, F.2    De Luis, D.3    Lopez-Menendez, M.4    Duenas Laita, A.5
  • 21
    • 37549068912 scopus 로고    scopus 로고
    • Cathepsin K inhibitors: A novel target for osteoporosis therapy
    • 18073778 10.1038/sj.clpt.6100450 1:CAS:528:DC%2BD2sXhsVylt7bM
    • Stoch SA, Wagner JA (2008) Cathepsin K inhibitors: a novel target for osteoporosis therapy. Clin Pharmacol Ther 83:172-176
    • (2008) Clin Pharmacol Ther , vol.83 , pp. 172-176
    • Stoch, S.A.1    Wagner, J.A.2
  • 22
  • 24
    • 37349065426 scopus 로고    scopus 로고
    • Cathepsin K inhibitors prevent matrix-derived growth factor degradation by human osteoclasts
    • 17962093 10.1016/j.bone.2007.09.044 1:CAS:528:DC%2BD2sXhsVOrtrvJ
    • Fuller K, Lawrence KM, Ross JL, Grabowska UB, Shiroo M, Samuelsson B, Chambers TJ (2008) Cathepsin K inhibitors prevent matrix-derived growth factor degradation by human osteoclasts. Bone 42:200-211
    • (2008) Bone , vol.42 , pp. 200-211
    • Fuller, K.1    Lawrence, K.M.2    Ross, J.L.3    Grabowska, U.B.4    Shiroo, M.5    Samuelsson, B.6    Chambers, T.J.7
  • 26
    • 79958803353 scopus 로고    scopus 로고
    • Safety and efficacy of the cathepsin K inhibitor, ONO-5334, in postmenopausal osteoporosis - The OCEAN study
    • 21312264 10.1002/jbmr.341 1:CAS:528:DC%2BC3MXnvFemu7g%3D
    • Eastell R, Nagase S, Ohyama M, Small M, Sawyer J, Boonen S, Spector T, Kuwayama T, Deacon S (2011) Safety and efficacy of the cathepsin K inhibitor, ONO-5334, in postmenopausal osteoporosis - the OCEAN study. J Bone Miner Res 26:1303-1312
    • (2011) J Bone Miner Res , vol.26 , pp. 1303-1312
    • Eastell, R.1    Nagase, S.2    Ohyama, M.3    Small, M.4    Sawyer, J.5    Boonen, S.6    Spector, T.7    Kuwayama, T.8    Deacon, S.9
  • 27
    • 84857370394 scopus 로고    scopus 로고
    • Balicatib, a cathepsin K inhibitor, stimulates periosteal bone formation in monkeys
    • 21380636 10.1007/s00198-011-1593-2 1:CAS:528:DC%2BC38XktVOlsQ%3D%3D
    • Jerome C, Missbach M, Gamse R (2012) Balicatib, a cathepsin K inhibitor, stimulates periosteal bone formation in monkeys. Osteoporos Int 23:339-349
    • (2012) Osteoporos Int , vol.23 , pp. 339-349
    • Jerome, C.1    Missbach, M.2    Gamse, R.3
  • 29
    • 56749095466 scopus 로고    scopus 로고
    • Effect of temporal changes in bone turnover on the bone mineralization density distribution: A computer simulation study
    • 18665790 10.1359/jbmr.080711 1:CAS:528:DC%2BD1MXosVylsb4%3D
    • Ruffoni D, Fratzl P, Roschger P, Phipps R, Klaushofer K, Weinkamer R (2008) Effect of temporal changes in bone turnover on the bone mineralization density distribution: a computer simulation study. J Bone Miner Res 23:1905-1914
    • (2008) J Bone Miner Res , vol.23 , pp. 1905-1914
    • Ruffoni, D.1    Fratzl, P.2    Roschger, P.3    Phipps, R.4    Klaushofer, K.5    Weinkamer, R.6
  • 30
    • 39149107458 scopus 로고    scopus 로고
    • Bone mineralization density distribution in health and disease
    • 18096457 10.1016/j.bone.2007.10.021 1:STN:280:DC%2BD1c7itVCrtw%3D%3D
    • Roschger P, Paschalis EP, Fratzl P, Klaushofer K (2008) Bone mineralization density distribution in health and disease. Bone 42:456-466
    • (2008) Bone , vol.42 , pp. 456-466
    • Roschger, P.1    Paschalis, E.P.2    Fratzl, P.3    Klaushofer, K.4
  • 31
    • 77953458201 scopus 로고    scopus 로고
    • Mineralization density distribution of postmenopausal osteoporotic bone is restored to normal after long-term alendronate treatment: QBEI and sSAXS data from the fracture intervention trial long-term extension (FLEX)
    • 19580465 10.1359/jbmr.090702 1:CAS:528:DC%2BC3cXksl2lu7Y%3D
    • Roschger P, Lombardi A, Misof BM, Maier G, Fratzl-Zelman N, Fratzl P, Klaushofer K (2010) Mineralization density distribution of postmenopausal osteoporotic bone is restored to normal after long-term alendronate treatment: qBEI and sSAXS data from the fracture intervention trial long-term extension (FLEX). J Bone Miner Res 25:48-55
    • (2010) J Bone Miner Res , vol.25 , pp. 48-55
    • Roschger, P.1    Lombardi, A.2    Misof, B.M.3    Maier, G.4    Fratzl-Zelman, N.5    Fratzl, P.6    Klaushofer, K.7
  • 32
    • 77649187517 scopus 로고    scopus 로고
    • Bisphosphonate treatment modifies canine bone mineral and matrix properties and their heterogeneity
    • 19925895 10.1016/j.bone.2009.11.011 1:CAS:528:DC%2BC3cXitV2gsrs%3D
    • Gourion-Arsiquaud S, Allen MR, Burr DB, Vashishth D, Tang SY, Boskey AL (2010) Bisphosphonate treatment modifies canine bone mineral and matrix properties and their heterogeneity. Bone 46:666-672
    • (2010) Bone , vol.46 , pp. 666-672
    • Gourion-Arsiquaud, S.1    Allen, M.R.2    Burr, D.B.3    Vashishth, D.4    Tang, S.Y.5    Boskey, A.L.6
  • 33
    • 84857340290 scopus 로고    scopus 로고
    • Reduced cortical bone compositional heterogeneity with bisphosphonate treatment in postmenopausal women with intertrochanteric and subtrochanteric fractures
    • 22072397 10.1002/jbmr.560 1:CAS:528:DC%2BC38XisFejtLo%3D
    • Donnelly E, Meredith DS, Nguyen JT, Gladnick BP, Rebolledo BJ, Shaffer AD, Lorich DG, Lane JM, Boskey AL (2012) Reduced cortical bone compositional heterogeneity with bisphosphonate treatment in postmenopausal women with intertrochanteric and subtrochanteric fractures. J Bone Miner Res 27:672-678
    • (2012) J Bone Miner Res , vol.27 , pp. 672-678
    • Donnelly, E.1    Meredith, D.S.2    Nguyen, J.T.3    Gladnick, B.P.4    Rebolledo, B.J.5    Shaffer, A.D.6    Lorich, D.G.7    Lane, J.M.8    Boskey, A.L.9
  • 34
    • 17644445505 scopus 로고    scopus 로고
    • Validation of quantitative backscattered electron imaging for the measurement of mineral density distribution in human bone biopsies
    • 9763143 10.1016/S8756-3282(98)00112-4 1:STN:280:DyaK1cvjsVWjtQ%3D%3D
    • Roschger P, Fratzl P, Eschberger J, Klaushofer K (1998) Validation of quantitative backscattered electron imaging for the measurement of mineral density distribution in human bone biopsies. Bone 23:319-326
    • (1998) Bone , vol.23 , pp. 319-326
    • Roschger, P.1    Fratzl, P.2    Eschberger, J.3    Klaushofer, K.4
  • 35
    • 0031006173 scopus 로고    scopus 로고
    • Mineralization of cancellous bone after alendronate and sodium fluoride treatment: A quantitative backscattered electron imaging study on minipig ribs
    • 9145235 10.1016/S8756-3282(97)00018-5 1:CAS:528:DyaK2sXjsV2iur0%3D
    • Roschger P, Fratzl P, Klaushofer K, Rodan G (1997) Mineralization of cancellous bone after alendronate and sodium fluoride treatment: a quantitative backscattered electron imaging study on minipig ribs. Bone 20:393-397
    • (1997) Bone , vol.20 , pp. 393-397
    • Roschger, P.1    Fratzl, P.2    Klaushofer, K.3    Rodan, G.4
  • 36
    • 0034906270 scopus 로고    scopus 로고
    • Alendronate increases degree and uniformity of mineralization in cancellous bone and decreases the porosity in cortical bone of osteoporotic women
    • 11502482 10.1016/S8756-3282(01)00485-9 1:CAS:528:DC%2BD3MXlvFWkurk%3D
    • Roschger P, Rinnerthaler S, Yates J, Rodan GA, Fratzl P, Klaushofer K (2001) Alendronate increases degree and uniformity of mineralization in cancellous bone and decreases the porosity in cortical bone of osteoporotic women. Bone 29:185-191
    • (2001) Bone , vol.29 , pp. 185-191
    • Roschger, P.1    Rinnerthaler, S.2    Yates, J.3    Rodan, G.A.4    Fratzl, P.5    Klaushofer, K.6
  • 37
    • 0035996567 scopus 로고    scopus 로고
    • Changes in bone remodeling rate influence the degree of mineralization of bone
    • 12489211 1:STN:280:DC%2BD38jislarsg%3D%3D
    • Boivin G, Meunier PJ (2002) Changes in bone remodeling rate influence the degree of mineralization of bone. Connect Tissue Res 43:535-537
    • (2002) Connect Tissue Res , vol.43 , pp. 535-537
    • Boivin, G.1    Meunier, P.J.2
  • 38
    • 0036973149 scopus 로고    scopus 로고
    • Effects of bisphosphonates on matrix mineralization
    • 15758388 1:CAS:528:DC%2BD3sXhtlKgsLc%3D
    • Boivin G, Meunier PJ (2002) Effects of bisphosphonates on matrix mineralization. J Musculoskelet Neuronal Interact 2:538-543
    • (2002) J Musculoskelet Neuronal Interact , vol.2 , pp. 538-543
    • Boivin, G.1    Meunier, P.J.2
  • 39
    • 33745485305 scopus 로고    scopus 로고
    • Effects of 3- and 5-year treatment with risedronate on bone mineralization density distribution in triple biopsies of the iliac crest in postmenopausal women
    • 16813531 10.1359/jbmr.060401 1:CAS:528:DC%2BD28XntlWqu7s%3D
    • Zoehrer R, Roschger P, Paschalis EP, Hofstaetter JG, Durchschlag E, Fratzl P, Phipps R, Klaushofer K (2006) Effects of 3- and 5-year treatment with risedronate on bone mineralization density distribution in triple biopsies of the iliac crest in postmenopausal women. J Bone Miner Res 21:1106-1112
    • (2006) J Bone Miner Res , vol.21 , pp. 1106-1112
    • Zoehrer, R.1    Roschger, P.2    Paschalis, E.P.3    Hofstaetter, J.G.4    Durchschlag, E.5    Fratzl, P.6    Phipps, R.7    Klaushofer, K.8
  • 40
    • 34547753938 scopus 로고    scopus 로고
    • Evidence that treatment with risedronate in women with postmenopausal osteoporosis affects bone mineralization and bone volume
    • 17612779 10.1007/s00223-007-9039-8 1:CAS:528:DC%2BD2sXosFOgsrk%3D
    • Fratzl P, Roschger P, Fratzl-Zelman N, Paschalis EP, Phipps R, Klaushofer K (2007) Evidence that treatment with risedronate in women with postmenopausal osteoporosis affects bone mineralization and bone volume. Calcif Tissue Int 81:73-80
    • (2007) Calcif Tissue Int , vol.81 , pp. 73-80
    • Fratzl, P.1    Roschger, P.2    Fratzl-Zelman, N.3    Paschalis, E.P.4    Phipps, R.5    Klaushofer, K.6
  • 41
    • 80052279445 scopus 로고    scopus 로고
    • The effects of the cathepsin K inhibitor odanacatib on osteoclastic bone resorption and vesicular trafficking
    • 21718816 10.1016/j.bone.2011.06.014 1:CAS:528:DC%2BC3MXhtFektbrJ
    • Leung P, Pickarski M, Zhuo Y, Masarachia PJ, Duong LT (2011) The effects of the cathepsin K inhibitor odanacatib on osteoclastic bone resorption and vesicular trafficking. Bone 49:623-635
    • (2011) Bone , vol.49 , pp. 623-635
    • Leung, P.1    Pickarski, M.2    Zhuo, Y.3    Masarachia, P.J.4    Duong, L.T.5
  • 42
    • 0042066351 scopus 로고    scopus 로고
    • Intrapopulation variability in mineralization density at the human femoral mid-shaft
    • 12924824 10.1046/j.1469-7580.2003.00212.x 1:STN:280: DC%2BD3szoslGqtA%3D%3D
    • Goldman HM, Bromage TG, Boyde A, Thomas CD, Clement JG (2003) Intrapopulation variability in mineralization density at the human femoral mid-shaft. J Anat 203:243-255
    • (2003) J Anat , vol.203 , pp. 243-255
    • Goldman, H.M.1    Bromage, T.G.2    Boyde, A.3    Thomas, C.D.4    Clement, J.G.5
  • 43
    • 0016206838 scopus 로고
    • Electron microprobe measurements of bone mineralization rate in vivo
    • 4811191 1:CAS:528:DyaE2cXhtVKhu7s%3D
    • Wergedal JE, Baylink DJ (1974) Electron microprobe measurements of bone mineralization rate in vivo. Am J Physiol 226:345-352
    • (1974) Am J Physiol , vol.226 , pp. 345-352
    • Wergedal, J.E.1    Baylink, D.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.