Inhibitory effects of blockage of intermediate conductance Ca 2+-activated K+ channels on proliferation of hepatocellular carcinoma cells

Journal of Huazhong University of Science and Technology - Medical Science

Volumn 33, Issue 1, 2013, Pages 86-89

  Yang, Xiao Wei ^a   Liu, Jin Wen ^a   Zhang, Ru Chao ^b   Yin, Qian ^a   Shen, Wen Zhuang ^a   Yi, Ji Lin ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b CHINA THREE GORGES UNIVERSITY   (China)

Author keywords

hepatocellular carcinoma; proliferation; TRAM 34

Indexed keywords

1 [(2 CHLOROPHENYL)DIPHENYLMETHYL] 1H PYRAZOLE; CALCIUM CHANNEL BLOCKING AGENT; INTERMEDIATE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; KCNN4 PROTEIN, HUMAN; POTASSIUM; PYRAZOLE DERIVATIVE;

ARTICLE; CELL PROLIFERATION; CHANNEL GATING; DRUG ANTAGONISM; DRUG EFFECT; HEPG2 CELL LINE; HUMAN; LIVER CELL CARCINOMA; LIVER TUMOR; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; TUMOR CELL CULTURE;

CALCIUM CHANNEL BLOCKERS; CARCINOMA, HEPATOCELLULAR; CELL PROLIFERATION; HEP G2 CELLS; HUMANS; INTERMEDIATE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; ION CHANNEL GATING; LIVER NEOPLASMS; POTASSIUM; PYRAZOLES; TUMOR CELLS, CULTURED;

EID: 84873697510     PISSN: 16720733     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11596-013-1076-0     Document Type: Article

References (15)

1. Parihar AS, Coghlan MJ, Gopalakrishnan M, et al. Effects of intermediate-conductance Ca2+-activated K+ channel modulators on human prostate cancer cell proliferation. Eur J Pharmacol, 2003,471(3):157-164
2. Jager H, Dreker T, Buck A, et al. Blockage of intermediate-conductance Ca2+-activated K+ channels inhibit human pancreatic cancer cell growth in vitro. Mol Pharmacol, 2004,65(3):630-638
3. Wang ZH, Shen B, Yao HL, et al. Blockage of intermediate-conductance- Ca(2+)-activated K(+) channels inhibits progression of human endometrial cancer. Oncogene, 2007,26(35):5107-5114
4. Ouadid-Ahidouch H, Roudbaraki M, Delcourt P, et al. Functional and molecular identification of intermediate-conductance Ca(2+)-activated K(+) channels in breast cancer cells: association with cell cycle progression. Am J Physiol Cell Physiol, 2004,287(1):C125-134
5. Lallet-Daher H, Roudbaraki M, Bavencoffe A, et al. Intermediate- conductance Ca2+-activated K+ channels (IKCa1) regulate human prostate cancer cell proliferation through a close control of calcium entry. Oncogene, 2009,28(15):1792-1806
6. Wulff H, Kolski-Andreaco A, Sankaranarayanan A, et al. Modulators of small- and intermediate-conductance calcium-activated potassium channels and their therapeutic indications. Curr Med Chem, 2007,14(13):1437-1457
7. Barfod ET, Moore AL, Roe MW, et al. Ca2+-activated IK1 channels associate with lipid rafts upon cell swelling and mediate volume recovery. J Biol Chem, 2007,282(12):8984-8993
8. Wulff H, Miller MJ, Hansel W, et al. Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant. Proc Natl Acad Sci USA, 2000, 97(14):8151-8156
9. Toyama K, Wulff H, Chandy KG, et al. The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans. J Clin Invest, 2008,118(9):3025-3037
10. Wang Z. Roles of K+ channels in regulating tumour cell proliferation and apoptosis. Pflugers Arch, 2004,48(3):274-286
11. Valverde P, Kawai T, Taubman MA. Potassium channel-blockers as therapeutic agents to interfere with bone resorption of periodontal disease. J Dent Res, 2005,84(6):488-499
12. El Boustany C, Bidaux G, Enfissi A, et al. Capacitative calcium entry and transient receptor potential canonical 6 expression control human hepatoma cell proliferation. Hepatology, 2008,47(6):2068-2077
13. Pena TL, Chen SH, Konieczny SF, et al. Ras/MEK/ERK up-regulation of the fibroblast KCa channel FIK is a common mechanism for basic fibroblast growth factor and transforming growth factor-beta suppression of myogenesis. J Biol Chem, 2000,275(18):13677-13682
14. Grgic I, Eichler I, Heinau P, et al. Selective blockade of the intermediate-conductance Ca2+-activated K+ channel suppresses proliferation of microvascular and macrovascular endothelial cells and angiogenesis in vivo. Arterioscler Thromb Vasc Biol, 2005,25(4):704-709
15. Minguez B, Tovar V, Chiang D, et al. Pathogenesis of hepatocellular carcinoma and molecular therapies. Curr Opin Gastroenterol, 2009,25(3):186-194