Robust perfusion deficits in cognitively impaired patients with secondary-progressive Multiple Sclerosis

American Journal of Neuroradiology

Volumn 34, Issue 1, 2013, Pages 62-67

  Francis, P L ^a   Jakubovic, R ^a   O'Connor, P ^b,c   Zhang, L ^a   Eilaghi, A ^a   Lee, L ^a,c   Carroll, T J ^d,e   Mouannes Srour, J ^d   Feinstein, A ^a,c   Aviv, R I ^a,c  

^a SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^b ST MICHAEL'S HOSPITAL   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d Northwestern University   (United States)

^e NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BRAIN DAMAGE; BRAIN PERFUSION; BRAIN SIZE; CAUDATE NUCLEUS; CLINICAL ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; FEMALE; GRAY MATTER; HUMAN; MALE; MULTIPLE SCLEROSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; THALAMUS; VOLUMETRY; WHITE MATTER;

CEREBROVASCULAR DISORDERS; COGNITION DISORDERS; FEMALE; HUMANS; MAGNETIC RESONANCE ANGIOGRAPHY; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE; NEURONS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 84873695904     PISSN: 01956108     EISSN: 1936959X     Source Type: Journal    
DOI: 10.3174/ajnr.A3148     Document Type: Article

References (40)

1. Rao SM, Leo GJ, Bernardin L, et al. Cognitive dysfunction in multiple sclerosis. I. Frequency, patterns, and prediction. Neurology 1991;41:685-91
2. Huijbregts SC, Kalkers NF, de Sonneville LM, et al. Differences in cognitive impairment of relapsing remitting, secondary, and primary progressive MS. Neurology 2004;63:335-39
3. Rao SM, Leo GJ, Ellington L, et al. Cognitive dysfunction in multiple sclerosis. II. Impact on employment and social functioning. Neurology 1991;41:692-96
4. Benedict RH, Wahlig E, Bakshi R, et al. Predicting quality of life in multiple sclerosis: accounting for physical disability, fatigue, cognition, mood disorder, personality, and behavior change. J Neurol Sci 2005;231:29-34
5. Hoffmann S, Tittgemeyer M, von Cramon DY. Cognitive impairment in multiple sclerosis. Curr Opin Neurol 2007;20:275-80
6. Chiaravalloti ND, DeLuca J. Cognitive impairment in multiple sclerosis. Lancet Neurol 2008;7:1139-51
7. Filippi M, Rocca MA, Benedict RH, et al. The contribution of MRI in assessing cognitive impairment in multiple sclerosis. Neurology 2010;75:2121-28
8. Langdon DW. Cognition in multiple sclerosis. Curr Opin Neurol 2011;24:244-49
9. Rovaris M, Comi G, Filippi M. MRI markers of destructive pathology in multiple sclerosis-related cognitive dysfunction. J Neurol Sci 2006;245:111-16
10. Benedict RH, Weinstock-Guttman B, Fishman I, et al. Prediction of neuropsychological impairment in multiple sclerosis: comparison of conventional magnetic resonance imaging measures of atrophy and lesion burden. Arch Neurol 2004;61:226-30
11. Houtchens MK, Benedict RH, Killiany R, et al. Thalamic atrophy and cognition in multiple sclerosis. Neurology 2007;69:1213-23
12. Piras MR, Magnano I, Canu ED, et al. Longitudinal study of cognitive dysfunction in multiple sclerosis: neuropsychological, neuroradiological, and neurophysiological findings. J Neurol Neurosurg Psychiatry 2003;74:878-85
13. Tekok-Kilic A, Benedict RH, Weinstock-Guttman B, et al. Independent contributions of cortical gray matter atrophy and ventricle enlargement for predicting neuropsychological impairment in multiple sclerosis. Neuroimage 2007;36:1294-300
14. Rovaris M, Filippi M, Minicucci L, et al. Cortical/subcortical disease burden and cognitive impairment in patients with multiple sclerosis. AJNR Am J Neuroradiol 2000;21:402-08
15. Roosendaal SD, Moraal B, Pouwels PJ, et al. Accumulation of cortical lesions in MS: relation with cognitive impairment. Mult Scler 2009;15:708-14
16. Calabrese M, Agosta F, Rinaldi F, et al. Cortical lesions and atrophy associated with cognitive impairment in relapsing-remitting multiple sclerosis. Arch Neurol 2009;66:1144-50
17. Shin W, Horowitz S, Ragin A, et al. Quantitative cerebral perfusion using dynamic susceptibility contrast MRI: evaluation of reproducibility and age-and gender-dependence with fully automatic image postprocessing algorithm. Magn Reson Med 2007;58:1232-41
18. Carroll TJ, Horowitz S, Shin W, et al. Quantification of cerebral perfusion using the "bookend technique": an evaluation in CNS tumors. Magn Reson Imaging 2008;26:1352-59
19. Srour JM, Shin W, Shah S, et al. Scale-PWI a pulse sequence for absolute quantitative cerebral perfusion imaging. J Cereb Blood Flow Metab 2011;31:1272-82
20. Inglese M, Adhya S, Johnson G, et al. Perfusion magnetic resonance imaging correlates of neuropsychological impairment in multiple sclerosis. J Cereb Blood Flow Metab 2008;28:164-71
21. Aviv RI, Francis PL, Tenenbein R, et al. Decreased frontal lobe gray matter perfusion in cognitively impaired secondary-progressive multiple sclerosis patients detected by the bookend technique. AJNR Am J Neuroradiol. In press
22. Benedict RH, Fischer JS, Archibald CJ, et al. Minimal neuropsychological assessment of MS patients: a consensus approach. Clin Neuropsychol 2002;16:381-97
23. Benedict RH, Zivadinov R. Predicting neuropsychological abnormalities in multiple sclerosis. J Neurol Sci 2006;245:67-72
24. Blinkenberg M, Rune K, Jensen CV, et al. Cortical cerebral metabolism correlates with MRI lesion load and cognitive dysfunction in MS. Neurology 2000;54:558-64
25. Rashid W, Parkes LM, Ingle GT, et al. Abnormalities of cerebral perfusion in multiple sclerosis. J Neurol Neurosurg Psychiatry 2004;75:1288-93
26. Morgen K, Sammer G, Courtney SM, et al. Evidence for a direct association between cortical atrophy and cognitive impairment in relapsing-remitting MS. Neuroimage 2006;30:891-98
27. Ashburner J. Computational anatomy with theSPMsoftware. Magn Reson Imaging 2009;27:1163-74
28. Trapp BD, Peterson J, Ransohoff RM, et al. Axonal transection in the lesions of multiple sclerosis. N Engl J Med 1998;338:278-85
29. Stuss DT, Alexander MP. Is there a dysexecutive syndrome? Philos Trans R Soc Lond B Biol Sci 2007;362:901-15
30. Pantoni L, Garcia JH. Pathogenesis of leukoaraiosis: a review. Stroke 1997;28:652-59
31. Rao SM. A Manual for the Brief Repeatable Battery of Neuropsychological Tests in Multiple Sclerosis. Milwaukee: Medical College of Wisconsin; 1990
32. Sperling RA, Guttmann CR, Hohol MJ, et al. Regional magnetic resonance imaging lesion burden and cognitive function in multiple sclerosis: a longitudinal study. Arch Neurol 2001;58:115-21
33. Huijbregts SC, Kalkers NF, de Sonneville LM, et al. Cognitive impairment and decline in different MS subtypes. J Neurol Sci 2006;245:187-94
34. Benedict RH, Cookfair D, Gavett R, et al. Validity of the minimal assessment of cognitive function in multiple sclerosis (MACFIMS). J Int Neuropsychol Soc 2006;12:549-58
35. Forn C, Belenguer A, Parcet-Ibars MA, et al. Information-processing speed is the primary deficit underlying the poor performance of multiple sclerosis patients in the Paced Auditory Serial Addition Test (PASAT). J Clin Exp Neuropsychol 2008;30:789-96
36. Strober L, Englert J, Munschauer F, et al. Sensitivity of conventional memory tests in multiple sclerosis: comparing the Rao Brief Repeatable Neuropsychological Battery and the Minimal Assessment of Cognitive Function in MS. Mult Scler 2009;15:1077-84
37. Drake AS, Weinstock-Guttman B, Morrow SA, et al. Psychometrics and normative data for the Multiple Sclerosis Functional Composite: replacing the PASAT with the Symbol Digit Modalities Test. Mult Scler 2010;16:228-37
38. Parmenter BA, Shucard JL, Benedict RH, et al. Working memory deficits in multiple sclerosis: comparison between the n-back task and the Paced Auditory Serial Addition Test. J Int Neuropsychol Soc 2006;12:677-87
39. Stuss DT, Floden D, Alexander MP, et al. Stroop performance in focal lesion patients: dissociation of processes and frontal lobe lesion location. Neuropsychologia. 2001;39:771-86
40. Alexander MP, Stuss DT, Picton T, et al. Regional frontal injuries cause distinct impairments in cognitive control. Neurology 2007;68:1515-23