The spectrum of acute heart failure after venlafaxine overdose

Clinical Toxicology

Volumn 51, Issue 2, 2013, Pages 92-95

  Batista, M ^a   Dugernier, T ^b   Simon, M ^c   Haufroid, V ^d   Capron, A ^d   Fonseca, S ^a   Bonbled, F ^a   Hantson, P ^a,d  

^a CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

^b Clinique Saint Pierre of Ottignies   (Belgium)

^c Cliniques du Sud Luxembourg   (Belgium)

^d UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

Autopsy; Cardiotoxicity; Echocardiography; Left ventricular failure; Overdose; Venlafaxine

Indexed keywords

BENZODIAZEPINE; DESVENLAFAXINE; DIAZEPAM; DOBUTAMINE; INSULIN; MILRINONE; NORADRENALIN; PHENYTOIN; TROPONIN I; VENLAFAXINE;

ACUTE HEART FAILURE; ACUTE KIDNEY FAILURE; ADULT; AGED; ANURIA; ARTICLE; ARTIFICIAL VENTILATION; CARDIOGENIC SHOCK; CARDIOTOXICITY; CASE REPORT; CAUSE OF DEATH; DEPRESSION; DRUG BLOOD LEVEL; DRUG OVERDOSE; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAPHY; ENDOTRACHEAL INTUBATION; EPILEPTIC STATE; HEART ARRHYTHMIA; HEART ATRIUM FIBRILLATION; HEART LEFT VENTRICLE CONTRACTILITY; HEART LEFT VENTRICLE EJECTION FRACTION; HUMAN; HYPOTENSION; HYPOXEMIA; LIVER ISCHEMIA; MALE; NYSTAGMUS; OLIGURIA; QRS COMPLEX; RESUSCITATION; RHABDOMYOLYSIS; SEIZURE; SEROTONIN SYNDROME; SINUS TACHYCARDIA; VISUAL HALLUCINATION;

ACUTE DISEASE; ADULT; AGED; ANOXIA; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; CYCLOHEXANOLS; DEATH, SUDDEN, CARDIAC; DELAYED-ACTION PREPARATIONS; ELECTROCARDIOGRAPHY; EPILEPSY, TONIC-CLONIC; FATAL OUTCOME; FEMALE; HEART FAILURE; HUMANS; LONG QT SYNDROME; MIDDLE AGED; RESPIRATION, ARTIFICIAL; SEROTONIN SYNDROME; SHOCK, CARDIOGENIC; STROKE VOLUME; SUICIDE, ATTEMPTED; VENTRICULAR FUNCTION, LEFT;

EID: 84873692787     PISSN: 15563650     EISSN: 15569519     Source Type: Journal    
DOI: 10.3109/15563650.2012.763133     Document Type: Article

References (18)

1. Howell C, Wilson AD, Waring WS. Cardiovascular toxicity due to venlafaxine poisoning in adults: a review of 235 consecutive cases. Br J Clin Pharmacol 2007; 64: 192-197.
2. Martinez C, Assimes TL, Mines D, Dell'aniello S, Suissa S. Use of venlafaxine compared with other antidepressants and the risk of sudden cardiac death or near death: a nested case-control study. BMJ 2010; 340: c249. doi: 10.1136/bmj.c249.
3. Isbister G. E lectrocardiogram changes and arrhythmias in venlafaxine overdose. Br J Clin Pharmacol 2009; 67: 572-576.
4. Höjer J, Hulting J, Salmonson H. Fatal cardiotoxicity induced by venlafaxine overdosage. Clin Toxicol 2008; 46: 336-337.
5. Khalifa M, Daleau P, Turgeon J. Mechanism of sodium channel block by venlafaxine in guinea pig ventricular myocytes. J Pharmacol Exp Ther 1999; 291: 280-284.
6. Bosse GM, Spiller HA, Collins AM. A fatal case of venlafaxine overdose. J Med Toxicol 2008; 4: 18-20.
7. Peano C, Leikin JB, Hanashiro PK. Seizures, ventricular tachycardia, and rhabdomyolysis as a result of ingestion of venlafaxine and lamotrigine. Ann Emerg Med 1997; 30: 704-708.
8. Malfroy S, Tassin C, Attof R, Perdrix JP, Piriou V. Cardiogenic shock after venlafaxine poisoning. Ann Fr Anesth Rean 2011; 30: 857-858.
9. Vinetti M, Haufroid V, Capron A, Classen JF, Marchandise S, Hantson P. Severe acute cardiomyopathy associated with venlafaxine overdose and possible role of CYP2D6 and CYP2C19 polymorphisms. Clin Toxicol 2011; 49: 865-869.
10. Caroselli C, Ricci G. The venlafaxine "heart revenge": a short report. Clin Cardiol 2010; 33: e46-e47.
11. Fangio P, De Jonghe B, Appéré-De-Vecchi C, Lachérade JC, Terville JP, Outin H. Acute heart failure associated with venlafaxine poisoning. Am J Emerg Med 2007; 25: 210-211.
12. Partridge SJ, MacIver DH, Solanki T. A depressed myocardium. J Toxicol Clin Toxicol 2000; 38: 453-455.
13. Godkar D, Stensby J, Sinnapunayagam S, Niranjan S. V enlafaxine induced acute myocardial infarction with normal coronary arteries. Am J Ther 2009; 16: 365-366.
14. Christoph M, Ebner B, Stolte D, Ibrahim K, Kolschmann S, Strasser RH. Broken heart syndrome: Tako tsubo cardiomyopathy associated with an overdose of the serotonin-norpepinephrine reuptake inhibitor venlafaxine. Eur Neuropsychopharmacol 2010; 20: 594-597.
15. De Roock S, Beauloye C, De Bauwer I, Vancraynest D, Gurne O, Gerber B. Tako-tsubo syndrome following nortriptyline overdose. Clin Toxicol 2008; 46: 475-478.
16. Neil CJA, Chong C-R, Nguyen TH, Horowitz JD. Occurrence of tako-tsubo cardiomyopathy in association with ingestion of serotonin/ noradrenaline reuptake inhibitors. Heart Lung Circ 2012; 21: 203-205.
17. Francino MC, Bretaudeau Deguigne M, Badin J, Turcant A, Perrotin D. Hypoglycaemia: a little known effect of venlafaxine overdose. Clin Toxicol (Phila) 2012; 50: 215-217.
18. Mégarbane B, Bloch V, Deye N, Baud F J. P harmacokinetic/ pharmacodynamic modelling of cardiac toxicity in venlafaxine overdose. Intensive Care Med 2007; 33: 195-196.