Mechanism of sodium channel block by venlafaxine in guinea pig ventricular myocytes

Journal of Pharmacology and Experimental Therapeutics

Volumn 291, Issue 1, 1999, Pages 280-284

  Khalifa, Majed ^a   Daleau, Pascal ^b   Turgeon, Jacques ^a,b  

^a LAVAL UNIVERSITY   (Canada)

^b UNIVERSITÉ LAVAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; ANTIDEPRESSANT AGENT; CALCIUM CHANNEL BLOCKING AGENT; NORADRENALIN; POTASSIUM CHANNEL BLOCKING AGENT; SODIUM CHANNEL BLOCKING AGENT; VENLAFAXINE;

ANIMAL CELL; ARTICLE; CARDIOTOXICITY; CONTROLLED STUDY; DRUG BINDING; DRUG INHIBITION; DRUG MECHANISM; GUINEA PIG; HEART MUSCLE CELL; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; SEIZURE; SODIUM CURRENT; TACHYCARDIA;

ANIMALS; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; CYCLOHEXANOLS; ELECTROPHYSIOLOGY; GUINEA PIGS; HEART; HEART VENTRICLES; KINETICS; MYOCARDIUM; SEROTONIN UPTAKE INHIBITORS; SODIUM CHANNEL BLOCKERS; TIME FACTORS;

EID: 0032873420     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Ballenger JC (1996) Clinical evaluation of venlafaxine. J Clin Psychopharmacol 16 (Suppl 2):S29S-S36.
2. Brosen K (1990) Recent developments in hepatic drug oxidation. Implications for clinical pharmacokinetics. Clin Pharmacokinet 18:220-239.
3. Caporaso NE and Shaw GL (1991) Clinical implications of the competitive inhibition of the debrisoquine-metabolizing isozyme by quinidine. Arch Intern Med 151: 1985-1992.
4. Chiu KC and McCarthy JE (1997) The insertion allele at the angiotensin I-converting enzyme gene locus is associated with insulin resistance. Metabolism 46:395-399.
5. Cunningham LA, Borison RL, Carman JS, Chouinard G, Crowder JE, Diamond BI, Fischer DE and Hearst E (1994) A comparison of venlafaxine, trazodone, and placebo in major depression. J Clin Psychopharmacol 14:99-106.
6. Dahl B, Crouch BI and Rollins D (1996) Death from venlafaxine overdose (Abstract). J Toxicol-Clin Toxic 34:557.
7. Daleau P, Lessard E, Groleau MF and Turgeon J (1995) Erythromycin blocks the rapid component of the delayed rectifier potassium current and lengthens repolarization of guinea pig ventricular myocytes. Circulation 91:3010-3016.
8. Devane CL (1994) Pharmacogenetics and drug metabolism of newer antidepressant agents. J Clin Psychiatry 55 (Suppl 12):38-45.
9. Duman RS, Heninger GR and Nestler EJ (1997) A molecular and cellular theory of depression. Arch Gen Psychiatry 54:597-606.
10. Durback LF and Scharman EJ (1996) Seizures associated with venlafaxine overdose (Abstract). J Toxicol-Clin Toxic 34:557.
11. Fantaskey A and Burkhart KK (1995) A case report of venlafaxine toxicity. J Toxicol-Clin Toxic 33:359-361.
12. Grunder G, Wetzel H, Schlober R and Benkert O (1996) Subchronic antidepressant treatment with venlafaxine or imipramine and effects on blood pressure and heart rate: assessment by automatic 24-hour monitoring. Pharmacopsychiatry 29:72-78.
13. Guelfi JD, White C, Hackett D, Guichoux JY and Magni G (1995) Effectiveness of venlafaxine in patients hospitalised for major depression and melancholia. J Clin Psychiatry 56:450-458.
14. Hamelin BA, Turgeon J, Vallée F, Bélanger PM, Paquet F and Lebel M (1996) Role of CYP2D6 in the demethylation of fluoxetine in vivo (Abstract). Clin Pharmacol Ther 59:137.
15. Hanck DA and Sheets MF (1992a) Extracellular divalent and trivalent cation effects on sodium current kinetics in single canine cardiac Purkinje cells. J Physiol (Lond) 454:267-298.
16. + current in single canine cardiac Purkinje cells. Am J Physiol 282:H1197-H1207.
17. Hondeghem LM (1987) Antiarrhythmic agents: Modulated receptor applications. Circulation 75:514-520.
18. Khan A (1998) Overall safety profile of venlafaxine: commentary. J Clin Psychopharmacol 16 (Suppl 2):S59-S61.
19. Klamerus KJ, Maloney K, Rudolph RL, Sisenwine SF, Jusko WJ and Chiang ST (1992) Introduction of a composite parameter to the pharmacokinetics of venlafaxine and its active-O-desmethyl metabolite. J Clin Pharmacol 32:716-724.
20. Kojima M, Hamamoto T and Ban T (1989) Sodium channel-blocking properties of flecainide, a class IC antiarrhythmic drug, in guinea-pig papillary muscles. An open channel blocker or an inactivated channel blocker. Naunyn-Schmeidebergs Arch Pharmacol 339:441-447.
21. Kokan L and Dart RC (1996) Life-threatening hypotension from venlafaxine overdose (Abstract). Ann Emerg Med 27:815.
22. + channels. Eur J Pharmacol 266:245-254.
23. Muir WW, Strauch SM and Schaal SF (1982) Effects of tricyclic antidepressant drugs on the electrophysiological properties of dog Purkinje fibers. J Cardiovasc Pharmacol 4:82-90.
24. Nierenberg AA, Feighner JP, Rudolph R, Cole JO and Sullivan J (1994) Venlafaxine for treatment-resistant unipolar depression. J Clin Psychopharmacol 14:419-423.
25. Ogata N and Narahashi T (1989) Block of sodium channels by psychotropic drugs in single guinea-pig cardiac myocytes. Br J Pharmacol 97:905-913.
26. Parsons AT, Anthony RM and Meeker JE (1996) Two fatal cases of venlafaxine poisoning. J Anal Toxicol 20:266-268.
27. Patat A, Troy S, Burke J, Trocherie S, Danjou P, Le Coz F, Allain H and Gandon JM (1998) Absolute bioavailability and electroencephalographic effects of conventional and extended-release formulations of venlafaxine in healthy subjects. J Clin Pharmacol 38:256-267.
28. Peano C, Leikin JB and Hanashiro PK (1997) Seizures, ventricular tachycardia, and rhabdomyolysis as a result of ingestion of venlafaxine and lamotrigine. Ann Emerg Med 30:704-708.
29. Rosen P, Marek M and Borys D (1997) Coma, hypotension, and intraventricular block in a patient with venlafaxine and clonazepam overdose (Abstract). J Toxicol-Clin Toxic 35:548.
30. Rudolph RL and Derivan AT (1996) The safety and tolerability of venlafaxine hydrochloride: analysis of the clinical trials database. J Clin Psychopharmacol 16 (Suppl 2):54S-61S.
31. Schauf CL, Davis FA and Kesler RL (1975) Actions of the antidepreseant drug imipramine on the voltage-clamped myxicola giant axon. J Pharmacol Exp Ther 193:669-675.
32. Thase ME (1996) Antidepressant options: venlafaxine in perspective. J Clin Psychopharmacol 16 (Suppl 2):10S-20S.
33. Van Gelder IC, Brugemann J and Crijns HJGM (1998) Current treatment recommendations in antiarrhythmic therapy. Drugs 55:331-346.
34. Wells KB, Hays RD, Burnam MA, Rogers W, Greenfield S and Ware JE Jr (1989) Detection of depressive disorder for patients receiving prepaid or fee-for-service care. J Am Med Assoc 262:3298-3302.
35. Zhalkovsky B, Walker D and Bourgeois JA (1997) Seizure activity and enzyme elevations after venlafaxine overdose. J Clin Psychopharmacol 17:490-491.