Quantitative structure-activity relationships for organophosphates binding to acetylcholinesterase

Archives of Toxicology

Volumn 87, Issue 2, 2013, Pages 281-289

  Ruark, Christopher D ^a   Hack, C Eric ^a   Robinson, Peter J ^a   Anderson, Paul E ^b   Gearhart, Jeffery M ^a  

^a AIR FORCE RESEARCH LABORATORY   (United States)

^b School of Business   (United States)

Author keywords

Acetylcholinesterase; Bimolecular; Chemical warfare nerve agent; Organophosphate; PBPK PD; QSAR

Indexed keywords

ACETYLCHOLINESTERASE; ORGANOPHOSPHATE;

ARTICLE; BINDING AFFINITY; CHEMICAL BINDING; CHEMICAL MODEL; CONSENSUS; ENZYME BINDING; ENZYME INHIBITION; MOLECULAR BIOLOGY; PEER REVIEW; PREDICTION; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RANDOMIZATION; REFERENCE VALUE; STRUCTURE ANALYSIS; TOXICITY TESTING; TOXICOKINETICS; VALIDATION PROCESS;

ACETYLCHOLINESTERASE; CHOLINESTERASE INHIBITORS; COMPUTER SIMULATION; HUMANS; ORGANOPHOSPHATES; PESTICIDES; PROTEIN BINDING; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84873679531     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-012-0934-z     Document Type: Article

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