Location of the clot and outcome of perfusion defects in acute anterior circulation stroke treated with intravenous thrombolysis

American Journal of Neuroradiology

Volumn 34, Issue 1, 2013, Pages 100-106

  Sillanpaa N ^a   Saarinen, J T ^b   Rusanen, H ^c   Elovaara, I ^b   Dastidar, P ^a   Soimakallio, S ^a  

^a TAMPERE UNIVERSITY HOSPITAL   (Finland)

^b TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^c OULU UNIVERSITY HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ALTEPLASE;

AGED; ARTICLE; BLOOD CLOT; BLOOD CLOT LYSIS; BLOOD VESSEL OCCLUSION; BRAIN PERFUSION; BRAIN TISSUE; CEREBROVASCULAR ACCIDENT; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; COMPUTER ASSISTED TOMOGRAPHY; CONTINUOUS INFUSION; CONTROLLED STUDY; FEMALE; HUMAN; INTERNAL CAROTID ARTERY; MAJOR CLINICAL STUDY; MALE; MIDDLE CEREBRAL ARTERY; OUTCOME ASSESSMENT; THROMBUS;

AGED; AGED, 80 AND OVER; BLOOD COAGULATION; CEREBRAL ANGIOGRAPHY; FEMALE; FIBRINOLYTIC AGENTS; HUMANS; INJECTIONS, INTRAVENOUS; INTRACRANIAL THROMBOSIS; MALE; MIDDLE AGED; PROGNOSIS; REPRODUCIBILITY OF RESULTS; RETROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY; STROKE; THROMBOLYTIC THERAPY; TOMOGRAPHY, X-RAY COMPUTED; TREATMENT OUTCOME;

EID: 84873636745     PISSN: 01956108     EISSN: 1936959X     Source Type: Journal    
DOI: 10.3174/ajnr.A3149     Document Type: Article

References (26)

1. Yoo AJ, Verduzco LA, Schaefer PW, et al. MRI-based selection for intra-arterial stroke therapy: value of pretreatment diffusionweighted imaging lesion volume in selecting patients with acute stroke who will benefit from early recanalization. Stroke 2009;40:2046-54
2. Soares BP, Tong E, Hom J, et al. Reperfusion is a more accurate predictor of follow-up infarct volume than recanalization: a proof of concept using CT in acute ischemic stroke patients. Stroke 2010;41:e34-40
3. del Zoppo GJ, Poeck K, Pessin MS, et al. Recombinant tissue plasminogen activator in acute thrombotic and embolic stroke. Ann Neurol 1992;32:78-86
4. Zangerle A, Kiechl S, Spiegel M, et al. Recanalization after thrombolysis in stroke patients: predictors and prognostic implications. Neurology 2007;68:39-44
5. Saqqur M, Uchino K, Demchuk AM, et al, for the CLOTBUST Investigators. Site of arterial occlusion identified by transcranial Doppler predicts the response to intravenous thrombolysis for stroke. Stroke 2007;38:948-54
6. Gralla J, Burkhardt M, Schroth G, et al. Occlusion length is a crucial determinant of efficiency and complication rate in thrombectomy for acute ischemic stroke. AJNR Am J Neuroradiol 2008;29:247-52
7. Linfante I, Llinas RH, Selim M, et al. Clinical and vascular outcome in internal carotid artery versus middle cerebral artery occlusions after intravenous tissue plasminogen activator. Stroke 2002;33: 2066-71
8. Smith WS, Tsao JW, Billings ME, et al. Prognostic significance of angiographically confirmed large vessel intracranial occlusion in patients presenting with acute brain ischemia. Neurocrit Care 2006;4:14-17
9. Puetz V, Dzialowski I, Hill MD, et al. Calgary CTA Study Group: Intracranial thrombus extent predicts clinical outcome, final infarct size and hemorrhagic transformation in ischemic stroke: the clot burden score. Int J Stroke 2008;3:230-36
10. Puetz V, Dzialowski I, Hill MD, et al. Malignant profile detected by CT angiographic information predicts poor prognosis despite thrombolysis within three hours from symptom onset. Cerebrovasc Dis 2010;29:584-91
11. Sillanpaa N, Saarinen JT, Rusanen H, et al. The clot burden score, the Boston Acute Stroke Imaging Scale, the cerebral blood volume ASPECTS and two novel imaging parameters in the prediction of clinical outcome of ischemic stroke patients receiving intravenous thrombolytic therapy. Neuroradiology 2011 Sep 9. [Epub ahead of print]
12. Kim YS, Garami Z, Mikulik R, et al, for the CLOTBUST Collaborators. Early recanalization rates and clinical outcomes in patients with tandem internal carotid artery/middle cerebral artery occlusion and isolated middle cerebral artery occlusion. Stroke 2005;36:869-71
13. Schellinger PD, Chalela JA, Kang DW, et al. Diagnostic and prognostic value of early MR imaging vessel signs in hyperacute stroke patients imaged <3 hours and treated with recombinant tissue plasminogen activator. AJNR Am J Neuroradiol 2005;26:618-24
14. Liebeskind DS, Sanossian N, YongWH,et al.CTandMRIearly vessel signs reflect clot composition in acute stroke. Stroke 2011;42: 1237-43
15. Kim EY, Heo JH, Lee SK, et al. Prediction of thrombolytic efficacy in acute ischemic stroke using thin-section noncontrast CT. Neurology 2006;67:1846-48
16. Obach V, Oleaga L, Urra X, et al. Multimodal CT-assisted thrombolysis in patients with acute stroke: a cohort study. Stroke 2011;42:1129-31
17. Rai AT, Carpenter JS, Peykanu JA, et al. The role of CT perfusion imaging in acute stroke diagnosis: a large single-center experience. J Emerg Med 2008;35:287-92
18. Wintermark M, Meuli R, Browaeys P, et al. Comparison of CT perfusion and angiography and MRI in selecting stroke patients for acute treatment. Neurology 2007;68:694-97
19. Adams HP Jr, Brott TG, Furlan AJ, et al. Guidelines for thrombolytic therapy for acute stroke: a supplement to the guidelines for the management of patients with acute ischemic stroke - a statement for healthcare professionals from a Special Writing Group of the Stroke Council, American Heart Association. Circulation 1996;94: 1167-74
20. Sillanpaa N, Saarinen JT, Rusanen H, et al.CTperfusion ASPECTS in the evaluation of acute ischemic stroke: thrombolytic therapy perspective. Cerebrovasc Dis Extra 2011;1:6-16
21. Lin K, Rapalino O, Law M, et al. Accuracy of the Alberta Stroke Program Early CT Score during the first 3 hours of middle cerebral artery stroke: comparison of noncontrast CT, CT angiography source images, and CT perfusion AJNR Am J Neuroradiol 2008;29:931-36
22. Wintermark M, Flanders AE, Velthuis B, et al. Perfusion-CT assessment of infarct core and penumbra: receiver operating characteristic curve analysis in 130 patients suspected of acute hemispheric stroke. Stroke 2006;37:979-85
23. Kamalian S, Kamalian S, Konstas AA, et al. CT perfusion mean transit time maps optimally distinguish benign oligemia from true "atrisk" ischemic penumbra, but thresholds vary by postprocessing technique. AJNR Am J Neuroradiol 2012;33:545-49
24. Campbell BC, Christensen S, Levi CR, et al. Cerebral blood flow is the optimal CT perfusion parameter for assessing infarct core. Stroke 2011;42:3435-40
25. Gasparotti R, Grassi M, Mardighian D, et al. PerfusionCTin patients with acute ischemic stroke treated with intra-arterial thrombolysis: predictive value of infarct core size on clinical outcome. AJNR Am J Neuroradiol 2009;30:722-27
26. Konstas AA, Lev MH. CT perfusion imaging of acute stroke: the need for arrival time, delay insensitive, and standardized postprocessing algorithms? Radiology 2010;254:22-25