메뉴 건너뛰기




Volumn 13, Issue 8, 2012, Pages 4147-4151

Silencing of PDK1 gene expression by RNA interference suppresses growth of esophageal cancer

Author keywords

3 phosphoinositide; Dependent protein kinase 1; Esophageal cancer cells; Rna interference

Indexed keywords


EID: 84873623573     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: 10.7314/APJCP.2012.13.8.4147     Document Type: Article
Times cited : (15)

References (21)
  • 1
    • 17244377075 scopus 로고    scopus 로고
    • Direct comparison of the specificity of gene silencing using antisense oligonucleotides and RNAi
    • Bilanges B, Stokoe D (2005). Direct comparison of the specificity of gene silencing using antisense oligonucleotides and RNAi. Biochemcal J, 388, 573-8
    • (2005) Biochemcal J , vol.388 , pp. 573-578
    • Bilanges, B.1    Stokoe, D.2
  • 2
    • 77949452524 scopus 로고    scopus 로고
    • The PKB/AKT pathway in cancer
    • Carnero A (2010). The PKB/AKT pathway in cancer. Curr Pharm Des, 16, 34-4
    • (2010) Curr Pharm Des , vol.16 , pp. 34-44
    • Carnero, A.1
  • 3
    • 20044375047 scopus 로고    scopus 로고
    • Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival
    • Carón RW, Yacoub A, Li M, et a1 (2005). Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival. Mol Cancer Ther, 4, 257-7
    • (2005) Mol Cancer Ther , vol.4 , pp. 257-267
    • Carón, R.W.1    Yacoub, A.2    Li, M.3
  • 4
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific interference by double-stranded RNA in Caenorhabditis elegans
    • Fire A, Xu S, Montgomery MK, et a1 (1998). Potent and specific interference by double-stranded RNA in Caenorhabditis elegans. Nature, 391, 806-1
    • (1998) Nature , vol.391 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3
  • 5
    • 32944465388 scopus 로고    scopus 로고
    • Handicapping the race to develop inhibitors of the phosphoinositide 3-kinase/Akt/mammalian target of rapamycin pathway
    • Granville CA, Memmott RM, Gills JJ, Dennis PA (2006). Handicapping the race to develop inhibitors of the phosphoinositide 3-kinase/Akt/mammalian target of rapamycin pathway. Clin Cancer Res, 12, 679-8
    • (2006) Clin Cancer Res , vol.12 , pp. 679-688
    • Granville, C.A.1    Memmott, R.M.2    Gills, J.J.3    Dennis, P.A.4
  • 6
    • 60849109531 scopus 로고    scopus 로고
    • Genetic variations in the PI3K/PTEN /AKT/mTOR pathway are associated with clinical outcomes in esophageal cancer patients treated with chemoradiotherapy
    • Hildebrandt MA, Yang H, Hung MC, et a1 (2009). Genetic variations in the PI3K/PTEN /AKT/mTOR pathway are associated with clinical outcomes in esophageal cancer patients treated with chemoradiotherapy. J Clin Oncol, 27, 857-7
    • (2009) J Clin Oncol , vol.27 , pp. 857-867
    • Hildebrandt, M.A.1    Yang, H.2    Hung, M.C.3
  • 7
    • 2342564353 scopus 로고    scopus 로고
    • A library of siRNA duplexes targeting the phosphoinositide 3-kinase pathway: determinants of gene silencing for use in cell-based screens
    • Hsieh AC, Bo R, Manola J, et a1 (2004). A library of siRNA duplexes targeting the phosphoinositide 3-kinase pathway: determinants of gene silencing for use in cell-based screens. Nucleic Acids Research, 32, 893-90
    • (2004) Nucleic Acids Research , vol.32 , pp. 893-990
    • Hsieh, A.C.1    Bo, R.2    Manola, J.3
  • 8
    • 58249090328 scopus 로고    scopus 로고
    • Parallel RNAi and compound screens identify the PDK1 pathway as a target for tamoxifen sensitisation
    • Iorns E, Lord CJ, Ashworth A (2009). Parallel RNAi and compound screens identify the PDK1 pathway as a target for tamoxifen sensitisation. Biochem J, 417, 361-7
    • (2009) Biochem J , vol.417 , pp. 361-367
    • Iorns, E.1    Lord, C.J.2    Ashworth, A.3
  • 9
    • 70349098422 scopus 로고    scopus 로고
    • Resveratrol downregulates PI3K/Akt/mTOR signaling pathways in human U251 glioma cells
    • Jiang H, Shang X, Wu H, et al (2009). Resveratrol downregulates PI3K/Akt/mTOR signaling pathways in human U251 glioma cells. J Exp Ther Oncol, 8, 25-3
    • (2009) J Exp Ther Oncol , vol.8 , pp. 25-33
    • Jiang, H.1    Shang, X.2    Wu, H.3
  • 10
    • 76649128715 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase (PI3K) pathway activation in bladder cancer
    • Knowles MA, Platt FM, Ross RL, Hurst CD (2009). Phosphatidylinositol 3-kinase (PI3K) pathway activation in bladder cancer. Cancer Metastasis Rev, 28, 305-1
    • (2009) Cancer Metastasis Rev , vol.28 , pp. 305-311
    • Knowles, M.A.1    Platt, F.M.2    Ross, R.L.3    Hurst, C.D.4
  • 11
    • 36148964068 scopus 로고    scopus 로고
    • Id-1 activation of PI3K/Akt/NFkB signaling pathway and its significance in promoting survival of esophageal cancer cells
    • Li B, Cheung PY, Wang X, Tsao SW, et al (2007). Id-1 activation of PI3K/Akt/NFkB signaling pathway and its significance in promoting survival of esophageal cancer cells. Carcinogenesis, 28, 2313-2
    • (2007) Carcinogenesis , vol.28 , pp. 2313-2322
    • Li, B.1    Cheung, P.Y.2    Wang, X.3    Tsao, S.W.4
  • 12
    • 33747610198 scopus 로고    scopus 로고
    • Differential roles of phosphoinositide-dependent protein kinase-1 and akt1 expression and phosphorylation in breast cancer cell resistance to Paclitaxel, Doxorubicin, and gemcitabine
    • Liang K, Lu Y, Li X, et al (2006). Differential roles of phosphoinositide-dependent protein kinase-1 and akt1 expression and phosphorylation in breast cancer cell resistance to Paclitaxel, Doxorubicin, and gemcitabine. Mol Pharmacol, 70, 1045-5
    • (2006) Mol Pharmacol , vol.70 , pp. 1045-1055
    • Liang, K.1    Lu, Y.2    Li, X.3
  • 13
    • 67649604297 scopus 로고    scopus 로고
    • Down-regulation of 3-phosphoinositide-dependent protein kinase-1 levels inhibits migration and experimental metastasis of human breast cancer cells
    • Liu Y, Wang J, Wu M, et al (2009). Down-regulation of 3-phosphoinositide-dependent protein kinase-1 levels inhibits migration and experimental metastasis of human breast cancer cells. Mol Cancer Res, 7, 944-5
    • (2009) Mol Cancer Res , vol.7 , pp. 944-945
    • Liu, Y.1    Wang, J.2    Wu, M.3
  • 14
    • 77957819681 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase/Akt/mTOR signaling network as a therapeutic target in acute myelogenous leukemia patients
    • Martelli AM, Evangelisti C, Chiarini F, McCubrey JA (2010). The phosphatidylinositol 3-kinase/Akt/mTOR signaling network as a therapeutic target in acute myelogenous leukemia patients. Oncotarget, 1, 89-10
    • (2010) Oncotarget , vol.1 , pp. 89-10
    • Martelli, A.M.1    Evangelisti, C.2    Chiarini, F.3    McCubrey, J.A.4
  • 15
    • 70350560575 scopus 로고    scopus 로고
    • Current perspectives on Akt Akt-ivation and Akt-ions
    • Matheny RW Jr, Adamo ML (2009). Current perspectives on Akt Akt-ivation and Akt-ions. Exp Biol Med, 234, 1264-7
    • (2009) Exp Biol Med , vol.234 , pp. 1264-1267
    • Matheny Jr., R.W.1    Adamo, M.L.2
  • 16
    • 67649295505 scopus 로고    scopus 로고
    • siRNA delivery systems for cancer treatment
    • Oh YK, Park TG (2009). siRNA delivery systems for cancer treatment. Advanced Drug Delivery Reviews, 61, 850-6
    • (2009) Advanced Drug Delivery Reviews , vol.61 , pp. 850-856
    • Oh, Y.K.1    Park, T.G.2
  • 17
    • 58249092754 scopus 로고    scopus 로고
    • New anti-cancer role for PDK1 inhibitors: preventing resistance to tamoxifen
    • Peifer C, Alessi DR (2009). New anti-cancer role for PDK1 inhibitors: preventing resistance to tamoxifen. Biochem J, 417, e5-7
    • (2009) Biochem J , vol.417
    • Peifer, C.1    Alessi, D.R.2
  • 18
    • 45049087900 scopus 로고    scopus 로고
    • Analysis of 3-phosphoinositide-dependent kinase-1 signaling and function in ES cells
    • Tamgüney T, Zhang C, Fiedler D, Shokat K, Stokoe D (2008). Analysis of 3-phosphoinositide-dependent kinase-1 signaling and function in ES cells. Exp Cell Res, 314, 2299-31
    • (2008) Exp Cell Res , vol.314 , pp. 2299-2231
    • Tamgüney, T.1    Zhang, C.2    Fiedler, D.3    Shokat, K.4    Stokoe, D.5
  • 19
    • 74249086913 scopus 로고    scopus 로고
    • Activation of PI3KAKT pathway in oral epithelial dysplasia and early cancer of tongue
    • Watanabe S, Sato K, Okazaki Y, et al (2009). Activation of PI3KAKT pathway in oral epithelial dysplasia and early cancer of tongue. Bull Tokyo Dent Coll, 50, 125-3
    • (2009) Bull Tokyo Dent Coll , vol.50 , pp. 125-123
    • Watanabe, S.1    Sato, K.2    Okazaki, Y.3
  • 20
    • 23944506289 scopus 로고    scopus 로고
    • RNA interference is an antiviral defence mechanism in Caenorhabditis elegans
    • Wilkins C, Dishongh R, Moore SC, et al (2005). RNA interference is an antiviral defence mechanism in Caenorhabditis elegans. Nature, 436, 1044-7
    • (2005) Nature , vol.436 , pp. 1044-1047
    • Wilkins, C.1    Dishongh, R.2    Moore, S.C.3
  • 21
    • 85008408631 scopus 로고    scopus 로고
    • Small interfering RNA PDK1 inhibits breast cancer cell line invasion and metastasis
    • Wu M, Wu J, Xu Y, et al (2009). Small interfering RNA PDK1 inhibits breast cancer cell line invasion and metastasis, Chinese J Clin Oncol, 36, 697-70
    • (2009) Chinese J Clin Oncol , vol.36 , pp. 697-670
    • Wu, M.1    Wu, J.2    Xu, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.