Silencing of lysyl oxidase gene expression by RNA Interference suppresses metastasis of breast cancer

Asian Pacific Journal of Cancer Prevention

Volumn 13, Issue 7, 2012, Pages 3507-3511

  Liu, Jian Lun ^a   Wei, Wei ^a   Tang, Wei ^a   Jiang, Yi ^a   Yang, Hua Wei ^a   Li, Jing Tao ^a   Zhou, Xiao ^a  

^a GUANGXI MEDICAL UNIVERSITY   (China)

Author keywords

Breast cancer; Lysyl oxidase; Matrix metalloproteinases; metastasis; RNA interference (RNAi)

Indexed keywords

EID: 84873599586     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: 10.7314/APJCP.2012.13.7.3507     Document Type: Article

References (21)

1. Akiri G, Sabo E, Dafni H, et al (2003). Lysyl oxidase-related protein-1 promotes tumorfibrosis and tumor progression in vivo. Cancer Res, 63, 1657-66.
2. Erler JT, Bennewith KL, Nicolau M, et al (2006). Lysyl oxidase is essential for hypoxia-induced metastasis. Nature, 440, 1222-6.
3. Erler JT, Giaccia AJ (2006). Lysyl oxidase mediates hypoxic control of metastasis. Cancer Res, 66, 10238-41.
4. Fong SF, Dietzsch E, Fong KS, et al (2007). Lysyl oxidase-like 2 expression is increased in colon and esophageal tumors and asociated with lass differentiated colon turners. Genes Chromosomes Cancer, 46, 644-55.
5. Hafez MM, Hassan ZK, Zekri AR, et al (2012). MicroRNAs and metastasis-related gene expression in Egyptian breast cancer patients. Asian Pac J Cancer Prev, 13, 591-8.
6. Holtmeier C, Gorogh T, Beier U, et al (2003). Overexpression of a novel lysyl oxidase-like gene in human head and neck squamous cell carcinomas. Anticancer Res, 23, 2585-91.
7. Jing DC, Blidaru A, Condrea I, et al (2006). MMP-9 and MMP-2 gelatinases and TIMP-1 and TIMP-2 inhibitors in breast cancer: correlations with prognostic factors. J Cell Mol Med, 10, 499-510.
8. Kirschmann DA, Payne SL, Seftor EA, et al (2005). Tumor suppressor gene Maspin and hypoxia inversely regulate lysyl oxidase facilitated breast cancer motility. Proc Amer Assoc Cancer Res, 46, 57-8.
9. Kirschmann DA, Seftor EA, Fong SF, et al (2002). A molecular role for lysyl oxidase in breast cancer invasion. Cancer Res, 62, 4478-83.
10. Lhotak S, Elavathil LJ, Vukmirovic-Popovic, et al (2000). Immunolocalization of matrix- metallo-proteinases and their inhibitors in clinical specimens of bone metastasis from breast carcinoma. Clin Exp Metastasis, 18, 463-70.
11. Liotta LA, Steeg PA, Stetler-stevenson WG (1991). Canaer metastasis and angiogensis: and imbalance of positive negative regulation. Cell, 64, 327-31.
12. Livak KJ, Schmittgen TD (2001). Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C (T)) Method. Methods, 25, 402-8.
13. Loh SY, Chew SL, Lee SY (2011). Physical Activity and Women with Breast Cancer: Insights from Expert Patients. Asian Pac J Cancer Prev, 12, 87-94.
14. Nakopoulou L, Katsarou S, Giannopoulou I, et al (2002). Correlation of tissue inhibitor of metalloproteinase- 2 with proliferative actixity and patients sunal in breast cancer. Mod Patho1, 15, 26-34.
15. Payne SL, Angela R. Hess AR, et al (2005). Lysyl oxidase facilitates intracellular signaling in invasive breast cancer cells. Proc Amer Assoc Cancer Res, 46, 67-8.
16. Peyrol S, Raccurt M, Gerard F, et al (1997). Lysy1 oxidase gene expression in the stromal reaction to in situ and invasive ductal breast carcinoma. Am J Pathol, 150, 497-507.
17. Sulaiman S, Shahril MR, Shaharudin SH, et al (2011). Fat intake and its relationship with pre- and postmenopausal breast cancer risk: a case-control study in Malaysia. Asian Pac J Cancer Prev, 12, 2167-78.
18. Talvensaari MA, Paakko P, Turpeenniemi HT (2003). Matrix metalloproteinase-2 (MMP-2) is associated with sunixal in breast carcinoma. Br J Cancer, 89, 1270-5.
19. Woznick AR, Braddock AL, Dulai M, et al (2005). Lysyl oxidase expression in bronchogenic carcinoma. Am J surg, 189, 297-301.
20. Yu Q, Stamenkovic I (2000). Cell surface-localized matrixmetalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis. Genes, 14, 163-76.
21. Zucker S, Hymowitz M, Rollo EE, et al (2001). Tumorigenic potential of extracellar matrix metalloproteinase inducer. Am J Pathol, 158, 1921-8.