Telomeres and chromosomal instability in chronic lymphocytic leukemia

Leukemia

Volumn 27, Issue 2, 2013, Pages 490-493

  Veronese L ^a,b   Tournilhac, O ^a,b   Callanan, M ^c,d   Prie, N ^a,b   Kwiatkowski, F ^b,e   Combes, P ^a,b   Chauvet, M ^c,d   Davi, F ^f   Gouas, L ^a,b   Verrelle, P ^b,e   Guieze R ^a,b   Vago, P ^a,b   Bay, J O ^a,b   Tchirkov, A ^a,b,e  

^a UNIVERSITY HOSPITAL OF CLERMONT FERRAND   (France)

^b UNIVERSITÉ CLERMONT AUVERGNE   (France)

^c INSERM   (France)

^d GRENOBLE UNIVERSITY HOSPITAL   (France)

^e CENTRE JEAN PERRIN   (France)

^f PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; CELL CULTURE; CHROMOSOMAL INSTABILITY; CHRONIC LYMPHATIC LEUKEMIA; CYTOGENETICS; DISEASE COURSE; FEMALE; FOLLOW UP; GENE DOSAGE; GENE EXPRESSION; HUMAN; IMMUNOSTIMULATION; KARYOTYPE; LETTER; MAJOR CLINICAL STUDY; MALE; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; PROSPECTIVE STUDY; REAL TIME POLYMERASE CHAIN REACTION; TELOMERE; TRISOMY 12;

AGED; CHROMOSOMAL INSTABILITY; DNA, NEOPLASM; FEMALE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MALE; NEOPLASM STAGING; PROGNOSIS; PROSPECTIVE STUDIES; REAL-TIME POLYMERASE CHAIN REACTION; TELOMERASE; TELOMERE; TELOMERE-BINDING PROTEINS; TELOMERIC REPEAT BINDING PROTEIN 1; TELOMERIC REPEAT BINDING PROTEIN 2; TUMOR MARKERS, BIOLOGICAL;

EID: 84873570463     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2012.194     Document Type: Letter

References (7)

1. Artandi SE, DePinho RA. Telomeres and telomerase in cancer. Carcinogenesis 2010; 31: 9-18.
2. Roos G, Kröber A, Grabowski P, Kienle D, Bühler A, Döhner H et al. Short telomeres are associated with genetic complexity, high-risk genomic aberrations, and short survival in chronic lymphocytic leukemia. Blood 2008; 111: 2246-2252.
3. Brugat T, Nguyen-Khac F, Grelier A, Merle-Bé ral H, Delic J. Telomere dysfunctioninduced foci arise with the onset of telomeric deletions and complex chromosomal aberrations in resistant chronic lymphocytic leukemia cells. Blood 2010; 116: 239-249.
4. Tchirkov A, Chaleteix C, Magnac C, Vasconcelos Y, Davi F, Michel A et al. hTERT expression and prognosis in B-chronic lymphocytic leukemia. Ann Oncol 2004; 10: 1476-1480.
5. Poncet D, Belleville A, t'kint de Roodenbeke C, Roborel de Climens A, Ben Simon E, Merle-Beral H et al. Changes in the expression of telomere maintenance genes suggest global telomere dysfunction in B-chronic lymphocytic leukemia. Blood 2008; 111: 2388-2391.
6. Britt-Compton B, Lin TT, Ahmed G, Weston V, Jones RE, Fegan C et al. Extreme telomere erosion in ATM-mutated and 11q-deleted CLL patients is independent of disease stage. Leukemia 2012; 26: 826-830.
7. Cookson JC, Laughton CA. The levels of telomere-binding proteins in human tumours and therapeutic implications. Eur J Cancer 2009; 45: 536-550.