-
1
-
-
33749017926
-
Phase II study of sorafenib in patients with advanced hepatocellular carcinoma
-
DOI 10.1200/JCO.2005.01.3441
-
Abou-Alfa GK, Schwartz L, Ricci S, Amadori D, Santoro A, Figer A, De Greve J, Douillard JY, Lathia C, Schwartz B, Taylor I, Moscovici M, Saltz LB (2006) Phase II study of sorafenib in patients with advanced hepatocellular carcinoma. J Clin Oncol 24(26): 4293-4300. (Pubitemid 46630787)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.26
, pp. 4293-4300
-
-
Abou-Alfa, G.K.1
Schwartz, L.2
Ricci, S.3
Amadori, D.4
Santoro, A.5
Figer, A.6
De Greve, J.7
Douillard, J.-Y.8
Lathia, C.9
Schwartz, B.10
Taylor, I.11
Moscovici, M.12
Saltz, L.B.13
-
2
-
-
80054023857
-
P73 regulates cisplatin-induced apoptosis in ovarian cancer cells via a calcium/calpain-dependent mechanism
-
Al-Bahlani S, Fraser M, Wong AY, Sayan BS, Bergeron R, Melino G, Tsang BK (2011) P73 regulates cisplatin-induced apoptosis in ovarian cancer cells via a calcium/calpain-dependent mechanism. Oncogene 30(41): 4219-4230.
-
(2011)
Oncogene
, vol.30
, Issue.41
, pp. 4219-4230
-
-
Al-Bahlani, S.1
Fraser, M.2
Wong, A.Y.3
Sayan, B.S.4
Bergeron, R.5
Melino, G.6
Tsang, B.K.7
-
3
-
-
17444386342
-
Pharmacological inhibitors of extracellular signal-regulated protein kinases attenuate the apoptotic action of cisplatin in human myeloid leukemia cells via glutathione-independent reduction in intracellular drug accumulation
-
DOI 10.1016/j.bbamcr.2004.10.009
-
Amran D, Sancho P, Fernandez C, Esteban D, Ramos AM, de Blas E, Gomez M, Palacios MA, Aller P (2005) Pharmacological inhibitors of extracellular signal-regulated protein kinases attenuate the apoptotic action of cisplatin in human myeloid leukemia cells via glutathione-independent reduction in intracellular drug accumulation. Biochim Biophys Acta 1743(3): 269-279. (Pubitemid 40544421)
-
(2005)
Biochimica et Biophysica Acta - Molecular Cell Research
, vol.1743
, Issue.3
, pp. 269-279
-
-
Amran, D.1
Sancho, P.2
Fernandez, C.3
Esteban, D.4
Ramos, A.M.5
De Blas, E.6
Gomez, M.7
Palacios, M.A.8
Aller, P.9
-
4
-
-
63649129676
-
Coadministration of sorafenib and cisplatin inhibits proliferation of hepatocellular carcinoma HepG2 cells in vitro
-
Chen FS, Cui YZ, Luo RC, WüJ, Zhang H (2008) [Coadministration of sorafenib and cisplatin inhibits proliferation of hepatocellular carcinoma HepG2 cells in vitro]. Nan Fang Yi Ke Da Xue Xue Bao 28(9): 1684-1687.
-
(2008)
Nan Fang Yi Ke Da Xue Xue Bao
, vol.28
, Issue.9
, pp. 1684-1687
-
-
Chen, F.S.1
Cui, Y.Z.2
Luo, R.C.3
Wü, J.4
Zhang, H.5
-
5
-
-
0017260918
-
Establishment of a cell line and its clonal sublines from a patient with hepatoblastoma
-
Doi I (1976) Establishment of a cell line and its clonal sublines from a patient with hepatoblastoma. Gann 67(1): 1-10.
-
(1976)
Gann
, vol.67
, Issue.1
, pp. 1-10
-
-
Doi, I.1
-
6
-
-
84858297002
-
Treatment effects of the multikinase inhibitor sorafenib on hepatoblastoma cell lines and xenografts in NMRI-Foxn1(nu) mice
-
Eicher C, Dewerth A, Kirchner B, Warmann SW, Fuchs J, Armeanu-Ebinger S (2012) Treatment effects of the multikinase inhibitor sorafenib on hepatoblastoma cell lines and xenografts in NMRI-Foxn1(nu) mice. Liver Int 32(4): 574-581.
-
(2012)
Liver Int
, vol.32
, Issue.4
, pp. 574-581
-
-
Eicher, C.1
Dewerth, A.2
Kirchner, B.3
Warmann, S.W.4
Fuchs, J.5
Armeanu-Ebinger, S.6
-
7
-
-
33746565515
-
Role of raf kinase in cancer: Therapeutic potential of targeting the raf/mek/erk signal transduction pathway
-
DOI 10.1053/j.seminoncol.2006.04.002, PII S009377540600176X
-
Gollob JA, Wilhelm S, Carter C, Kelley SL (2006) Role of Raf kinase in cancer: Therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway. Semin Oncol 33(4): 392-406. (Pubitemid 44142735)
-
(2006)
Seminars in Oncology
, vol.33
, Issue.4
, pp. 392-406
-
-
Gollob, J.A.1
Wilhelm, S.2
Carter, C.3
Kelley, S.L.4
-
8
-
-
13844267552
-
The Raf kinase inhibitor BAY 43-9006 reduces cellular uptake of platinum compounds and cytotoxicity in human colorectal carcinoma cell lines
-
DOI 10.1097/00001813-200502000-00003
-
Heim M, Scharifi M, Zisowsky J, Jaehde U, Voliotis D, Seeber S, Strumberg D (2005) The Raf kinase inhibitor BAY 43-9006 reduces cellular uptake of platinum compounds and cytotoxicity in human colorectal carcinoma cell lines. Anticancer Drugs 16(2): 129-136. (Pubitemid 40250607)
-
(2005)
Anti-Cancer Drugs
, vol.16
, Issue.2
, pp. 129-136
-
-
Heim, M.1
Scharifi, M.2
Zisowsky, J.3
Jaehde, U.4
Voliotis, D.5
Seeber, S.6
Strumberg, D.7
-
9
-
-
33645511438
-
Adduct-specific monoclonal antibodies for the measurement of cisplatin-induced DNA lesions in individual cell nuclei
-
Liedert B, Pluim D, Schellens J, Thomale J (2006) Adduct-specific monoclonal antibodies for the measurement of cisplatin-induced DNA lesions in individual cell nuclei. Nucleic Acids Res 34(6): E47.
-
(2006)
Nucleic Acids Res
, vol.34
, Issue.6
-
-
Liedert, B.1
Pluim, D.2
Schellens, J.3
Thomale, J.4
-
10
-
-
47949116252
-
Sorafenib in advanced hepatocellular carcinoma
-
Llovet JM, Ricci S, Mazzaferro V, Hilgard P, Gane E, Blanc JF, de Oliveira AC, Santoro A, Raoul JL, Forner A, Schwartz M, Porta C, Zeuzem S, Bolondi L, Greten TF, Galle PR, Seitz JF, Borbath I, Haussinger D, Giannaris T, Shan M, Moscovici M, Voliotis D, Bruix J (2008) Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 359(4): 378-390.
-
(2008)
N Engl J Med
, vol.359
, Issue.4
, pp. 378-390
-
-
Llovet, J.M.1
Ricci, S.2
Mazzaferro, V.3
Hilgard, P.4
Gane, E.5
Blanc, J.F.6
De Oliveira, A.C.7
Santoro, A.8
Raoul, J.L.9
Forner, A.10
Schwartz, M.11
Porta, C.12
Zeuzem, S.13
Bolondi, L.14
Greten, T.F.15
Galle, P.R.16
Seitz, J.F.17
Borbath, I.18
Haussinger, D.19
Giannaris, T.20
Shan, M.21
Moscovici, M.22
Voliotis, D.23
Bruix, J.24
more..
-
11
-
-
84866159110
-
Sorafenib and bevacizumab for recurrent metastatic hepatoblastoma: Stable radiographic disease with decreased AFP
-
Marsh AM, Lo L, Cohen RA, Feusner JH (2012) Sorafenib and bevacizumab for recurrent metastatic hepatoblastoma: Stable radiographic disease with decreased AFP. Pediatr Blood Cancer 59(5): 939-940.
-
(2012)
Pediatr Blood Cancer
, vol.59
, Issue.5
, pp. 939-940
-
-
Marsh, A.M.1
Lo, L.2
Cohen, R.A.3
Feusner, J.H.4
-
12
-
-
70350333890
-
Cisplatin versus cisplatin plus doxorubicin for standard-risk hepatoblastoma
-
Perilongo G, Maibach R, Shafford E, Brugieres L, Brock P, Morland B, de Camargo B, Zsiros J, Roebuck D, Zimmermann A, Aronson D, Childs M, Widing E, Laithier V, Plaschkes J, Pritchard J, Scopinaro M, MacKinlay G, Czauderna P (2009) Cisplatin versus cisplatin plus doxorubicin for standard-risk hepatoblastoma. N Engl J Med 361(17): 1662-1670.
-
(2009)
N Engl J Med
, vol.361
, Issue.17
, pp. 1662-1670
-
-
Perilongo, G.1
Maibach, R.2
Shafford, E.3
Brugieres, L.4
Brock, P.5
Morland, B.6
De Camargo, B.7
Zsiros, J.8
Roebuck, D.9
Zimmermann, A.10
Aronson, D.11
Childs, M.12
Widing, E.13
Laithier, V.14
Plaschkes, J.15
Pritchard, J.16
Scopinaro, M.17
MacKinlay, G.18
Czauderna, P.19
-
13
-
-
0029942491
-
Characterization of the continuous cell line HepT1 derived from a human hepatoblastoma
-
Pietsch T, Fonatsch C, Albrecht S, Maschek H, Wolf HK, von Schweinitz D (1996) Characterization of the continuous cell line HepT1 derived from a human hepatoblastoma. Lab Invest 74(4): 809-818. (Pubitemid 26117140)
-
(1996)
Laboratory Investigation
, vol.74
, Issue.4
, pp. 809-818
-
-
Pietsch, T.1
Fonatsch, C.2
Albrecht, S.3
Maschek, H.4
Wolf, H.K.5
Von Schweinitz, D.6
-
14
-
-
84856852669
-
Sorafenib and cisplatin/doxorubicin (PLADO) in pediatric hepatocellular carcinoma
-
Schmid I, Haberle B, Albert MH, CorbacioglüS, Frohlich B, Graf N, Kammer B, Kontny U, Leuschner I, Scheel-Walter HG, Scheurlen W, Werner S, Wiesel T, von Schweinitz D (2012) Sorafenib and cisplatin/doxorubicin (PLADO) in pediatric hepatocellular carcinoma. Pediatr Blood Cancer 58(4): 539-544.
-
(2012)
Pediatr Blood Cancer
, vol.58
, Issue.4
, pp. 539-544
-
-
Schmid, I.1
Haberle, B.2
Albert, M.H.3
Corbacioglü, S.4
Frohlich, B.5
Graf, N.6
Kammer, B.7
Kontny, U.8
Leuschner, I.9
Scheel-Walter, H.G.10
Scheurlen, W.11
Werner, S.12
Wiesel, T.13
Von Schweinitz, D.14
-
15
-
-
4143131243
-
Cisplatin-induced apoptosis in human malignant testicular germ cell lines depends on MEK/ERK activation
-
DOI 10.1038/sj.bjc.6601919
-
Schweyer S, Soruri A, Meschter O, Heintze A, Zschunke F, Miosge N, Thelen P, Schlott T, Radzun HJ, Fayyazi A (2004) Cisplatin-induced apoptosis in human malignant testicular germ cell lines depends on MEK/ERK activation. Br J Cancer 91(3): 589-598. (Pubitemid 39093583)
-
(2004)
British Journal of Cancer
, vol.91
, Issue.3
, pp. 589-598
-
-
Schweyer, S.1
Soruri, A.2
Meschter, O.3
Heintze, A.4
Zschunke, F.5
Miosge, N.6
Thelen, P.7
Schlott, T.8
Radzun, H.J.9
Fayyazi, A.10
-
16
-
-
78649991678
-
An ERK-dependent pathway to Noxa expression regulates apoptosis by platinum-based chemotherapeutic drugs
-
Sheridan C, Brumatti G, Elgendy M, Brunet M, Martin SJ (2010) An ERK-dependent pathway to Noxa expression regulates apoptosis by platinum-based chemotherapeutic drugs. Oncogene 29(49): 6428-6441.
-
(2010)
Oncogene
, vol.29
, Issue.49
, pp. 6428-6441
-
-
Sheridan, C.1
Brumatti, G.2
Elgendy, M.3
Brunet, M.4
Martin, S.J.5
-
17
-
-
0034671751
-
Requirement for ERK activation in cisplatin-induced apoptosis
-
DOI 10.1074/jbc.M004583200
-
Wang X, Martindale JL, Holbrook NJ (2000) Requirement for ERK activation in cisplatin-induced apoptosis. J Biol Chem 275(50): 39435-39443. (Pubitemid 32058968)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.50
, pp. 39435-39443
-
-
Wang, X.1
Martindale, J.L.2
Holbrook, N.J.3
-
18
-
-
0842311702
-
P-Glycoprotein modulation improves in vitro chemosensitivity in malignant pediatric liver tumors
-
Warmann S, Gohring G, Teichmann B, Geerlings H, Pietsch T, Fuchs J (2003) P-glycoprotein modulation improves in vitro chemosensitivity in malignant pediatric liver tumors. Anticancer Res 23(6C): 4607-4611. (Pubitemid 38173874)
-
(2003)
Anticancer Research
, vol.23
, Issue.6 C
, pp. 4607-4611
-
-
Warmann, S.1
Gohring, G.2
Teichmann, B.3
Geerlings, H.4
Pietsch, T.5
Fuchs, J.6
-
19
-
-
0034759244
-
Successful therapy of subcutaneously growing human hepatoblastoma xenografts with topotecan
-
DOI 10.1002/mpo.1228
-
Warmann SW, Fuchs J, Wilkens L, Gratz KF, von Schweinitz D, Mildenberger H (2001) Successful therapy of subcutaneously growing human hepatoblastoma xenografts with topotecan. Med Pediatr Oncol 37(5): 449-454. (Pubitemid 33029639)
-
(2001)
Medical and Pediatric Oncology
, vol.37
, Issue.5
, pp. 449-454
-
-
Warmann, S.W.1
Fuchs, J.2
Wilkens, L.3
Gratz, K.F.4
Von Schweinitz, D.5
Mildenberger, H.6
-
20
-
-
22244489738
-
Effects of P-glycoprotein modulation on the chemotherapy of xenotransplanted human hepatoblastoma
-
DOI 10.1080/08880010590964192
-
Warmann SW, Heitmann H, Teichmann B, Gratz KF, Ruck P, Hunger M, Fuchs J (2005) Effects of P-glycoprotein modulation on the chemotherapy of xenotransplanted human hepatoblastoma. Pediatr Hematol Oncol 22(5): 373-386. (Pubitemid 40993600)
-
(2005)
Pediatric Hematology and Oncology
, vol.22
, Issue.5
, pp. 373-386
-
-
Warmann, S.W.1
Heitmann, H.2
Teichmann, B.3
Gratz, K.F.4
Ruck, P.5
Hunger, M.6
Fuchs, J.7
-
21
-
-
55749088393
-
Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling
-
Wilhelm SM, Adnane L, Newell P, Villanueva A, Llovet JM, Lynch M (2008) Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling. Mol Cancer Ther 7(10): 3129-3140.
-
(2008)
Mol Cancer Ther
, vol.7
, Issue.10
, pp. 3129-3140
-
-
Wilhelm, S.M.1
Adnane, L.2
Newell, P.3
Villanueva, A.4
Llovet, J.M.5
Lynch, M.6
-
22
-
-
4944249117
-
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
-
DOI 10.1158/0008-5472.CAN-04-1443
-
Wilhelm SM, Carter C, Tang L, Wilkie D, McNabola A, Rong H, Chen C, Zhang X, Vincent P, McHugh M, Cao Y, Shujath J, Gawlak S, Eveleigh D, Rowley B, LiüL, Adnane L, Lynch M, Auclair D, Taylor I, Gedrich R, Voznesensky A, Riedl B, Post LE, Bollag G, Trail PA (2004) BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 64(19): 7099-7109. (Pubitemid 39331023)
-
(2004)
Cancer Research
, vol.64
, Issue.19
, pp. 7099-7109
-
-
Wilhelm, S.M.1
Carter, C.2
Tang, L.3
Wilkie, D.4
McNabola, A.5
Rong, H.6
Chen, C.7
Zhang, X.8
Vincent, P.9
McHugh, M.10
Cao, Y.11
Shujath, J.12
Gawlak, S.13
Eveleigh, D.14
Rowley, B.15
Liu, L.16
Adnane, L.17
Lynch, M.18
Auclair, D.19
Taylor, I.20
Gedrich, R.21
Voznesensky, A.22
Riedl, B.23
Post, L.E.24
Bollag, G.25
Trail, P.A.26
more..
-
23
-
-
77952812169
-
Guidelines for the welfare and use of animals in cancer research
-
Workman P, Aboagye EO, Balkwill F, Balmain A, Bruder G, Chaplin DJ, Double JA, Everitt J, Farningham DA, Glennie MJ, Kelland LR, Robinson V, Stratford IJ, Tozer GM, Watson S, Wedge SR, Eccles SA (2010) Guidelines for the welfare and use of animals in cancer research. Br J Cancer 102(11): 1555-1577.
-
(2010)
Br J Cancer
, vol.102
, Issue.11
, pp. 1555-1577
-
-
Workman, P.1
Aboagye, E.O.2
Balkwill, F.3
Balmain, A.4
Bruder, G.5
Chaplin, D.J.6
Double, J.A.7
Everitt, J.8
Farningham, D.A.9
Glennie, M.J.10
Kelland, L.R.11
Robinson, V.12
Stratford, I.J.13
Tozer, G.M.14
Watson, S.15
Wedge, S.R.16
Eccles, S.A.17
-
24
-
-
77956405067
-
Successful treatment of childhood high-risk hepatoblastoma with doseintensive multiagent chemotherapy and surgery: Final results of the SIOPEL-3HR study
-
Zsiros J, Maibach R, Shafford E, Brugieres L, Brock P, Czauderna P, Roebuck D, Childs M, Zimmermann A, Laithier V, Otte JB, de Camargo B, MacKinlay G, Scopinaro M, Aronson D, Plaschkes J, Perilongo G (2010) Successful treatment of childhood high-risk hepatoblastoma with doseintensive multiagent chemotherapy and surgery: Final results of the SIOPEL-3HR study. J Clin Oncol 28(15): 2584-2590.
-
(2010)
J Clin Oncol
, vol.28
, Issue.15
, pp. 2584-2590
-
-
Zsiros, J.1
Maibach, R.2
Shafford, E.3
Brugieres, L.4
Brock, P.5
Czauderna, P.6
Roebuck, D.7
Childs, M.8
Zimmermann, A.9
Laithier, V.10
Otte, J.B.11
De Camargo, B.12
MacKinlay, G.13
Scopinaro, M.14
Aronson, D.15
Plaschkes, J.16
Perilongo, G.17
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