Modulating the inflammatory properties of activated microglia with Docosahexaenoic acid and Aspirin

Lipids in Health and Disease

Volumn 12, Issue 1, 2013, Pages

  Pettit, Lauren K ^a   Varsanyi, Christopher ^a   Tadros, James ^b   Vassiliou, Evros ^a  

^a KEAN UNIVERSITY   (United States)

^b Colfax Oncology Center ^*  (United States)

Author keywords

Aspirin; Cytokines; Docosahexaenoic acid; Glutathione; Inflammation; Microglia; Nitric oxide

Indexed keywords

ACETYLSALICYLIC ACID; DOCOSAHEXAENOIC ACID; GLUTATHIONE; IMIQUIMOD; INTERLEUKIN 6; NITRIC OXIDE; NONSTEROID ANTIINFLAMMATORY AGENT; OMEGA 3 FATTY ACID; REACTIVE OXYGEN METABOLITE; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7; TUMOR NECROSIS FACTOR ALPHA;

ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN FUNCTION; BRAIN LEVEL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIETARY INTAKE; INFLAMMATION; MICROGLIA; OXIDATIVE STRESS;

ANTI-INFLAMMATORY AGENTS; ASPIRIN; CELLS, CULTURED; DOCOSAHEXAENOIC ACIDS; GLUTATHIONE; HUMANS; INFLAMMATION; INTERLEUKIN-6; MACROPHAGES; MICROGLIA; NEURODEGENERATIVE DISEASES; NITRIC OXIDE; SUPEROXIDES; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 84873506533     PISSN: None     EISSN: 1476511X     Source Type: Journal    
DOI: 10.1186/1476-511X-12-16     Document Type: Article

References (28)

1. Series introduction: neurodegeneration: what is it and where are we? Przedborski S, Vila M, Jackson-Lewis V, J Clin Invest 2003 111 3 10 12511579 (Pubitemid 36134839)
2. Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration. Qin L, Wu X, Block ML, Liu Y, Breese GR, Hon JS, Knapp DJ, Crews FT, Glia 2007 55 452 462
3. Inflammatory neurodegeneration mediated by nitric oxide from activated glia-inhibiting neuronal respiration, causing glutamate release andexcitotoxicity. Bal-Price A, Brown GC, J Neurosci 2001 31 6480 6491 (Pubitemid 32781092)
4. Neurodegeneration and inflammation. DeLegge MH, Smoke A, Nutr Clin Pract 2008 23 35 41 10.1177/011542650802300135 18203962 (Pubitemid 351438966)
5. Activated microglia intitate motor neuron injury by a nitric oxide and glutamate-mediated mechanism. Zhao W, Xie W, Le W, Beers DR, He Y, Henkel JS, Simpson EP, Yen AA, Xiao Q, Appel SH, J Neuropathol Exp Neurol 2004 63 964 977 15453095 (Pubitemid 39202499)
6. Activated microglia mediate neuronal cell injury via a nitric oxide mechanism. Chao CC, Hu S, Molitor TW, Shaskan EG, Peterson PK, J Immunol 1992 149 2736 2741 1383325
7. Docosahexaenoic acid suppressesneuroinflammatory responses and induces heme oxygenase-I expression in BV-2 microglia: implications of antidepressant effects for omega-3 fatty acids. Lu DY, Tsao YY, Leung YM, Su KP, Neuropsychopharmacol 2010 35 2238 2248 10.1038/npp.2010.98
8. Toll-like receptor expression and signaling in glia cells in neuro-amyloidogenic diseases: towards future therapeutic applications. Trudler D, Farfara D, Frenkel D, Mediat Inflamm 2010 2010 1 12
9. Chronic microglial activation and excitotoxicity secondary to excessive immune stimulation: possible factors in gulf war syndrome and autism. Blaylock RL, J Am Phys Sur 2004 9 46 51
10. The link between inflammation, synaptic transmission and neurodegeneration. Centonze D, Muzio L, Rossi S, Furlan R, Bernardi G, Martino G, Cell Death Differ 2010 17 1083 1091 10.1038/cdd.2009.179 19927157
11. Tumor necrosis factor-α induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner. Takeuchi H, Jin S, Wang J, Zhang G, Kawanokuchi J, Kuno R, Sonobe Y, Mizuno T, Suzumura A, J Biol Chem 2006 281 21362 21368 10.1074/jbc.M600504200 16720574 (Pubitemid 44115475)
12. Docosahexaenoic acid suppresses nitric oxide production and inducible nitric oxide synthase expression in interferon-γ plus lipopolysaccharide- stimulated murine macrophages by inhibiting oxidative stress. Komatsu W, Ishihara K, Murata M, Saito H, Shinohara K, Free Radical Biol Med 2003 34 1006 1016 10.1016/S0891-5849(03)00027-3 (Pubitemid 36398560)
13. Modulation of inducible nitric oxide synthase and related proinflammatory genes by the omega-3 fatty acid docosahexaenoic acid in human colon cancer cells. Narayanan BA, Narayanan NK, Simi B, Reddy BS, Cancer Res 2003 63 972 979 12615711 (Pubitemid 36278427)
14. Bioenergetic and oxidative stress in neurodegenerative diseases. Bowling AC, Beal BF, Life Sci 1995 56 1151 1171 10.1016/0024-3205(95)00055-B 7475893
15. Docosahexaenoic acid modulates inflammatory and antineurogenic functions of activated microglial cells. Ajmone-Cat MA, Salvatori ML, De Simone R, Mancini M, Biagioni S, Bernardo A, Cacci E, Minghetti L, J Neurosci Res 2011 90 1 13 21922512
16. Novel proresolving aspirin-triggered DHA pathway. Serhan CN, Fredman G, Yang R, Karamnov S, Belayev LS, Bazan NG, Zhu M, Winkler JW, Petasis NA, Chem Biol 2011 18 8 976 987 10.1016/j.chembiol.2011.06.008 21867913
17. Neuroprotective action of omega-3 polyunsaturated fatty acids against neurodegnerative diseases: evidence from animal studies. Calon F, Cole G, Prostag Leukotr Ess 2007 77 287 293 10.1016/j.plefa.2007.10.019 (Pubitemid 350198857)
18. Omega-3 essential fatty acids modulate initiation and progression of neurodegenerative disease. Palacios-Pelaez R, Lukiw WJ, Bazan NG, Mol Neurobiol 2010 41 367 374 10.1007/s12035-010-8139-z 20467837
19. The onset of brain injury and neurodegeneration triggers the synthesis of docosanoid neuroprotective signaling. Bazan NG, Cell Mol Bio 2006 26 901 913
20. Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs. Olson JK, Miller SD, J Immunol 2004 173 3916 3924 15356140 (Pubitemid 39280755)
21. Altered glutathione homeostasis in animals prenatally exposed to lipopolysaccharide. Zhu Y, Carvey PM, Ling Z, Neurochem Int 2007 50 671 680 10.1016/j.neuint.2006.12.013 17291629 (Pubitemid 46329837)
22. Docosahexaenoic acid supplementation induces dose and time dependent oxidative changes in C6 glioma cells. Leonardi F, Attorri L, Di Benedetto R, Di Biase A, Sanchez M, Pellizzari Tregno F, Nardini M, Salvati S, Free Radic Res 2007 41 748 756 10.1080/10715760701324067 17577735 (Pubitemid 46995256)
23. NSAID and antioxidant prevention of Alzheimer's disease. Cole GM, Morihara T, Lim GP, Yang FF, Begum A, Frautschy SA, Ann NY Acad Sci 2004 1034 68 84
24. Prevention of Alzheimer's disease: omega-3 fatty acid and phenolic anti-oxidant interventions. Cole GM, Lim GP, Yang F, Teter B, Begum A, Ma Q, Harris-White ME, Frautschy SA, Neurobiol Aging 2005 26S 133 S136
25. Polyunsaturated fatty acids, neuroinflammation and well being. Laye S, Prostag Leukotr Ess 2010 82 295 303 10.1016/j.plefa.2010.02.006
26. Neuroprotective effects of nonsteroidal anti- inflammatory drugs on neurodegenerative diseases. Asanuma M, Miyazaki I, Ogawa N, Curr Pharm Des 2004 10 695 700 10.2174/1381612043453072 14965332 (Pubitemid 38292397)
27. Molecular targets of non-steroidal anti-inflammatory drugs in neurodegenerative diseases. Lleo A, Galea E, Sastre M, Cell Mol Life Sci 2007 64 1403 1418 10.1007/s00018-007-6516-1 17447008 (Pubitemid 46889230)
28. Non-steroidal anti-inflammatory drugs (NSAIDs) and other anti-inflammatory agents in the treatment of neurodegenerative disease. Klegeris A, McGeer PL, Curr Alzheimer Res 2005 2 355 365 10.2174/1567205054367883 15974901 (Pubitemid 40980194)