Identification of cellular proteins interacting with influenza a virus PB1-F2 protein

Acta Virologica

Volumn 56, Issue 3, 2012, Pages 199-207

  Guan, Z H ^a   Zhang, M L ^a   Hou, P L ^b   Duan, M ^a   Cui, Y M ^b   Wang, X R ^a  

^a JILIN UNIVERSITY   (China)

^b JILIN AGRICULTURAL UNIVERSITY   (China)

Author keywords

Influenza a virus; PB1 F2; Protein protein interaction; Yeast two hybrid

Indexed keywords

CELL PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; HYBRID PROTEIN; MACROPHAGE MIGRATION INHIBITION FACTOR; PB1 F2 PROTEIN; UNCLASSIFIED DRUG; VIRULENCE FACTOR; VIRUS PROTEIN; CELL SURFACE RECEPTOR; GNB2 PROTEIN, HUMAN; GNB2L1 PROTEIN, HUMAN; GUANINE NUCLEOTIDE BINDING PROTEIN; ISOMERASE; MIF PROTEIN, HUMAN; PB1 F2 PROTEIN, INFLUENZA A VIRUS; PB1-F2 PROTEIN, INFLUENZA A VIRUS; TUMOR PROTEIN;

APOPTOSIS; ARTICLE; CELLULAR DISTRIBUTION; CONFOCAL LASER MICROSCOPY; CYTOPLASM; DNA LIBRARY; ESCHERICHIA COLI; HUMAN; HUMAN CELL; INFLUENZA VIRUS A; LEUKOCYTE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SACCHAROMYCES CEREVISIAE; STRUCTURAL GENE; VIRUS REPLICATION; GENETICS; INFLUENZA; INFLUENZA VIRUS A H1N1; METABOLISM; PROTEIN BINDING; TWO HYBRID SYSTEM; VIROLOGY;

GTP-BINDING PROTEINS; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA, HUMAN; INTRAMOLECULAR OXIDOREDUCTASES; MACROPHAGE MIGRATION-INHIBITORY FACTORS; NEOPLASM PROTEINS; PROTEIN BINDING; RECEPTORS, CELL SURFACE; TWO-HYBRID SYSTEM TECHNIQUES; VIRAL PROTEINS;

EID: 84873499696     PISSN: 0001723X     EISSN: None     Source Type: Journal    
DOI: 10.4149/av_2012_03_199     Document Type: Article

References (42)

1. Al-Abed Y, Dabideen D, Aljabari B, Valster A, Messmer D, Ochani M, Tanovic M, Ochani K, Bacher M, Nicoletti F, Metz C, Pavlov VA, Miller EJ, Tracey KJ (2005): ISO-1 binding to the tautomerase active site of MIF inhibits its proinflammatory activity and increases survival in severe sepsis. J. Biol. Chem. 280, 36541-36544. http://dx.doi.org/10.1074/jbc.C500243200
2. Arjona A, Foellmer HG, Town T, Leng L, McDonald C, Wang T, Wong SJ, Montgomery RR, Fikrig E, Bucala R (2007): Abrogation of macrophage migration inhibitory factor decreases West Nile virus lethality by limiting viral neuroinvasion. J. Clin. Invest. 117, 3059-3066. http://dx.doi.org/10.1172/JCI32218
3. Arndt U, Wennemuth G, Barth P, Nain M, Al-Abed Y, Meinhardt A, Gemsa D, Bacher M (2002): Release of macrophage migration inhibitory factor and CXCL 8/interleukin-8 from lung epithelial cells rendered necrotic by influenza A virus infection. J. Virol. 76, 9298-9306. http://dx.doi.org/10.1128/JVI.76.18.9298-9306.2002
4. Assuncao-Miranda I, Amaral FA, Bozza FA, Fagundes CT, Sousa LP, Souza DG, Pacheco P, Barbosa-Lima G, Gomes RN, Bozza PT, Da Poian AT, Teixeira MM, Bozza MT (2010): Contribution of macrophage migration inhibitory factor to the pathogenesis of Dengue virus infection. FASEB J. 24, 218-228. http://dx.doi.org/10.1096/fj.09-139469
5. Bloom BR, Bennett B (1966): Mechanism of a reaction in vitro associated with delayed-type hypersensitivity. Science 153, 80-82. http://dx.doi.org/10.1126/science.153.3731.80
6. Bruns K, Studtrucker N, Sharma A, Fossen T, Mitzner D, Eissmann A, Tessmer U, Roder R, Henklein P, Wray V, Schubert U (2007): Structural characterization and oligomerization of PB1-F2, a proapoptotic influenza A virus protein. J. Biol. Chem. 282, 353-363. http://dx.doi.org/10.1074/jbc.M606494200
7. Chen LC, Lei HY, Liu CC, Shiesh SC, Chen SH, Liu HS, Lin YS, Wang ST, Shyu HW, Yeh TM (2006): Correlation of serum levels of macrophage migration inhibitory factor with disease severity and clinical outcome in dengue patients. Am. J. Trop. Med. Hyg. 74, 142-147.
8. Chen R, Chang PA, Long DX, Liu CY, Yang L, Wu YJ (2007): G protein beta2 subunit interacts directly with neuropathy target esterase and regulates its activity. Int. J. Biochem. Cell Biol. 39, 124-132. http://dx.doi.org/10.1016/j.biocel.2006.08.001
9. Chen W, Calvo PA, Malide D, Gibbs J, Schubert U, Bacik I, Basta S, O'Neill R, Schickli J, Palese P, Henklein P, Bennink JR, Yewdell JW (2001): A novel influenza A virus mitochondrial protein that induces cell death. Nat. Med. 7, 1306-1312. http://dx.doi.org/10.1038/nm1201-1306
10. Conenello GM, Tisoncik JR, Rosenzweig E, Varga ZT, Palese P, Katze MG (2011): A single N66S mutation in the PB1-F2 protein of influenza A virus increases virulence by inhibiting the early interferon response in vivo. J. Virol. 85, 652-662. http://dx.doi.org/10.1128/JVI.01987-10
11. Conenello GM, Zamarin D, Perrone LA, Tumpey T, Palese P (2007): A single mutation in the PB1-F2 of H5N1 (HK /97) and 1918 influenza A viruses contributes to increased virulence. PLoS Pathog. 3, 1414-1421. http://dx.doi.org/10.1371/journal.ppat.0030141
12. David JR (1966): Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoidcell-antigen interaction. Proc. Natl. Acad. Sci. USA 56, 72-77. http://dx.doi.org/10.1073/pnas.56.1.72
13. Donnelly SC, Haslett C, Reid PT, Grant IS, Wallace WA, Metz CN, Bruce LJ, Bucala R (1997): Regulatory role for macrophage migration inhibitory factor in acute respiratory distress syndrome. Nat. Med. 3, 320-323. http://dx.doi.org/10.1038/nm0397-320
14. Durfee T, Becherer K, Chen PL, Yeh SH, Yang Y, Kilburn AE, Lee WH, and Elledge SJ (1993): The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit. Genes Dev. 7, 555-569. http://dx.doi.org/10.1101/gad.7.4.555
15. Gibbs JS, Malide D, Hornung F, Bennink JR, Yewdell JW (2003): The influenza A virus PB1-F2 protein targets the inner mitochondrial membrane via a predicted basic amphipathic helix that disrupts mitochondrial function. J. Virol. 77, 7214-7224. http://dx.doi.org/10.1128/JVI.77.13.7214-7224.2003
16. Guan ZH, Liu D, Mi SF, Zhang J, Ye QN, Wang M, Gao GF, Yan JH (2010): Interaction of Hsp40 with influenza virus M2 protein: implications for PKR signaling pathway. Protein Cell 1, 944-955. http://dx.doi.org/10.1007/s13238-010-0115-x
17. Hou XQ, Gao YW, Yang ST, Wang CY, Ma ZY, Xia XZ (2009): Role of macrophage migration inhibitory factor in influenza H5N1 virus pneumonia. Acta Virol. 53, 225-231. http://dx.doi.org/10.4149/av_2009_04_225
18. Jung H, Seong HA, Ha H (2008): Direct interaction between NM23- H1 and macrophage migration inhibitory factor (MIF) is critical for alleviation of MIF-mediated suppression of p53 activity. J. Biol. Chem. 283, 32669-32679. http://dx.doi.org/10.1074/jbc.M806225200
19. Juno JA, Fowke KR (2010): Clarifying the role of G protein signaling in HIV infection: new approaches to an old question. AIDS Rev. 12, 164-176.
20. Kino T, Tiulpakov A, Ichijo T, Chheng L, Kozasa T, Chrousos GP (2005): G protein beta interacts with the glucocorticoid receptor and suppresses its transcriptional activity in the nucleus. J. Cell Biol. 169, 885-896. http://dx.doi.org/10.1083/jcb.200409150
21. Le Goffic R, Bouguyon E, Chevalier C, Vidic J, Da Costa B, Leymarie O, Bourdieu C, Decamps L, Dhorne-Pollet S, Delmas B (2010): Influenza A virus protein PB1-F2 exacerbates IFN-beta expression of human respiratory epithelial cells. J. Immunol. 185, 4812-4823. http://dx.doi.org/10.4049/jimmunol.0903952
22. Li X, Hummer A, Han J, Xie M, Melnik-Martinez K, Moreno RL, Buck M, Mark MD, Herlitze S (2005): G protein beta2 subunit-derived peptides for inhibition and induction of G protein pathways. Examination of voltage-gated Ca2+ and G protein inwardly rectifying K+ channels. J. Biol. Chem. 280, 23945-23959. http://dx.doi.org/10.1074/jbc.M414078200
23. Liu L, Chen J, Ji C, Zhang J, Sun J, Li Y, Xie Y, Gu S, Mao Y (2008): Macrophage migration inhibitory factor (MIF) interacts with Bim and inhibits Bim-mediated apoptosis. Mol. Cells 26, 193-199.
24. Liu L, Ji C, Chen J, Li Y, Fu X, Xie Y, Gu S, Mao Y (2008): A global genomic view of MIF knockdown-mediated cell cycle arrest. Cell Cycle 7, 1678-1692. http://dx.doi.org/10.4161/cc.7.11.6011
25. Mazur I, Anhlan D, Mitzner D, Wixler L, Schubert U, Ludwig S (2008): The proapoptotic influenza A virus protein PB1- F2 regulates viral polymerase activity by interaction with the PB1 protein. Cell Microbiol. 10, 1140-1152. http://dx.doi.org/10.1111/j.1462-5822.2008.01116.x
26. McAuley JL, Hornung F, Boyd KL, Smith AM, McKeon R, Bennink J, Yewdell JW, McCullers JA (2007): Expression of the 1918 influenza A virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumonia. Cell Host Microbe 2, 240-249. http://dx.doi.org/10.1016/j.chom.2007.09.001
27. Mitchell RA (2004): Mechanisms and effectors of MIF-dependent promotion of tumourigenesis. Cell Signal. 16, 13-19. http://dx.doi.org/10.1016/j.cellsig.2003.07.002
28. Mitchell RA, Liao H, Chesney J, Fingerle-Rowson G, Baugh J, David J, Bucala R (2002): Macrophage migration inhibitory factor (MIF) sustains macrophage proinflammatory function by inhibiting p53: regulatory role in the innate immune response. Proc. Natl. Acad. Sci. USA 99, 345-350. http://dx.doi.org/10.1073/pnas.012511599
29. Mitzner D, Dudek SE, Studtrucker N, Anhlan D, Mazur I, Wissing J, Jansch L, Wixler L, Bruns K, Sharma A, Wray V, Henklein P, Ludwig S, Schubert U (2009): Phosphorylation of the influenza A virus protein PB1-F2 by PKC is crucial for apoptosis promoting functions in monocytes. Cell Microbiol. 11, 1502-1516. http://dx.doi.org/10.1111/j.1462-5822.2009.01343.x
30. Morand EF (2005): New therapeutic target in inflammatory disease: macrophage migration inhibitory factor. Intern. Med. J. 35, 419-426. http://dx.doi.org/10.1111/j.1445-5994.2005.00853.x
31. Regis EG, Barreto-de-Souza V, Morgado MG, Bozza MT, Leng L, Bucala R, Bou-Habib DC (2010): Elevated levels of macrophage migration inhibitory factor (MIF) in the plasma of HIV-1-infected patients and in HIV-1-infected cell cultures: a relevant role on viral replication. Virology 399, 31-38. http://dx.doi.org/10.1016/j.virol.2009.12.018
32. Waragai M, Nagamitsu S, Xu W, Li YJ, Lin X and Ashizawa T (2006): Ataxin 10 induces neuritogenesis via interaction with Gprotein beta2 subunit. J. Neurosci. Res. 83, 1170-1178. http://dx.doi.org/10.1002/jnr.20807
33. Wise HM, Foeglein A, Sun J, Dalton RM, Patel S, Howard W, Anderson EC, Barclay WS, Digard P (2009): A complicated message: Identification of a novel PB1-related protein translated from influenza A virus segment 2 mRN A. J. Virol. 83, 8021-8031. http://dx.doi.org/10.1128/JVI.00826-09
34. Wu HC, Huang PH, Chiu CY, Lin CT (2001): G protein beta2 subunit antisense oligonucleotides inhibit cell proliferation and disorganize microtubule and mitotic spindle organization. J. Cell Biochem. 83, 136-146. http://dx.doi.org/10.1002/jcb.1210
35. Yamada H, Chounan R, Higashi Y, Kurihara N, Kido H (2004): Mitochondrial targeting sequence of the influenza A virus PB1-F2 protein and its function in mitochondria. FEBS Lett. 578, 331-336. http://dx.doi.org/10.1016/j.febslet.2004.11.017
36. Zamarin D, Garcia-Sastre A, Xiao X, Wang R, Palese P (2005): Influenza virus PB1-F2 protein induces cell death through mitochondrial ANT3 and VDAC1. PLoS Pathog. 1, e4. http://dx.doi.org/10.1371/journal.ppat.0010004
37. Zamarin D, Ortigoza MB, Palese P (2006): Influenza A virus PB1-F2 protein contributes to viral pathogenesis in mice. J. Virol. 80, 7976-7983. http://dx.doi.org/10.1128/JVI.00415-06
38. Zell R, Krumbholz A, Eitner A, Krieg R, Halbhuber KJ, Wutzler P (2007): Prevalence of PB1-F2 of influenza A viruses. J. Gen. Virol. 88, 536-546. http://dx.doi.org/10.1099/vir.0.82378-0
39. Zhang J, Liu W, Liu J, Xiao W, Liu L, Jiang C, Sun X, Liu P, Zhu Y, Zhang C, Chen Q (2010): G-protein beta2 subunit interacts with mitofusin 1 to regulate mitochondrial fusion. Nat. Commun. 1, 101. http://dx.doi.org/10.1038/ncomms1099
40. Zhang S, Lin R, Zhou Z, Wen S, Lin L, Chen S, Shan Y, Cong Y, Wang S (2006): Macrophage migration inhibitory factor interacts with HBx and inhibits its apoptotic activity. Biochem. Biophys. Res. Commun. 342, 671-679. http://dx.doi.org/10.1016/j.bbrc.2006.01.180
41. Zhang W, Yue B, Wang GQ, Lu SL (2002): Serum and ascites levels of macrophage migration inhibitory factor, TNF-alpha and IL-6 in patients with chronic virus hepatitis B and hepatitis cirrhosis. Hepatobiliary Pancreat Dis. Int. 1, 577-580.
42. Zhu H, Li GJ, Ding L, Cui X, Berg H, Assmann SM, Xia Y (2009): Arabidopsis extra large G-protein 2 (XLG2) interacts with the G beta subunit of heterotrimeric G protein and functions in disease resistance. Mol. Plant. 2, 513-525. http://dx.doi.org/10.1093/mp/ssp001