A novel polyherbal preparation for the management of type-2 diabetes mellitus: A clinical study

International Journal of Pharmacy and Pharmaceutical Sciences

Volumn 4, Issue SUPPL.3, 2012, Pages 495-500

  Ismail Khan, A ^a   Balaji, V ^a   Anne Williams, A ^a   Sathish, S ^a   Mayilvanan, C ^a   Balasubramanian, K ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

Cytokines; Diabetes mellitus; Medicinal plants; Polyherbal preparation; Sex steroids

Indexed keywords

ADIPOCYTOKINE; C PEPTIDE; GLUCOSE; HEMOGLOBIN A1C; HERBACEOUS AGENT; INSULIN; MONOCYTE CHEMOTACTIC PROTEIN 1; RESISTIN; TESTOSTERONE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; ELISA KIT; FEMALE; HUMAN; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; RADIOIMMUNOASSAY;

EID: 84873498556     PISSN: None     EISSN: 09751491     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. James R. Members of the expert committee on the diagnosis and classification of Diabetes Mellitus. Dia Care 2005; 28: 37-42.
2. Rebecca K, Ramaswamy R, Ganapathi B, Anura VK. Effect of supplementation of Coccinia cordifolia extract on newly detected diabetic patients. Dia Care 2008; 31: 216-20.
3. Grover JK, Vats V, Rathi SS. Anti-hyperglycemic effect of Eugenia jambolana and Tinospora cordifolia in experimental diabetes and theireffects on key metabolic enzymes involved in carbohydrate metabolism. J Ethnopharmacol 2000; 73: 461-70.
4. th ed. Vol. 2. New York: Pergamon Press, Maxwell Macmillan International editions, 1991: 1463-95.
5. Yadav M, Lavania A, Tomar R, Prasad GB, et al. Complementary and comparative study on hypoglycemic and antihyperglycemic activity of various extracts of Eugenia jambolana seed, Momordica charantia fruits, Gymnema sylvestre, and Trigonella foenum graecum seeds in rats. Appl Biochem Biotechnol 2010; 160: 2388-400.
6. Kaushik G, Satya S, Rakesh Kumar K, Naik SN. Commonly consumed Indian plant food materials in the management of diabetes mellitus. Dia & Metab Synd: Clin Res & Rev 2010; 4: 21-40.
7. Udayakumar R, Kasthurirengan S, Mariashibu TS, Rajesh M, et al. Hypoglycaemic and Hypolipidaemic effects of Withania somnifera root and leaf extracts on alloxan-induced diabetic rats. Int J Mol Sci 2009; 20: 2367-82.
8. Alam Morshed M, Anwarul Haque, Begum Rokeya, Liaquat A. Anti-hyperglycemic and lipid lowering effect of terminalia arjuna bark extract on streptozotocin indiced type 2 diabetic model rats. Int J Pharm Pharm Sci 2011; 3: 450-454.
9. Abdulmaged MT, Farid Saad, Andre Guay. The dark side of testosterone deficiency: II. Type 2 Diabetes and Insulin Resistance. J Androl 2009; 30: 23-32.
10. Livingstone C, Collison M. Sex steroids and insulin resistance. Clin Sci 2002; 102: 151-6.
11. Boujon CE, Bestetti GE, Abramo F, et al. The reduction of circulating growth hormone and prolactin in streptozotocin-induced diabetic male rats is possibly caused by hypothalamic rather than pituitary changes. J Endocrinol 1995; 145: 19-26.
12. Sudha S, Ravisankar B, Valli G, et al. Streptozotocin-diabetes impairs prolactin binding to Leydig cells in prepubertal and pubertal rats. Horm Metab Res 1999; 31: 538-86.
13. Sudha S, Ravisankar B, Julie P. M, et al. Influence of streptozotocin-induced diabetes and insulin replacement on the pituitary-testicular axis during sexual maturation in rats. Exp Clin Endocrinol Diab 2000; 108: 14-20.
14. Duccluzeau PH, Fletcher LM, Vidal H, et al. Molecular mechanisms of insulin-stimulated glucose uptake in adipocytes. Dia Metab 2002; 28: 85-92.
15. Ismail khan A, Yuvaraj S, Suthagar E, et al. Studies on hypoglycaemic effects of polyherbal preparation in streptozotocin-induced diabetic male albino rats. Hum & Exp Toxicol 2009; 28: 679-87.
16. Bisse E, Abraham EC. New less temperature-sensitive microchromatographic method for the separation and quantitation of glycosylated hemoglobins using a non-cyanide buffer system. J Chromatogr 1983; 344: 81-91.
17. Thefeld W, Hoffmeister H, Busch EW, et al. Referenzwertte fur die Bestimmungender Transaminasen GOT and GPT sowie der alkalischen Phosphatase im Serum mit optimiertten Standardmethoden. Dtsh Med Wochenschr 1974; 99: 343-51.
18. Bergmeyer HU, Scheibe P, Wahlefeld AW. Optimization of methods for aspartate aminotransferase and alanine aminotransferase. Clin Chem 1978; 24: 58-73.
19. Bretaudiere JP, Vassault A, Amsellem L, Pourci ML, et al. Criteria for establishing a standardized method for determining alkaline phosphatase activity in human serum. Clin Chem Acta 1977; 23: 2263-74.
20. Hallett CJ, Cook JG. Reduced nicotinamide adenine dinucleotide-coupled reaction for emergency blood urea estimation. Clin Chem Acta 1971; 35: 33-37.
21. Kaltwasser H, Schlegel HG. NADH-dependent coupled enzyme assay for urease and other ammonia-producing systems. Ann Biochem 1996; 16: 132-38.
22. nd ed WB Saunders Co. Philadelphia P. A. (1976) 47-51.
23. Kammeraat C. Modification of the alkaline picrate assay for creatinine to prevent spuriously elevated values by keto acids. Clin Chem Acta 1978; 84: 119-28.
24. Sahana DA, Shivprakash G, Raghavendra B, et al. Effect of Eugenia Jambolana on Plasma Glucose, Insulin Sensititvity and HDL-C Levels: Preliminary results of a randomized clinical trial. J Pharmacy Res 2010; 3: 1268-70.
25. Ansarullah, Bhavna B, Patel V, Ramachandran A. V. Oreocnide integrifolia (Gaud.) Miq leaf water extract improves metabolic alterations in high fructose fed insulin resistant and hypertensive rats. Euro J of Integ Med 2010; 2: 79-87.
26. Carl de L, Jerrold MO. Inflammation and Insulin resistance. FEBS Letters 2008; 582: 97-105.
27. Zhiuang XF, Zhao MM, Weng CL, Sun LN. Adipocytokines: A bridge connecting obesity and insulin resistance. Medical Hypothesis 2009; 73: 981-85.
28. Ding EL, Song Y, Malik VS, Liu S. Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta-analysis. JAMA 2006; 295: 288-99.
29. Fukui M, Soh J, Tanaka M, Kitagawa Y, et al. Low serum testosterone concentration in middle-aged men with type 2 diabetes. Endocr J 2007; 54: 871-7.
30. Grossman M, Thomas MC, Panagiotopoulos S, et al. Low testosterone levels are common and associated with insulin resistance in men with diabetes. J Clin Endocrinol Metab 2008; 93: 1834-40.
31. Sharma B, Balomajumder C, Roy P. Hypoglycemic and hypolipidemic effects of flavonoid rich extract from Eugenia jambolana seeds on streptozotocin induced diabetic rats. Food Chem Toxicol 2008; 46: 2376-83.
32. Sasa M, Inoue I, Shinoda Y, Takahashi S, et al. Activating effect of momordin, extract of bitter melon (Momordica Charantia L.), on the promoter of human PPARdelta. J Atheroscler Thromb 2009; 16: 888-92.
33. McCarty MF. Does bitter melon contain an activator of AMP-activated kinase?. Medical Hypothesis 2004; 63: 340-3.
34. Shibib BA, Khan LA, Rahman R. Hypoglycemic activity of Coccinia indica ana and Momordica charantia in diabetic rats: depresión of the hepatic gluconeogenic enzymes glucose-6-phosphatase and fructose-1, 6-bisphosphatase and elevation of both liver and red-cell shunt enzyme glucose-6-phosphate dehydrogenase. Biochem J 1993; 292: 267-70.
35. Mithieux G, Guignot L, Bordet JC, Wiernsperger N. Intra-hepatic mechanisms underlying the effect of metformin in decreasing basal glucose production in rats fed a high-fat diet. Diabetes 2002; 51: 139-43.
36. Mohamed Farook S and Clement Atlee W. Antidiabetic and hypolipidemic potential of Tragia Involucrata linn. in streptozotocin-nicotinamide induced type II diabetic rats. Int J Pharm Pharm Sci 2011; 3: 103-109.
37. Miura T, Itoh C, Iwamoto N, et al. Hypoglycemic activity of the fruit of the Momordica charantia in Type 2 diabetic mice. J Nutr Sci Vitaminol 2001; 47: 340-44.
38. Babu PV, Gokulakrishnan A, Dhandayuthabani R, Ameethkhan D, et al. Protective effect of Withania somnifera (Solanaceae) on collagen glycation and cross-linking. Comp Biochem Physiol B Biochem Mol Biol 2007; 147: 308-13.