Transfection efficiency and transgene expression kinetics of mRNA delivered in naked and nanoparticle format

Journal of Controlled Release

Volumn 166, Issue 3, 2013, Pages 227-233

  Phua, Kyle K L ^a   Leong, Kam W ^a,b   Nair, Smita K ^b  

^a Duke University   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Dendritic cell; Kinetics; mRNA; Nanoparticle; Non viral gene therapy; Transfection

Indexed keywords

DENDRITIC CELLS; DENDRITIC CELLS (DCS); GENE PRODUCTS; IN-VITRO; IN-VIVO; MESSENGER RNAS (MRNA); MRNA; MRNA TRANSFECTION; NONVIRAL GENE THERAPY; PROTEIN EXPRESSIONS; TRANSFECTION; TRANSFECTION EFFICIENCY; TRANSGENE EXPRESSION;

CELLS; EFFICIENCY; ENZYME KINETICS; GENE EXPRESSION; KINETICS; MOLECULAR BIOLOGY; PROTEINS; RNA;

NANOPARTICLES;

GREEN FLUORESCENT PROTEIN; LUCIFERASE; MESSENGER RNA; NANOPARTICLE; RIBONUCLEASE INHIBITOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; DRUG HALF LIFE; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTERMETHOD COMPARISON; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; SUSTAINED DRUG RELEASE; TRANSGENE;

ADMINISTRATION, INTRANASAL; ANIMALS; CELLS, CULTURED; DENDRITIC CELLS; DRUG CARRIERS; GENE EXPRESSION; HUMANS; INJECTIONS, INTRAVENOUS; INJECTIONS, SUBCUTANEOUS; KINETICS; LUCIFERASES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; NANOPARTICLES; PRIMARY CELL CULTURE; REGRESSION ANALYSIS; RNA, MESSENGER; TISSUE DISTRIBUTION; TRANSFECTION; TRANSGENES;

EID: 84873477636     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.12.029     Document Type: Article

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