Evaluation of immune responses and analysis of the effect of vaccination of the Leishmania major recombinant ribosomal proteins L3 or L5 in two different murine models of cutaneous leishmaniasis

Vaccine

Volumn 31, Issue 9, 2013, Pages 1312-1319

  Ramírez, Laura ^a   Santos, Diego M ^b   Souza, Ana P ^b   Coelho, Eduardo A F ^c   Barral, Aldina ^b   Alonso, Carlos ^a   Escutia, Marta R ^d   Bonay, Pedro ^a   de Oliveira, Camila I ^b   Soto, Manuel ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

^c FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^d St Louis University (Madrid Campus)   (Spain)

Author keywords

BALB c mice; Leishmania; Recombinant ribosomal proteins; Th1 Th2 Immune responses; Vaccines

Indexed keywords

CPG OLIGODEOXYNUCLEOTIDE; GAMMA INTERFERON; INTERLEUKIN 10; LEISHMANIA VACCINE; PARASITE ANTIGEN; RIBOSOME PROTEIN; RIBOSOME PROTEIN L3; RIBOSOME PROTEIN L5; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; IMMUNE RESPONSE; LEISHMANIA BRAZILIENSIS; LEISHMANIA MAJOR; MOUSE; NONHUMAN; PARASITE IMMUNITY; PARASITE LOAD; PRIORITY JOURNAL; SKIN LEISHMANIASIS; TH1 CELL; VACCINATION;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; INTERFERON-GAMMA; INTERLEUKIN-10; LEISHMANIA BRAZILIENSIS; LEISHMANIA MAJOR; LEISHMANIASIS VACCINES; LEISHMANIASIS, CUTANEOUS; LEUKOCYTES, MONONUCLEAR; MICE; MICE, INBRED BALB C; OLIGODEOXYRIBONUCLEOTIDES; RECOMBINANT PROTEINS; RIBOSOMAL PROTEINS; VACCINES, SYNTHETIC;

EID: 84873470686     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2012.12.071     Document Type: Article

References (28)

1. Herwaldt B.L. Leishmaniasis. Lancet 1999, 354(9185):1191-1199.
2. Kaye P., Scott P. Leishmaniasis: complexity at the host-pathogen interface. Nat Rev Microbiol 2011, 9(8):604-615.
3. Nylen S., Gautam S. Immunological perspectives of leishmaniasis. J Glob Infect Dis 2010, 2(2):135-146.
4. Iborra S., Parody N., Abanades D.R., Bonay P., Prates D., Novais F.O., et al. Vaccination with the Leishmania major ribosomal proteins plus CpG oligodeoxynucleotides induces protection against experimental cutaneous leishmaniasis in mice. Microbes Infect 2008, 10(10-11):1133-1141.
5. Ramirez L., Iborra S., Cortes J., Bonay P., Alonso C., Barral-Netto M., et al. BALB/c mice vaccinated with Leishmania major ribosomal proteins extracts combined with CpG oligodeoxynucleotides become resistant to disease caused by a secondary parasite challenge. J Biomed Biotechnol 2010, 2010:181690.
6. Chavez-Fumagalli M.A., Costa M.A., Oliveira D.M., Ramirez L., Costa L.E., Duarte M.C., et al. Vaccination with the Leishmania infantum ribosomal proteins induces protection in BALB/c mice against Leishmania chagasi and Leishmania amazonensis challenge. Microbes Infect 2010, 12(12-13):967-977.
7. Iborra S., Carrion J., Anderson C., Alonso C., Sacks D., Soto M. Vaccination with the Leishmania infantum acidic ribosomal P0 protein plus CpG oligodeoxynucleotides induces protection against cutaneous leishmaniasis in C57BL/6 mice but does not prevent progressive disease in BALB/c mice. Infect Immun 2005, 73(9):5842-5852.
8. Rhee E.G., Mendez S., Shah J.A., Wu C.Y., Kirman J.R., Turon T.N., et al. Vaccination with heat-killed Leishmania antigen or recombinant leishmanial protein and CpG oligodeoxynucleotides induces long-term memory CD4+ and CD8+ T cell responses and protection against Leishmania major infection. J Exp Med 2002, 195(12):1565-1573.
9. Mager W.H., Planta R.J., Ballesta J.G., Lee J.C., Mizuta K., Suzuki K., et al. A new nomenclature for the cytoplasmic ribosomal proteins of Saccharomyces cerevisiae. Nucleic Acids Res 1997, 25(24):4872-4875.
10. Shi P.Y., Maizels N., Weiner A.M. Recovery of soluble, active recombinant protein from inclusion bodies. BioTech 1997, 23(6):1036-1038.
11. Coelho E.A., Ramirez L., Costa M.A., Coelho V.T., Martins V.T., Chavez-Fumagalli M.A., et al. Specific serodiagnosis of canine visceral leishmaniasis using Leishmania species ribosomal protein extracts. Clin Vaccine Immunol 2009, 16(12):1774-1780.
12. Soto M., Requena J.M., Quijada L., Perez M.J., Nieto C.G., Guzman F., et al. Antigenicity of the Leishmania infantum histones H2B and H4 during canine viscerocutaneous leishmaniasis. Clin Exp Immunol 1999, 115(2):342-349.
13. Soto M., Requena J.M., Quijada L., Angel S.O., Gomez L.C., Guzman F., et al. During active viscerocutaneous leishmaniasis the anti-P2 humoral response is specifically triggered by the parasite P proteins. Clin Exp Immunol 1995, 100(2):246-252.
14. de Moura T.R., Oliveira F., Rodrigues G.C., Carneiro M.W., Fukutani K.F., Novais F.O., et al. Immunity to Lutzomyia intermedia saliva modulates the inflammatory environment induced by Leishmania braziliensis. PLoS Negl Trop Dis 2010, 4(6):e712.
15. Buffet P.A., Sulahian A., Garin Y.J., Nassar N., Derouin F. Culture microtitration: a sensitive method for quantifying Leishmania infantum in tissues of infected mice. Antimicrob Agents Chemoter 1995, 39(9):2167-2168.
16. Skeiky Y.A., Benson D.R., Elwasila M., Badaro R., Burns J.M., Reed S.G. Antigens shared by Leishmania species and Trypanosoma cruzi: immunological comparison of the acidic ribosomal P0 proteins. Infect Immun 1994, 62(5):1643-1651.
17. Soto M., Requena J.M., Quijada L., Guzman F., Patarroyo M.E., Alonso C. Identification of the Leishmania infantum P0 ribosomal protein epitope in canine visceral leishmaniasis. Immunol Lett 1995, 48(1):23-28.
18. Thomas M.C., Martinez-Carretero E., Carmelo E., Gonzalez A.C., Valladares B. Molecular characterization of the Leishmania braziliensis L6 ribosomal protein. J Parasitol 2004, 90(4):908-913.
19. Coelho V.T., Oliveira J.S., Valadares D.G., Chavez-Fumagalli M.A., Duarte M.C., Lage P.S., et al. Identification of proteins in promastigote and amastigote-like Leishmania using an immunoproteomic approach. PLoS Negl Trop Dis 2012, 6(1):e1430.
20. Goto Y., Howard R.F., Bhatia A., Trigo J., Nakatani M., Netto E.M., et al. Distinct antigen recognition pattern during zoonotic visceral leishmaniasis in humans and dogs. Vet Parasitol 2009, 160(3-4):215-220.
21. Stober C.B., Lange U.G., Roberts M.T., Gilmartin B., Francis R., Almeida R., et al. From genome to vaccines for leishmaniasis: screening 100 novel vaccine candidates against murine Leishmania major infection. Vaccine 2006, 24(14):2602-2616.
22. Badiee A., Jaafari M.R., Samiei A., Soroush D., Khamesipour A. Coencapsulation of CpG oligodeoxynucleotides with recombinant Leishmania major stress-inducible protein 1 in liposome enhances immune response and protection against leishmaniasis in immunized BALB/c mice. Clin Vaccine Immunol 2008, 15(4):668-674.
23. Soto M., Ramírez L., Pineda M.A., González V.M., Entringer P.F., Indiani de Oliveira, et al. Searching genes encoding Leishmania antigens for diagnosis and protection. Sch Res Exch 2009, 2009:ID173039.
24. de Moura T.R., Novais F.O., Oliveira F., Clarencio J., Noronha A., Barral A., et al. Toward a novel experimental model of infection to study American cutaneous leishmaniasis caused by Leishmania braziliensis. Infect Immun 2005, 73(9):5827-5834.
25. Salay G., Dorta M.L., Santos N.M., Mortara R.A., Brodskyn C., Oliveira C.I., et al. Testing of four Leishmania vaccine candidates in a mouse model of infection with Leishmania (Viannia) braziliensis, the main causative agent of cutaneous leishmaniasis in the New World. Clin Vaccine Immunol 2007, 14(9):1173-1181.
26. Tonui W.K., Titus R.G. Cross-protection against Leishmania donovani but not L. braziliensis caused by vaccination with L. major soluble promastigote exogenous antigens in BALB/c mice. Am J Trop Med Hyg 2007, 76(3):579-584.
27. Santos D.M., Carneiro M.W., de Moura T.R., Fukutani K., Clarencio J., Soto M., et al. Towards development of novel immunization strategies against leishmaniasis using PLGA nanoparticles loaded with kinetoplastid membrane protein-11. Int J Nanomedicine 2012, 7:2115-2127.
28. Samuelson J., Lerner E., Tesh R., Titus R. A mouse model of Leishmania braziliensis braziliensis infection produced by coinjection with sand fly saliva. J Exp Med 1991, 173(1):49-54.