메뉴 건너뛰기




Volumn 7, Issue , 2012, Pages 2115-2127

Towards development of novel immunization strategies against leishmaniasis using PLGA nanoparticles loaded with kinetoplastid membrane protein-11

Author keywords

Kinetoplastid membrane protein 11; Leishmania; Nanoparticle; Vaccine

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G2A ANTIBODY; KINETOPLASTID MEMBRANE PROTEIN 11; LEISHMANIA VACCINE; NANOPARTICLE; PLASMID DNA; POLYGLACTIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CYTOKINE; DNA VACCINE; LACTIC ACID; PARASITE ANTIGEN; POLYGLYCOLIC ACID; POLYLACTIC ACID POLYGLYCOLIC ACID COPOLYMER; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER; PROTOZOAL PROTEIN; PROTOZOON ANTIBODY; RECOMBINANT PROTEIN;

EID: 84866749418     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S30093     Document Type: Article
Times cited : (40)

References (46)
  • 1
    • 3042555141 scopus 로고    scopus 로고
    • Leishmaniasis: Current situation and new perspectives
    • Desjeux P. Leishmaniasis: current situation and new perspectives. Comp Immunol Microbiol Infect Dis. 2004;27(5):305-318.
    • (2004) Comp Immunol Microbiol Infect Dis. , vol.27 , Issue.5 , pp. 305-318
    • Desjeux, P.1
  • 2
    • 0022836755 scopus 로고
    • Mucosal leishmaniasis ("espundia" Escomel, 1911)
    • Marsden PD. Mucosal leishmaniasis ("espundia" Escomel, 1911). Trans R Soc Trop Med Hyg. 1986;80(6):859-876.
    • (1986) Trans R Soc Trop Med Hyg. , vol.80 , Issue.6 , pp. 859-876
    • Marsden, P.D.1
  • 3
    • 84870314662 scopus 로고
    • 2nd ed. Doerr W, Seifert G, editors. Tropical Pathology. Berlin: Springer
    • Bittencourt A, Barral-Netto M. Leishmaniasis. Vol 8. 2nd ed. Doerr W, Seifert G, editors. Tropical Pathology. Berlin: Springer; 1995.
    • (1995) Leishmaniasis. , vol.8
    • Bittencourt, A.1    Barral-Netto, M.2
  • 5
    • 0024236111 scopus 로고
    • Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens
    • Scott P, Natovitz P, Coffman RL, Pearce E, Sher A. Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens. J Exp Med. 1988;168(5):1675-1684.
    • (1988) J Exp Med. , vol.168 , Issue.5 , pp. 1675-1684
    • Scott, P.1    Natovitz, P.2    Coffman, R.L.3    Pearce, E.4    Sher, A.5
  • 6
    • 0025300228 scopus 로고
    • Macrophage killing of Leishmania parasite in vivo is mediated by nitric oxide from L-arginine
    • Liew FY, Millott S, Parkinson C, Palmer RM, Moncada S. Macrophage killing of Leishmania parasite in vivo is mediated by nitric oxide from L-arginine. J Immunol. 1990;144(12):4794-4797.
    • (1990) J Immunol. , vol.144 , Issue.12 , pp. 4794-4797
    • Liew, F.Y.1    Millott, S.2    Parkinson, C.3    Palmer, R.M.4    Moncada, S.5
  • 8
    • 70349548782 scopus 로고    scopus 로고
    • Vaccines and vaccination strategies against human cutaneous leishmaniasis
    • Okwor I, Uzonna J. Vaccines and vaccination strategies against human cutaneous leishmaniasis. Hum Vaccin. 2009;5(5):291-301.
    • (2009) Hum Vaccin. , vol.5 , Issue.5 , pp. 291-301
    • Okwor, I.1    Uzonna, J.2
  • 9
    • 0034176364 scopus 로고    scopus 로고
    • The prime-boost strategy: Exciting prospects for improved vaccination
    • Ramshaw IA, Ramsay AJ. The prime-boost strategy: exciting prospects for improved vaccination. Immunol Today. 2000;21(4):163-165.
    • (2000) Immunol Today. , vol.21 , Issue.4 , pp. 163-165
    • Ramshaw, I.A.1    Ramsay, A.J.2
  • 10
    • 0037726800 scopus 로고    scopus 로고
    • Protection in dogs against visceral leishmaniasis caused by Leishmania infantum is achieved by immunization with a heterologous prime-boost regime using DNA and vaccinia recombinant vectors expressing LACK
    • Ramiro MJ, Zarate JJ, Hanke T, et al. Protection in dogs against visceral leishmaniasis caused by Leishmania infantum is achieved by immunization with a heterologous prime-boost regime using DNA and vaccinia recombinant vectors expressing LACK. Vaccine. 2003;21(19-20):2474-2484.
    • (2003) Vaccine. , vol.21 , Issue.19-20 , pp. 2474-2484
    • Ramiro, M.J.1    Zarate, J.J.2    Hanke, T.3
  • 11
    • 23344439229 scopus 로고    scopus 로고
    • Heterologous prime-boost vaccination with the LACK antigen protects against murine visceral leishmaniasis
    • Dondji B, Perez-Jimenez E, Goldsmith-Pestana K, Esteban M, McMahon-Pratt D. Heterologous prime-boost vaccination with the LACK antigen protects against murine visceral leishmaniasis. Infect Immun. 2005;73(8):5286-5289.
    • (2005) Infect Immun. , vol.73 , Issue.8 , pp. 5286-5289
    • Dondji, B.1    Perez-Jimenez, E.2    Goldsmith-Pestana, K.3    Esteban, M.4    McMahon-Pratt, D.5
  • 12
    • 38649134178 scopus 로고    scopus 로고
    • Leishmania infantum: Prime boost vaccination with C-terminal extension of cysteine proteinase type I displays both type 1 and 2 immune signatures in BALB/c mice
    • Rafati S, Zahedifard F, Azari MK, Taslimi Y, Taheri T. Leishmania infantum: prime boost vaccination with C-terminal extension of cysteine proteinase type I displays both type 1 and 2 immune signatures in BALB/c mice. Exp Parasitol. 2008;118(3):393-401.
    • (2008) Exp Parasitol. , vol.118 , Issue.3 , pp. 393-401
    • Rafati, S.1    Zahedifard, F.2    Azari, M.K.3    Taslimi, Y.4    Taheri, T.5
  • 13
    • 0037081386 scopus 로고    scopus 로고
    • A heterologous prime-boost regime using DNA and recombinant vaccinia virus expressing the Leishmania infantum P36/LACK antigen protects BALB/c mice from cutaneous leishmaniasis
    • Gonzalo RM, del Real G, Rodriguez JR, et al. A heterologous prime-boost regime using DNA and recombinant vaccinia virus expressing the Leishmania infantum P36/LACK antigen protects BALB/c mice from cutaneous leishmaniasis. Vaccine. 2002;20(7-8):1226-1231.
    • (2002) Vaccine. , vol.20 , Issue.7-8 , pp. 1226-1231
    • Gonzalo, R.M.1    del Real, G.2    Rodriguez, J.R.3
  • 14
    • 0037295526 scopus 로고    scopus 로고
    • The combination of DNA vectors expressing IL-12 EEIL-18 elicits high protective immune response against cutaneous leishmaniasis after priming with DNA-p36/LACK and the cytokines, followed by a booster with a vaccinia virus recombinant expressing p36/LACK
    • Tapia E, Perez-Jimenez E, Lopez-Fuertes L, Gonzalo R, Gherardi MM, Esteban M. The combination of DNA vectors expressing IL-12 EEIL-18 elicits high protective immune response against cutaneous leishmaniasis after priming with DNA-p36/LACK and the cytokines, followed by a booster with a vaccinia virus recombinant expressing p36/LACK. Microbes Infect. 2003;5(2):73-84.
    • (2003) Microbes Infect. , vol.5 , Issue.2 , pp. 73-84
    • Tapia, E.1    Perez-Jimenez, E.2    Lopez-Fuertes, L.3    Gonzalo, R.4    Gherardi, M.M.5    Esteban, M.6
  • 15
    • 79951721466 scopus 로고    scopus 로고
    • Evaluation of DNA/DNA and prime-boost vaccination using LPG3 against Leishmania major infection in susceptible BALB/c mice and its antigenic properties in human leishmaniasis
    • Abdian N, Gholami E, Zahedifard F, Safaee N, Rafati S. Evaluation of DNA/DNA and prime-boost vaccination using LPG3 against Leishmania major infection in susceptible BALB/c mice and its antigenic properties in human leishmaniasis. Exp Parasitol. 2011;127(3):627-636.
    • (2011) Exp Parasitol. , vol.127 , Issue.3 , pp. 627-636
    • Abdian, N.1    Gholami, E.2    Zahedifard, F.3    Safaee, N.4    Rafati, S.5
  • 16
    • 0025730382 scopus 로고
    • Biodegradable microparticles as controlled release antigen delivery systems
    • O'Hagan DT, Rahman D, McGee JP, et al. Biodegradable microparticles as controlled release antigen delivery systems. Immunology. 1991;73(2): 239-242.
    • (1991) Immunology. , vol.73 , Issue.2 , pp. 239-242
    • O'Hagan, D.T.1    Rahman, D.2    McGee, J.P.3
  • 17
    • 1842613560 scopus 로고    scopus 로고
    • Potent, long lasting systemic antibody levels and mixed Th1/ Th2 immune response after nasal immunization with malaria antigen loaded PLGA microparticles
    • Carcaboso AM, Hernandez RM, Igartua M, Rosas JE, Patarroyo ME, Pedraz JL. Potent, long lasting systemic antibody levels and mixed Th1/ Th2 immune response after nasal immunization with malaria antigen loaded PLGA microparticles. Vaccine. 2004;22(11-12):1423-1432.
    • (2004) Vaccine. , vol.22 , Issue.11-12 , pp. 1423-1432
    • Carcaboso, A.M.1    Hernandez, R.M.2    Igartua, M.3    Rosas, J.E.4    Patarroyo, M.E.5    Pedraz, J.L.6
  • 18
    • 50549086919 scopus 로고    scopus 로고
    • Co-delivery of cancer-associated antigen and Toll-like receptor 4 ligand in PLGA nanoparticles induces potent CD8ppT cell-mediated anti-tumor immunity
    • Hamdy S, Molavi O, Ma Z, et al. Co-delivery of cancer-associated antigen and Toll-like receptor 4 ligand in PLGA nanoparticles induces potent CD8ppT cell-mediated anti-tumor immunity. Vaccine. 2008; 26(39):5046-5057.
    • (2008) Vaccine. , vol.26 , Issue.39 , pp. 5046-5057
    • Hamdy, S.1    Molavi, O.2    Ma, Z.3
  • 19
    • 11844263890 scopus 로고    scopus 로고
    • Enhancement of T helper type 1 immune responses against hepatitis B virus core antigen by PLGA nanoparticle vaccine delivery
    • Chong CSW, Cao M, Wong WW, et al. Enhancement of T helper type 1 immune responses against hepatitis B virus core antigen by PLGA nanoparticle vaccine delivery. J Control Release. 2005;102(1):85-99.
    • (2005) J Control Release. , vol.102 , Issue.1 , pp. 85-99
    • Chong, C.S.W.1    Cao, M.2    Wong, W.W.3
  • 20
    • 79960109323 scopus 로고    scopus 로고
    • Delivery of a cocktail DNA vaccine encoding cysteine proteinases type I, II and III with solid lipid nanoparticles potentiate protective immunity against Leishmania major infection
    • Doroud D, Zahedifard F, Vatanara A, et al. Delivery of a cocktail DNA vaccine encoding cysteine proteinases type I, II and III with solid lipid nanoparticles potentiate protective immunity against Leishmania major infection. J Control Release. 2011;153(2):154-162.
    • (2011) J Control Release. , vol.153 , Issue.2 , pp. 154-162
    • Doroud, D.1    Zahedifard, F.2    Vatanara, A.3
  • 21
    • 79956217016 scopus 로고    scopus 로고
    • Immunization against leishmaniasis by PLGA nanospheres encapsulated with autoclaved Leishmania major (ALM) and CpG-ODN
    • Tafaghodi M, Khamesipour A, Jaafari MR. Immunization against leishmaniasis by PLGA nanospheres encapsulated with autoclaved Leishmania major (ALM) and CpG-ODN. Parasitol Res. 2011;108(5): 1265-1273.
    • (2011) Parasitol Res. , vol.108 , Issue.5 , pp. 1265-1273
    • Tafaghodi, M.1    Khamesipour, A.2    Jaafari, M.R.3
  • 22
    • 0028854812 scopus 로고
    • Isolation and structural characterization of the Leishmania donovani kinetoplastid membrane protein-11, a major immunoreactive membrane glycoprotein
    • Jardim A, Funk V, Caprioli RM, Olafson RW. Isolation and structural characterization of the Leishmania donovani kinetoplastid membrane protein-11, a major immunoreactive membrane glycoprotein. Biochem J. 1995;305(Pt 1):307-313.
    • (1995) Biochem J. , vol.305 , Issue.PART 1 , pp. 307-313
    • Jardim, A.1    Funk, V.2    Caprioli, R.M.3    Olafson, R.W.4
  • 23
    • 0031848371 scopus 로고    scopus 로고
    • Humoral and cellular immune responses to synthetic peptides of the Leishmania donovani kinetoplastid membrane protein-11
    • Jensen AT, Gasim S, Ismail A, et al. Humoral and cellular immune responses to synthetic peptides of the Leishmania donovani kinetoplastid membrane protein-11. Scand J Immunol. 1998;48(1):103-109.
    • (1998) Scand J Immunol. , vol.48 , Issue.1 , pp. 103-109
    • Jensen, A.T.1    Gasim, S.2    Ismail, A.3
  • 24
    • 0033966160 scopus 로고    scopus 로고
    • Molecular characterization of KMP11 from Trypanosoma cruzi: A cytoskeletonassociated protein regulated at the translational level
    • Thomas MC, Garcia-Perez JL, Alonso C, Lopez MC. Molecular characterization of KMP11 from Trypanosoma cruzi: a cytoskeletonassociated protein regulated at the translational level. DNA Cell Biol. 2000;19(1):47-57.
    • (2000) DNA Cell Biol. , vol.19 , Issue.1 , pp. 47-57
    • Thomas, M.C.1    Garcia-Perez, J.L.2    Alonso, C.3    Lopez, M.C.4
  • 25
    • 18944378937 scopus 로고    scopus 로고
    • Kinetoplastid membrane protein-11 DNA vaccination induces complete protection against both pentavalent antimonial-sensitive and-resistant strains of Leishmania donovani that correlates with inducible nitric oxide synthase activity and IL-4 generation: Evidence for mixed Th1-and Th2-like responses in visceral leishmaniasis
    • Basu R, Bhaumik S, Basu JM, Naskar K, De T, Roy S. Kinetoplastid membrane protein-11 DNA vaccination induces complete protection against both pentavalent antimonial-sensitive and-resistant strains of Leishmania donovani that correlates with inducible nitric oxide synthase activity and IL-4 generation: evidence for mixed Th1-and Th2-like responses in visceral leishmaniasis. J Immunol. 2005;174(11): 7160-7171.
    • (2005) J Immunol. , vol.174 , Issue.11 , pp. 7160-7171
    • Basu, R.1    Bhaumik, S.2    Basu, J.M.3    Naskar, K.4    De, T.5    Roy, S.6
  • 26
    • 59849102406 scopus 로고    scopus 로고
    • KMP-11 DNA immunization significantly protects against L. donovani infection but requires exogenous IL-12 as an adjuvant for comparable protection against L. major
    • Bhaumik S, Basu R, Sen S, Naskar K, Roy S. KMP-11 DNA immunization significantly protects against L. donovani infection but requires exogenous IL-12 as an adjuvant for comparable protection against L. major. Vaccine. 2009;27(9):1306-1316.
    • (2009) Vaccine. , vol.27 , Issue.9 , pp. 1306-1316
    • Bhaumik, S.1    Basu, R.2    Sen, S.3    Naskar, K.4    Roy, S.5
  • 28
    • 0034847257 scopus 로고    scopus 로고
    • Calciuminduced conformational changes in Leishmania infantum kinetoplastid membrane protein-11
    • Fuertes MA, Perez JM, Soto M, Lopez MC, Alonso C. Calciuminduced conformational changes in Leishmania infantum kinetoplastid membrane protein-11. J Biol Inorg Chem. 2001;6(1):107-117.
    • (2001) J Biol Inorg Chem. , vol.6 , Issue.1 , pp. 107-117
    • Fuertes, M.A.1    Perez, J.M.2    Soto, M.3    Lopez, M.C.4    Alonso, C.5
  • 29
    • 0033106288 scopus 로고    scopus 로고
    • Folding stability of the kinetoplastid membrane protein-11 (KMP-11) from Leishmania infantum
    • Fuertes MA, Berberich C, Lozano RM, Gimenez-Gallego G, Alonso C. Folding stability of the kinetoplastid membrane protein-11 (KMP-11) from Leishmania infantum. Eur J Biochem.1999;260(2): 559-567.
    • (1999) Eur J Biochem. , vol.260 , Issue.2 , pp. 559-567
    • Fuertes, M.A.1    Berberich, C.2    Lozano, R.M.3    Gimenez-Gallego, G.4    Alonso, C.5
  • 30
    • 1842655961 scopus 로고    scopus 로고
    • Loading of plasmid DNA into PLGA microparticles using TROMS (total recirculation one-machine system): Evaluation of its integrity and controlled release properties
    • del Barrio GG, Novo FJ, Irache JM. Loading of plasmid DNA into PLGA microparticles using TROMS (total recirculation one-machine system): evaluation of its integrity and controlled release properties. J Control Release. 2003;86(1):123-130.
    • (2003) J Control Release. , vol.86 , Issue.1 , pp. 123-130
    • del Barrio, G.G.1    Novo, F.J.2    Irache, J.M.3
  • 31
    • 23944486753 scopus 로고    scopus 로고
    • Vaccination with the Leishmania infantum acidic ribosomal P0 protein plus CpG oligodeoxynucleotides induces protection against cutaneous leishmaniasis in C57BL/6 mice but does not prevent progressive disease in BALB/c mice
    • Iborra S, Carrion J, Anderson C, Alonso C, Sacks D, Soto M. Vaccination with the Leishmania infantum acidic ribosomal P0 protein plus CpG oligodeoxynucleotides induces protection against cutaneous leishmaniasis in C57BL/6 mice but does not prevent progressive disease in BALB/c mice. Infect Immun. 2005;73(9):5842-5852.
    • (2005) Infect Immun. , vol.73 , Issue.9 , pp. 5842-5852
    • Iborra, S.1    Carrion, J.2    Anderson, C.3    Alonso, C.4    Sacks, D.5    Soto, M.6
  • 32
    • 23944521372 scopus 로고    scopus 로고
    • Toward a novel experimental model of infection to study American cutaneous leishmaniasis caused by Leishmania braziliensis
    • de Moura TR, Novais FO, Oliveira F, et al. Toward a novel experimental model of infection to study American cutaneous leishmaniasis caused by Leishmania braziliensis. Infect Immun. 2005;73(9):5827-5834.
    • (2005) Infect Immun. , vol.73 , Issue.9 , pp. 5827-5834
    • de Moura, T.R.1    Novais, F.O.2    Oliveira, F.3
  • 33
    • 77956989885 scopus 로고    scopus 로고
    • Immunity to Lutzomyia intermedia saliva modulates the inflammatory environment induced by Leishmania braziliensis
    • de Moura TR, Oliveira F, Rodrigues GC, et al. Immunity to Lutzomyia intermedia saliva modulates the inflammatory environment induced by Leishmania braziliensis. PLoS Negl Trop Dis. 2010;4(6):e712.
    • (2010) PLoS Negl Trop Dis. , vol.4 , Issue.6
    • de Moura, T.R.1    Oliveira, F.2    Rodrigues, G.C.3
  • 34
    • 42549148646 scopus 로고    scopus 로고
    • Enhanced Leishmania braziliensis infection following pre-exposure to sandfly saliva
    • de Moura TR, Oliveira F, Novais FO, et al. Enhanced Leishmania braziliensis infection following pre-exposure to sandfly saliva. PLoS Negl Trop Dis. 2007;1(2):e84.
    • (2007) PLoS Negl Trop Dis. , vol.1 , Issue.2
    • de Moura, T.R.1    Oliveira, F.2    Novais, F.O.3
  • 35
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta c(t) method
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta c(t) method. Methods. 2001;25(4):402-408.
    • (2001) Methods. , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 36
    • 77954385672 scopus 로고    scopus 로고
    • The systemic toxicity of positively charged lipid nanoparticles and the role of Toll-like receptor 4 in immune activation
    • Kedmi R, Ben-Arie N, Peer D. The systemic toxicity of positively charged lipid nanoparticles and the role of Toll-like receptor 4 in immune activation. Biomaterials. 2010;31(26):6867-6875.
    • (2010) Biomaterials. , vol.31 , Issue.26 , pp. 6867-6875
    • Kedmi, R.1    Ben-Arie, N.2    Peer, D.3
  • 37
    • 0034933019 scopus 로고    scopus 로고
    • Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells
    • Krug A, Rothenfusser S, Hornung V, et al. Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells. Eur J Immunol 2001;31(7): 2154-2163.
    • (2001) Eur J Immunol , vol.31 , Issue.7 , pp. 2154-2163
    • Krug, A.1    Rothenfusser, S.2    Hornung, V.3
  • 38
    • 12244263784 scopus 로고    scopus 로고
    • Characterization of the immune response to Leishmania infantum recombinant antigens
    • de Carvalho LP, Soto M, Jeronimo S, et al. Characterization of the immune response to Leishmania infantum recombinant antigens. Microbes Infect. 2003;5(1):7-12.
    • (2003) Microbes Infect. , vol.5 , Issue.1 , pp. 7-12
    • de Carvalho, L.P.1    Soto, M.2    Jeronimo, S.3
  • 39
    • 18344366537 scopus 로고    scopus 로고
    • Effect of LACK and KMP11 on IFN-gamma production by peripheral blood mononuclear cells from cutaneous and mucosal leishmaniasis patients
    • Carvalho LP, Passos S, Dutra WO, et al. Effect of LACK and KMP11 on IFN-gamma production by peripheral blood mononuclear cells from cutaneous and mucosal leishmaniasis patients. Scand J Immunol. 2005;61(4):337-342.
    • (2005) Scand J Immunol. , vol.61 , Issue.4 , pp. 337-342
    • Carvalho, L.P.1    Passos, S.2    Dutra, W.O.3
  • 40
    • 2242423605 scopus 로고    scopus 로고
    • CD44 CD25CCregulatory T cells control Leishmania major persistence and immunity
    • Belkaid Y, Piccirillo CA, Mendez S, Shevach EM, Sacks DL. CD44 CD25CCregulatory T cells control Leishmania major persistence and immunity. Nature. 2002;420(6915):502-507.
    • (2002) Nature. , vol.420 , Issue.6915 , pp. 502-507
    • Belkaid, Y.1    Piccirillo, C.A.2    Mendez, S.3    Shevach, E.M.4    Sacks, D.L.5
  • 41
    • 0034681126 scopus 로고    scopus 로고
    • Cationic microparticles: A potent delivery system for DNA vaccines
    • Singh M, Briones M, Ott G, O'Hagan D. Cationic microparticles: a potent delivery system for DNA vaccines. Proc Natl Acad Sci U S A. 2000;97(2):811-816.
    • (2000) Proc Natl Acad Sci U S A. , vol.97 , Issue.2 , pp. 811-816
    • Singh, M.1    Briones, M.2    Ott, G.3    O'Hagan, D.4
  • 42
    • 79955717998 scopus 로고    scopus 로고
    • Cysteine proteinase type I, encapsulated in solid lipid nanoparticles induces substantial protection against Leishmania major infection in C57BL/6 mice
    • Doroud D, Zahedifard F, Vatanara A, Najafabadi AR, Rafati S. Cysteine proteinase type I, encapsulated in solid lipid nanoparticles induces substantial protection against Leishmania major infection in C57BL/6 mice. Parasite Immunol. 2011;33(6):335-348.
    • (2011) Parasite Immunol. , vol.33 , Issue.6 , pp. 335-348
    • Doroud, D.1    Zahedifard, F.2    Vatanara, A.3    Najafabadi, A.R.4    Rafati, S.5
  • 44
    • 9344271546 scopus 로고    scopus 로고
    • Immunity in response to particulate antigen-delivery systems
    • Storni T, Kundig TM, Senti G, Johansen P. Immunity in response to particulate antigen-delivery systems. Adv Drug Deliv Rev. 2005;57(3): 333-355.
    • (2005) Adv Drug Deliv Rev. , vol.57 , Issue.3 , pp. 333-355
    • Storni, T.1    Kundig, T.M.2    Senti, G.3    Johansen, P.4
  • 45
    • 34948860200 scopus 로고    scopus 로고
    • Testing of four Leishmania vaccine candidates in a mouse model of infection with Leishmania (Viannia) braziliensis, the main causative agent of cutaneous leishmaniasis in the New World
    • Salay G, Dorta ML, Santos NM, et al. Testing of four Leishmania vaccine candidates in a mouse model of infection with Leishmania (Viannia) braziliensis, the main causative agent of cutaneous leishmaniasis in the New World. Clin Vaccine Immunol. 2007;14(9):1173-1181.
    • (2007) Clin Vaccine Immunol. , vol.14 , Issue.9 , pp. 1173-1181
    • Salay, G.1    Dorta, M.L.2    Santos, N.M.3
  • 46
    • 34247120998 scopus 로고    scopus 로고
    • Cross-protection against Leishmania donovani but not L. Braziliensis caused by vaccination with L. major soluble promastigote exogenous antigens in BALB/c mice
    • Tonui WK, Titus RG. Cross-protection against Leishmania donovani but not L. Braziliensis caused by vaccination with L. major soluble promastigote exogenous antigens in BALB/c mice. Am J Trop Med Hyg. 2007;76(3):579-584.
    • (2007) Am J Trop Med Hyg. , vol.76 , Issue.3 , pp. 579-584
    • Tonui, W.K.1    Titus, R.G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.