The Inhibin B Response in Male Rats Treated with Two Drug Candidates

Birth Defects Research Part B - Developmental and Reproductive Toxicology

Volumn 98, Issue 1, 2013, Pages 54-62

  Chapin, Robert E ^a   Alvey, James D ^a   Goldstein, Richard A ^a   Dokmanovich, Melba G ^a   Reagan, William J ^a   Johnson, Kjell ^a,b   Geoly, Frank J ^a  

^a PFIZER INC   (United States)

^b Lonnie E Grantham II   (United States)

Author keywords

circulating biomarker; drug candidate; Inhibin B; testis histopathology

Indexed keywords

ANTIINFECTIVE AGENT; ANTIVIRUS AGENT; FOLLITROPIN; INHIBIN B; LUTEINIZING HORMONE; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MEGADOSE; DRUG RESPONSE; FEMALE; FOLLITROPIN BLOOD LEVEL; FOLLOW UP; LUTEINIZING HORMONE BLOOD LEVEL; MALE; MALE FERTILITY; NONHUMAN; PRIORITY JOURNAL; RAT; SPERMATOZOON MOTILITY; TESTIS INJURY; TESTIS WEIGHT; TESTOSTERONE BLOOD LEVEL;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTIVIRAL AGENTS; FOLLICLE STIMULATING HORMONE; HORMONES; INHIBINS; MALE; ORGAN SIZE; RATS; SPERMATOZOA; TESTIS;

EID: 84873462909     PISSN: 15429733     EISSN: 15429741     Source Type: Journal    
DOI: 10.1002/bdrb.21040     Document Type: Article

References (2)

1. Coulson M, Bickerton S, Betts C, Jacobsen M, Stewart J, Chapin R, Reagan WJ, Alvey J, Erdos Z, Saldutti LP, Sonee M, Bogdan N, Singer M, Vinken M, Barlow V, Czajkowski K. 2013. Analytic validation of a human ELISA kit for measurement of inhibin B in rat samples. Birth Def Res B this issue.
2. Institute of Laboratory Animal Research, Commission on Life Sciences, National Research Council. 1996. Guide for the care and use of laboratory animals. Washington, DC: The National Academies Press.