Hepatitis viruses (other than hepatitis B and C viruses) as causes of hepatocellular carcinoma: An update

Journal of Viral Hepatitis

Volumn 20, Issue 3, 2013, Pages 149-157

  Kew, M C ^a,b  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b UNIVERSITY OF THE WITWATERSRAND   (South Africa)

Author keywords

hepatitis Delta virus; hepatitis G virus; hepatocellular carcinoma; SEN virus; TT virus

Indexed keywords

CANCER RISK; CHRONIC HEPATITIS; DELTA AGENT HEPATITIS; HEPATITIS B; HEPATITIS B VIRUS; HEPATITIS C; HEPATITIS DELTA VIRUS; HEPATITIS G; HEPATITIS G VIRUS; HEPATITIS NON A TO E; HEPATITIS VIRUS; HUMAN; LIVER CELL CARCINOMA; MALIGNANT TRANSFORMATION; MIXED INFECTION; NONHUMAN; PREVALENCE; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SEN VIRUS; SEN VIRUS INFECTION; TORQUE TENO VIRUS; TORQUE TENO VIRUS INFECTION; VIRUS REPLICATION; VIRUS TRANSMISSION;

ANIMALS; CARCINOMA, HEPATOCELLULAR; GB VIRUS C; HEPATITIS DELTA VIRUS; HUMANS; LIVER NEOPLASMS; TORQUE TENO VIRUS;

EID: 84873459669     PISSN: 13520504     EISSN: 13652893     Source Type: Journal    
DOI: 10.1111/jvh.12043     Document Type: Review

References (113)

1. Rizzetto M, Ponzetto A, Bonino F, Verme G,. Hepatitis Delta virus infection: clinical and epidemiological aspects. In:, Zuckerman AJ, ed. Viral Hepatitis and Liver Disease, New York: Alan R. Liss, 1988: 389-394.
2. Gerin JL, Casey JL, Purcell RH,. Hepatitis Delta virus. In:, Hollinger FB, Purcell RH, Gerin JL, Ganem DE, Feinstone FM, eds. Viral Hepatitis, USA: Lippincott Williams and Wilkins, 2002: 169-192.
3. Taylor JM,. Hepatitis Delta virus. Virology 2006; 344: 71-76.
4. Taylor JM,. Hepatitis Delta virus and its replication. In:, Fields BN, Knipe DM, Howley PM, eds. Fundamental Virology, 3rd edn. Philadelphia: Lippincott-Raven Publishers, 1996: 1235-1244.
5. Bergmann KF, Gerin JL,. Antigens of hepatitis Delta virus in the liver and serum of humans and animals. J Infect Dis 1986; 154: 702-706.
6. Bonino F, Heermann KH, Rizzetto M, Gerlich WH,. Hepatitis Delta virus: protein composition of Delta antigen and its hepatitis B virus-derived envelope. J Virol 1986; 58: 945-950.
7. Wang KS, Choo QL, Weiner AJ, et al,. Structure, sequence and expression of the hepatitis Delta genome. Nature 1986; 323: 508-514.
8. Glen JS, Watson JA, Havel CM, White JM,. Identification of a prenylation site in Delta virus large antigen. Science 1992; 256: 1331-1333.
9. Van Regenmortel MHV, Fauquet CM, Bishop DHL, et al,. Virus Taxonomy: The Classification and Nomenclature of Viruses. The seventh report of the International Committee on Taxonomy of Viruses. San Diego: Academic Press, 2000.
10. Fattovich G, Boscaro S, Noventa F, et al,. Influence of hepatitis Delta virus infection on progression to cirrhosis in chronic hepatitis B. J Infect Dis 1987; 155: 931-935.
11. Yurdaydin C, Idilman R, Bozkaya H, Bozdayi AM,. Natural history and treatment of chronic Delta hepatitis. J Viral Hepat 2010; 17: 749-756.
12. Niro GA, Smedile A, Ippolito AM, et al,. Outcome of chronic delta hepatitis in Italy: a long-term cohort study. J Hepatol 2010; 53: 834-840.
13. Sagnelli E, Felaco FM, Filippini E, et al,. Influence of HDV infection on clinical, biochemical and histological presentation of HBsAg-positive chronic hepatitis. Liver 1989; 9: 229-234.
14. Schaper M, Rodriguez-Frias R, Jardi D, et al,. Quantitative long-term evaluations of hepatitis Delta virus RNA and hepatitis B virus DNA shows a dynamic complex replicative profile in chronic B and Delta. J Hepatol 2010; 52: 658-664.
15. Cross TJS, Rizzi P, Horner N, et al,. The increasing prevalence of hepatitis Delta virus infection in South London. J Med Virol 2008; 80: 277-282.
16. Romeo R, Del Ninno E, Rumi M, et al,. A 28-year study of chronic hepatitis Delta infection: a risk factor for cirrhosis and hepatocellular carcinoma. Gastroenterology 2009; 136: 1629-1638.
17. Hadziyannis S,. Hepatitis Delta: an overview. In:, Rizzetto M, Purcell RH, Gerin HE, Verme G, eds. Viral Hepatitis and Liver Disease, Turin: Edizioni Minerva Medica, 1997: 283-289.
18. Farci P,. Delta hepatitis: an update. J Hepatol 2003; 39: S212-S219.
19. Hadziyannis SJ, Sherman M, Lieberman HL, Shafritz DA,. Liver disease activity and hepatitis B virus replication in chronic Delta antigen-positive hepatitis B virus carriers. Hepatology 1985; 5: 544-547.
20. Heidrich B, Serrano BZ, Idilman R, et al,. HBeAg-positive hepatitis Delta: virological patterns and clinical long-term outcome. Liver Int 2012; 32: 1415-1425.
21. Wedemeyer H, Heinrich B, Manns MP,. Hepatitis delta infection-not a vanishing disease in Europe. Hepatology 2007; 45: 1331-1332.
22. Wedemeyer H,. Hepatitis D revival. Liver Int 2011; 31 (Suppl 1): 140-144.
23. D'Amelio R, Matricardi PM, Biselli R, et al,. Changing epidemiology of hepatitis B in Italy: public health implications. Am J Epidemiol 1992; 135: 1012-1018.
24. Rosina F, Consoscitore P, Cuppone R, et al,. Changing pattern of chronic hepatitis D in southern Europe. Gastroenterology 1999; 117: 161-166.
25. Govindarajan S, Hevia FJ, Peters RL,. Prevalence of Delta antigen/antibody in B viral-associated hepatocellular carcinoma. Cancer 1984; 53: 1692-1695.
26. Verme G, Brunetto MR, Oliver F, et al,. Role of Delta virus infection in hepatocellular carcinoma. Dig Dis Sci 1991; 36: 1134-1136.
27. Wu JC, Chen TZ, Huang YS, et al,. Natural history of hepatitis D viral superinfection: significance of viremia detected by polymerase chain reaction. Gastroenterology 1995; 108: 796-802.
28. Colombo M, Cambieri R, Rumi MG, Ranchi MG, Del Ninno E, De Franchis R,. Long-term Delta superinfection in HBsAg Carriers and its relationship to the causes of chronic hepatitis. Gastroenterology 1983; 85: 235-239.
29. Raimondo G, Craxi A, Longo G, et al,. Delta antigen in hepatocellular carcinoma positive for hepatitis B surface antigen. Ann Intern Med 1984; 101: 343-344.
30. Tapalaga D, Forzani B, Hele C, Paravini C, Ponzetto A, Theilman L,. Prevalence of hepatitis Delta in Rumania. Hepatogastroenterology 1986; 33: 238-239.
31. Tassopoulos NC, Theodoropoulos G, Sjogren MSD, Engle R, Purcell RH,. Serological markers of hepatitis B and hepatitis Delta infections in Greek adults. Infection 1989; 17: 17-19.
32. Ashraf SJ, Arya SC, Parande E, Sachay R, Ageel AR,. Anti-Delta antibody in primary hepatocellular carcinoma patients in the Gizan area of Saudi Arabia. Infection 1986; 14: 250-251.
33. Rezvan H, Forouzanandeh B, Taroyan S, Fadaiee S, Azordegen F,. A study on Delta virus infection and its clinical impact in Iran. Infection 1990; 18: 34-36.
34. Cronberg S, Hansson BG, Thermos M, Moestrop P, Sow AM,. Hepatitis D (Delta agent) in primary hepatocellular carcinoma and liver disease in Senegal. Liver 1984; 4: 275-279.
35. Cenac A, Develou M, Lamothe F, et al,. Delta superinfection in patients with chronic hepatitis, cirrhosis, and hepatocellular carcinoma in a Sahelian area. Study of 112 cases and 46 controls. Trans Roy Soc Trop Med Hyg 1987; 81: 994-997.
36. Kew MC, Hadziyannis SJ, Dusheiko GM, et al,. Does Delta infection play a part in the pathogenesis of hepatitis B virus-related hepatocellular carcinoma? Brit Med J 1984; 288: 1727.
37. Kew MC,. Hepatitis Delta and hepatocellular carcinoma. Vir Hepat Rev 1996; 4: 285-290.
38. Beral V, Blum H, Buendia MA, et al,. IARC Monographs on the Evaluation of Carcinogenic Risks in Humans. Vol. 59, Hepatitis Viruses. Lyon: International Agency for Research on Cancer, 1994.
39. Fattovich G, Giustina V, Christensen E, et al,. Influence of hepatitis Delta virus infection on morbidity and mortality in compensated cirrhosis type B. Gut 2000; 46: 420-426.
40. Ji J, Sundquist K, Sundquist J,. A population-based study of hepatitis D virus as a potential risk factor for hepatocellular carcinoma. J Natl Cancer Inst 2012; 104: 790-792.
41. Buti M, Horns M, Rodriquez-Frias F, et al,. Clinical outcome of acute and chronic Delta hepatitis over time: along-term follow-up study. J Viral Hepat 2011; 18: 434-442.
42. Leary TP, Muerhoff AS, Simons JM, et al,. Sequence and genomic organization of GBV-C: a novel member of the Flaviviridae associated with human non A-E hepatitis. J Med Virol 1995; 48: 60-67.
43. Kim JP, Fry KE,. Molecular characterisation of hepatitis G virus. J Viral Hepat 1997; 4: 77-79.
44. Simons JN, Desai SM, Mushahwar JK,. The GB viruses: isolation, characterization, diagnosis and epidemiology. Vir Hepat Rev 1996; 2: 229-246.
45. Linnen J, Wages J, Zang-Keck ZY, et al,. Molecular cloning and disease association of hepatitis G virus: a transmissible agent. Science 1996; 271: 505-508.
46. Masuko K, Mitsui T, Iwano K, et al,. Infection with hepatitis GB virus C in patients on maintenance hemodialysis. New Engl J Med 1996; 334: 1485-1490.
47. Alter HJ, Nakatsuiji Y, Melpoder J, et al,. The incidence of blood transfusiõn-associated hepatitis G virus infection and its relation to liver disease. N Engl J Med 1997; 336: 747-754.
48. Alter MJ,. The cloning and clinical implications of HGV and HGBV-C. New Engl J Med 1996; 334: 1536-1537.
49. Yoshibo M, Okamoto H, Mishiro S, et al,. Detection of GBV-C virus genome in serum of patients with fulminant hepatitis of unknown origin. Lancet 1995; 346: 1131-1134.
50. Dawson GJ, Schlauder GG, Pitot-Mathias TJ, et al,. Prevalence studies of GB virus C infection using reverse transcriptase-polymerase chain reaction. J Med Virol 1996; 50: 97-103.
51. Kanda T, Yokosuka O, Imazeki F, et al,. GB-virus C RNA in Japanese patients with hepatocellular carcinoma and cirrhosis. J Hepatol 1997; 27: 464-469.
52. Jeon MJ, Shin JH, Suh SP, Lim YC, Ryang DW,. TT virus and hepatitis G virus infections in Korean blood donors and patients with chronic liver disease. World J Gastroenterol 2003; 9: 741-744.
53. Jarvis LM, Davidson FM, Hanley JP, Yap PL, Ludlam CA, Simmonds P,. Infection with hepatitis GB virus C among recipients of plasma products. Lancet 1996; 348: 1352-1355.
54. Fiordalisi G, Zanella I, Mantero G, et al,. High prevalence of GB virus C infection in a Group of Italian patients with hepatitis of unknown origin. J Infect Dis 1996; 174: 181-183.
55. Heringlake S, Osterkamp S, Trautwein C, et al,. Association between fulminant hepatic failure and a strain of GB virus C. Lancet 1998; 348: 1626-1629.
56. Haydon GH, Jarvis LM, Simpson KJ, Hayes PC, Simmonds P,. The clinical significance of the detection of hepatitis GBV-C RNA in the serum of patients with fulminant presumed viral hepatitis. J Viral Hepat 1997; 4: 45-49.
57. Lightfoot K, Skelton M, Kew MC, Kedda MA, Coppin A, Hodkinson J,. Does hepatitis G virus infection cause hepatocellular carcinoma in black Africans? Hepatology 1997; 26: 740-742.
58. Kakumu S, Sato K, Morishita T, et al,. Prevalence of hepatitis B, hepatitis C and hepatitis GBV-C/hepatitis G virus infections in liver disease in inhabitants in Ho Chi Min, Vietnam. J Med Virol 1998; 54: 243-248.
59. Cao K, Mizokami M, Orito E, et al,. GB virus C/hepatitis G virus infection among patients with hepatocellular carcinoma in the inshore of the Yangste River, China. J Gastroenterol Hepatol 1998; 13: 1241-1248.
60. Meng XW, Komatsu M, Ohshuma S, et al,. GB virus C infection: clinical significance. Can J Gastroenterol 1999; 13: 814-818.
61. Nishiyama Y, Hino K, Sawada N, Tsuda F,. Little contribution of GB virus-C to the development of primary hepatocellular carcinoma in Japan. J Gastroenterol 1999; 34: 494-497.
62. Ding X, Mizokami M, Kang LY, et al,. Prevalence of TTV and GBV-C infections among patients with liver diseases and the general population in Shanghai, China. Virus Genes 1999; 19: 51-58.
63. Kubo S, Nishiguchi S, Kuroki T, et al,. Poor association between GBV-C viremia with hepatocellular carcinoma. J Hepatol 1997; 27: 91-95.
64. Yuan JM, Govindarajan S, Gao YT, Ross RK, Yu MC,. Prospective evaluation of hepatitis G virus in relation to hepatocellular carcinoma in Shanghai, China. J Infect Dis 2000; 183: 1300-1303.
65. Leao-Filho GC, Lopes EPA, Ferraz AAB, et al,. Hepatitis G virus infection in patients with hepatocellular carcinoma in Recife, Brazil. Jpn J Clin Oncol 2007; 37: 632-636.
66. Tagger A, Donato F, Ribero ML, et al,. A case/control study of hepatitis GB virus C/hepatitis G infection and hepatocellular carcinoma. Hepatology 1997; 26: 1653-1657.
67. Chiesa R, Donato F, Tagger A, et al,. Etiology of hepatocellular carcinoma in Italian patients with and without cirrhosis. Cancer Epidemiol Biomarker Prev 2000; 9: 213-216.
68. Lei X, Yoshihero A, Liu L, Zhao L,. GBV infection in Chinese patients with hepatocellular carcinoma. Hua Zi Yi Ke Da Xui Xui Bao 1999; 30: 431-433.
69. Yuan JM, Govindarajan S, Ross RK, Yu MC,. Chronic infection of hepatitis G virus in relation to hepatocellular carcinoma in non-Asians in Los Angeles county, California. Cancer 1999; 86: 936-943.
70. Nishikawa T, Okamoto H, Konishi K, Yoshikawa H, Miyakawa Y, Mayumi M,. A novel DNA virus (TTV) associated with elevated transaminase levels in post-transfusion non-A-G hepatitis. Biochem Biophys Res Commun 1997; 241: 92-97.
71. Okamoto H, Akahane Y, Ukita M, et al,. Fecal excretion of a non-enveloped DNA virus (TTV) associated with post-transfusion non -A-G hepatitis. J Med Virol 1998; 56: 128-132.
72. Mushahwar IK, Erker JC, Muerhoff JF, et al,. Molecular and biophysical characterisation of the TT virus: evidence for a new virus family affecting humans. Proc Natl Acad Sci USA 1999; 16: 3177-3182.
73. Diniz-Mendez L, DeValle S, Niel C,. Genomic characterization of a Brazilian TT virus isolate closely related to SEN virus F. Mem Inst Oswaldo Cuiz 2004; 99: 301-306.
74. Okamoto H, Ukita M, Nishizawa T, et al,. Circular double-stranded forms of TT virus DNA in the liver. J Virol 2000; 74: 5161-5167.
75. Jelcic I, Holtz-Wagenblattt A, Huzaiker A, Zurhausen H, De Villiers EM,. Isolation of multiple TT virus genotypes from spleen biopsy tissue from a Hodgkin's disease patient. Genomic re-organization and diversity in the hypervariable region. J Virol 2004; 78: 7498-7507.
76. Shang D, Lin YH, Rigopoulou I, Chen B, Alexander GJ, Allain JP,. Detection of TTV virus DNA in patients with liver disease and recipients of liver transplants. J Med Virol 2000; 61: 455-461.
77. Dai CY, Yu ML, Chang WY, et al,. The prevalence of TT virus and GB virus C infection in indivuals with raised liver enzymes but without HBV or HCV infection in Taiwan. Epidemiol Infect 2002; 129: 307-313.
78. Naumov NV, Petrova EP, Thomas MG, Williams R,. Presence of a newly described human DNA virus (TTV) in patients with liver disease. Lancet 1998; 352: 195-197.
79. Theamboonlers A, Jantaradsamee P, Wuttirattanakowit N, Poovorawan Y,. TT virus infection in high-risk groups. Infection 1988; 26: 355-358.
80. Hohne M, Berg T, Muller AR, Schreier E,. Detection of sequences of TT virus, a novel DNA virus, in German patients. J Gen Virol 1998; 789: 2761-2764.
81. Viazov S, Ross RS, Varenholz C, et al,. Lack of evidence for an association between TT infection and severe liver disease. J Clin Virol 1998; 11: 183-187.
82. Tanaka H, Okamoto H, Luengrojanakul F, et al,. Infection with an unenveloped DNA virus (TTV) associated with post-transfusion non-A to G hepatitis patients and healthy blood donors in Thailand. J Med Virol 1998; 28: 839-842.
83. Charlton M, Adjei P, Poerucha J, et al,. TT virus infection in North American blood donors, patients with fulminant hepatic failure and cryptogenic cirrhosis. Hepatology 1998; 28: 839-842.
84. Kobayashi M, Chayama K, Arase Y, et al,. Presence od TT Virus before and after blood transfusion in patients with chronic liver disease treated surgically for hepatocellular carcinoma. J Gastroenterol Hepatol 1999; 14: 358-363.
85. Simmonds P, Davidson F, Lycett C, et al,. Detection of a novel DNA virus (TTV) in blood donors and blood products. Lancet 1998; 352: 191-195.
86. Wang JT, Lee CZ, Kao JH, Sheu JC, Wang TH, Chen DS,. Incidence and clinical presentation of posttransfusion TT virus infection in prospectively followed transfusion recipients: emphasis on its relevance to hepatitis. Transfusion 2000; 40: 596-601.
87. Deng X, Terunuma H, Handema R, et al,. Higher prevalence and viral load of TT virus in saliva than in the corresponding serum: another possible transmission route and replication site of TT virus. J Med Virol 2000; 62: 531-537.
88. Huang YH, Wu JC, Lin CC, et al,. Prevalence and risk factor analysis of TTV infection in prostitutes. J Med Virol 2000; 60: 393-395.
89. Yazici M, Comert M, Mas R, Guney C, Cinar E, Kocar IH,. Transfusion transmitted virus prevalence in subjects at high risk of sexually transmitted infection in Turkey. Clin Microbiol Infect 2002; 8: 363-367.
90. Chattopadhyay S, Rao S, Das S, Singh NP, Kar P,. Prevalence of transfusion transmitted virus infection in patients on maintenance hemodialysis from New Delhi, India. Hemodial Int 2005; 9: 362-365.
91. Zhu F, Qian JM, Yang XO, Sun G, Lu CM,. Relationship between TT virus infection and hepatocellular carcinoma. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2001; 23: 627-630.
92. Yoshida H, Kato N, Shiratori Y, et al,. Poor association of TT virus viremia with hepatocellular carcinoma. Liver 2000; 20: 247-252.
93. Tokita H, Murai S, Kamitsukasa H, et al,. High TT virus loads as an independent factor associated with the occurrence of hepatocellular carcinoma among patients with hepatitis C virus -related chronic liver disease. J Med Virol 2002; 67: 501-509.
94. Skelton M, Kew MC, Yu MC, Crookes RL, Swanevelder JP, Hodkinson J,. Transfusion-transmissible virus and hepatocellular carcinoma; a case/control study. J Viral Hepat 2000; 7: 230-234.
95. Tanaka Y, Primi D, Wang RY, et al,. Genomic and molecular evolutionary analysis of a newly identified infectious agent (SEN virus) and its relationship to the TT virus family. J Infect Dis 2001; 183: 359-367.
96. Unemura T, Yeo AE, Sottini E, et al,. SEN virus infection and its relationship to transfusion-associated hepatitis. Hepatology 2001; 33: 1303-1311.
97. Akiba K, Umemura T, Alter HJ, Kojiro M, Tabor E,. SEN virus: epidemiology and characteristics of a transfusion-transmitted virus. Transfusion 2005; 45: 1084-1088.
98. Unemura T, Tanaka Y, Kiyosawa K, Alter HJ, Shih JW,. Observation of positive selection within hypervariable regions of a newly identified DNA virus (SEN virus). FEBS Lett 2002; 510: 171-174.
99. Mikuni M, Moriyama M, Tanaka N, Abe F, Arakawa Y,. SEN virus infection does not affect progression of non-A to-E liver disease. J Med Virol 2002; 67: 624-629.
100. Schroter M, Laufs R, Zollner B, et al,. Prevalence of SENV-H viremia among healthy subjects and individuals for parenterally transmitted diseases in Germany. J Viral Hepat 2002; 9: 455-459.
101. Kao JH, Chen WM, Chen PJ, Lai MY, Chen DS,. Prevalence and implication of a newly identified infectious agent (SEN virus) in Taiwan. J Infect Dis 2002; 185: 389-392.
102. Wilson LE, Unemura T, Astembjorki J, et al,. Dynamics of SEN virus infection among injection drug users. J Infect Dis 2001; 184: 1315-1319.
103. Yoshida H, Kato N, Shiratori Y, et al,. Weak association between SEN virus viremia and liver disease. J Clin Microbiol 2002; 40: 3140-3145.
104. Unemura T, Tanaka E, Ostapowicz G, et al,. Investigation of SEN virus infection in patients with cryptogenic acute liver failure, hepatitis-associated aplastic anemia, or acute and chronic non A-E hepatitis. J Infect Dis 2003; 188: 1545-1552.
105. Pirovana S, Bellinzoni M, Matteelli A, Ballerinin C, Albertini A, Imberti L,. Transmission of SEN virus from mothers to their babies. J Med Virol 2002; 66: 421-427.
106. Shibata M, Wang RY, Yoshiba M, Shin JW, Alter HJ, Mitamura K,. The presence of a newly recognised infectious agent (SEN virus) in patients with liver diseases and blood donors in Japan. J Infect Dis 2001; 184: 400-404.
107. Tang ZH, Chen XH, Yu YS, Zhang GQ,. Prevalence and clinical significance of SEN virus infection in patients with non-A-E hepatitis and volunteer blood donors. World J Gastroenterol 2008; 14: 4204-4208.
108. Tangkijvanitz P, Theamboolers A, Sriponthong M, Kullavanijaya P, Poorvorawoon Y,. SEN virus infection in patients with chronic liver disease and hepatocellular carcinoma in Thailand. Am J Gastroenterol 2003; 98: 2500-2504.
109. Rigas B, Hasan I, Rehman R, Donahue P, Wittkowski KM, Lebovics E,. Effect on treatment outcome of co-infection with SEN viruses in patients with hepatitis C. Lancet 2001; 358: 1961-1962.
110. Moriyama M, Mikuni M, Matsumura H, et al,. SEN virus infection influences the pathological findings in liver but does not affect the incidence of hepatocellular carcinoma in patients with chronic hepatitis C and liver cirrhosis. Liver Int 2005; 25: 226-235.
111. Smuts HEM, Badri M, Kew MC,. SEN virus and hepatocellular carcinoma in southern African Blacks. Niger J Gastroenterol Hepatol 2010; 2: 2-11.
112. Alam El-Din HM, Abo-Shadi MA, Helal A,. Impact of SEN virus on immunoblot INNO-LIA HCV reactivity pattern and disease outcome in Egyptian hepatocellular carcinoma patients. Egypt J Immunol 2007; 14: 1-19.
113. Momosaki S, Umemura T, Scudamore CH, Kojiro M, Alter HJ, Tabor El,. SEN virus infection in patients with hepatocellular carcinoma. J Viral Hepat 2005; 12: 435-438.