Mutation of the ATP-gated P2X2 receptor leads to progressive hearing loss and increased susceptibility to noise

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 6, 2013, Pages 2228-2233

  Yan, Denise ^a   Zhu, Yan ^b   Walsh, Tom ^c   Xie, Dinghua ^d   Yuan, Huijun ^e   Sirmaci, Asli ^a   Fujikawa, Taro ^f   Wong, Ann Chi Yan ^g   Loh, Tze L ^g   Du, Lilin ^a   Grati, M'hamed ^a,f   Vlajkovic, Srdjan M ^h   Blanton, Susan ^a   Ryan, Allen F ⁱ   Chen, Zheng Yi ^j   Thorne, Peter R ^h   Kachar, Bechara ^f   Tekin, Mustafa ^a   Zhao, Hong Bo ^b   Housley, Gary D ^g   King, Mary Claire ^c   Liu, Xue Z ^a,d   more..

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d CENTRAL SOUTH UNIVERSITY   (China)

^e CHINESE PLA GENERAL HOSPITAL   (China)

^f NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS   (United States)

^g UNIVERSITY OF NEW SOUTH WALES   (Australia)

^h UNIVERSITY OF AUCKLAND   (New Zealand)

ⁱ UNIVERSITY OF CALIFORNIA   (United States)

^j HARVARD MEDICAL SCHOOL   (United States)

more..

Author keywords

Channel; Deafness; Genomics; Presbycusis

Indexed keywords

ADENOSINE TRIPHOSPHATE; FLUORESCENT DYE; LEUCINE; MUTANT PROTEIN; PURINERGIC P2X2 RECEPTOR;

ADULTHOOD; ALLELE; AMINO ACID SUBSTITUTION; ARTICLE; COCHLEA; CONTROLLED STUDY; GENETIC ANALYSIS; HAIR CELL; HEARING IMPAIRMENT; HETEROZYGOSITY; HUMAN; HUMAN CELL; LOSS OF FUNCTION MUTATION; MEMBRANE PERMEABILITY; NOISE; PERCEPTION DEAFNESS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; WILD TYPE;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; ANIMALS; DISEASE MODELS, ANIMAL; EVOKED POTENTIALS, AUDITORY; FEMALE; GENES, DOMINANT; HEARING LOSS, NOISE-INDUCED; HEARING LOSS, SENSORINEURAL; HETEROZYGOTE; HUMANS; ION CHANNEL GATING; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; PEDIGREE; PENETRANCE; RECEPTORS, PURINERGIC P2X2; SEQUENCE HOMOLOGY, AMINO ACID; YOUNG ADULT;

EID: 84873458287     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1222285110     Document Type: Article

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