The regulation of apoptosis in intrauterine growth restriction: A study of Bcl-2 and Bax gene expression in human placenta

Journal of Maternal-Fetal and Neonatal Medicine

Volumn 26, Issue 4, 2013, Pages 347-350

  Börzsönyi, Balázs ^a   Demendi, Csaba ^a   Rigó Jr , János ^b   Szentpéteri, Imre ^c   Rab, Attila ^d   Joó, József Gábor ^b  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b SEMMELWEIS UNIVERSITY   (Hungary)

^c Praxis für Gynäkologie und Geburtshilfe und allgemeine Medizin ^*  (Germany)

^d Hospital Telki   (Hungary)

Author keywords

Apoptosis; Bax gene; Bcl 2 gene; Intrauterine growth restriction; Placenta

Indexed keywords

PROTEIN BAX; PROTEIN BCL 2;

ADULT; APOPTOSIS; ARTICLE; BAX GENE; BCL 2 GENE; BIRTH WEIGHT; BODY MASS; CONTROLLED STUDY; FEMALE; FETUS DISEASE; GENE ACTIVITY; GENE EXPRESSION; GROWTH DISORDER; HUMAN; HUMAN TISSUE; INTRAUTERINE GROWTH RESTRICTION; MAJOR CLINICAL STUDY; MALE; MATERNAL AGE; PLACENTA; PREGNANCY; PRIORITY JOURNAL; RISK FACTOR; WEIGHT GAIN;

ADULT; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BODY MASS INDEX; FEMALE; FETAL GROWTH RETARDATION; GENE EXPRESSION; GENES, BCL-2; HUMANS; MALE; PLACENTA; PREGNANCY; WEIGHT GAIN;

EID: 84873435065     PISSN: 14767058     EISSN: 14764954     Source Type: Journal    
DOI: 10.3109/14767058.2012.733770     Document Type: Article

References (30)

1. Wollmann HA. Intrauterine growth restriction: Definition and etiology. Horm Res 1988;49 (SUPPL2):1-6
2. Sheikh S, Satoskar P, Bhartiya D. Expression of insulin-like growth factor-I and placental growth hormone mRNA in placentae: A comparison between normal and intrauterine growth retardation pregnancies. Mol Hum Reprod 2001;7:287-292
3. Gluckman PD, Harding JE. The physiology and pathophysiology of intrauterine growth retardation. Horm Res 1997;48 SUPPL1:11-16
4. Marconi AM, Cetin I, Davoli E, Baggiani AM, Fanelli R, Fennessey PV, Battaglia FC, Pardi G. An evaluation of fetal glucogenesis in intrauterine growth-retarded pregnancies. Metab Clin Exp 1993;42:860-864
5. Magnusson AL, Powell T, Wennergren M, Jansson T. Glucose metabolism in the human preterm and term placenta of IUGR fetuses. Placenta 2004;25:337-346
6. Economides DL, Nicolaides KH. Blood glucose and oxygen tension levels in small-for-gestational-Age fetuses. Am J Obstet Gynecol 1989;160:385-389
7. Ola MS, Nawaz M, Ahsan H. Role of Bcl-2 family proteins and caspases in the regulation of apoptosis. Mol Cell Biochem 2011;351:41-58
8. Daher S, Guimars AJ, Mattar R, Ishigai MM, Barreiro EG, Bevilacqua E. Bcl-2 and Bax expressions in pre-Term, term and post-Term placentas. Am J Reprod Immunol 2008;60:172-178
9. Agata KB, Anita S, Urszula KK, Agnieszka NK, Grzegorz B. Expression of caspase-3, Bax nad Bcl-2 in placentas from pregnancies complicated by treated and non-Treated fetal growth restriction. Ginekol Pol 2009;80:652-656
10. Heazell AE, Sharp AN, Baker PN, Crocker IP. Intra-uterine growth restriction is associated with increased apoptosis and altered expression of proteins in the p53 pathway in villous trophoblast. Apoptosis 2011;16:135-144
11. Ray J, Jurisicova A, Caniggia I. IFPA Trophoblast Research Award Lecture: The dynamic role of Bcl-2 family members in trophoblast cell fate. Placenta 2009;30 SUPPLA:S96-100
12. Petros AM, Olejniczak ET, Fesik SW. Structural biology of the Bcl-2 family of proteins. Biochim Biophys Acta 2004;1644:83-94
13. Germain M, Shore GC. Cellular distribution of Bcl-2 family proteins. Sci STKE 2003;173:pe10
14. Budd RC. Activation-induced cell death. Curr Opin Immunol 2001;13:356-362
15. Ratts VS, Tao XJ, Webster CB, Swanson PE, Smith SD, Brownbill P, Krajewski S, et al. Expression of BCL-2, BAX and BAK in the trophoblast layer of the term human placenta: A unique model of apoptosis within a syncytium. Placenta 2000;21:361-366
16. De Falco M, De Luca L, Acanfora F, Cavallotti I, Cottone G, Laforgia V, De Luca B, et al. Alteration of the Bcl-2:Bax ratio in the placenta as pregnancy proceeds. Histochem J 2001;33:421-425
17. Straszewski-Chavez SL, Abrahams VM, Mor G. The role of apoptosis in the regulation of trophoblast survival and differentiation during pregnancy. Endocr Rev 2005;26:877-897
18. Smith SC, Baker PN, Symonds EM. Placental apoptosis in normal human pregnancy. Am J Obstet Gynecol 1997;177:57-65
19. Halperin R, Peller S, Rotschild M, Bukovsky I, Schneider D. Placental apoptosis in normal and abnormal pregnancies. Gynecol Obstet Invest 2000;50:84-87
20. Endo H, Okamoto A, Yamada K, Nikaido T, Tanaka T. Frequent apoptosis in placental villi from pregnancies complicated with intrauterine growth restriction and without maternal symptoms. Int J Mol Med 2005;16:79-84
21. Diplas AI, Lambertini L, Lee MJ, Sperling R, Lee YL, Wetmur J, Chen J. Differential expression of imprinted genes in normal and IUGR human placentas. Epigenetics 2009;4:235-240
22. Allaire AD, Ballenger KA, Wells SR, McMahon MJ, Lessey BA. Placental apoptosis in preeclampsia. Obstet Gynecol 2000;96:271-276
23. Hu R, Zhou S, Li X. Altered Bcl-2 and Bax expression is associated with cultured first trimester human cytotrophoblasts apoptosis induced by hypoxia. Life Sci 2006;79:351-355
24. Hung TH, Chen SF, Liou JD, Hsu JJ, Li MJ, Yeh YL, Hsieh TT. Bax, Bak and mitochondrial oxidants are involved in hypoxia-reoxygenationinduced apoptosis in human placenta. Placenta 2008;29:565-583
25. Ishihara N, Matsuo H, Murakoshi H, Laoag-Fernandez J, Samoto T, Maruo T. Changes in proliferative potential, apoptosis and Bcl-2 protein expression in cytotrophoblasts and syncytiotrophoblast in human placenta over the course of pregnancy. Endocr J 2000;47:317-327
26. Cirelli N, Moens A, Lebrun P, Gueuning C, Delogne-Desnoeck J, Vanbellinghen AM, Meuris S. Apoptosis in human term placenta is not increased during labor but can be massively induced in vitro. Biol Reprod 1999;61:458-463
27. Sgarbosa F, Barbisan LF, Brasil MA, Costa E, Calderon IM, Gonlves CR, Bevilacqua E, Rudge MV. Changes in apoptosis and Bcl-2 expression in human hyperglycemic, term placental trophoblast. Diabetes Res Clin Pract 2006;73:143-149
28. McLaren J, Taylor DJ, Bell SC. Increased incidence of apoptosis in non-labour-Affected cytotrophoblast cells in term fetal membranes overlying the cervix. Hum Reprod 1999;14:2895-2900
29. Barrio E, Calvo MT, Romo A, Alvarez R, Gutirez JI, Naval J, Ferrdez Long A. Intrauterine growth retardation: Study of placental apoptosis. J Pediatr Endocrinol Metab 2004;17 SUPPL3:451-456
30. Fraser AM, Brockert JE, Ward RH. Association of young maternal age with adverse reproductive outcomes. N Engl J Med 1995;332:1113-1117