Life-threatening scrub typhus with hemophagocytosis and acute respiratory distress syndrome in an infant

Journal of Tropical Pediatrics

Volumn 59, Issue 1, 2013, Pages 67-69

  Kwon, Hyo Jin ^a   Yoo, In Hyuk ^b   Lee, Jae Wook ^b   Chung, Nak Gyun ^b   Cho, Bin ^b   Kim, Hack Ki ^b   Kang, Jin Han ^b  

^a Korea University College of Medicine   (South Korea)

^b The Catholic University of Korea   (South Korea)

Author keywords

Hemophagocytic syndrome; Infant; Orientia tsutsugamushi; Scrub typhus

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ASPARTATE AMINOTRANSFERASE; CLARITHROMYCIN; D DIMER; DEXAMETHASONE; ETOPOSIDE; FERRITIN; FIBRINOGEN; FRUCTOSE BISPHOSPHATE; HEMOGLOBIN; IMMUNOGLOBULIN M ANTIBODY; LACTATE DEHYDROGENASE; PERFORIN; PROTHROMBIN;

ADULT RESPIRATORY DISTRESS SYNDROME; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLEEDING; CASE REPORT; CONVALESCENCE; DISEASE COURSE; DISEASE DURATION; DISSEMINATED INTRAVASCULAR CLOTTING; ENDEMIC DISEASE; EPILEPTIC STATE; EXTUBATION; FERRITIN BLOOD LEVEL; FEVER; HEMOGLOBIN BLOOD LEVEL; HEMOPHAGOCYTIC SYNDROME; HEPATOSPLENOMEGALY; HOSPITAL ADMISSION; HUMAN; INFANT; INFANT DISEASE; INGUINAL REGION; INTENSIVE CARE; INTENSIVE CARE UNIT; LACTATE DEHYDROGENASE BLOOD LEVEL; LEUKOCYTE COUNT; LUNG HEMORRHAGE; MALE; MECHANICAL VENTILATOR; MEDICAL HISTORY; NONHUMAN; ORIENTIA TSUTSUGAMUSHI; PALLOR; PARTIAL THROMBOPLASTIN TIME; PHYSICAL EXAMINATION; PROTHROMBIN TIME; RESPIRATORY FAILURE; RURAL AREA; SCRUB TYPHUS; SEROLOGY; THORAX RADIOGRAPHY; TONIC CLONIC SEIZURE; TREATMENT DURATION; UPPER RESPIRATORY TRACT INFECTION;

ANTI-BACTERIAL AGENTS; CLARITHROMYCIN; DISSEMINATED INTRAVASCULAR COAGULATION; HEMAGGLUTINATION; HUMANS; INFANT; LYMPHOHISTIOCYTOSIS, HEMOPHAGOCYTIC; MALE; ORIENTIA TSUTSUGAMUSHI; SCRUB TYPHUS; SEVERE ACUTE RESPIRATORY SYNDROME; STATUS EPILEPTICUS; TREATMENT OUTCOME;

EID: 84873427973     PISSN: 01426338     EISSN: 14653664     Source Type: Journal    
DOI: 10.1093/tropej/fms030     Document Type: Article

References (12)

1. Jeong YJ, Kim S, Wook YD, et al. Scrub typhus: clinical, pathologic, and imaging findings. Radiographics 2007;27:161-72.
2. Strickman D, Smith CD, Corcoran KD, et al. Pathology of Rickettsia tsutsugamushi infection in Bandicota savilei, a natural host in Thailand. Am J Trop Med Hyg 1994;51:416-23.
3. Chen YC, Chao TY, Chin JC. Scrub typhus-associated hemophagocytic syndrome. Infection 2000;28:178-9.
4. Gopal GK, Anugrah C, Boorugu H. Scrub typhus associated macrophage activation syndrome. Trop Doct 2010;40:249-50.
5. Yasunaga H, Horiguchi H, Kuwabara K, et al. Delay in tetracycline treatment increases the risk of complications in Tsutsugamushi disease: data from the Japanese Diagnosis Procedure Combination database. Intern Med 2011;50:37-42.
6. Chi WC, Huang JJ, Sung JM, et al. Scrub typhus associated with multiorgan failure: a case report. Scand J Infect Dis 1997;29:634-35.
7. Park JS, Jee YK, Lee KY, et al. Acute respiratory distress syndrome associated with scrub typhus: diffuse alveolar damage without pulmonary vasculitis. J Korean Med Sci 2000;15:343-5.
8. Janka GE. Familial and acquired hemophagocytic lymphohistiocytosis. Eur J Pediatr 2007;166:95-109.
9. Valsalan R, Kosaraju K, Sohanlal T, et al. Hemophagocytosis in scrub typhus. J Postgrad Med 2010;56: 301-2.
10. Nahum E, Ben-Ari J, Stain J, et al. Hemophagocytic lymphohistiocytic syndrome: Unrecognized cause of multiple organ failure. Pediatr Crit Care Med 2000;1: 51-4.
11. Fitzgerald NE, MacClain KL. Imaging characteristics of hemophagocytic lymphohistiocytosis. Pediatr Radiol 2003;33:392-401.
12. Lee KY, Lee HS, Hong JH, et al. Roxithromycin treatment of scrub typhus (tsutsugamushi disease) in children. Pediatr Infect Dis J 2003;22:130-3.