Roxithromycin treatment of scrub typhus (tsutsugamushi disease) in children

Pediatric Infectious Disease Journal

Volumn 22, Issue 2, 2003, Pages 130-133

  Lee, Kyung Yil ^a,b   Lee, Hyung Shin ^a   Hong, Ja Hyun ^a   Hur, Jae Kyun ^a   Whang, Kyung Tai ^a  

^a The Catholic University of Korea   (South Korea)

^b Daejeon St Mary's Hospital   (South Korea)

Author keywords

Children; Chloramphenicol; Doxycycline; Macrolide; Roxithromycin; Scrub typhus

Indexed keywords

BACTERIUM ANTIBODY; CHLORAMPHENICOL; DOXYCYCLINE; ROXITHROMYCIN;

ADOLESCENT; ANTIBIOTIC THERAPY; APLASTIC ANEMIA; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE DURATION; DRUG EFFICACY; FEMALE; FEVER; HOSPITAL ADMISSION; HUMAN; INFANT; LEUKOCYTE COUNT; LIVER FUNCTION; MALE; ORIENTIA TSUTSUGAMUSHI; PRIORITY JOURNAL; RASH; SCRUB TYPHUS; SIDE EFFECT; TOOTH COLOR; TOOTH DISEASE; TREATMENT OUTCOME;

EID: 0037326213     PISSN: 08913668     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.inf.0000047864.80791.20     Document Type: Article

References (24)

1. Chang WH. Current status of tsutsugamushi disease in Korea. J Korean Med Sci 1995;10:227-38.
2. Park BK, Kim SH, Oh YG, et al. Clinical features and serial changes in the indirect immunofluorescence antibody titers by the duration of illness in 28 children with scrub typhus. Korean J Infect Dis 1993;25:109-23.
3. Song JY, Han JW, Lee KY, et al. A clinical study of tsutsugamushi disease in children. J Korean Pediatr Soc 1995;38:641-8.
4. Strickman D, Sheer T, Salata K, et al. In vitro effectiveness of azithromycin against doxycycline-resistant and -susceptible strains of Rickettsia tsutsugamushi, etiologic agent of scrub typhus. Antimicrob Agents Chemother 1995;39:2406-10.
5. Watt G, Kantipong P, Jongsakul K, Watcharapichat P, Phulsuksombati D. Azithromycin activities against Orienta tsutsugamushi strains isolated in cases of scrub typhus in Northern Thailand. Antimicrob Agents Chemother 1999;43:2817-8.
6. Choi EK, Pai H. Azithromycin therapy for scrub typhus during pregnancy. Clin Infect Dis 1998;27:1538-9.
7. Rapmund G. Rickettsial disease of the Far East: new perspectives. J Infect Dis 1984;149:330-8.
8. Rhee HI, Lee IY, Cho MK. Determination of the vector species of tsutsugamushi disease in Korea. Korean J Parasitol 1991;29:87-92.
9. Shirai A, Collaugh JC, Gan E. Serologic analysis of scrub typhus isolates from the Pescardores and Philippine Islands. Jpn J Med Sci Biol 1982;35:255-9.
10. Tamura A, Takahashi K, Tsuruhara T. Isolation of Rickettsia tsutsugamushi antigenically different from Kato, Karp and Gilliam strains from patients. Microbiol Immunol 1984;26:873-82.
11. Chang WH, Kang JS, Lee WK, Choi MS. Serological classification by monoclonal antibodies of Rickettsia tsutsugamushi isolated in Korea. J Clin Micobiol 1990;28:685-8.
12. Nagano I, Kasuya S, Noda N, Yamashita T. Virulence in mice of Orientia tsutsugamushi isolated from patients in a new endemic area in Japan. Microbiol Immunol 1996;40:743-7.
13. Lee JK, Lee BS, Shin OS, Shin KC, Oh YK, Ki SG. A clinical study of tsutsugamushi disease that occurred in the autumns of 1989 and 1990. Korean J Intern Med 1991;41:558-63.
14. Jeon KY, Choi YS. Clinical observation of 98 cases of tsutsugamushi disease (1986-1991). Korean J Intern Med 45:177-86, 1993.
15. Moon B, Paek KW, Kim GT, et al. A Clinical study of 120 cases with tsutsugamushi disease. Korean J Infect Dis 1995;27:273-9.
16. Lee HS, Kim DS, Chin YJ, et al. A study of interstitial pneumonia in scrub typhus. Korean J Intern Med 1996;50:77-86.
17. Kim YO, Jeon HK, Cho SK, et al. The role of hypoalbuminemia as a marker of the severity of disease in patients with tsutsugamushi disease. Korean J Intern Med 2000;59:516-21.
18. Yi KS, Yoo SK, Ko W, Lee WY, Pai CK, Kim KI. Reevaluation of the importance of finding rash, lymphadenitis and eschars for the early clinical diagnosis of tsutsugamushi disease. Korean J Infect Dis 1991;23:163-9.
19. Sheehy TW, Hazlett D, Turk RE. Scrub typhus: a comparison of chloramphenicol and tetracycline in its treatment. Arch Intern Med 1973;132:77-80.
20. Brown GW, Saunders JP, Singh S, Huxsoll DL, Shirai A. Single dose doxycycline therapy for scrub typhus. Trans R Soc Trop Med Hyg 1978;72:412-6.
21. Song JH, LeeCW, Chang WH et al. Short-course doxycycline treatment versus conventional tetracycline therapy for scrub typhus: a multicenter randomized trial. Clin Infect Dis 1995;21:506-10.
22. Feder HM Jr, Osier C, Maderazo EG. Chloramphenicol: a review of its use in clinical practice. Rev Infect Dis 1981;3:479-91.
23. Lochary ME, Lockhart PB, Williams WT Jr. Doxycycline and staining of permanent teeth. Pediatr Infect Dis J 1998;17:429-31.
24. Breitschwerdt EB, Papich MG, Hegarty BC, Gilger B, Hancock SI, Davidson MG. Efficacy of doxycycline, azithromycin, or trovafloxacin for treatment of experimental Rocky Mountain spotted fever in dogs. Antimicrob Agents Chemother 1999;43:813-21.