A regulated delivery system for inner ear drug application

Journal of Controlled Release

Volumn 166, Issue 3, 2013, Pages 268-276

  Lajud, Shayanne A ^a   Han, Zhao ^b   Chi, Fang Lu ^b   Gu, Rende ^c   Nagda, Danish A ^a   Bezpalko, Orysia ^a   Sanyal, Samudra ^a   Bur, Andres ^a   Han, Ziying ^a   O'Malley Jr , Bert W ^a   Li, Daqing ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b FUDAN UNIVERSITY   (China)

^c Sound Pharmaceuticals Inc   (United States)

Author keywords

Chitosan glycerophosphate; Chitosanase; Drug delivery; Ear; Gentamicin; Hydrogel

Indexed keywords

ANTI-MICROBIAL ACTIVITY; CHITOSANASE; CLINICAL APPLICATION; DELIVERY SYSTEMS; DRUG DELIVERY SYSTEM; EAR; EUSTACHIAN TUBE; FLUORESCENCE INTENSITIES; GENTAMICIN; GLYCEROPHOSPHATE; HAIR CELLS; IN-VITRO; IN-VIVO; INNER EAR; LC-MS/MS; MOUSE MODELS; POTENTIAL DRUG; REDUCING SUGARS; REGULATORY EFFECTS; SIDE EFFECT; TANDEM MASS SPECTROMETRY;

CHITOSAN; DRUG DELIVERY; DRUG INTERACTIONS; FLUORESCENCE MICROSCOPY; MASS SPECTROMETRY; PHOSPHOLIPIDS;

HYDROGELS;

CHITOSAN DERIVATIVE; CHITOSAN GLYCEROPHOSPHATE; CHITOSANASE; GENTAMICIN; GLYCEROPHOSPHATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ARTICLE; AUDITORY TUBE; COCHLEA FENESTRA; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG STRUCTURE; DRUG TISSUE LEVEL; DRUG UPTAKE; ENZYME ACTIVITY; ENZYME PURIFICATION; FEMALE; FLUORESCENCE ANALYSIS; FLUORESCENCE MICROSCOPY; HYDROGEL; IN VITRO STUDY; IN VIVO STUDY; INNER EAR; LIQUID CHROMATOGRAPHY; MALE; MOUSE; NONHUMAN; PERILYMPH; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; WESTERN BLOTTING;

ANIMALS; ANTI-BACTERIAL AGENTS; BLOTTING, WESTERN; CHITOSAN; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; EAR, INNER; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ESCHERICHIA COLI; FEMALE; GENTAMICINS; GLYCEROPHOSPHATES; GLYCOSIDE HYDROLASES; HYDROGELS; LABYRINTH DISEASES; MALE; MICE; MICE, INBRED STRAINS; MICROSCOPY, FLUORESCENCE; MODELS, BIOLOGICAL; PLASMIDS; STAPHYLOCOCCUS AUREUS; TISSUE DISTRIBUTION;

EID: 84873416395     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.12.031     Document Type: Article

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