Idiopathic and secondary osteonecrosis of the femoral head show different thrombophilic changes and normal or higher levels of platelet growth factors

Acta Orthopaedica

Volumn 82, Issue 1, 2011, Pages 42-49

  Cenni, Elisabetta ^a   Fotia, Caterina ^a   Rustemi, Enis ^b   Yuasa, Kimitachi ^c   Caltavuturo, Giuseppe ^d   Giunti, Armando ^a,b   Baldini, Nicola ^a,b  

^a RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c MIE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d MAGGIORE HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHROMBIN III; D DIMER; PLASMINOGEN; PLASMINOGEN ACTIVATOR INHIBITOR 1; PLATELET DERIVED GROWTH FACTOR BB; PROTEIN C; THROMBOCYTE FACTOR 4; TRANSFORMING GROWTH FACTOR BETA1; VASCULOTROPIN;

ADULT; AGED; ARTICLE; BLOOD CLOTTING; BONE NECROSIS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FEMUR HEAD; FIBRINOLYSIS; HUMAN; HYPERCOAGULABILITY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; SMOKING; THROMBOCYTE RICH PLASMA; THROMBOPHILIA;

ADRENAL CORTEX HORMONES; ADULT; AGED; BLOOD COAGULATION TESTS; BLOOD PROTEINS; FEMALE; FEMUR HEAD NECROSIS; FIBRINOLYSIS; HUMANS; MALE; MIDDLE AGED; PLATELET-DERIVED GROWTH FACTOR; THROMBOPHILIA; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 79751469309     PISSN: 17453674     EISSN: 17453682     Source Type: Journal    
DOI: 10.3109/17453674.2011.555368     Document Type: Article

References (38)

1. Almeida Matos M. The role of protein C defciency in the etiology of Perthes disease. Ortop Traumatol Rehabil 2008; 10 (3): 274-8.
2. Asano T, Takahashi K A, Fujioka M, Inoue S, Ueshima K, Hirata T, Okamoto M, Satomi Y, Nishino H, Tanaka T, Hirota Y, Kubo T. Relationship between postrenal transplant osteonecrosis of the femoral head and gene polymor-phisms related to the coagulation and fbrinolytic systems in Japanese sub-jects. Transplantation 2004; 77 (2): 220-5. (Pubitemid 38155750)
3. Aso Y. Plasminogen activator inhibitor (PAI)-1 in vascular infammation and thrombosis. Front Biosci 2007; 12: 2957-66.
4. Assouline-Dayan Y, Chang C, Greenspan A, Shoenfeld Y, Gershwin M E. Pathogenesis and natural history of osteonecrosis. Semin Arthritis Rheum 2002; 32 (2): 94-124. (Pubitemid 35351246)
5. Benowitz N L, Fitzgerald G A, Wilson M, Zhang Q. Nicotine effects on eico-sanoid formation and hemostatic function\comparison of transdermal nicotine and cigarette-smoking. J Am Coll Cardiol 1993; 22 (4): 1159-67. (Pubitemid 23285770)
6. Björkman A, Svensson P J, Hillarp A, Burtscher I M, Rünow A, Benoni G. Factor V Leiden and prothrombin gene mutation: risk factors for osteo-necrosis of the femoral head in adults. Clin Orthop 2004; (425): 168-72. (Pubitemid 39062765)
7. Brotman D J, Girod J P, Posch A, Jani J T, Patel J V, Gupta M, Lip G Y, Reddy S, Kickler T S. Effects of short-term glucocorticoids on hemostatic factors in healthy volunteers. Thromb Res 2006; 118 (2): 247-52. (Pubitemid 43833323)
8. Glueck C J, Freiberg R A, Crawford A, Gruppo R, Roy D, Tracy T, Sieve-Smith L, Wang P. Secondhand smoke, hypofbrinolysis, and Legg-Perthes disease. Clin Orthop 1998; (352): 159-67. (Pubitemid 28326295)
9. Glueck C J, Fontaine R N, Gruppo R, Stroop D, Sieve-Smith L, Tracy T, Wang P. The plasminogen activator inhibitor-1 gene, hypofbrinolysis, and osteonecrosis. Clin Orthop 1999; (366): 133-46. (Pubitemid 29439347)
10. Glueck C J, Freiberg R A, Wang P. Role of thrombosis in osteonecrosis. Curr Hematol Rep 2003; 2 (5): 417-22.
11. Halleux C M, Declerck P J, Tran S L, Detry R, Brichard S M. Hormonal con-trol of plasminogen activator inhibitor-1 gene expression and production in human adipose tissue: stimulation by glucocorticoids and inhibition by catecholamines. J Clin Endocrinol Metab 1999; 84 (11): 4097-105. (Pubitemid 30644201)
12. Kaplan K L. Proteins secreted by platelets: signifcance in detecting thrombo-sis. Adv Exp Med Biol 1978; 102: 105-19.
13. Kerachian M A, Séguin C, Harvey E J. Glucocorticoids in osteonecrosis of the femoral head: a new understanding of the mechanisms of action. J Steroid Biochem Mol Biol 2009; 114 (3-5): 121-8.
14. Koo K H, Song H R, Ha Y C, Kim J R, Kim S J, Kim KI, Chang KC, Ahn I O, Cho S H. Role of thrombotic and fbrinolytic disorders in the etiology of Perthes' disease. Clin Orthop 2002; (399): 162-7. (Pubitemid 34596109)
15. Kruithof E K. Regulation of plasminogen activator inhibitor type 1 gene expression by infammatory mediators and statins. Thromb Haemost 2008; 100 (6): 969-75.
16. Kuo B S, Dryjski M, Bjornsson T D. Infuence of nicotine and cotinine on the expression of plasminogen activator activity in bovine aortic endothelial cells. Thromb Haemost 1989; 61 (1): 70-6. (Pubitemid 19092671)
17. Lee J S, Koo K H, Ha Y C, Koh K K, Kim S J, Kim J R, Song H R, Cho S H. Role of thrombotic and fbrinolytic disorders in osteonecrosis of the femo-ral head. Clin Orthop 2003; (417): 270-6. (Pubitemid 37499533)
18. Lijnen H R. Obesity and vascular risk. Hamostaseologie 2009; 29 (1): 44-5.
19. Marx R E. Reconstruction of defects caused by bisphosphonate-induced osteonecrosis of the jaws. J Oral Maxillofac Surg (5 Suppl) 2009; 67: 107-19.
20. Mehsen N, Barnetche T, Redonnet-Vernhet I, Guérin V, Bentaberry F, Gon-net-Gracia C, Schaeverbeke T. Coagulopathies frequency in aseptic osteo-necrosis patients. Joint Bone Spine 2009; 76 (2): 166-9.
21. Mehta J S, Conybeare M E, Hinves B L, Winter J B. Protein C levels in patients with Legg-Calve-Perthes disease: is it a true defciency? J Pediatr Orthop 2006; 26 (2): 200-3. (Pubitemid 44357086)
22. Min B W, Song K S, Cho C H, Lee S M, Lee K J. Untreated asymptomatic hips in patients with osteonecrosis of the femoral head. Clin Orthop 2008; (466) (5): 1087-92.
23. Mont M A, Jones L C, Seyler T M, Marulanda G A, Saleh K J, Delanois R E. New treatment approaches for osteonecrosis of the femoral head: an overview. Instr Course Lect 2007; 56: 197-212.
24. Pósán E, Szepesi K, Gáspár L, Csernátony Z, Hársfalvi J, Ajzner E, Tóth A, Udvardy M. Thrombotic and fbrinolytic alterations in the aseptic necrosis of femoral head. Blood Coagul Fibrinolysis 2003; 14 (3): 243-8. (Pubitemid 36589145)
25. Rabquer B J, Tan G J, Shaheen P J, Haines G K 3rd, Urquhart A G, Koch A E. Synovial infammation in patients with osteonecrosis of the femoral head. Clin Transl Sci 2009; 2 (4): 273-8.
26. Sakaguchi M, Tanaka T, Fukushima W, Kubo T, Hirota Y. Impact of oral corti-costeroid use for idiopathic osteonecrosis of the femoral head: a nationwide multicenter case-control study in Japan. J Orthop Sci 2010; 15 (2): 185-91.
27. Salgado A, Bóveda J L, Monasterio J, Segura R M, Mourelle M, Gómez-Jiménez J, Peracaula R. Infammatory mediators and their infuence on haemostasis. Haemostasis 1994; 24 (2): 132-8. (Pubitemid 24234491)
28. Séguin C, Kassis J, Busque L, Bestawros A, Theodoropoulos J, Alonso M L, Harvey E J. Non-traumatic necrosis of bone (osteonecrosis) is associ-ated with endothelial cell activation but not thrombophilia. Rheumatology (Oxford) 2008; 47 (8): 1151-5. (Pubitemid 352038218)
29. Sugano N, Atsumi T, Ohzono K, Kubo T, Hotokebuchi T, Takaoka K. The 2001 revised criteria for diagnosis, classifcation, and staging of idiopathic osteonecrosis of the femoral head. J Orthop Sci 2002; 7 (5): 601-5. (Pubitemid 35238873)
30. Tapson V F. The role of smoking in coagulation and thromboembolism in chronic obstructive pulmonary disease. Proc Am Thorac Soc 2005; 2 (1): 71-7. (Pubitemid 40562966)
31. Wannamethee S G, Lowe G D, Shaper A G, Rumley A, Lennon L, Whincup P H. Associations between cigarette smoking, pipe/cigar smoking, and smok-ing cessation, and haemostatic and infammatory markers for cardiovascu-lar disease. Eur Heart J 2005; 26 (17): 1765-73. (Pubitemid 41219850)
32. Winniford M D, Jansen D E, Reynolds G A, Apprill P, Black W H, Hillis L D. Cigarette smoking-induced coronary vasoconstriction in atherosclerotic coronary artery disease and prevention by calcium antagonists and nitro-glycerin. Am J Cardiol 1987; 59 (4): 203-7. (Pubitemid 17036937)
33. Wu X, Yang S, Duan D, Zhang Y, Wang J. Experimental osteonecrosis induced by a combination of low-dose lipopolysaccharide and high-dose methylprednisolone in rabbits. Joint Bone Spine 2008; 75 (5): 573-8.
34. Yanbaeva D G, Dentener M A, Creutzberg E C, Wesseling G, Wouters E F. Systemic effects of smoking. Chest 2007; 131 (5): 1557-66. (Pubitemid 46762366)
35. Yokota K, Ishida O, Sunagawa T, Suzuki O, Nakamae A, Ochi M. Platelet-rich plasma accelerated surgical angiogenesis in vascular-implanted necrotic bone: an experimental study in rabbits. Acta Orthop 2008; 79 (1): 106-10. (Pubitemid 351271891)
36. Zalavras C, Dailiana Z, Elisaf M, Bairaktari E, Vlachogiannopoulos P, Kat-saraki A, Malizos K N. Potential aetiological factors concerning the devel-opment of osteonecrosis of the femoral head. Eur J Clin Invest 2000; 30 (3): 215-21. (Pubitemid 30153662)
37. Zidovetzki R, Chen P, Fisher M, Hofman F M, Faraci F M. Nicotine increases plasminogen activator inhibitor-1 production by human brain endothelial cells via protein kinase C-associated pathway. Stroke 1999; 30 (3): 651-5. (Pubitemid 29115406)
38. Zimmermann R, Arnold D, Strasser E, Ringwald J, Schlegel A, Wiltfang J, Eckstein R. Sample preparation technique and white cell content infuence the detectable levels of growth factors in platelet concentrates. Vox Sang 2003; 85 (4): 283-9. (Pubitemid 37522602)