Functional heartburn: Clinical characteristics and outcome

European Journal of Gastroenterology and Hepatology

Volumn 25, Issue 3, 2013, Pages 282-290

  Surdea Blaga, Teodora ^a,b,c   Dumitrascu, Dan ^c   Galmiche, Jean Paul ^a   Bruley Des Varannes, Stanislas ^a,b  

^a NANTES UNIVERSITY HOSPITAL   (France)

^b UNIVERSITÉ DE NANTES   (France)

^c BABE BOLYAI UNIVERSITY   (Romania)

Author keywords

functional heartburn; gastro oesophageal reflux; oesophageal manometry; pH impedancemetry

Indexed keywords

ANTACID AGENT; DOMPERIDONE; PARACETAMOL; PROTON PUMP INHIBITOR; SPASMOLYTIC AGENT; TRICYCLIC ANTIDEPRESSANT AGENT;

ADULT; ANALYTIC METHOD; ARTICLE; CLINICAL ARTICLE; DISEASE SEVERITY; ESOPHAGUS MANOMETRY; ESOPHAGUS MOTILITY; ESOPHAGUS PRESSURE; FEMALE; FUNCTIONAL HEARTBURN; GASTROESOPHAGEAL REFLUX; HEARTBURN; HIGH RESOLUTION OESOPHAGEAL PRESSURE TOPOGRAPHY; HUMAN; IMPEDANCE; MALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; QUALITY OF LIFE; REFLUX DISEASE QUESTIONNAIRE; RETROSPECTIVE STUDY; STRUCTURED QUESTIONNAIRE;

ADULT; ANALYSIS OF VARIANCE; CHRONIC DISEASE; ENDOSCOPY, GASTROINTESTINAL; ESOPHAGEAL PH MONITORING; ESOPHAGUS; FEMALE; GASTROESOPHAGEAL REFLUX; HEARTBURN; HUMANS; MALE; MANOMETRY; MIDDLE AGED; PERISTALSIS; PREDICTIVE VALUE OF TESTS; PRESSURE; PROTON PUMP INHIBITORS; QUALITY OF LIFE; QUESTIONNAIRES; RETROSPECTIVE STUDIES; TIME FACTORS; TREATMENT FAILURE;

EID: 84873410913     PISSN: 0954691X     EISSN: 14735687     Source Type: Journal    
DOI: 10.1097/MEG.0b013e32835b108f     Document Type: Article

References (44)

1. Bretagne JF, Honnorat C, Richard-Molard B, Caekaert A, Barthe'lemy P. Comparative study of characteristics and disease management between subjects with frequent and occasional gastro-oesophageal reflux symptoms. Aliment Pharmacol Ther 2006; 23:607-616
2. Des Varannes Bruley, Marek L, Humeau B, Lecasble M, Colin R. Gastroesophageal reflux disease in primary care. Prevalence, epidemiology and quality of life of patients. Gastroenterol Clin Biol 2006; 30:364-370
3. El-Serag HB, Petersen NJ, Carter J, Graham DY, Richardson P, Genta RM, et al. Gastroesophageal reflux among different racial groups in the United States. Gastroenterology 2004; 126:1692-1699
4. Martinez SD, Malagon IB, Garewal HS, Cui H, Fass R. Non-Erosive reflux disease (NERD) - Acid reflux and symptom patterns. Aliment Pharmacol Ther 2003; 17:537-545
5. Lind T, Havelund T, Carlsson R, Anker-Hansen O, Glise H, Hernqvist H, et al. Heartburn without esophagitis: Efficacy of omeprazole therapy and features determining therapeutic response. Scand J Gastroenterol 1997; 32:974-979
6. Bruley des Varannes S. The proton-pump inhibitor test: Pros and cons. Eur J Gastroenterol Hepatol 2004; 16:847-852
7. Bruley desVarannes S, Sacher-Huvelin S, Vavasseur F, Masliah C, Le Rhun M, Aygalenq P, et al. Rabeprazole test for the diagnosis of gastro-oesophageal reflux disease: Results of a study in a primary care setting. World J Gastroenterol 2006; 28:2569-2573
8. Galmiche JP, Clouse RA, Balint A, Cook IJ, Kahrilas PJ, Paterson WG, et al. Functional esophageal disorders. Gastroenterology 2006; 130:1459-1465
9. Van Malenstein H, Farre R, Sifrim D. Esophageal dilated intercellular spaces (DIS) and nonerosive reflux disease. Am J Gastroenterol 2008; 103:1021-1028
10. Kandulski A, Kuester D, Caro C, Weigt J, Wex T, Malfertheiner P. Differentiation of gastroesophageal reflux disease (GERD) and functional heartburn (FH) by histopathological changes in patients with refractory heartburn. Gastroenterology 2012; 142:S167
11. Bruley des Varannes S, Zerbib F, Galmiche JP. Functional heartburn. In: Vela M, Richter JE, Pandolfino JA, editors. Practical manual of gastroesophageal reflux disease. New York: John Wiley & Sons Ltd.; 2012. (in press
12. Fass R. Functional heartburn: What it is and how to treat it. Gastrointest Endosc Clin N Am 2009; 19:23-33
13. Savarino E, Marabotto E, Zentilin P, Frazzoni M, Sammito G, Bonfanti D, et al. The added value of impedance-pH monitoring to Rome III criteria in distinguishing heartburn from non-Erosive reflux disease. Dig Liver Dis 2011; 43:542-547
14. Frazzoni M, Conigliaro R, Mirante VG, Melotti G. The added value of quantitative analysis of on-Therapy impedance-pH parameters in distinguishing refractory non-Erosive reflux disease from functional heartburn. Neurogastroenterol Motil 2012; 24:141-147
15. Zerbib F, Bruley des Varannes S, Roman S, Pouderoux P, Artigue F, Chaput U, et al. Normal values and day-To-Day variability of 24-h ambulatory oesophageal impedance-Ph monitoring in a Belgian-French cohort of healthy subjects. Aliment Pharmacol Ther 2005; 22:1011-1021
16. Zerbib F, Roman S, Ropert A, des Varannes SB, Pouderoux P, Chaput U, et al. Esophageal pH-impedance monitoring and symptom analysis in GERD: A study in patients off and on therapy. Am J Gastroenterol 2006; 101:1956-1963
17. Wiener GJ, Richter JE, Copper JB, Wu WC, Castell DO. The symptom index: A clinically important parameter of ambulatory 24 h esophageal pH monitoring. Am J Gastroenterol 1988; 83:358-361
18. Weusten BL, Roelofs JM, Akkermans LM, Van Berge-henegouwen GP, Smout AJ. The symptom-Association probability: An improved method for symptom analysis of 24 h esophageal pH data. Gastroenterology 1994; 107:1741-1745
19. Pandolfino JE, Fox MR, Bredenoord AJ, Kahrilas PJ. High-resolution manometry in clinical practice: Utilizing pressure topography to classify oesophageal motility abnormalities. Neurogastroenterol Motil 2009; 21:796-806
20. Pandolfino JE, Ghosh SK, Rice J, Clarke JO, Kwiatek MA, Kahrilas PJ, et al. Classifying esophageal motility by pressure topography characteristics: A study of 400 patients and 75 controls. Am J Gastroenterol 2008; 103:27-37
21. Roman S, Lin Z, Kwiatek MA, Kahrilas PJ. Weak peristalsis in esophageal pressure topography: Classification and association with dysphagia. Am J Gastroenterol 2011; 106:349-356
22. Pandolfino JE, Roman S, Carlson D, Luger D, Bidari K, Boris L, et al. Distal esophageal spasm in high-resolution esophageal pressure topography: Defining clinical phenotypes. Gastroenterology 2011; 141:469-475
23. Shaw M, Talley NJ, Beebe T, Rockwood T, Carlsson R, Adlis S, et al. Initial validation of a diagnostic questionnaire for gastroesophageal reflux disease. Am J Gastroenterol 2001; 96:52-57
24. Shaw M, Dent J, Beebe T, Junghard O, Wiklund I, Lind T, et al. The reflux disease questionnaire: A measure for assessment of treatment response in clinical trials. Health Qual Life Outcomes 2008;30
25. Amouretti M, Nalet B, Robaszkiewicz M, Wainsten JP, de la Loge C, Benmedjahed K, et al. Validation of the short-form REFLUX-QUAL (RQS), a gastro-Esophageal reflux disease (GERD) specific quality of life questionnaire. Gastroenterol Clin Biol 2005; 29:793-801
26. Savarino E, Zentilin P, Tutuian R, Pohl D, Casa DD, Frazzoni M, et al. The role of non-Acid reflux in NERD: Lessons learned from impedance-pH monitoring in 150 patients off therapy. Am J Gastroenterol 2008; 103: 2685-2693
27. Savarino E, Gemignani L, Pohl D, Zenntilin P, Dulbecco P, Assandri L, et al. Oesophageal motility and bolus transit abnormalities increase in parallel with the severity of gastro-oesophageal reflux disease. Aliment Pharmacol Ther 2011; 34:476-486
28. Hershcovici T, Zimmerman J. Functional heartburn vs. non-Erosive reflux disease: Similarities and differences. Aliment Pharmacol Ther 2008; 27:1103-1109
29. Lee KJ, Kwon HC, Cheong JY, Cho SW. Demographic, clinical, and psychological characteristics of the heartburn groups classified using the Rome III criteria and factors associated with the responsiveness to proton pump inhibitors in the gastroesophageal reflux disease group. Digestion 2009; 79:131-136
30. Shapiro M, Green C, Bautista JM, Peru RL, Malagon IB, Corvo M, et al. Functional heartburn patients demonstrate traits of functional bowel disorder but lack a uniform increase of chemoreceptor sensitivity to acid. Am J Gastroenterol 2006; 101:1084-1091
31. Savarino E, Pohl D, Zentilin P, Dulbecco P, Sammito G, Sconfienza L, et al. Functional heartburn has more in common with functional dyspepsia than with non-Erosive reflux disease. Gut 2009; 58:1185-1191
32. Ortiz V, Ponce M, Ferna'ndez A, Martinez B, Ponce JL, Garrigues V, et al. Value of heartburn for diagnosing gastroesophageal reflux disease in severely obese patients. Obesity 2006; 14:696-700
33. Boyd C, Abraham S, Kellow J. Appearance and disappearance of functional gastrointestinal disorders in patients with eating disorders. Neurogastroenterol Motil 2010; 22:1279-1283
34. Isolauri J, Luostarinen M, Isolauri E, Reinikainene P, Viljakka M, Keyrilä inen O, et al. Natural course of gastro-oesophageal reflux disease: 17-22 year follow-up of 60 patients. Am J Gastroenterol 1997; 92:37-41
35. Pace F, Bollani S, Molteni P, Bianchi-Porro G. Natural history of gastrooesophageal reflux disease without oesophagitis (NERD) - A reappraisal 10 years on. Dig Liver Dis 2004; 36:111-115
36. Mc Dougall NI, Johnston BT, Collins JS, McFarland RJ, Love AH. Disease progression in gastro-oesophageal reflux disease as determined by repeat oesophageal pH monitoring and endoscopy 3 to 4.5 years after diagnosis. Eur J Gastroenterol Hepatol 1997; 9:1161-1167
37. Emerenziani S, Sifrim D, Habib FI, Ribolsi M, Guarino MPO, Rizzi M, et al. Presence of gas in the refluxate enhances reflux perception in non-Erosive patients with physiological acid exposure of the oesophagus. Gut 2008; 57:443-447
38. Zerbib F, Duriez A, Roman S, Capdepont M, Mion F. Determinants of gastrooesophageal reflux perception in patients with persistent symptoms despite proton pump inhibitors. Gut 2008; 57:156-160
39. Karamanolis G, Stevens W, Vos R, Tack J, Clave P, Sifrim D, et al. Oesophageal tone and sensation in the transition zone between proximal striated and distal smooth muscle oesophagus. Neurogastroenterol Motil 2008; 20:291-297
40. Sifrim D, Zerbib F. Diagnosis and management of patients with reflux symptoms refractory to proton pump inhibitors. Gut 2012; 61:1340-1354
41. Hong SJ, Ko BM, Jung IS, Ryu CB, Moon JH, Cho JY, et al. Relevance of ineffective esophageal motility and hyperactive acid sensitization in patients with gastroesophageal reflux. J Gastroenterol Hepatol 2007; 22:1662-1665
42. Porter RF, Kumar N, Drapekin JE, Gyawali CP. Fragmented esophageal smooth muscle contraction segments on high resolution manometry: A marker of esophageal hypomotility. Neurogastroenterol Motil 2012; 24:763-769
43. Barlow WJ, Orlando RC. The pathogenesis of heartburn in nonerosive reflux disease: A unifying hypothesis. Gastroenterology 2005; 128:771-778
44. Bredenoord AJ, Fox M, Kahrilas PJ, Pandolfino JE, Schwizer W, Smont JA, et al. Chicago classification criteria of esophageal motility disorders defined in high resolution esophageal pressure topography. Neurogastroenterol Motil 2012; 24 (SUPPL1):57-65