Advances in pathogenesis through animal models and imaging

Nature Reviews Rheumatology

Volumn 9, Issue 2, 2013, Pages 72-74

  Maksymowych, Walter P ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADALIMUMAB; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 23; INTERLEUKIN 23 RECEPTOR; TUMOR NECROSIS FACTOR ALPHA INHIBITOR; ABATACEPT; ANTIBODY CONJUGATE; ANTIRHEUMATIC AGENT; TUMOR NECROSIS FACTOR ALPHA;

CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CLINICAL FEATURE; CYTOKINE PRODUCTION; DIAGNOSTIC IMAGING; DISEASE ASSOCIATION; DISEASE COURSE; EXPERIMENTAL MODEL; IMAGE ANALYSIS; INNATE IMMUNITY; LYMPHOCYTIC INFILTRATION; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PATIENT ASSESSMENT; PREDICTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION; SPONDYLARTHRITIS; TH17 CELL; UPREGULATION; ANIMAL; DISEASE MODEL; DRUG ANTAGONISM; HUMAN; MOUSE; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; ANTIRHEUMATIC AGENTS; DISEASE MODELS, ANIMAL; HUMANS; IMMUNOCONJUGATES; INTERLEUKIN-17; INTERLEUKIN-23; MICE; SIGNAL TRANSDUCTION; SPONDYLARTHRITIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84873408211     PISSN: 17594790     EISSN: 17594804     Source Type: Journal    
DOI: 10.1038/nrrheum.2012.233     Document Type: Review

References (10)

1. Song, I. et al. Treatment of active ankylosing spondylitis with abatacept: an open-label, 24-week pilot study. Ann. Rheum. Dis. 70, 1108-1110 (2011).
2. Brown, M. A. Progress in the genetics of ankylosing spondylitis. Brief. Funct. Genomics 10, 249-257 (2011).
3. Maksymowych, W. P. et al. Suppression of inflammation and effects on new bone formation in ankylosing spondylitis: evidence for a window of opportunity in disease modification. Ann. Rheum. Dis. 72, 23-28 (2013).
4. Shen, H., Goodall, J. C. & Hill Gaston, J. S. Frequency and phenotype of peripheral blood 2012.235TH17 cells in ankylosing spondylitis and rheumatoid arthritis. Arthritis Rheum. 60, 1647-1656 (2009).
5. Noordenbos, T. et al. Interleukin-17-positive mast cells contribute to synovial inflammation in spondylarthritis. Arthritis Rheum. 64, 99-109 (2012).
6. Kenna, T. J. et al. Enrichment of circulating interleukin-17-secreting interleukin-23 receptor-positive γ/σ T cells in patients with active ankylosing spondylitis. Arthritis Rheum. 64, 1420-1429 (2012).
7. Appel, H. et al. Analysis of IL-17+ cells in facet joints of patients with spondyloarthritis suggests that the innate immune pathway might be of greater relevance than the TH17-mediated adaptive immune response. Arthritis Res. Ther. 13, R95 (2011).
8. Ruutu, M. et al. β-glucan triggers spondylarthritis and Crohn's disease-like ileitis in SKG mice. Arthritis Rheum. 64, 2211-2222 (2012).
9. Kontoyiannis, D. et al. Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies. Immunity 10, 387-398 (1999).
10. Sherlock, J. P. et al. IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4-CD8- entheseal resident T cells. Nat. Med. 18, 1069-1076 (2012).