Quality controls in cellular immunotherapies: Rapid assessment of clinical grade dendritic cells by gene expression profiling

Molecular Therapy

Volumn 21, Issue 2, 2013, Pages 476-484

  Castiello, Luciano ^a   Sabatino, Marianna ^a   Zhao, Yingdong ^b   Tumaini, Barbara ^a   Ren, Jiaqiang ^a   Ping, Jin ^a   Wang, Ena ^c   Wood, Lauren V ^b   Marincola, Francesco M ^c   Puri, Raj K ^d   Stroncek, David F ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c Clinical Center and Center for Human Immunology CHI   (United States)

^d CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CCL1 CHEMOKINE; CD70 ANTIGEN; DENDRITIC CELL VACCINE;

ANALYTICAL PARAMETERS; ARRAY VARIABILITY; ARTICLE; BIOTECHNOLOGICAL PRODUCTION; CCL1GENE; CCRL1GENE; CD70 GENE; CD80 GENE; CELL CONSISTENCY; CELL STABILITY; CELL THERAPY; CELL VARIABILITY; CLINICAL ASSESSMENT; CONTROLLED STUDY; CORRELATION COEFFICIENT; DENDRITIC CELL; FLOW CYTOMETRY; GENE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENETIC MARKER; GENETIC VARIABILITY; HUMAN; HUMAN CELL; IMMUNOTHERAPY; IN VITRO STUDY; INDEX OF VARIABILITY; MATURE DENDRITIC CELL; MICROARRAY ANALYSIS; MONOCYTE; QUALITY CONTROL; ROBUSTNESS;

EID: 84873405592     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2012.89     Document Type: Article

References (28)

1. Stroncek, D F, Jin, P, Ren, J, Feng, J, Castiello, L, Civini, S et al. (2010). Quality assessment of cellular therapies: the emerging role of molecular assays. Korean J Hematol 45: 14-22.
2. Hinz, T, Buchholz, CJ, van der Stappen, T, Cichutek, K and Kalinke, U (2006). Manufacturing and quality control of cell-based tumor vaccines: a scientifc and a regulatory perspective. J Immunother 29: 472-476.
3. Center for BIologics Evaluation and Research, FaDA. Potency Tests for Cellular and Gene Therapy Products, 2011.
4. Committee for Medicinal Product for Human Use, EMA. Guideline on Human Cell-based Medicinal Products, 2008.
5. Steinman, RM and Banchereau, J (2007). Taking dendritic cells into medicine. Nature 449: 419-426.
6. Kalinski, P, Urban, J, Narang, R, Berk, E, Wieckowski, E and Muthuswamy, R (2009). Dendritic cell-based therapeutic cancer vaccines: what we have and what we need. Future Oncol 5: 379-390.
7. Banchereau, J and Palucka, AK (2005). Dendritic cells as therapeutic vaccines against cancer. Nat Rev Immunol 5: 296-306.
8. Castiello, L, Sabatino, M, Jin, P, Clayberger, C, Marincola, FM, Krensky, AM et al. (2011). Monocyte-derived DC maturation strategies and related pathways: a transcriptional view. Cancer Immunol Immunother 60: 457-466.
9. Anguille, S, Smits, EL, Cools, N, Goossens, H, Berneman, ZN and Van Tendeloo, VF (2009). Short-term cultured, interleukin-15 differentiated dendritic cells have potent immunostimulatory properties. J Transl Med 7: 109.
10. Kalinski, P, Wieckowski, E, Muthuswamy, R and de Jong, E (2010). Generation of stable Th1/CTL-, Th2-, and Th17-inducing human dendritic cells. Methods Mol Biol 595: 117-133.
11. Kwon, HK, Lee, CG, So, JS, Chae, CS, Hwang, JS, Sahoo, A et al. (2010). Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders. Proc Natl Acad Sci USA 107: 2159-2164.
12. Tahara, H, Sato, M, Thurin, M, Wang, E, Butterfeld, LH, Disis, ML et al. (2009). Emerging concepts in biomarker discovery; the US-Japan Workshop on Immunological Molecular Markers in Oncology. J Transl Med 7: 45.
13. Shi, L, Reid, LH, Jones, WD, Shippy, R, Warrington, JA, Baker, SC et al.; MAQC Consortium. (2006). The MicroArray Quality Control (MAQC) project shows interand intraplatform reproducibility of gene expression measurements. Nat Biotechnol 24: 1151-1161.
14. Gombert, M, Dieu-Nosjean, MC, Winterberg, F, Bünemann, E, Kubitza, RC, Da Cunha, L et al. (2005). CCL1-CCR8 interactions: an axis mediating the recruitment of T cells and Langerhans-type dendritic cells to sites of atopic skin infammation. J Immunol 174: 5082-5091.
15. Comerford, I, Milasta, S, Morrow, V, Milligan, G and Nibbs, R (2006). The chemokine receptor CCX-CKR mediates effective scavenging of CCL19 in vitro. Eur J Immunol 36: 1904-1916.
16. Van Deusen, KE, Rajapakse, R and Bullock, TN (2010). CD70 expression by dendritic cells plays a critical role in the immunogenicity of CD40-independent, CD4+ T cell-dependent, licensed CD8+ T cell responses. J Leukoc Biol 87: 477-485.
17. Kvistborg, P, Bechmann, CM, Pedersen, AW, Toh, HC, Claesson, MH and Zocca, MB (2009). Comparison of monocyte-derived dendritic cells from colorectal cancer patients, non-small-cell-lung-cancer patients and healthy donors. Vaccine 28: 542-547.
18. Decker, P, Kötter, I, Klein, R, Berner, B and Rammensee, HG (2006). Monocyte-derived dendritic cells over-express CD86 in patients with systemic lupus erythematosus. Rheumatology (Oxford) 45: 1087-1095.
19. Cuellar, A, Santander, SP, Thomas, Mdel C, Guzmán, F, Gómez, A, López, MC et al. (2008). Monocyte-derived dendritic cells from chagasic patients vs healthy donors secrete differential levels of IL-10 and IL-12 when stimulated with a protein fragment of Trypanosoma cruzi heat-shock protein-70. Immunol Cell Biol 86: 255-260.
20. van den Heuvel, MM, Vanhee, DD, Postmus, PE, Hoefsmit, EC and Beelen, RH (1998). Functional and phenotypic differences of monocyte-derived dendritic cells from allergic and nonallergic patients. J Allergy Clin Immunol 101(1 Pt 1): 90-95.
21. Carrasco, YR, Fleire, SJ, Cameron, T, Dustin, ML and Batista, FD (2004). LFA-1/ICAM-1 interaction lowers the threshold of B cell activation by facilitating B cell adhesion and synapse formation. Immunity 20: 589-599.
22. Sheikh, NA and Jones, LA (2008). CD54 is a surrogate marker of antigen presenting cell activation. Cancer Immunol Immunother 57: 1381-1390.
23. Food and Drug Administration. Provenge: Highlights of Prescribing Information, 2010.
24. Trinchieri, G (2003). Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol 3: 133-146.
25. Lebre, MC, Burwell, T, Vieira, PL, Lora, J, Coyle, AJ, Kapsenberg, ML et al. (2005). Differential expression of infammatory chemokines by Th1-and Th2-cell promoting dendritic cells: a role for different mature dendritic cell populations in attracting appropriate effector cells to peripheral sites of infammation. Immunol Cell Biol 83: 525-535.
26. Korn, EL, Habermann, JK, Upender, MB, Ried, T and McShane, LM (2004). Objective method of comparing DNA microarray image analysis systems. BioTechniques 36: 960-967.
27. Wright, GW and Simon, RM (2003). A random variance model for detection of differential gene expression in small microarray experiments. Bioinformatics 19: 2448-2455.
28. Edgar, R, Domrachev, M and Lash, AE (2002). Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res 30: 207-210.