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Volumn 20, Issue 2, 2013, Pages 100-106

The thorny issue of relapsed acute myeloid leukemia

Author keywords

acute myeloid leukemia; allogeneic stem cell transplantation; chemotherapy; prognostic factors; targeted therapy

Indexed keywords

ANTINEOPLASTIC AGENT; CD135 ANTIGEN; CLADRIBINE; CLOFARABINE; CYTARABINE; ELACYTARABINE; ETOPOSIDE; GEMTUZUMAB OZOGAMICIN; GRANULOCYTE COLONY STIMULATING FACTOR; ISOCITRATE DEHYDROGENASE 1; LAROMUSTINE; LESTAURTINIB; LINTUZUMAB; MITOXANTRONE; NUCLEOPHOSMIN; QUIZARTINIB; RG 7112; SORAFENIB; TOSEDOSTAT; TRAMETINIB; UNCLASSIFIED DRUG; VOSAROXIN;

EID: 84873398483     PISSN: 10656251     EISSN: 15317048     Source Type: Journal    
DOI: 10.1097/MOH.0b013e32835dd99d     Document Type: Review
Times cited : (7)

References (49)
  • 1
    • 0030722602 scopus 로고    scopus 로고
    • Long-term survival in acute myeloid leukemia: The Eastern Cooperative Oncology Group experience
    • Bennett JM, Young ML, Andersen JW, et al. Long-term survival in acute myeloid leukemia: the Eastern Cooperative Oncology Group experience. Cancer 1997; 80:2205-2209.
    • (1997) Cancer , vol.80 , pp. 2205-2209
    • Bennett, J.M.1    Young, M.L.2    Andersen, J.W.3
  • 2
    • 23644455476 scopus 로고    scopus 로고
    • Drug therapy for acute myeloid leukemia
    • Tallman MS, Gilliland DG, Rowe JM. Drug therapy for acute myeloid leukemia. Blood 2005; 106:1154-1163.
    • (2005) Blood , vol.106 , pp. 1154-1163
    • Tallman, M.S.1    Gilliland, D.G.2    Rowe, J.M.3
  • 4
    • 0030663565 scopus 로고    scopus 로고
    • Long-term follow-up of patients with newly diagnosed acute myeloid leukemia treated at the University of Texas M.D
    • Estey E, deLima M, Strom S, et al. Long-term follow-up of patients with newly diagnosed acute myeloid leukemia treated at the University of Texas M.D. Anderson Cancer Center. Cancer 1997; 80:2176-2180.
    • (1997) Anderson Cancer Center. Cancer , vol.80 , pp. 2176-2180
    • Estey, E.1    De Lima, M.2    Strom, S.3
  • 5
    • 0029916143 scopus 로고    scopus 로고
    • Treatment of newly-diagnosed acute myelogenous leukaemia in patients aged 80 years and above
    • DeLima M, Ghaddar H, Pierce S, Estey E. Treatment of newly-diagnosed acute myelogenous leukaemia in patients aged 80 years and above. Br J Haematol 1996; 93:89-95.
    • (1996) Br J Haematol , vol.93 , pp. 89-95
    • Delima, M.1    Ghaddar, H.2    Pierce, S.3    Estey, E.4
  • 6
    • 0037114753 scopus 로고    scopus 로고
    • Pretreatment cytogenetic abnormalities are predictive of induction success cumulative incidence of relapse and overall survival in adult patients with de novo acute myeloid leukemia: Results from Cancer and Leukemia Group B (CALGB 8461)
    • Byrd JC, Mrozek K, Dodge RK, et al. Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461). Blood 2002; 100:4325-4336.
    • (2002) Blood , vol.100 , pp. 4325-4336
    • Byrd, J.C.1    Mrozek, K.2    Dodge, R.K.3
  • 7
    • 0032188805 scopus 로고    scopus 로고
    • The importance of diagnostic cytogenetics on outcome in AML: Analysis of 1,612 patients entered into the MRC AML 10 trial
    • Grimwade D, Walker H, Oliver F, et al. The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. Blood 1998; 92:2322-2333.
    • (1998) Blood , vol.92 , pp. 2322-2333
    • Grimwade, D.1    Walker, H.2    Oliver, F.3
  • 8
    • 0035469883 scopus 로고    scopus 로고
    • The predictive value of hierarchical cytogenetic classification in older adults with acute myeloid leukemia (AML): Analysis of 1065 patients entered into the United Kingdom Medical Research Council AML11 trial
    • Grimwade D, Walker H, Harrison G, et al. The predictive value of hierarchical cytogenetic classification in older adults with acute myeloid leukemia (AML): analysis of 1065 patients entered into the United Kingdom Medical Research Council AML11 trial. Blood 2001; 98:1312-1320.
    • (2001) Blood , vol.98 , pp. 1312-1320
    • Grimwade, D.1    Walker, H.2    Harrison, G.3
  • 9
    • 0035885955 scopus 로고    scopus 로고
    • The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: Analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials
    • Kottaridis PD, Gale RE, Frew ME, et al. The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials. Blood 2001; 98:1752-1759.
    • (2001) Blood , vol.98 , pp. 1752-1759
    • Kottaridis, P.D.1    Gale, R.E.2    Frew, M.E.3
  • 10
    • 42949142189 scopus 로고    scopus 로고
    • Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia
    • Schlenk RF, Dohner K, Krauter J, et al. Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia. N Engl J Med 2008; 358:1909-1918.
    • (2008) N Engl J Med , vol.358 , pp. 1909-1918
    • Schlenk, R.F.1    Dohner, K.2    Krauter, J.3
  • 11
    • 77954921625 scopus 로고    scopus 로고
    • Prognostic significance of CEBPA mutations in a large cohort of younger adult patients with acute myeloid leukemia: Impact of double CEBPA mutations and the interaction with FLT3 and NPM1 mutations
    • Green CL, Koo KK, Hills RK, et al. Prognostic significance of CEBPA mutations in a large cohort of younger adult patients with acute myeloid leukemia: impact of double CEBPA mutations and the interaction with FLT3 and NPM1 mutations. J Clin Oncol 2010; 28:2739-2747.
    • (2010) J Clin Oncol , vol.28 , pp. 2739-2747
    • Green, C.L.1    Koo, K.K.2    Hills, R.K.3
  • 12
    • 77957771067 scopus 로고    scopus 로고
    • IDH1 mutations are detected in 6.6% of 1414 AML patients and are associated with intermediate risk karyotype and unfavorable prognosis in adults younger than 60 years and unmutated NPM1 status
    • Schnittger S, Haferlach C, Ulke M, et al. IDH1 mutations are detected in 6.6% of 1414 AML patients and are associated with intermediate risk karyotype and unfavorable prognosis in adults younger than 60 years and unmutated NPM1 status. Blood 2010; 116:5486-5496.
    • (2010) Blood , vol.116 , pp. 5486-5496
    • Schnittger, S.1    Haferlach, C.2    Ulke, M.3
  • 13
    • 84863393263 scopus 로고    scopus 로고
    • Prognostic relevance of integrated genetic profiling in acute myeloid leukemia
    • Patel JP, Gonen M, Figueroa ME, et al. Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. N Engl J Med 2012; 366:1079-1089.
    • (2012) N Engl J Med , vol.366 , pp. 1079-1089
    • Patel, J.P.1    Gonen, M.2    Figueroa, M.E.3
  • 14
    • 20244361887 scopus 로고    scopus 로고
    • Prognostic index for adult patients with acute myeloid leukemia in first relapse
    • Breems DA, Van Putten WL, Huijgens PC, et al. Prognostic index for adult patients with acute myeloid leukemia in first relapse. J Clin Oncol 2005; 23:1969-1978.
    • (2005) J Clin Oncol , vol.23 , pp. 1969-1978
    • Breems, D.A.1    Van Putten, W.L.2    Huijgens, P.C.3
  • 15
    • 79958108730 scopus 로고    scopus 로고
    • A new Leukemia Prognostic Scoring System for refractory/relapsed adult acute myelogeneous leukaemia patients: A GOELAMS study
    • Chevallier P, Labopin M, Turlure P, et al. A new Leukemia Prognostic Scoring System for refractory/relapsed adult acute myelogeneous leukaemia patients: a GOELAMS study. Leukemia 2011; 25:939-944.
    • (2011) Leukemia , vol.25 , pp. 939-944
    • Chevallier, P.1    Labopin, M.2    Turlure, P.3
  • 16
    • 0034009065 scopus 로고    scopus 로고
    • Treatment of relapsed and refractory acute myelogenous leukemia
    • Estey EH. Treatment of relapsed and refractory acute myelogenous leukemia. Leukemia 2000; 14:476-479.
    • (2000) Leukemia , vol.14 , pp. 476-479
    • Estey, E.H.1
  • 17
    • 80054771760 scopus 로고    scopus 로고
    • Treatment of FLT3-ITDpositive acute myeloid leukemia relapsing after allogeneic stem cell transplantation with sorafenib
    • Sharma M, Ravandi F, Bayraktar UD, et al. Treatment of FLT3-ITDpositive acute myeloid leukemia relapsing after allogeneic stem cell transplantation with sorafenib. Biol Blood Marrow Transplant 2011; 17:1874-1877.
    • (2011) Biol Blood Marrow Transplant , vol.17 , pp. 1874-1877
    • Sharma, M.1    Ravandi, F.2    Bayraktar, U.D.3
  • 18
    • 56949083913 scopus 로고    scopus 로고
    • Sorafenib (Nexavar) induces molecular remission and regression of extramedullary disease in a patient with FLT3-ITD \+ acute myeloid leukemia
    • Safaian NN, Czibere A, Bruns I, et al. Sorafenib (Nexavar) induces molecular remission and regression of extramedullary disease in a patient with FLT3-ITD \+ acute myeloid leukemia. Leuk Res 2009; 33:348-350.
    • (2009) Leuk Res , vol.33 , pp. 348-350
    • Safaian, N.N.1    Czibere, A.2    Bruns, I.3
  • 19
    • 69249221392 scopus 로고    scopus 로고
    • Compassionate use of sorafenib in FLT3-ITD-positive acute myeloid leukemia: Sustained regression before and after allogeneic stem cell transplantation
    • Metzelder S, Wang Y, Wollmer E, et al. Compassionate use of sorafenib in FLT3-ITD-positive acute myeloid leukemia: sustained regression before and after allogeneic stem cell transplantation. Blood 2009; 113:6567-6571.
    • (2009) Blood , vol.113 , pp. 6567-6571
    • Metzelder, S.1    Wang, Y.2    Wollmer, E.3
  • 20
    • 78149237935 scopus 로고    scopus 로고
    • Prognostic factors and outcomes of adult patients with acute myeloid leukemia after first relapse
    • Kurosawa S, Yamaguchi T, Miyawaki S, et al. Prognostic factors and outcomes of adult patients with acute myeloid leukemia after first relapse. Haematologica 2010; 95:1857-1864.
    • (2010) Haematologica , vol.95 , pp. 1857-1864
    • Kurosawa, S.1    Yamaguchi, T.2    Miyawaki, S.3
  • 21
    • 77957278020 scopus 로고    scopus 로고
    • Hematopoietic stem-cell transplantation for acute leukemia in relapse or primary induction failure
    • Duval M, Klein JP, He W, et al. Hematopoietic stem-cell transplantation for acute leukemia in relapse or primary induction failure. J Clin Oncol 2010; 28:3730-3738.
    • (2010) J Clin Oncol , vol.28 , pp. 3730-3738
    • Duval, M.1    Klein, J.P.2    He, W.3
  • 22
    • 0030451886 scopus 로고    scopus 로고
    • Probability of long-term disease-free survival for acute myeloid leukemia patients after first relapse: A single-centre experience
    • Vignetti M, Orsini E, Petti MC, et al. Probability of long-term disease-free survival for acute myeloid leukemia patients after first relapse: a single-centre experience. Ann Oncol 1996; 7:933-938.
    • (1996) Ann Oncol , vol.7 , pp. 933-938
    • Vignetti, M.1    Orsini, E.2    Petti, M.C.3
  • 23
    • 38049153331 scopus 로고    scopus 로고
    • Cladribine combined with high doses of arabinoside cytosine, mitoxantrone, and G-CSF (CLAG-M) is a highly effective salvage regimen in patients with refractory and relapsed acute myeloid leukemia of the poor risk: A final report of the Polish Adult Leukemia Group
    • Wierzbowska A, Robak T, Pluta A, et al. Cladribine combined with high doses of arabinoside cytosine, mitoxantrone, and G-CSF (CLAG-M) is a highly effective salvage regimen in patients with refractory and relapsed acute myeloid leukemia of the poor risk: a final report of the Polish Adult Leukemia Group. Eur J Haematol 2008; 80:115-126.
    • (2008) Eur J Haematol , vol.80 , pp. 115-126
    • Wierzbowska, A.1    Robak, T.2    Pluta, A.3
  • 24
    • 0042333501 scopus 로고    scopus 로고
    • A multicenter, open, noncomparative, phase II study of the combination of cladribine (2-chlorodeoxyadenosine), cytarabine, and G-CSF as induction therapy in refractory acute myeloid leukemia-A report of the Polish Adult Leukemia Group (PALG)
    • Wrzesien-Kus A, Robak T, Lech-Maranda E, et al. A multicenter, open, noncomparative, phase II study of the combination of cladribine (2-chlorodeoxyadenosine), cytarabine, and G-CSF as induction therapy in refractory acute myeloid leukemia-a report of the Polish Adult Leukemia Group (PALG). Eur J Haematol 2003; 71:155-162.
    • (2003) Eur J Haematol , vol.71 , pp. 155-162
    • Wrzesien-Kus, A.1    Robak, T.2    Lech-Maranda, E.3
  • 25
    • 0035136931 scopus 로고    scopus 로고
    • A multicentre, open, noncomparative phase II study of a combination of fludarabine phosphate, cytarabine and granulocyte colony-stimulating factor in relapsed and refractory acute myeloid leukaemia and de novo refractory anaemia with excess of blasts in transformation
    • Jackson G, Taylor P, Smith GM, et al. A multicentre, open, noncomparative phase II study of a combination of fludarabine phosphate, cytarabine and granulocyte colony-stimulating factor in relapsed and refractory acute myeloid leukaemia and de novo refractory anaemia with excess of blasts in transformation. Br J Haematol 2001; 112:127-137.
    • (2001) Br J Haematol , vol.112 , pp. 127-137
    • Jackson, G.1    Taylor, P.2    Smith, G.M.3
  • 26
    • 0033963520 scopus 로고    scopus 로고
    • Cyclophosphamide, ara-C and topotecan (CAT) for patients with refractory or relapsed acute leukemia
    • Cortes J, Estey E, Beran M, et al. Cyclophosphamide, ara-C and topotecan (CAT) for patients with refractory or relapsed acute leukemia. Leuk Lymphoma 2000; 36:479-484.
    • (2000) Leuk Lymphoma , vol.36 , pp. 479-484
    • Cortes, J.1    Estey, E.2    Beran, M.3
  • 27
    • 0028077347 scopus 로고
    • A phase III trial of high-dose cytosine arabinoside with or without etoposide in relapsed and refractory acute myelogenous leukemia
    • A Southeastern Cancer Study Group trial
    • Vogler WR, McCarley DL, StaggM, et al. A phase III trial of high-dose cytosine arabinoside with or without etoposide in relapsed and refractory acute myelogenous leukemia. A Southeastern Cancer Study Group trial. Leukemia 1994; 8:1847-1853.
    • (1994) Leukemia , vol.8 , pp. 1847-1853
    • Vogler, W.R.1    McCarley, D.L.2    Stagg, M.3
  • 28
    • 0032809362 scopus 로고    scopus 로고
    • A phase III comparison of high dose ARA-C (HIDAC) versus HIDAC plus mitoxantrone in the treatment of first relapsed or refractory acute myeloid leukemia Southwest Oncology Group Study
    • Karanes C, Kopecky KJ, Head DR, et al. A phase III comparison of high dose ARA-C (HIDAC) versus HIDAC plus mitoxantrone in the treatment of first relapsed or refractory acute myeloid leukemia Southwest Oncology Group Study. Leuk Res 1999; 23:787-794.
    • (1999) Leuk Res , vol.23 , pp. 787-794
    • Karanes, C.1    Kopecky, K.J.2    Head, D.R.3
  • 29
    • 79952102924 scopus 로고    scopus 로고
    • Salvage chemotherapy regimens for acute myeloid leukemia: Is one better? Efficacy comparison between CLAG and MEC regimens
    • Price SL, Lancet JE, George TJ, et al. Salvage chemotherapy regimens for acute myeloid leukemia: Is one better? Efficacy comparison between CLAG and MEC regimens. Leuk Res 2011; 35:301-304.
    • (2011) Leuk Res , vol.35 , pp. 301-304
    • Price, S.L.1    Lancet, J.E.2    George, T.J.3
  • 30
    • 19944433802 scopus 로고    scopus 로고
    • Results of a phase 1-2 study of clofarabine in combination with cytarabine (ara-C) in relapsed and refractory acute leukemias
    • Faderl S, Gandhi V, O'Brien S, et al. Results of a phase 1-2 study of clofarabine in combination with cytarabine (ara-C) in relapsed and refractory acute leukemias. Blood 2005; 105:940-947.
    • (2005) Blood , vol.105 , pp. 940-947
    • Faderl, S.1    Gandhi, V.2    O'Brien, S.3
  • 31
    • 0141482004 scopus 로고    scopus 로고
    • Phase 2 clinical and pharmacologic study of clofarabine in patients with refractory or relapsed acute leukemia
    • Kantarjian H, Gandhi V, Cortes J, et al. Phase 2 clinical and pharmacologic study of clofarabine in patients with refractory or relapsed acute leukemia. Blood 2003; 102:2379-2386.
    • (2003) Blood , vol.102 , pp. 2379-2386
    • Kantarjian, H.1    Gandhi, V.2    Cortes, J.3
  • 32
    • 84864050584 scopus 로고    scopus 로고
    • Clofarabine plus cytarabine compared with cytarabine alone in older patients with relapsed or refractory acute myelogenous leukemia: Results from the CLASSIC i Trial
    • Faderl S, Wetzler M, Rizzieri D, et al. Clofarabine plus cytarabine compared with cytarabine alone in older patients with relapsed or refractory acute myelogenous leukemia: results from the CLASSIC I Trial. J Clin Oncol 2012; 30:2492-2499.
    • (2012) J Clin Oncol , vol.30 , pp. 2492-2499
    • Faderl, S.1    Wetzler, M.2    Rizzieri, D.3
  • 33
    • 83555165090 scopus 로고    scopus 로고
    • A phase Ib study of vosaroxin, an anticancer quinolone derivative, in patients with relapsed or refractory acute leukemia
    • Lancet JE, Ravandi F, Ricklis RM, et al. A phase Ib study of vosaroxin, an anticancer quinolone derivative, in patients with relapsed or refractory acute leukemia. Leukemia 2011; 25:1808-1814.
    • (2011) Leukemia , vol.25 , pp. 1808-1814
    • Lancet, J.E.1    Ravandi, F.2    Ricklis, R.M.3
  • 35
    • 84865273611 scopus 로고    scopus 로고
    • Elacytarabine has single-agent activity in patients with advanced acute myeloid leukaemia
    • O'Brien S, Rizzieri DA, Vey N, et al. Elacytarabine has single-agent activity in patients with advanced acute myeloid leukaemia. Br J Haematol 2012; 158:581-588.
    • (2012) Br J Haematol , vol.158 , pp. 581-588
    • O'Brien, S.1    Rizzieri, D.A.2    Vey, N.3
  • 36
    • 77950456892 scopus 로고    scopus 로고
    • Phase 3 randomized, placebo-controlled, double-blind study of high-dose continuous infusion cytarabine alone or with laromustine (VNP40101M) in patients with acute myeloid leukemia in first relapse
    • Giles F, Vey N, DeAngelo D, et al. Phase 3 randomized, placebo-controlled, double-blind study of high-dose continuous infusion cytarabine alone or with laromustine (VNP40101M) in patients with acute myeloid leukemia in first relapse. Blood 2009; 114:4027-4033.
    • (2009) Blood , vol.114 , pp. 4027-4033
    • Giles, F.1    Vey, N.2    Deangelo, D.3
  • 37
    • 25144485908 scopus 로고    scopus 로고
    • Final report of the efficacy and safety of gemtuzumab ozogamicin (Mylotarg) in patients with CD33-positive acute myeloid leukemia in first recurrence
    • Larson RA, Sievers EL, Stadtmauer EA, et al. Final report of the efficacy and safety of gemtuzumab ozogamicin (Mylotarg) in patients with CD33-positive acute myeloid leukemia in first recurrence. Cancer 2005; 104:1442-1452.
    • (2005) Cancer , vol.104 , pp. 1442-1452
    • Larson, R.A.1    Sievers, E.L.2    Stadtmauer, E.A.3
  • 38
    • 77957711298 scopus 로고    scopus 로고
    • Preliminary results of Southwest Oncology Group Study S0106: An international intergroup phase 3 randomized trial comparing the addition of gemtuzumab ozogamicin to standard induction therapy versus standard induction therapy followed by a second randomization to post-consolidation gemtuzumab ozogamicin versus no additional therapy for previously untreated acute myeloid leukemia [abstract]
    • Petersdorf S, Kopecky K, Stuart RK, et al. Preliminary results of Southwest Oncology Group Study S0106: an international intergroup phase 3 randomized trial comparing the addition of gemtuzumab ozogamicin to standard induction therapy versus standard induction therapy followed by a second randomization to post-consolidation gemtuzumab ozogamicin versus no additional therapy for previously untreated acute myeloid leukemia [abstract]. ASH Annual Meeting Abstracts 2009; 114:790.
    • (2009) ASH Annual Meeting Abstracts , vol.114 , pp. 790
    • Petersdorf, S.1    Kopecky, K.2    Stuart, R.K.3
  • 39
    • 23044471884 scopus 로고    scopus 로고
    • Phase III randomized multicenter study of a humanized anti-CD33monoclonal antibody, lintuzumab, incombination with chemotherapy, versus chemotherapy alone in patients with refractory or firstrelapsed acute myeloid leukemia
    • Feldman EJ, Brandwein J, Stone R, et al. Phase III randomized multicenter study of a humanized anti-CD33monoclonal antibody, lintuzumab, incombination with chemotherapy, versus chemotherapy alone in patients with refractory or firstrelapsed acute myeloid leukemia. J Clin Oncol 2005; 23:4110-4116.
    • (2005) J Clin Oncol , vol.23 , pp. 4110-4116
    • Feldman, E.J.1    Brandwein, J.2    Stone, R.3
  • 40
    • 76349102339 scopus 로고    scopus 로고
    • A randomized phase i clinical and biologic study of two schedules of sorafenib in patients with myelodysplastic syndrome or acute myeloid leukemia: A NCIC (National Cancer Institute of Canada) Clinical Trials Group Study
    • Crump M, Hedley D, Kamel-Reid S, et al. A randomized phase I clinical and biologic study of two schedules of sorafenib in patients with myelodysplastic syndrome or acute myeloid leukemia: a NCIC (National Cancer Institute of Canada) Clinical Trials Group Study. Leuk Lymphoma 2010; 51:252-260.
    • (2010) Leuk Lymphoma , vol.51 , pp. 252-260
    • Crump, M.1    Hedley, D.2    Kamel-Reid, S.3
  • 41
    • 84861906112 scopus 로고    scopus 로고
    • Sorafenib treatment of FLT3-ITD(\+) acute myeloid leukemia: Favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation
    • Man CH, Fung TK, Ho C, et al. Sorafenib treatment of FLT3-ITD(\+) acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation. Blood 2012; 119:5133-5143.
    • (2012) Blood , vol.119 , pp. 5133-5143
    • Man, C.H.1    Fung, T.K.2    Ho, C.3
  • 42
    • 84866495319 scopus 로고    scopus 로고
    • A phase II open-label Ac220 monotherapy efficacy study in patients with refractory/relapsed FLT3-ITD positive acute myeloid leukemia: Updated interim results [abstract]
    • Cortes JE, Perl AE, Smith CC, et al. A phase II open-label, Ac220 monotherapy efficacy study in patients with refractory/relapsed FLT3-ITD positive acute myeloid leukemia: updated interim results [abstract]. ASH Annual Meeting Abstracts 2011; 118:2576.
    • (2011) ASH Annual Meeting Abstracts , vol.118 , pp. 2576
    • Cortes, J.E.1    Perl, A.E.2    Smith, C.C.3
  • 43
    • 79953124734 scopus 로고    scopus 로고
    • Results from a randomized trial of salvage chemotherapy followed by lestaurtinib for patients with FLT3 mutant AML in first relapse
    • Levis M, Ravandi F, Wang ES, et al. Results from a randomized trial of salvage chemotherapy followed by lestaurtinib for patients with FLT3 mutant AML in first relapse. Blood 2011; 117:3294-3301.
    • (2011) Blood , vol.117 , pp. 3294-3301
    • Levis, M.1    Ravandi, F.2    Wang, E.S.3
  • 44
    • 53049086918 scopus 로고    scopus 로고
    • CHR-2797: An antiproliferative aminopeptidase inhibitor that leads to amino acid deprivation in human leukemic cells
    • Krige D, Needham LA, Bawden LJ, et al. CHR-2797: an antiproliferative aminopeptidase inhibitor that leads to amino acid deprivation in human leukemic cells. Cancer Res 2008; 68:6669-6679.
    • (2008) Cancer Res , vol.68 , pp. 6669-6679
    • Krige, D.1    Needham, L.A.2    Bawden, L.J.3
  • 45
    • 78049441128 scopus 로고    scopus 로고
    • Phase I/II clinical study of tosedostat, an inhibitor of aminopeptidases, in patients with acute myeloid leukemia and myelodysplasia
    • Lowenberg B, Morgan G, Ossenkoppele GJ, et al. Phase I/II clinical study of tosedostat, an inhibitor of aminopeptidases, in patients with acute myeloid leukemia and myelodysplasia. J Clin Oncol 2010; 28:4333-4338.
    • (2010) J Clin Oncol , vol.28 , pp. 4333-4338
    • Lowenberg, B.1    Morgan, G.2    Ossenkoppele, G.J.3
  • 46
    • 84866503821 scopus 로고    scopus 로고
    • Results of the OPAL Study: A phase II study to evaluate the efficacy, safety and tolerability of tosedostat (CHR-2797) in elderly subjects with treatment refractory or relapsed acute myeloid leukemia [abstract]
    • Cortes JE, Feldman EJ, Yee K, et al. Results of the OPAL Study: a phase II study to evaluate the efficacy, safety and tolerability of tosedostat (CHR-2797) in elderly subjects with treatment refractory or relapsed acute myeloid leukemia [abstract]. ASH Annual Meeting Abstracts 2011; 118:767.
    • (2011) ASH Annual Meeting Abstracts , vol.118 , pp. 767
    • Cortes, J.E.1    Feldman, E.J.2    Yee, K.3
  • 47
    • 84893670456 scopus 로고    scopus 로고
    • Results of the phase 1 trial of RG7112, a small-molecule MDM2 antagonist, in acute leukemia [abstract]
    • Andreeff M, Kelly KR, Yee K, et al. Results of the phase 1 trial of RG7112, a small-molecule MDM2 antagonist, in acute leukemia [abstract]. ASH Annual Meeting Abstracts 2012; 120:675.
    • (2012) ASH Annual Meeting Abstracts , vol.120 , pp. 675
    • Andreeff, M.1    Kelly, K.R.2    Yee, K.3
  • 48
    • 84873364607 scopus 로고    scopus 로고
    • Phase I/II trial of the MEK1/2 inhibitor trametinib (GSK1120212) in relapsed/refractory myeloid malignancies: Evidence of activity in patients with RAS mutation-positive disease [abstract]
    • Borthakur G, Popplewell L, Boyiadzis M, et al. Phase I/II trial of the MEK1/2 inhibitor trametinib (GSK1120212) in relapsed/refractory myeloid malignancies: evidence of activity in patients with RAS mutation-positive disease [abstract]. ASH Annual Meeting Abstracts 2012; 120:677.
    • (2012) ASH Annual Meeting Abstracts , vol.120 , pp. 677
    • Borthakur, G.1    Popplewell, L.2    Boyiadzis, M.3
  • 49
    • 70350619986 scopus 로고    scopus 로고
    • Quantifying the survival benefit for allogeneic hematopoietic stem cell transplantation in relapsed acute myelogenous leukemia
    • Armistead PM, de Lima M, Pierce S, et al. Quantifying the survival benefit for allogeneic hematopoietic stem cell transplantation in relapsed acute myelogenous leukemia. Biol Blood Marrow Transplant 2009; 15:1431-1438.
    • (2009) Biol Blood Marrow Transplant , vol.15 , pp. 1431-1438
    • Armistead, P.M.1    De Lima, M.2    Pierce, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.