A longitudinal study of differences in late- and early-onset geriatric depression: Depressive symptoms and psychosocial, cognitive, and neurological functioning

Aging and Mental Health

Volumn 17, Issue 1, 2013, Pages 1-11

  Sachs Ericsson, Natalie ^a   Corsentino, Elizabeth ^a   Moxley, Jerad ^a   Hames, Jennifer L ^a   Rushing, Nicole C ^a   Sawyer, Kathryn ^a   Joiner, Thomas ^a   Selby, Edward A ^b   Zarit, Steven ^c   Gotlib, Ian H ^d   Steffens, David C ^e  

^a FLORIDA STATE UNIVERSITY   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c PENNSYLVANIA STATE UNIVERSITY   (United States)

^d STANFORD UNIVERSITY   (United States)

^e DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

cognition; early onset depression; hippocampus; late onset depression

Indexed keywords

AGE; AGED; AGING; ARTICLE; BRAIN CORTEX; COGNITION; DEPRESSION; FEMALE; GERIATRIC ASSESSMENT; HIPPOCAMPUS; HUMAN; LONGITUDINAL STUDY; MAJOR DEPRESSION; MALE; MIDDLE AGED; NEUROLOGIC EXAMINATION; NUCLEAR MAGNETIC RESONANCE IMAGING; ONSET AGE; PATHOLOGY; PSYCHOLOGICAL ASPECT; QUALITY OF LIFE; SEVERITY OF ILLNESS INDEX; SOCIAL SUPPORT;

AGE FACTORS; AGE OF ONSET; AGED; AGING; CEREBRAL CORTEX; COGNITION; DEPRESSION; DEPRESSIVE DISORDER, MAJOR; FEMALE; GERIATRIC ASSESSMENT; HIPPOCAMPUS; HUMANS; LONGITUDINAL STUDIES; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NEUROLOGIC EXAMINATION; QUALITY OF LIFE; SEVERITY OF ILLNESS INDEX; SOCIAL SUPPORT;

MLCS; MLOWN;

EID: 84873394440     PISSN: 13607863     EISSN: 13646915     Source Type: Journal    
DOI: 10.1080/13607863.2012.717253     Document Type: Article

References (69)

1. Alexopoulos, G.S. (2006). The vascular depression hypothesis: 10 years later. Biological Psychiatry, 60, 1304-1305.
2. Alexopoulos, G.S., Meyers, B.S., Young, R.C., Kakuma, T., Silbersweig, D., & Charlson, M. (1997). Clinically defined vascular depression. American Journal of Psychiatry, 154, 562-565.
3. APA (1994). DSM-IV: Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: American Psychiatric Association.
4. APA (2000). DSM-IV-TR: Diagnostic and statistical manual of mental disorders (Text Revision, 4th ed.). Washington, DC: American Psychiatric Association.
5. Baldwin, R.C., & O'Brien, J. (2002). Vascular basis of late- onset depressive disorder. The British Journal of Psychiatry, 180, 157-160.
6. Ballmaier, M., Narr, K.L., Toga, A.W., Elderkin-Thompson, V., Thompson, P.M., Hamilton, L., & Kumar, A. (2008). Hippocampal morphology and distinguishing late-onset from early-onset elderly depression. American Journal of Psychiatry, 165, 229-237.
7. Baron, J.C., Chetelat, G., Desgranges, B., Perchey, G., Landeau, B., de la Sayette, V., & Eustache, F. (2001). In vivo mapping of gray matter loss with voxel-based morphometry in mild Alzheimer's disease. Neuroimage, 14, 298-309.
8. Baudic, S., Tzortzis, C., Barba, G.D., & Traykov, L. (2004). Executive deficits in elderly patients with major unipolar depression. Journal of Geriatric Psychiatry and Neurology, 17, 195-201.
9. Beekman, A.T., de Beurs, E., van Balkom, A.J., Deeg, D.J., van Dyck, R., & van Tilburg, W. (2000). Anxiety and depresion in later life: Co-occurrence and communality of risk factors. American Journal of Psychiatry, 157, 89-95.
10. Blazer, D., & Hughes, D. (1991). Subjective social support and depressive symptoms: Separate phenomena or epiphe- nomenona. Journal of Psychiatric Research, 2, 191-203.
11. Burvill, P.W., Hall, W.D., Stampfer, H.G., & Emmerson, J.P. (1989). A comparison of early-onset and late-onset depressive illness in the elderly. The British Journal of Psychiatry, 155, 673-679.
12. Chen, P.S., McQuoid, D.R., Payne, M.E., & Steffens, D.C. (2006). White matter and subcortical gray matter lesion volume changes and late-life depression outcome: A 4-year magnetic resonance imaging study. International Psychogeriatrics, 18, 445-456.
13. Cohen, J., Cohen, P., West, S.G., & Aiken, L.S. (2003). Applied multiple regression/correlation analysis for the behavioral sciences (3rd ed.). Hillsdale, IN: Erlbaum.
14. Cole, M.G., McCusker, J., Elie, M., Dendukuri, N., Latimer, E., & Bel, E. (2006). Systematic detection and multi- disciplinary care of depression in older medical inpatients: A randomized trial. Canadian Medical Association Journal, 174, 38-44.
15. Dillon, C., Allegri, R.F., Serrano, C.M., Iturry, M., Salgado, P., Glaser, F.B., & Taragano, F.E. (2009). Late- versus early-onset geriatric depression in a memory research center. Neuropsychiatric Disease and Treatment, 5, 517-526.
16. Farrell, K.R., & Ganzini, L. (1995). Misdiagnosing delirium as depression in medically ill elderly patients. Archives of Internal Medicine, 155, 2459-2464.
17. Ferro, J.M., & Madureira, S. (2002). Age-related white matter changes and cognitive impairment. Journal of Neurological Sciences, 203-204, 221-225.
18. Folstein, M., Folstein, S., & McHugh, P. (1975). Mini- mental state: A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189-198.
19. Gerritsen, L., Comijs, H.C., van der Graaf, Y., Knoops, A.J., Penninx, B.W., & Geerlings, M.I. (2011). Depression, hypothalamic pituitary adrenal axis, and hippocampal and entorhinal cortex volumes - The SMART Medea study. Biological Psychiatry, 70, 373-380.
20. Green, R.C., Cupples, L.A., Kurz, A., Auerbach, S., Go, R., Sadovnick, D., & Farrer, L. (2003). Depression as a risk factor for Alzheimer disease: The MIRAGE study. Archives of Neurology, 60, 753-59.
21. Hajcak, G., & Simons, R.F. (2002). Error-related brain activity in obsessive-compulsive undergraduates. Psychiatry Research, 110, 63-72.
22. Herrmann, L.L., Le Masurier, M., & Ebmeier, K.P. (2008). White matter hyperintensities in late life depression: A systematic review. Journal of Neurology, Neurosurgery & Psychiatry, 79, 619-624.
23. Janssen, J., Hulshoff Pol, H.E., de Leeuw, F.E., Schnack, H.G., Lampe, I.K., Kok, R.M., & Heeren, T.J. (2007). Hippocampal volume and subcortical white matter lesions in late life depression: Comparison of early and late onset depression. Journal of Neurology, Neurosurgery & Psychiatry, 78, 638-640.
24. Kendler, K.S., Neale, M.C., Maclean, C.J., Health, A.C., Eaves, L.J., & Kessler, R.C. (1993). Smoking and major depression: A causal analysis. Archives of General Psychiatry, 50, 36-43.
25. Kessler, R.C., McGonagle, K., Swartz, M., Blazer, D.G., & Nelson, C.R. (1993). Sex and depression in the national comorbidity survey I: Lifetime prevalence, chronicity and recurrence. Journal of Affective Disorders, 29, 85-96.
26. Klein, D.N., Schatzberg, A.F., McCullough, J.P., Dowling, F., Goodman, D., Howland, R.H., & Keller, M.B. (1999). Age of onset in chronic major depression: Relation to demographic and clinical variables, family history, and treatment response. Journal of Affective Disorders, 55, 149-157.
27. Knauper, B., Cannell, C.F., Schwarz, N., Bruce, M.L., & Kessler, R.C. (1999). Improving accuracy of major depression age-of-onset reports in the US National Comorbidity Survey. International Journal of Methods in Psychiatric Research, 8, 39-48.
28. Koenig, H., Larson, D., Hays, J., McCullough, M., George, L., Branch, P., & Kuchibhatla, M. (1998). Religion and survival of 1010 male veterans hospitalized with medical illness. Journal of Religion and Health, 37, 15-29.
29. Koga, H., Yuzuriha, T., Yao, H., Endo, K., Hiejima, S., Takashima, Y., & Tashiro, N. (2002). Quantitative MRI findings and cognitive impairment among community dwelling elderly subjects. Journal of Neurology, Neurosurgery & Psychiatry, 72, 737-741.
30. Laakso, M.P., Soininen, H., Partanen, K., Lehtovirta, M., Hallikainen, M., Hanninen, T., & Riekkinen Sr, P.J. (1998). MRI of the hippocampus in Alzheimer's disease: Sensitivity, specificity, and analysis of the incorrectly classified subjects. Neurobiology of Aging, 19, 23-31.
31. Landerman, R., George, L.K., Campbell, R.T., & Blazer, D.G. (1989). Alternative models of the stress buffering hypothesis. American Journal of Community Psychology, 17, 625-641.
32. Li, G., Wang, L.Y., Shofer, J.B., Thompson, M.L., Peskind, E.R., McCormick, W., ...Larson, E.B. (2011). Temporal relationship between depression and dementia: Findings from a large community-based 15-year follow-up study. Archives of General Psychiatry, 68, 970-977.
33. Lloyd, A.J., Ferrier, I.N., Barber, R., Gholkar, A., Young, A.H., & O'Brien, J.T. (2004). Hippocampal volume change in depression: Late- and early-onset illness compared. The British Journal of Psychiatry, 184, 488-495.
34. Lopez, O.L., Jagust, W.J., DeKosky, S.T., Becker, J.T., Fitzpatrick, A., Dulberg, C., & Kuller, L.H. (2003). Prevalence and classification of mild cognitive impairment in the Cardiovascular Health Study Cognition Study: Part 1. Archives of Neurology, 60, 1385-1389.
35. Lupien, S., de Leon, M., De Santi, S., Convit, A., Tarshish, C., Nair, N., & Meaney, M. (1998). Cortisol levels during human aging predict hippocampal atrophy and memory deficits. Nature Neuroscience, 1, 69-73.
36. McEwen, B.S. (1998). Protective and damaging effects of stress mediators. New England Journal of Medicine, 338, 171-179.
37. McEwen, B.S. (2002). Sex, stress and the hippocampus: Allostasis, allostatic load and the aging process. Neurobiology of Aging, 23, 921-939.
38. Mondimore, F.M., Zandi, P.P., MacKinnon, D.F., Mclnnis, M.G., Miller, E.B., Crowe, R.P., & Potash, J.B. (2006). Familial aggregation of illness chronicity in recurrent, early-onset major depression pedigrees. American Journal of Psychiatry, 163, 1554-1560.
39. O'Brien, J.T., Wiseman, R., Burton, E.J., Barber, B., Wesnes, K., Saxby, B., & Ford, G.A. (2002). Cognitive associations of subcortical white matter lesions in older people. Annals of the New York Academy of Sciences, 977, 436-444.
40. Parker, R.D., Elizabeth, P.F., Hayden, B.B., Carl, F.P., & David, C.S. (2003). A three-factor analytic model of the MADRS in geriatric depression. International Journal of Geriatric Psychiatry, 18, 73-77.
41. Parker, G., Willhelm, K., & Asghari, A. (1997). Early onset depression: The relevance of anxiety. Social Psychiatry and Psychiatric Epidemiology, 32, 30-37.
42. Piccinelli, M., & Wilkinson, G. (2000). Gender differences in depression. British Journal of Psychiatry, 177, 486-492.
43. Radloff, L. (1977). The CES-D scale: A self-report depression scale for research in the general population. Applied Psychological Measures, 1, 385-401.
44. Robins, L.N., Helzer, J.E., Croughan, J., & Ratcliff, K.S. (1981). National institute of mental health diagnostic interview schedule: Its history, characteristics, and validity. Archives of General Psychiatry, 38, 381-389.
45. Sachs-Ericsson, N., & Ciarlo, J. (2000). Gender, social roles and mental health: An epidemiological perspective. Sex Roles A Journal of Research, 43, 339-362.
46. Salat, D.H., Greve, D.N., Pacheco, J.L., Quinn, B.T., Helmer, K.G., Buckner, R.L., & Fischl, B. (2009). Regional white matter volume differences in nondemen- ted aging and Alzheimer's disease. Neuroimage, 44, 1247-1258.
47. Salloway, S., Malloy, P., Kohn, R., Gillard, E., Duffy, J., Rogg, J., & Westlake, R. (1996). MRI and neuropsycho- logical differences in early- and late-life-onset geriatric depression. Neurology, 46, 1567-1574.
48. Sapolsky, R.M. (1996). Why stress is bad for your brain. Science, 273, 749-750.
49. Sapolsky, R.M. (2000). Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. Archives of General Psychiatry, 57, 925-935.
50. Sheline, Y.I., Sanghavi, M., Mintun, M.A., & Gado, M.H. (1999). Depression duration but not age predicts hippo-campal volume loss in medically healthy women with recurrent major depression. Journal of Neuroscience, 19, 5034-5043.
51. Singer, J.D., & Willett, J.B. (1993). It's about time: Using discrete-time survival analysis to study duration and the timing of events. Journal of Educational Statistics, 18, 155-195.
52. Singer, J.D., & Willett, J. (2003). Applied longitudinal data analysis: Modeling change and event occurrence. New York, NY: Oxford University Press.
53. Singh-Manoux, A., Akbaraly, T.N., Marmot, M., Melchior, M., Ankri, J., Sabia, S., & Ferrie, J.E. (2010). Persistent depressive symptoms and cognitive function in late midlife: The Whitehall II study. Journal of Clinical Psychiatry, 71, 1379-1385.
54. Steffens, D.C., MacFall, J.R., Payne, M.E., Welsh-Bohmer, K.A., & Krishnan, K.R. (2000). Grey-matter lesions and dementia. The Lancet, 356, 1686.
55. Steffens, D.C., McQuoid, D.R., & Krishnan, K.R. (2002). The Duke somatic treatment algorithm for geriatric depression (STAGED) approach. Psychopharmacology Bulletin, 36, 58-68.
56. Steffens, D.C., McQuoid, D.R., Payne, M.E., & Potter, G.G. (2011). Change in hippocampal volume on magnetic resonance imaging and cognitive decline among older depressed and nondepressed subjects in the neurocognitive outcomes of depression in the elderly study. American Journal of Geriatric Psychiatry, 19, 4-12.
57. Steffens, D.C., McQuoid, D.R., & Potter, G.G. (2009). Outcomes of older cognitively impaired individuals with current and past depression in the NCODE study. Journal of Geriatric Psychiatry and Neurology, 22, 52-61.
58. Steffens, D.C., Payne, M., Greenberg, D., Byrum, C., Welsh- Bohmer, K., Wagner, H., & MacFall, J. (2002). Hippocampal volume and incident dementia in geriatric depression. American Journal of Geriatric Psychiatry, 10, 62-71.
59. Taylor, W.D., Bae, J.N., MacFall, J.R., Payne, M.E., Provenzale, J.M., Steffens, D.C., & Krishnan, K.R. (2007a). Widespread effects of hyperintense lesions on cerebral white matter structure. American Journal of Roentgenology, 188, 1695-1704.
60. Taylor, W.D., MacFall, J.R., Payne, M.E., McQuoid, D.R., Steffens, D.C., Provenzale, J.M., & Krishnan, K.R. (2007b). Orbitofrontal cortex volume in late life depression: Influence of hyperintense lesions and genetic polymorphisms. Psychological Medicine, 37, 1763-1773.
61. Thompson, A. (2008). Younger onset of depression is associated with greater suicidal intent. Social Psychiatry and Psychiatric Epidemiology, 43, 538-544.
62. Thompson, P.M., Hayashi, K.M., de Zubicaray, G., Janke, A.L., Rose, S.E., Semple, J., & Toga, A.W. (2003). Dynamics of gray matter loss in normal aging and Alzheimer's disease. Journal of Neuroscience, 23, 994-1005.
63. van Reekum, R., Simard, M., Clarke, D., Binns, M.A., & Conn, D. (1999). Late-life depression as a possible predictor of dementia: Cross-sectional and short-term follow-up results. American Journal of Geriatric Psychiatry, 7, 151-159.
64. Videbech, P., & Ravnkilde, B. (2004). Hippocampal volume and depression: A meta-analysis of MRI studies. American Journal of Psychiatry, 161, 1957-1966.
65. Williams, J.B.W., & Kobak, K.A. (2008). Development and reliability of a structured interview guide for the Montgomery-Asberg depression rating scale (SIGMA). The British Journal of Psychiatry, 192, 52-58.
66. Wilson, R.S., Barnes, L.L., Mendes de Leon, C.F., Aggarwal, N.T., Schneider, J.S., Bach, J., & Bennett, D.A. (2002). Depressive symptoms, cognitive decline, and risk of AD in older persons. Neurology, 59, 364-370.
67. Yaffe, K., Blackwell, T., Gore, R., Sands, L., Reus, V., & Browner, W.S. (1999). Depressive symptoms and cognitive decline in nondemented elderly women: A prospective study. Archives of General Psychiatry, 56, 425-430.
68. Zisook, S., Lesser, I., Stewart, J.W., Wisniewski, S.R., Balasubramani, G.K., Fava, M., & Rush, A.J. (2007). Effect of age at onset on the course of major depressive disorder. American Journal of Psychiatry, 164, 1539-1546.
69. Zubenko, G.S., Zubenko, W.N., McPherson, S., Spoor, E., Marin, D.B., Farlow, M.R., & Sunderland, T. (2003). A collaborative study of the emergence and clinical features of the major depressive syndrome of Alzheimer's disease. American Journal of Psychiatry, 160, 857-866.