Microbial transformation of 20(S)-protopanaxadiol by Absidia corymbifera. Cytotoxic activity of the metabolites against human prostate cancer cells

Fitoterapia

Volumn 84, Issue 1, 2013, Pages 6-10

  Chen, Guangtong ^a   Yang, Min ^b   Nong, Shaojun ^a   Yang, Xue ^a   Ling, Yong ^a   Wang, Donggeng ^a   Wang, Xinyang ^a   Zhang, Wei ^a  

^a NANTONG MEDICAL COLLEGE   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

20(S) Protopanaxadiol; Absidia corymbifera AS 3.3387; Cytotoxic activity; Dehydrogenation; Hydroxylation; Microbial transformation

Indexed keywords

23, 24 EN 25 HYDROXYL 20 PROTOPANAXADIOL; 25 HYDROXYL 20 PROTOPANAXADIOL; 26 HYDROXYL 20 PROTOPANAXADIOL; 7 OXO 20 PROTOPANAXATRIOL; 7BETA HYDROXYL 20 PROTOPANAXADIOL; PROTOPANAXADIOL; UNCLASSIFIED DRUG;

ABSIDIA; ARTICLE; CATALYSIS; CONTROLLED STUDY; CYTOTOXICITY; DEHYDROGENATION; DRUG POTENCY; DRUG TRANSFORMATION; HUMAN; HUMAN CELL; HYDROXYLATION; MALE; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROSTATE CANCER;

ABSIDIA; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; HUMANS; MALE; MOLECULAR STRUCTURE; PROSTATIC NEOPLASMS; SAPOGENINS;

EID: 84873393469     PISSN: 0367326X     EISSN: 18736971     Source Type: Journal    
DOI: 10.1016/j.fitote.2012.09.018     Document Type: Article

References (16)

1. W.H. Fu, E. Madan, M. Yee, and H.T. Zhang Progress of molecular targeted therapies for prostate cancers BBA-Rev. Cancer 1825 2012 140 152
2. S.J. Freedland, E.B. Humphreys, L.A. Mangold, M. Eisenberger, F.J. Dorey, and P.C. Walsh Risk of prostate cancer-specific mortality following biochemical recurrence after radical prostatectomy JAMA 294 2005 433 439
3. M.R. Cooperberg, A.J. Vickers, J.M. Broering, and P.R. Carroll Comparative risk adjusted mortality outcomes after primary surgery, radiotherapy, or androgen-deprivation therapy for localized prostate cancer Cancer 116 2010 5226 5234
4. A.J. Stephenson, M.W. Kattan, J.A. Eastham, Z.A. Dotan, F.J. Bianco, and H. Lilja Defining biochemical recurrence of prostate cancer after radical prostatectomy: a proposal for a standardized definition J. Clin. Oncol. 24 2006 3973 3978
5. J.S. Bono, S. Oudard, M. Ozguroglu, S. Hansen, J.P. Machiels, and I. Kocak Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial Lancet 376 2010 1147 1154
6. D.G. Popovich, and D.D. Kitts Structure-function relationship exists for ginsenosides in reducing cell proliferation and inducing apoptosis in the human leukemia (THP-1) cell line Arch. Biochem. Biophys. 406 2002 1 8
7. 1 and protopanaxatriol J. Pharmacol. Sci. 109 2009 504 510
8. H.X. Sun, Z.G. Yang, and Y.P. Ye Structure and biological activity of protopanaxatriol-type saponins from the roots of Panax notoginseng Int. Immunopharmacol. 6 2006 14 25
9. H.C. Ren, J.G. Sun, A.J.Y. Wang GJ, H.T. Xie, and W.B. Zha Sensitive determination of 20(S)-protopanaxadiol in rat plasma using HPLC-APCI-MS: application of pharmacokinetic study in rats J. Pharm. Biomed. Anal. 48 2008 1476 1480
10. D. Zhang, Y.W. Wang, J.B. Han, W.S. Yu, L.L. Deng, and J.P. Fawcett Rapid and sensitive LC-MS/MS assay for the quantitation of 20(S)-protopanaxadiol in human plasma J. Chromatogr. B 877 2009 581 585
11. D.G. Popovich, and D.D. Kitts Structure-function relationship exists for ginsenosides in reducing cell proliferation and including apoptosis in the human leukemia (THP-1) cell line Arch. Biochem. Biophys. 406 2002 1 8
12. A. Saklani, and S.K. Kutty Plant-derived compounds in clinical trials Drug Discov. Today 13 2008 161 171
13. J.F. Cui, P. Eneroth, J.G. Beuhn, S. Arihara, and K. Yoshikawa Alkaline cleavage of gypenosides and characterization of dammarane-type aglycons by gas chromatography-mass spectrometry Phytochem. Anal. 9 3 1998 128 133
14. T.M. Hung, D.M. Hoang, J.C. Kim, H.S. Jang, J.S. Ahn, and B.S. Min Protein tyrosine phosphatase 1B inhibitory by dammaranes from Vietnamese Giao-Co-Lam tea J. Ethnopharmacol. 124 2009 240 245
15. Y.Q. Zhao, C.F. Wu, R.W. Zhang, J.Y. Yang, W. Wang, and H. Zhang Preparation and application of two protopanaxadiol derivatives Faming Zhuangli Shenqing Gongkai Shuomingshu 2008 7
16. G.T. Chen, M. Yang, Z.Q. Lu, J.Q. Zhang, and H.L. Huang Microbial transformation of 20(S)-protopanaxadiol-type saponins by Absidia coerulea J. Nat. Prod. 70 2007 1203 1206