Interplay between drying and stability of a TIM barrel protein: A combined simulation-experimental study

Journal of the American Chemical Society

Volumn 135, Issue 5, 2013, Pages 1882-1890

  Das, Payel ^a   Kapoor, Divya ^b   Halloran, Kevin T ^b   Zhou, Ruhong ^a,c   Matthews, C Robert ^b  

^a IBM T J WATSON RESEARCH CENTER   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^c Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALIPHATIC AMINO ACIDS; DE-WETTING; DEWETTING TRANSITION; FOLDING DYNAMICS; HYDROPHOBIC AMINO ACIDS; INTERMEDIATE STATE; ISOSTERIC; MOLECULAR DYNAMICS SIMULATIONS; N-TERMINALS; NANO SCALE; PARTIAL DRYING; PROTEIN STABILITY; SECONDARY STRUCTURES; STRUCTURAL DISTORTIONS; TIM BARRELS; WATER DENSITY;

DRYING; HYDROPHOBICITY; MOLECULAR DYNAMICS; PROTEINS; STABILITY; STRUCTURE (COMPOSITION);

AMINO ACIDS;

AMINO ACID; ASPARAGINE; ISOLEUCINE; LEUCINE; PROTEIN; TIM BARREL PROTEIN; UNCLASSIFIED DRUG; VALINE;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; EXPERIMENTAL STUDY; HYDRATION; HYDROPHOBICITY; MUTATION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; PROTEIN STRUCTURE; SIMULATION;

MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MUTAGENESIS, SITE-DIRECTED; PROTEIN FOLDING; PROTEIN STABILITY; THERMODYNAMICS; TRIOSE-PHOSPHATE ISOMERASE;

EID: 84873367094     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja310544t     Document Type: Article

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