Structural Analysis of Kinetic Folding Intermediates for a TIM Barrel Protein, Indole-3-glycerol Phosphate Synthase, by Hydrogen Exchange Mass Spectrometry and Gō Model Simulation

Journal of Molecular Biology

Volumn 374, Issue 2, 2007, Pages 528-546

  Gu, Zhenyu ^a   Rao, Maithreyi K ^b   Forsyth, William R ^a   Finke, John M ^b   Matthews, C Robert ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b OAKLAND UNIVERSITY   (United States)

Author keywords

kinetic folding mechanism; misfolded intermediate; protein folding; stable intermediate; topology

Indexed keywords

INDOLE 3 GLYCEROL PHOSPHATE SYNTHASE; UREA;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; ENERGY; ENZYME KINETICS; FLUORESCENCE; MASS SPECTROMETRY; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN STRUCTURE; SIMULATION; STRUCTURE ANALYSIS; SULFOLOBUS SOLFATARICUS;

SULFOLOBUS SOLFATARICUS;

EID: 35548965931     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2007.09.024     Document Type: Article

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